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The map label for this gene is serA [H]

Identifier: 85059987

GI number: 85059987

Start: 3465531

End: 3466763

Strand: Reverse

Name: serA [H]

Synonym: SG2009

Alternate gene names: 85059987

Gene position: 3466763-3465531 (Counterclockwise)

Preceding gene: 85059988

Following gene: 85059984

Centisome position: 83.11

GC content: 54.83

Gene sequence:

>1233_bases
ATGGCAAAAGTATCGTTGGAAAAAGATAAGATTAAGTTTCTGCTGGTGGAAGGTGTTCACCCGTCGGCACTGGAGAACTT
GAAGCGCGCCGGTTACACCAATATTGAGTATCACAAAGGCGCATTGGATACCGAAACGCTGAAAAACGCGATCCGCGACG
CTCACTTTGTCGGCATCCGTTCCCGCACCCATCTAACGGAAGAGGTTTTCGCCGTGGCGGAAAAACTGGTGGCGGTAGGC
TGTTTTTGCATCGGCACCAACCAGGTCGATCTGCCGGCAGCGATGAAGCGAGGCGTTCCGGTATTCAATGCGCCTTTCTC
CAACACGCGCTCCGTGGCGGAAATGGTGCTGGGGGAGATGCTGCTCATGATGCGCGGTATCCCGGAAGCCAATGCCCGGG
CCCATCGCGGTCAATGGAACAAACAGGCGCAGGGCAGTTATGAAGCGCGCGGTAAAAAGCTCGGGATTGTGGGTTATGGC
CACATCGGCACCCAATTAAGTATTTTGGCGGAAAGCCTGGGTATGCAGGTGTTCTTCTACGATATCGAAAGCAAGCTGAC
GCTGGGTAATGCGCAACAGGTCTCCACGCTGGCCGAACTGCTGGCCATGAGTGATGTAGTAAGTCTGCATGTGCCGGATA
CGCTGTCGACGCGCAATATGATGGGGAAAACGGAACTCGCCCAAATGAAACCCGGTTCGTTGTTAATCAACGCCTCACGC
GGCACGGTTGTGGATATTCCTGCGCTGTGCGCGGCGATGGCCAGCAAACATCTGGCCGGGGCGGCGATAGACGTTTTCCC
GCAGGAGCCGGCCACCAACAGCGACCCCTTCACGTCGCCGCTGTGTGAATTCGATAACGTTATTCTGACGCCGCATATTG
GCGGCTCTACTCAGGAAGCCCAGGAGAATATCGGCATTGAAGTGGCCGGCAAACTGGTCAAATATTCCGATAACGGTTCT
ACCCTGTTGGCGGTGAATTTCCCCGAGGTGTCGCTGCCGGAGCATGGCGAACGCGTCAGCCGTTTGTTGCATATCCATGA
AAACCGTCCCGGCGTGTTAACCCGCATCAACCAGATTTTTGCCGAGCTGGGGATCAATATCGCCGCACAGTATCTGCAAA
CGACGCCAGAAATCGGTTATGTGGTCATTGATGTTGAAACCGCGGCGAAAGACACCGCTCTGCAATTGATGAAAGCGATT
TCGGGCACCATTCGTGCCCGTTTGCTTTACTGA

Upstream 100 bases:

>100_bases
GCCCCCGGCCCCATGCCGGTTGCCGGCCCGGTAAATTTTGTTATTTTGTCGGAGTGCTGCGCGTCGCAGCCGCATCGTGA
GTATCTTAAAGGGTCGGGAA

Downstream 100 bases:

>100_bases
TGGCTTAAAGCAATGCTCGGTGCGTGATGGCTATCACCGCCGCCGGCGAGTATAGGGAAACCCGGCGCATGCCTTGGCGC
CATTCCAGTTTGGGAAATAA

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MAKVSLEKDKIKFLLVEGVHPSALENLKRAGYTNIEYHKGALDTETLKNAIRDAHFVGIRSRTHLTEEVFAVAEKLVAVG
CFCIGTNQVDLPAAMKRGVPVFNAPFSNTRSVAEMVLGEMLLMMRGIPEANARAHRGQWNKQAQGSYEARGKKLGIVGYG
HIGTQLSILAESLGMQVFFYDIESKLTLGNAQQVSTLAELLAMSDVVSLHVPDTLSTRNMMGKTELAQMKPGSLLINASR
GTVVDIPALCAAMASKHLAGAAIDVFPQEPATNSDPFTSPLCEFDNVILTPHIGGSTQEAQENIGIEVAGKLVKYSDNGS
TLLAVNFPEVSLPEHGERVSRLLHIHENRPGVLTRINQIFAELGINIAAQYLQTTPEIGYVVIDVETAAKDTALQLMKAI
SGTIRARLLY

Sequences:

>Translated_410_residues
MAKVSLEKDKIKFLLVEGVHPSALENLKRAGYTNIEYHKGALDTETLKNAIRDAHFVGIRSRTHLTEEVFAVAEKLVAVG
CFCIGTNQVDLPAAMKRGVPVFNAPFSNTRSVAEMVLGEMLLMMRGIPEANARAHRGQWNKQAQGSYEARGKKLGIVGYG
HIGTQLSILAESLGMQVFFYDIESKLTLGNAQQVSTLAELLAMSDVVSLHVPDTLSTRNMMGKTELAQMKPGSLLINASR
GTVVDIPALCAAMASKHLAGAAIDVFPQEPATNSDPFTSPLCEFDNVILTPHIGGSTQEAQENIGIEVAGKLVKYSDNGS
TLLAVNFPEVSLPEHGERVSRLLHIHENRPGVLTRINQIFAELGINIAAQYLQTTPEIGYVVIDVETAAKDTALQLMKAI
SGTIRARLLY
>Mature_409_residues
AKVSLEKDKIKFLLVEGVHPSALENLKRAGYTNIEYHKGALDTETLKNAIRDAHFVGIRSRTHLTEEVFAVAEKLVAVGC
FCIGTNQVDLPAAMKRGVPVFNAPFSNTRSVAEMVLGEMLLMMRGIPEANARAHRGQWNKQAQGSYEARGKKLGIVGYGH
IGTQLSILAESLGMQVFFYDIESKLTLGNAQQVSTLAELLAMSDVVSLHVPDTLSTRNMMGKTELAQMKPGSLLINASRG
TVVDIPALCAAMASKHLAGAAIDVFPQEPATNSDPFTSPLCEFDNVILTPHIGGSTQEAQENIGIEVAGKLVKYSDNGST
LLAVNFPEVSLPEHGERVSRLLHIHENRPGVLTRINQIFAELGINIAAQYLQTTPEIGYVVIDVETAAKDTALQLMKAIS
GTIRARLLY

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=317, Percent_Identity=34.7003154574132, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI61743967, Length=260, Percent_Identity=30.7692307692308, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI145580578, Length=246, Percent_Identity=30.8943089430894, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI4557499, Length=246, Percent_Identity=30.8943089430894, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI4557497, Length=260, Percent_Identity=30, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI145580575, Length=249, Percent_Identity=31.7269076305221, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI6912396, Length=297, Percent_Identity=26.9360269360269, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI1789279, Length=412, Percent_Identity=79.6116504854369, Blast_Score=676, Evalue=0.0,
Organism=Escherichia coli, GI87082289, Length=237, Percent_Identity=32.0675105485232, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1787645, Length=232, Percent_Identity=28.8793103448276, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1788660, Length=253, Percent_Identity=26.8774703557312, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=322, Percent_Identity=31.9875776397516, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI25147481, Length=258, Percent_Identity=29.0697674418605, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6322116, Length=415, Percent_Identity=47.9518072289157, Blast_Score=384, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6320925, Length=415, Percent_Identity=48.433734939759, Blast_Score=383, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6324964, Length=240, Percent_Identity=30, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324055, Length=254, Percent_Identity=27.1653543307087, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324980, Length=220, Percent_Identity=28.6363636363636, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6321253, Length=165, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI19921140, Length=306, Percent_Identity=31.0457516339869, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI28574286, Length=263, Percent_Identity=29.277566539924, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24646446, Length=238, Percent_Identity=31.5126050420168, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24646448, Length=238, Percent_Identity=31.5126050420168, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24646452, Length=238, Percent_Identity=31.5126050420168, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24646450, Length=238, Percent_Identity=31.5126050420168, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI62472511, Length=238, Percent_Identity=31.5126050420168, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28571528, Length=298, Percent_Identity=27.5167785234899, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24585514, Length=249, Percent_Identity=24.8995983935743, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI28574282, Length=249, Percent_Identity=24.8995983935743, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI45551003, Length=249, Percent_Identity=24.8995983935743, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI45552429, Length=249, Percent_Identity=24.8995983935743, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI28574284, Length=249, Percent_Identity=24.8995983935743, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24585516, Length=250, Percent_Identity=26.4, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 44414; Mature: 44283

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKVSLEKDKIKFLLVEGVHPSALENLKRAGYTNIEYHKGALDTETLKNAIRDAHFVGIR
CCCCCCCCCCEEEEEEECCCHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHEEEEC
SRTHLTEEVFAVAEKLVAVGCFCIGTNQVDLPAAMKRGVPVFNAPFSNTRSVAEMVLGEM
CHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHCCCCEEECCCCCHHHHHHHHHHHH
LLMMRGIPEANARAHRGQWNKQAQGSYEARGKKLGIVGYGHIGTQLSILAESLGMQVFFY
HHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCCEEEEEEECCCHHHHHHHHHHHCCEEEEE
DIESKLTLGNAQQVSTLAELLAMSDVVSLHVPDTLSTRNMMGKTELAQMKPGSLLINASR
EECCEEECCCHHHHHHHHHHHHHHHHHEEECCCCCCHHHHCCCHHHHHCCCCCEEEECCC
GTVVDIPALCAAMASKHLAGAAIDVFPQEPATNSDPFTSPLCEFDNVILTPHIGGSTQEA
CCEEEHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCHHCCCCEEEECCCCCCCHHH
QENIGIEVAGKLVKYSDNGSTLLAVNFPEVSLPEHGERVSRLLHIHENRPGVLTRINQIF
HHCCCEEEEEEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHH
AELGINIAAQYLQTTPEIGYVVIDVETAAKDTALQLMKAISGTIRARLLY
HHHCHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHEEEECC
>Mature Secondary Structure 
AKVSLEKDKIKFLLVEGVHPSALENLKRAGYTNIEYHKGALDTETLKNAIRDAHFVGIR
CCCCCCCCCEEEEEEECCCHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHEEEEC
SRTHLTEEVFAVAEKLVAVGCFCIGTNQVDLPAAMKRGVPVFNAPFSNTRSVAEMVLGEM
CHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHCCCCEEECCCCCHHHHHHHHHHHH
LLMMRGIPEANARAHRGQWNKQAQGSYEARGKKLGIVGYGHIGTQLSILAESLGMQVFFY
HHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCCEEEEEEECCCHHHHHHHHHHHCCEEEEE
DIESKLTLGNAQQVSTLAELLAMSDVVSLHVPDTLSTRNMMGKTELAQMKPGSLLINASR
EECCEEECCCHHHHHHHHHHHHHHHHHEEECCCCCCHHHHCCCHHHHHCCCCCEEEECCC
GTVVDIPALCAAMASKHLAGAAIDVFPQEPATNSDPFTSPLCEFDNVILTPHIGGSTQEA
CCEEEHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCHHCCCCEEEECCCCCCCHHH
QENIGIEVAGKLVKYSDNGSTLLAVNFPEVSLPEHGERVSRLLHIHENRPGVLTRINQIF
HHCCCEEEEEEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHH
AELGINIAAQYLQTTPEIGYVVIDVETAAKDTALQLMKAISGTIRARLLY
HHHCHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]