Click here to switch to the map view.

The map label for this gene is rnc

Identifier: 85059765

GI number: 85059765

Start: 3051636

End: 3052316

Strand: Reverse

Name: rnc

Synonym: SG1787

Alternate gene names: 85059765

Gene position: 3052316-3051636 (Counterclockwise)

Preceding gene: 85059766

Following gene: 85059764

Centisome position: 73.18

GC content: 54.63

Gene sequence:

>681_bases
ATGAATCCCATCTTAACAAATAGGCTCCAGAAGAAACTGGGCTACACTTTTCAACAGCACGATCTATTGTTACAGGCGTT
AACGCACCGCAGCGCTAGTAGCAAACATAATGAGCGGCTGGAATTTTTGGGCGATTCTATACTGAGCTATGTTATCGCCA
ACGCGCTTTATCAGCGTTTCCCCCGCGTTGACGAGGGCGACATGAGCCGGATGCGCGCGACGCTGGTCCGCGGCAATACG
CTTGCGGAAATGGCGCGTGAGTTTGAGCTGGGCGAATGTTTACGTCTGGGGCCGGGAGAGCTAAAAAGCGGCGGTTTTCG
CCGTGAATCGATTTTAGCCGACACCGTGGAAGCGTTAATCGGCGGCGTATTCCTGGACAGCGATATCCGAACCGTCGAAA
AGTTGATTCTTGACTGGTACCGCTCCCGTCTGGATGAAATCAGCCCCGGCGATAAACAAAAAGACCCGAAAACCCGATTG
CAGGAATATCTCCAGGGACGCCATTTGCCGCTGCCAACTTACCAGGTGGTGCAGGTGCGTGGTGAGGCGCACGATCAGGA
GTTTACTATACATTGCCAGGTCAGCGGGCTGGCGCAGCCGGTGGTCGGTAATGGCTCAAGCCGTCGTAAAGCCGAGCAGG
CCGCGGCGGAGCAGGCACTCAAATTGTTGGAGCTTGAATGA

Upstream 100 bases:

>100_bases
GGAGCCACTGCAAACGAAACAGTTTTGGACAGGCGTGCTGATCCCAGACCTGTTCCGTCTGCTGCGGTTTTTTTACGCAT
GGTTGAGTTATTTGTAACGC

Downstream 100 bases:

>100_bases
GCGAACAGACGACCTATTGTGGGTTTGTGGCGATAGTGGGCCGGCCGAACGTCGGTAAATCCACGCTGCTGAATCAGTTT
TTAGGGCAGAAGGTCTCTAT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MNPILTNRLQKKLGYTFQQHDLLLQALTHRSASSKHNERLEFLGDSILSYVIANALYQRFPRVDEGDMSRMRATLVRGNT
LAEMAREFELGECLRLGPGELKSGGFRRESILADTVEALIGGVFLDSDIRTVEKLILDWYRSRLDEISPGDKQKDPKTRL
QEYLQGRHLPLPTYQVVQVRGEAHDQEFTIHCQVSGLAQPVVGNGSSRRKAEQAAAEQALKLLELE

Sequences:

>Translated_226_residues
MNPILTNRLQKKLGYTFQQHDLLLQALTHRSASSKHNERLEFLGDSILSYVIANALYQRFPRVDEGDMSRMRATLVRGNT
LAEMAREFELGECLRLGPGELKSGGFRRESILADTVEALIGGVFLDSDIRTVEKLILDWYRSRLDEISPGDKQKDPKTRL
QEYLQGRHLPLPTYQVVQVRGEAHDQEFTIHCQVSGLAQPVVGNGSSRRKAEQAAAEQALKLLELE
>Mature_226_residues
MNPILTNRLQKKLGYTFQQHDLLLQALTHRSASSKHNERLEFLGDSILSYVIANALYQRFPRVDEGDMSRMRATLVRGNT
LAEMAREFELGECLRLGPGELKSGGFRRESILADTVEALIGGVFLDSDIRTVEKLILDWYRSRLDEISPGDKQKDPKTRL
QEYLQGRHLPLPTYQVVQVRGEAHDQEFTIHCQVSGLAQPVVGNGSSRRKAEQAAAEQALKLLELE

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=223, Percent_Identity=29.5964125560538, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI155030236, Length=223, Percent_Identity=29.5964125560538, Blast_Score=96, Evalue=3e-20,
Organism=Escherichia coli, GI1788920, Length=226, Percent_Identity=91.5929203539823, Blast_Score=409, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17506883, Length=237, Percent_Identity=30.379746835443, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI193202651, Length=227, Percent_Identity=30.8370044052863, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6323895, Length=112, Percent_Identity=34.8214285714286, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17137682, Length=229, Percent_Identity=28.3842794759825, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 25558; Mature: 25558

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPILTNRLQKKLGYTFQQHDLLLQALTHRSASSKHNERLEFLGDSILSYVIANALYQRF
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
PRVDEGDMSRMRATLVRGNTLAEMAREFELGECLRLGPGELKSGGFRRESILADTVEALI
CCCCCCHHHHHHHHHHCCHHHHHHHHHHCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
GGVFLDSDIRTVEKLILDWYRSRLDEISPGDKQKDPKTRLQEYLQGRHLPLPTYQVVQVR
HHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHEEC
GEAHDQEFTIHCQVSGLAQPVVGNGSSRRKAEQAAAEQALKLLELE
CCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNPILTNRLQKKLGYTFQQHDLLLQALTHRSASSKHNERLEFLGDSILSYVIANALYQRF
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
PRVDEGDMSRMRATLVRGNTLAEMAREFELGECLRLGPGELKSGGFRRESILADTVEALI
CCCCCCHHHHHHHHHHCCHHHHHHHHHHCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
GGVFLDSDIRTVEKLILDWYRSRLDEISPGDKQKDPKTRLQEYLQGRHLPLPTYQVVQVR
HHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHEEC
GEAHDQEFTIHCQVSGLAQPVVGNGSSRRKAEQAAAEQALKLLELE
CCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA