Click here to switch to the map view.

The map label for this gene is lpxD

Identifier: 85059911

GI number: 85059911

Start: 3336479

End: 3337501

Strand: Reverse

Name: lpxD

Synonym: SG1933

Alternate gene names: 85059911

Gene position: 3337501-3336479 (Counterclockwise)

Preceding gene: 85059912

Following gene: 85059910

Centisome position: 80.01

GC content: 56.21

Gene sequence:

>1023_bases
ATGTCTTCAATTCGACTGGCTGATTTAGCACAGCAGTTGGATGCACAATTGCACGGTGATGGCGATATTGTCATCACCGG
CATTGCCTCCATGGGCAGCGCGCAAGCGGGCCAGATTACGTTTCTCTCGGACAGCCGCTTTCGTGAAAAACTCTCTTCCT
GTCAGGCGTCCGCGGTGGTGCTCACCGCCGACAGTCTGCCTTTCTTCACCGGCGCCGCGCTGGTGGTCAGAAACCCTTAC
CTGACTTACGCTCGTATGGCGCAGTTGATGGACATCACGCCAAAACCCGCCGAGGATATCGGCGCCGGGGCTGTCATTGC
GCCGGATGCAACCTTGGGACAGCGGGTGGCGGTGGGCGCTAACGCCGTGATCGAATCTGGCGTCGTGCTCGGGGATGACG
TGATAATCGGCCCTGGTTGTTTTGTCGGTAAAAATACCCGTATTGGCGCCGGCACGCGCTTATGGGCCAACGTCACCGTG
TATCACGATATTTCCATCGGCGAGCGTTGTCTGATTCAATCCGGCACCGTGATCGGTGCAGACGGTTTCGGCTATGCCAA
CGATCGCGGCAACTGGATCAAAATACCGCAGCTGGGCCGCGTTATCATTGGCGATCGGGTTGAAATCGGCGCTTGCACCA
CCATCGATCGCGGCGCGCTGGACGATACCCGCATCGGCAACGGCGTGATTATTGATAATCAGTGCCAGATTGCACATAAC
GTGGTTATTGGTGACAATACCGCGGTCGCCGGCGGTGTTATCATGGCGGGCAGCCTGACCATTGGCCGCTATTGCATGAT
TGGCGGCGCGAGCGTCATCAATGGTCATATGGCTATCTGCGATAAAGTCACGGTAACCGGCATGGGCATGGTAATGCGCC
CGATAACCGAACCCGGCGTTTACTCATCCGGGATCCCGCTGCAGCCGAATAAAGAGTGGCGGAAGACCGCCGCATTAGTC
ATGAATATCAGCGATATGAGCAAGCGGATGAAAGCTATCGAGCGAAAATTAGCAAAAAACTAA

Upstream 100 bases:

>100_bases
CAAAGAAGGCTATGACGTAGTGATCGATGCTAACTCCGTGGCTTATGCCACCAACGCTAAAGACATTACCGCTGACGTTC
TGAAGCAGGTTAAATAAGTC

Downstream 100 bases:

>100_bases
TCGCTCCCGCCCCTTATAGAGGATAACGCGCGTCACGGCACCGTTGCCCGGCGAGCCATTATTATATTCGCTGCCTGCTT
GTTTTGTCCTGCCGGGATTA

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MSSIRLADLAQQLDAQLHGDGDIVITGIASMGSAQAGQITFLSDSRFREKLSSCQASAVVLTADSLPFFTGAALVVRNPY
LTYARMAQLMDITPKPAEDIGAGAVIAPDATLGQRVAVGANAVIESGVVLGDDVIIGPGCFVGKNTRIGAGTRLWANVTV
YHDISIGERCLIQSGTVIGADGFGYANDRGNWIKIPQLGRVIIGDRVEIGACTTIDRGALDDTRIGNGVIIDNQCQIAHN
VVIGDNTAVAGGVIMAGSLTIGRYCMIGGASVINGHMAICDKVTVTGMGMVMRPITEPGVYSSGIPLQPNKEWRKTAALV
MNISDMSKRMKAIERKLAKN

Sequences:

>Translated_340_residues
MSSIRLADLAQQLDAQLHGDGDIVITGIASMGSAQAGQITFLSDSRFREKLSSCQASAVVLTADSLPFFTGAALVVRNPY
LTYARMAQLMDITPKPAEDIGAGAVIAPDATLGQRVAVGANAVIESGVVLGDDVIIGPGCFVGKNTRIGAGTRLWANVTV
YHDISIGERCLIQSGTVIGADGFGYANDRGNWIKIPQLGRVIIGDRVEIGACTTIDRGALDDTRIGNGVIIDNQCQIAHN
VVIGDNTAVAGGVIMAGSLTIGRYCMIGGASVINGHMAICDKVTVTGMGMVMRPITEPGVYSSGIPLQPNKEWRKTAALV
MNISDMSKRMKAIERKLAKN
>Mature_339_residues
SSIRLADLAQQLDAQLHGDGDIVITGIASMGSAQAGQITFLSDSRFREKLSSCQASAVVLTADSLPFFTGAALVVRNPYL
TYARMAQLMDITPKPAEDIGAGAVIAPDATLGQRVAVGANAVIESGVVLGDDVIIGPGCFVGKNTRIGAGTRLWANVTVY
HDISIGERCLIQSGTVIGADGFGYANDRGNWIKIPQLGRVIIGDRVEIGACTTIDRGALDDTRIGNGVIIDNQCQIAHNV
VIGDNTAVAGGVIMAGSLTIGRYCMIGGASVINGHMAICDKVTVTGMGMVMRPITEPGVYSSGIPLQPNKEWRKTAALVM
NISDMSKRMKAIERKLAKN

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=339, Percent_Identity=81.1209439528024, Blast_Score=573, Evalue=1e-165,
Organism=Escherichia coli, GI1786378, Length=195, Percent_Identity=29.2307692307692, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_SODGM (Q2NRL7)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_455613.1
- ProteinModelPortal:   Q2NRL7
- STRING:   Q2NRL7
- GeneID:   3867845
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG1933
- NMPDR:   fig|343509.6.peg.4187
- eggNOG:   COG1044
- HOGENOM:   HBG469615
- OMA:   CFVGKNT
- PhylomeDB:   Q2NRL7
- ProtClustDB:   PRK00892
- BioCyc:   SGLO343509:SG1933-MONOMER
- HAMAP:   MF_00523
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 35660; Mature: 35528

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSIRLADLAQQLDAQLHGDGDIVITGIASMGSAQAGQITFLSDSRFREKLSSCQASAVV
CCCCHHHHHHHHHHHEECCCCCEEEEEECCCCCCCCCEEEEECCHHHHHHHHCCCCEEEE
LTADSLPFFTGAALVVRNPYLTYARMAQLMDITPKPAEDIGAGAVIAPDATLGQRVAVGA
EEECCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCHHHHCCCEEECCCCCCCCEEECCC
NAVIESGVVLGDDVIIGPGCFVGKNTRIGAGTRLWANVTVYHDISIGERCLIQSGTVIGA
HHHHHCCEEECCCEEECCCEEECCCCCCCCCCEEEEEEEEEEECCCCCEEEEECCCEEEC
DGFGYANDRGNWIKIPQLGRVIIGDRVEIGACTTIDRGALDDTRIGNGVIIDNQCQIAHN
CCCCCCCCCCCEEECCCCCEEEECCCEEECEECCCCCCCCCCCCCCCEEEECCCCEEEEE
VVIGDNTAVAGGVIMAGSLTIGRYCMIGGASVINGHMAICDKVTVTGMGMVMRPITEPGV
EEECCCCEEECCEEEECCEEECCEEEECCCHHHCCCEEEECEEEEECCCEEEECCCCCCC
YSSGIPLQPNKEWRKTAALVMNISDMSKRMKAIERKLAKN
CCCCCCCCCCHHHHHHHHHEEEHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSIRLADLAQQLDAQLHGDGDIVITGIASMGSAQAGQITFLSDSRFREKLSSCQASAVV
CCCHHHHHHHHHHHEECCCCCEEEEEECCCCCCCCCEEEEECCHHHHHHHHCCCCEEEE
LTADSLPFFTGAALVVRNPYLTYARMAQLMDITPKPAEDIGAGAVIAPDATLGQRVAVGA
EEECCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCHHHHCCCEEECCCCCCCCEEECCC
NAVIESGVVLGDDVIIGPGCFVGKNTRIGAGTRLWANVTVYHDISIGERCLIQSGTVIGA
HHHHHCCEEECCCEEECCCEEECCCCCCCCCCEEEEEEEEEEECCCCCEEEEECCCEEEC
DGFGYANDRGNWIKIPQLGRVIIGDRVEIGACTTIDRGALDDTRIGNGVIIDNQCQIAHN
CCCCCCCCCCCEEECCCCCEEEECCCEEECEECCCCCCCCCCCCCCCEEEECCCCEEEEE
VVIGDNTAVAGGVIMAGSLTIGRYCMIGGASVINGHMAICDKVTVTGMGMVMRPITEPGV
EEECCCCEEECCEEEECCEEECCEEEECCCHHHCCCEEEECEEEEECCCEEEECCCCCCC
YSSGIPLQPNKEWRKTAALVMNISDMSKRMKAIERKLAKN
CCCCCCCCCCHHHHHHHHHEEEHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA