Click here to switch to the map view.

The map label for this gene is pepB [H]

Identifier: 85059746

GI number: 85059746

Start: 3022227

End: 3023522

Strand: Reverse

Name: pepB [H]

Synonym: SG1768

Alternate gene names: 85059746

Gene position: 3023522-3022227 (Counterclockwise)

Preceding gene: 85059747

Following gene: 85059745

Centisome position: 72.49

GC content: 59.88

Gene sequence:

>1296_bases
ATGACCGAAGCGATGCATCTCACGCTATCTACCGCACCCGCCGACCCGCGCTGGGGTGAAAAAGCGTTATTGAGCGCCGA
TGAGCGCGGAATGACCATCCATTTGACGGGCGATGATGCGCTAAGCGACATTCAGCGCGCGGGGCGCAAAATCGACGGGC
AAGGGATAAAGCAGATTGCGTTGGTGGGAGATGCGTGGGATCTGGCGCGCTGCTGGGCATTCTGGCAAGGCTATCGGTCC
CCCAAAGGCGAGCGCCAGGTGACTTGGCCGACGCTGCCCGAAACGGCGCGCAATGAGCTGGACGACCGACTGCAAATCAT
TGACTGGGTGCGTCATACAATCAATACGCCGGCGGAAGAGCTGGGTCCGGAACAACTGGCGCAGCGCGCGGTGGACATCA
TGTCTGCCGTGGCTGACGATGCCATCAGCTATCGCATCATGAAAGCCGACGATCTGTTTGATAACCAGTATACGGGGCTG
CATACCGTCGGCCGCGGTTCCGATCGCCAACCGGTGTTGTTGACGCTGGACTACAATCCTGGTGGCGATGCGGAGACGCC
GGTGCTGGCGTGTCTGGTGGGGAAAGGAATCACCTTCGATACCGGCGGTTACAGCCTGAAAGGCAGCAGCTCCATGGATT
CCATGAAGTCTGATATGGGCGGTGCCGCCACGCTGACGGGTGCGCTGGCGCTGGCCATCAGCCGCGGCCTGAACAAACGG
GTACGGCTGATTTTGTGCTGTGCCGACAATATGGTGAGCGGCAATGCCTTCAAATTGGGCGATATCATCCGTTATCGCAA
CGGCAAATCGGTCGAAGTAATGAACACCGACGCTGAAGGCCGCCTGGTATTGGCGGACGGACTTATTGACGCCAGTGCGG
CCAAACCGCAGCTGATTATTGACTGCGCCACCCTGACCGGCGCCGCAAAAACCGCGTTGGGCAATGATTATCATGCGTTG
TTCAGCTTCGATGACGCTCTGGTGGCGGCGCTGATGCAAAGCGCCAATGAAGAGAATGAACCTTTCTGGCGTCTGCCGCT
GGCGGAGTTCCACCGTCAGCATCTGCCGTCCAATTTCGCCGACATGAGCAATTTAGCGGGCAGCGCGCACAGCGTAGGCG
CCAGCACCGCCGCGGCGTTCTTATCTCATTTCGTGGAAAATTATCGTCAGGGCTGGCTGCATATCGACTGCTCCGCCACC
TACCGTAAAGGCGCGGTGGATCAGTGGTCCGCCGGCGCGACCGGGCTGGGCGTACGCACGCTGGCCAATCTGCTGCTGGC
CCAGGCGCAGGACTGA

Upstream 100 bases:

>100_bases
GATGAGCGCAATAGCAGGTGGTCACGAACCGCGATGACACCCTACTGTACCGGATATGTACAGACGGCATTACTACCCTA
ATTATTGGAGCAGTCTCATG

Downstream 100 bases:

>100_bases
TGCCCATGCACGTCGATGCGACTGTCGCCTGGATGCCCGTAACAGCCCGCGCGCGGGTCGACCAACCGTTTGACATGACG
GCCGCTCAGGCGGCGACTGG

Product: aminopeptidase B

Products: NA

Alternate protein names: Aminopeptidase B [H]

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MTEAMHLTLSTAPADPRWGEKALLSADERGMTIHLTGDDALSDIQRAGRKIDGQGIKQIALVGDAWDLARCWAFWQGYRS
PKGERQVTWPTLPETARNELDDRLQIIDWVRHTINTPAEELGPEQLAQRAVDIMSAVADDAISYRIMKADDLFDNQYTGL
HTVGRGSDRQPVLLTLDYNPGGDAETPVLACLVGKGITFDTGGYSLKGSSSMDSMKSDMGGAATLTGALALAISRGLNKR
VRLILCCADNMVSGNAFKLGDIIRYRNGKSVEVMNTDAEGRLVLADGLIDASAAKPQLIIDCATLTGAAKTALGNDYHAL
FSFDDALVAALMQSANEENEPFWRLPLAEFHRQHLPSNFADMSNLAGSAHSVGASTAAAFLSHFVENYRQGWLHIDCSAT
YRKGAVDQWSAGATGLGVRTLANLLLAQAQD

Sequences:

>Translated_431_residues
MTEAMHLTLSTAPADPRWGEKALLSADERGMTIHLTGDDALSDIQRAGRKIDGQGIKQIALVGDAWDLARCWAFWQGYRS
PKGERQVTWPTLPETARNELDDRLQIIDWVRHTINTPAEELGPEQLAQRAVDIMSAVADDAISYRIMKADDLFDNQYTGL
HTVGRGSDRQPVLLTLDYNPGGDAETPVLACLVGKGITFDTGGYSLKGSSSMDSMKSDMGGAATLTGALALAISRGLNKR
VRLILCCADNMVSGNAFKLGDIIRYRNGKSVEVMNTDAEGRLVLADGLIDASAAKPQLIIDCATLTGAAKTALGNDYHAL
FSFDDALVAALMQSANEENEPFWRLPLAEFHRQHLPSNFADMSNLAGSAHSVGASTAAAFLSHFVENYRQGWLHIDCSAT
YRKGAVDQWSAGATGLGVRTLANLLLAQAQD
>Mature_430_residues
TEAMHLTLSTAPADPRWGEKALLSADERGMTIHLTGDDALSDIQRAGRKIDGQGIKQIALVGDAWDLARCWAFWQGYRSP
KGERQVTWPTLPETARNELDDRLQIIDWVRHTINTPAEELGPEQLAQRAVDIMSAVADDAISYRIMKADDLFDNQYTGLH
TVGRGSDRQPVLLTLDYNPGGDAETPVLACLVGKGITFDTGGYSLKGSSSMDSMKSDMGGAATLTGALALAISRGLNKRV
RLILCCADNMVSGNAFKLGDIIRYRNGKSVEVMNTDAEGRLVLADGLIDASAAKPQLIIDCATLTGAAKTALGNDYHALF
SFDDALVAALMQSANEENEPFWRLPLAEFHRQHLPSNFADMSNLAGSAHSVGASTAAAFLSHFVENYRQGWLHIDCSATY
RKGAVDQWSAGATGLGVRTLANLLLAQAQD

Specific function: Probably plays an important role in intracellular peptide degradation [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=325, Percent_Identity=39.0769230769231, Blast_Score=198, Evalue=7e-51,
Organism=Homo sapiens, GI47155554, Length=323, Percent_Identity=33.1269349845201, Blast_Score=147, Evalue=2e-35,
Organism=Escherichia coli, GI87082123, Length=427, Percent_Identity=74.2388758782201, Blast_Score=666, Evalue=0.0,
Organism=Escherichia coli, GI1790710, Length=319, Percent_Identity=36.9905956112853, Blast_Score=182, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17556903, Length=308, Percent_Identity=33.1168831168831, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17565172, Length=199, Percent_Identity=31.6582914572864, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI221379063, Length=333, Percent_Identity=31.8318318318318, Blast_Score=161, Evalue=7e-40,
Organism=Drosophila melanogaster, GI221379062, Length=333, Percent_Identity=31.8318318318318, Blast_Score=161, Evalue=7e-40,
Organism=Drosophila melanogaster, GI21357381, Length=333, Percent_Identity=31.8318318318318, Blast_Score=161, Evalue=9e-40,
Organism=Drosophila melanogaster, GI21355725, Length=319, Percent_Identity=28.8401253918495, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24661038, Length=368, Percent_Identity=26.9021739130435, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24662227, Length=326, Percent_Identity=30.6748466257669, Blast_Score=125, Evalue=8e-29,
Organism=Drosophila melanogaster, GI161077148, Length=294, Percent_Identity=31.2925170068027, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI20130057, Length=294, Percent_Identity=31.2925170068027, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI20129969, Length=325, Percent_Identity=28.9230769230769, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI20129963, Length=289, Percent_Identity=30.1038062283737, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI21355645, Length=324, Percent_Identity=27.1604938271605, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24662223, Length=324, Percent_Identity=27.1604938271605, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI19922386, Length=292, Percent_Identity=28.0821917808219, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24646701, Length=206, Percent_Identity=27.6699029126214, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24646703, Length=206, Percent_Identity=27.6699029126214, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21358201, Length=206, Percent_Identity=27.6699029126214, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008330
- InterPro:   IPR011356
- InterPro:   IPR000819 [H]

Pfam domain/function: PF00883 Peptidase_M17 [H]

EC number: =3.4.11.23 [H]

Molecular weight: Translated: 46525; Mature: 46394

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEAMHLTLSTAPADPRWGEKALLSADERGMTIHLTGDDALSDIQRAGRKIDGQGIKQIA
CCCEEEEEEECCCCCCCCCCHHHHCCCCCCEEEEEECCHHHHHHHHHCCCCCCCCCEEEE
LVGDAWDLARCWAFWQGYRSPKGERQVTWPTLPETARNELDDRLQIIDWVRHTINTPAEE
EECCCHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHH
LGPEQLAQRAVDIMSAVADDAISYRIMKADDLFDNQYTGLHTVGRGSDRQPVLLTLDYNP
CCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCEEECCCCCCCCEEEEEECCC
GGDAETPVLACLVGKGITFDTGGYSLKGSSSMDSMKSDMGGAATLTGALALAISRGLNKR
CCCCCCCEEHHHHCCCCEECCCCCEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCE
VRLILCCADNMVSGNAFKLGDIIRYRNGKSVEVMNTDAEGRLVLADGLIDASAAKPQLII
EEEEEEECCCCCCCCCEEHHHHHEECCCCEEEEEECCCCCEEEEECCCCCCCCCCCEEEE
DCATLTGAAKTALGNDYHALFSFDDALVAALMQSANEENEPFWRLPLAEFHRQHLPSNFA
EEEHHCCHHHHHCCCCEEEEEECCHHHHHHHHHHCCCCCCCEEECCHHHHHHHHCCCHHH
DMSNLAGSAHSVGASTAAAFLSHFVENYRQGWLHIDCSATYRKGAVDQWSAGATGLGVRT
HHHHHCCCCHHCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCHHHH
LANLLLAQAQD
HHHHHHHHCCC
>Mature Secondary Structure 
TEAMHLTLSTAPADPRWGEKALLSADERGMTIHLTGDDALSDIQRAGRKIDGQGIKQIA
CCEEEEEEECCCCCCCCCCHHHHCCCCCCEEEEEECCHHHHHHHHHCCCCCCCCCEEEE
LVGDAWDLARCWAFWQGYRSPKGERQVTWPTLPETARNELDDRLQIIDWVRHTINTPAEE
EECCCHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHH
LGPEQLAQRAVDIMSAVADDAISYRIMKADDLFDNQYTGLHTVGRGSDRQPVLLTLDYNP
CCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCEEECCCCCCCCEEEEEECCC
GGDAETPVLACLVGKGITFDTGGYSLKGSSSMDSMKSDMGGAATLTGALALAISRGLNKR
CCCCCCCEEHHHHCCCCEECCCCCEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCE
VRLILCCADNMVSGNAFKLGDIIRYRNGKSVEVMNTDAEGRLVLADGLIDASAAKPQLII
EEEEEEECCCCCCCCCEEHHHHHEECCCCEEEEEECCCCCEEEEECCCCCCCCCCCEEEE
DCATLTGAAKTALGNDYHALFSFDDALVAALMQSANEENEPFWRLPLAEFHRQHLPSNFA
EEEHHCCHHHHHCCCCEEEEEECCHHHHHHHHHHCCCCCCCEEECCHHHHHHHHCCCHHH
DMSNLAGSAHSVGASTAAAFLSHFVENYRQGWLHIDCSATYRKGAVDQWSAGATGLGVRT
HHHHHCCCCHHCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCHHHH
LANLLLAQAQD
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA