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The map label for this gene is uxuB [H]

Identifier: 85059815

GI number: 85059815

Start: 3120805

End: 3121572

Strand: Reverse

Name: uxuB [H]

Synonym: SG1837

Alternate gene names: 85059815

Gene position: 3121572-3120805 (Counterclockwise)

Preceding gene: 85059816

Following gene: 85059814

Centisome position: 74.84

GC content: 58.46

Gene sequence:

>768_bases
ATGGAAACAACTATCGCCACCGGTATGCTGAGCGTTGCCCGGCCCGCCTGGGATACCTCACGCCTGACGGCGCGGATGGT
GCATTTAGGCTGCGGCGCCTTTCATCGCGCCCATCAAGCGCTGTTCACCCATCATCTGCTGGAAACGACGACATCGGACT
GGGGGTATTGCGAAGTCAATCTGATGCCCGGCAACGATCGGCTTTTGATTGATGCCCTGCGCAAACAACACTTTCTCTAC
ACTGTCGCGGAAAAGGGCGCCGAGGCCACCGAACTGAAGATTATCGGTTCAATGAAAGAAGCACTGCATCCCGAGCTGGA
TGGTTGTCGCGCCACTCTGGAAGCCATGGTCCACCCGGAAACGGCCATCGTATCGCTGACCGTGACCGAAAAAGGGTATT
GCGCCGAAGCGGCCAGCGGTGAACTCGATCTGACAAATCCACTGATTAAGCATGACTTGGCCACGCCAGATCAACCACGT
TCCGCCATCGGCTATATCGTTGAAGCGCTGCGCATGCGTCGGCAACGGGGCCTACCGCCCTTTACCGTGATGTCCTGCGA
CAATCTGCGCGAAAATGGCCATGTGGCGCGGGTAGCCGTTCTGGGACTTGCCTGGGCGCGCGACGCCGGCCTCGCCGACT
GGATAGCGAATAAGGTGACTTTTCCCTGCACGATGGTTGACTGCATTGTTCCCGCCGCGACCCCGGAAGTGTTAGACGAG
ATTGCCGGCAGCCTCGGGATTTACGATCCCTGCTTCATCGCCTGCTAA

Upstream 100 bases:

>100_bases
CTGAACCGCTTTGGCACGGTAGATCCGTGCCGTTTGCTAAAAATCCCTTCGGCTTATCGTCCGGTCATTTTGCCGGCGGG
CCTAGGGGCAGGAGGCTTTC

Downstream 100 bases:

>100_bases
CCTTTCCGCCAGTGGGTAATCGAAGATAACTTCGTCAACGGCTGCCCCGATTGGGACCGCGTCGGCGCACAGTTTGTGGA
TGATGTGGTTCCCTTTGAAA

Product: putative mannonate oxidoreductase

Products: NA

Alternate protein names: Fructuronate reductase [H]

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
METTIATGMLSVARPAWDTSRLTARMVHLGCGAFHRAHQALFTHHLLETTTSDWGYCEVNLMPGNDRLLIDALRKQHFLY
TVAEKGAEATELKIIGSMKEALHPELDGCRATLEAMVHPETAIVSLTVTEKGYCAEAASGELDLTNPLIKHDLATPDQPR
SAIGYIVEALRMRRQRGLPPFTVMSCDNLRENGHVARVAVLGLAWARDAGLADWIANKVTFPCTMVDCIVPAATPEVLDE
IAGSLGIYDPCFIAC

Sequences:

>Translated_255_residues
METTIATGMLSVARPAWDTSRLTARMVHLGCGAFHRAHQALFTHHLLETTTSDWGYCEVNLMPGNDRLLIDALRKQHFLY
TVAEKGAEATELKIIGSMKEALHPELDGCRATLEAMVHPETAIVSLTVTEKGYCAEAASGELDLTNPLIKHDLATPDQPR
SAIGYIVEALRMRRQRGLPPFTVMSCDNLRENGHVARVAVLGLAWARDAGLADWIANKVTFPCTMVDCIVPAATPEVLDE
IAGSLGIYDPCFIAC
>Mature_255_residues
METTIATGMLSVARPAWDTSRLTARMVHLGCGAFHRAHQALFTHHLLETTTSDWGYCEVNLMPGNDRLLIDALRKQHFLY
TVAEKGAEATELKIIGSMKEALHPELDGCRATLEAMVHPETAIVSLTVTEKGYCAEAASGELDLTNPLIKHDLATPDQPR
SAIGYIVEALRMRRQRGLPPFTVMSCDNLRENGHVARVAVLGLAWARDAGLADWIANKVTFPCTMVDCIVPAATPEVLDE
IAGSLGIYDPCFIAC

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family. UxuB subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790779, Length=253, Percent_Identity=77.0750988142292, Blast_Score=411, Evalue=1e-116,
Organism=Escherichia coli, GI1788497, Length=255, Percent_Identity=52.9411764705882, Blast_Score=267, Evalue=4e-73,
Organism=Escherichia coli, GI1787823, Length=241, Percent_Identity=50.207468879668, Blast_Score=238, Evalue=4e-64,
Organism=Saccharomyces cerevisiae, GI6324401, Length=239, Percent_Identity=41.4225941422594, Blast_Score=180, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6320765, Length=239, Percent_Identity=41.4225941422594, Blast_Score=180, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.57 [H]

Molecular weight: Translated: 27825; Mature: 27825

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METTIATGMLSVARPAWDTSRLTARMVHLGCGAFHRAHQALFTHHLLETTTSDWGYCEVN
CCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
LMPGNDRLLIDALRKQHFLYTVAEKGAEATELKIIGSMKEALHPELDGCRATLEAMVHPE
EECCCCCHHHHHHHHHHHEEEHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
TAIVSLTVTEKGYCAEAASGELDLTNPLIKHDLATPDQPRSAIGYIVEALRMRRQRGLPP
EEEEEEEEECCCCCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
FTVMSCDNLRENGHVARVAVLGLAWARDAGLADWIANKVTFPCTMVDCIVPAATPEVLDE
EEEEECCCCCCCCCEEHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHCCCCCHHHHHH
IAGSLGIYDPCFIAC
HHHHCCCCCCCEECC
>Mature Secondary Structure
METTIATGMLSVARPAWDTSRLTARMVHLGCGAFHRAHQALFTHHLLETTTSDWGYCEVN
CCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
LMPGNDRLLIDALRKQHFLYTVAEKGAEATELKIIGSMKEALHPELDGCRATLEAMVHPE
EECCCCCHHHHHHHHHHHEEEHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
TAIVSLTVTEKGYCAEAASGELDLTNPLIKHDLATPDQPRSAIGYIVEALRMRRQRGLPP
EEEEEEEEECCCCCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
FTVMSCDNLRENGHVARVAVLGLAWARDAGLADWIANKVTFPCTMVDCIVPAATPEVLDE
EEEEECCCCCCCCCEEHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHCCCCCHHHHHH
IAGSLGIYDPCFIAC
HHHHCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503 [H]