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The map label for this gene is dapA

Identifier: 85059704

GI number: 85059704

Start: 2940620

End: 2941498

Strand: Reverse

Name: dapA

Synonym: SG1726

Alternate gene names: 85059704

Gene position: 2941498-2940620 (Counterclockwise)

Preceding gene: 85059708

Following gene: 85059703

Centisome position: 70.52

GC content: 57.22

Gene sequence:

>879_bases
ATGTTTACGGGAAGCATAGTTGCACTGGTTACTCCGATGGACGAAAAGGGCGCCATCGACCGGGTCAGTCTGAAAAAATT
AATCGATTATCATGTCGCCAGCGGTACCGCAGCGATCGTGGCCGTGGGAACGACCGGTGAAACGTCTACCCTGAGCCACG
AAGAGCATGGTGATGTGGTGATGTGGACCCTTGAGCTCAGCGACGGGCGCGTTCCCGTTATCGCGGGCACCGGTGCCAAT
TCTACCTCCGAGGCCGTGTCGCTGACCCGCCGCTTTAACGACAGCGGAGTGGTGGGATGCCTCAGCGTTACGCCGTATTA
CAATCGGCCGAGTCAGGAAGGGTTGTTTCAGCATTTCAGGGCCATCGCCGAAAGAAGCGATTTGCCGCAAATTCTGTACA
ATGTGCCGGCGCGCACCGGCTGCGATATGCTGCCGCCTACCGTTGCCCGTCTGGCGGAAATCAAAAATATTATCGGTATT
AAGGAAGCAACGGGGAACTTAAGCCGTGTCAGCCAGATCCAAGAGCTGGTCAATGACGATTTCCTGCTGCTGAGCGGCGA
CGACGCCAGCGCATTGGACTTCATACAACTGGGCGGCAAAGGGGTGATTTCCGTGACGGCGAACGTTGCCGCGAAGGAGA
TGGCGCAGCTTTGTGCCCTTGCGGCCGACGGCAATTATGCCGATGCGCGCCGTCTTAATCAGCGCTTGATGCCGCTGCAT
CAGAAACTCTTTTTTGAACCCAGCCCCATACCGGTTAAATGGGCTTGTAAAGCATTGGGATTAATGGCGACCGACACCCT
GCGCCTGCCGATGACGCCCCTGACCCGGGCGGGCAGCCGCGTGGTAAGACAGGCGTTAACGGATGCGGGTTTGCTGTAA

Upstream 100 bases:

>100_bases
AAAAAAAACCTGCTGCCAAGGGCTTACCGGGCCGATGTTTGCTTGCTTTTGGATAGGTGACAAAAGTACCATGAATAACC
TGTTTGTGGAGAGATGGTCA

Downstream 100 bases:

>100_bases
CTCTTAGGGAGATTTAATGGCTTATTCAATGCAAAAGTCGCAGGTAGCGAAAGTGGTCGGCGTCTCGCTTATCATGCTGC
TCTCGGCCTGTACCAGCGAT

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MFTGSIVALVTPMDEKGAIDRVSLKKLIDYHVASGTAAIVAVGTTGETSTLSHEEHGDVVMWTLELSDGRVPVIAGTGAN
STSEAVSLTRRFNDSGVVGCLSVTPYYNRPSQEGLFQHFRAIAERSDLPQILYNVPARTGCDMLPPTVARLAEIKNIIGI
KEATGNLSRVSQIQELVNDDFLLLSGDDASALDFIQLGGKGVISVTANVAAKEMAQLCALAADGNYADARRLNQRLMPLH
QKLFFEPSPIPVKWACKALGLMATDTLRLPMTPLTRAGSRVVRQALTDAGLL

Sequences:

>Translated_292_residues
MFTGSIVALVTPMDEKGAIDRVSLKKLIDYHVASGTAAIVAVGTTGETSTLSHEEHGDVVMWTLELSDGRVPVIAGTGAN
STSEAVSLTRRFNDSGVVGCLSVTPYYNRPSQEGLFQHFRAIAERSDLPQILYNVPARTGCDMLPPTVARLAEIKNIIGI
KEATGNLSRVSQIQELVNDDFLLLSGDDASALDFIQLGGKGVISVTANVAAKEMAQLCALAADGNYADARRLNQRLMPLH
QKLFFEPSPIPVKWACKALGLMATDTLRLPMTPLTRAGSRVVRQALTDAGLL
>Mature_292_residues
MFTGSIVALVTPMDEKGAIDRVSLKKLIDYHVASGTAAIVAVGTTGETSTLSHEEHGDVVMWTLELSDGRVPVIAGTGAN
STSEAVSLTRRFNDSGVVGCLSVTPYYNRPSQEGLFQHFRAIAERSDLPQILYNVPARTGCDMLPPTVARLAEIKNIIGI
KEATGNLSRVSQIQELVNDDFLLLSGDDASALDFIQLGGKGVISVTANVAAKEMAQLCALAADGNYADARRLNQRLMPLH
QKLFFEPSPIPVKWACKALGLMATDTLRLPMTPLTRAGSRVVRQALTDAGLL

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=232, Percent_Identity=28.8793103448276, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI13540533, Length=252, Percent_Identity=26.5873015873016, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1788823, Length=292, Percent_Identity=78.4246575342466, Blast_Score=496, Evalue=1e-142,
Organism=Escherichia coli, GI87082415, Length=296, Percent_Identity=29.7297297297297, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1786463, Length=245, Percent_Identity=31.8367346938775, Blast_Score=127, Evalue=9e-31,
Organism=Escherichia coli, GI1789620, Length=231, Percent_Identity=28.1385281385281, Blast_Score=104, Evalue=6e-24,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_SODGM (Q2NS74)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_455406.1
- HSSP:   Q9X1K9
- ProteinModelPortal:   Q2NS74
- SMR:   Q2NS74
- STRING:   Q2NS74
- GeneID:   3866865
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG1726
- NMPDR:   fig|343509.6.peg.3659
- eggNOG:   COG0329
- HOGENOM:   HBG358848
- OMA:   GMYRHFK
- PhylomeDB:   Q2NS74
- ProtClustDB:   PRK03170
- BioCyc:   SGLO343509:SG1726-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 31261; Mature: 31261

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 161-161 BINDING 106-106

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTGSIVALVTPMDEKGAIDRVSLKKLIDYHVASGTAAIVAVGTTGETSTLSHEEHGDVV
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCEE
MWTLELSDGRVPVIAGTGANSTSEAVSLTRRFNDSGVVGCLSVTPYYNRPSQEGLFQHFR
EEEEEECCCCEEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHH
AIAERSDLPQILYNVPARTGCDMLPPTVARLAEIKNIIGIKEATGNLSRVSQIQELVNDD
HHHHHCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCHHHCCCCHHHHHHHHHHHCCC
FLLLSGDDASALDFIQLGGKGVISVTANVAAKEMAQLCALAADGNYADARRLNQRLMPLH
EEEEECCCCCHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
QKLFFEPSPIPVKWACKALGLMATDTLRLPMTPLTRAGSRVVRQALTDAGLL
HHHCCCCCCCCHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFTGSIVALVTPMDEKGAIDRVSLKKLIDYHVASGTAAIVAVGTTGETSTLSHEEHGDVV
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCEE
MWTLELSDGRVPVIAGTGANSTSEAVSLTRRFNDSGVVGCLSVTPYYNRPSQEGLFQHFR
EEEEEECCCCEEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHH
AIAERSDLPQILYNVPARTGCDMLPPTVARLAEIKNIIGIKEATGNLSRVSQIQELVNDD
HHHHHCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCHHHCCCCHHHHHHHHHHHCCC
FLLLSGDDASALDFIQLGGKGVISVTANVAAKEMAQLCALAADGNYADARRLNQRLMPLH
EEEEECCCCCHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
QKLFFEPSPIPVKWACKALGLMATDTLRLPMTPLTRAGSRVVRQALTDAGLL
HHHCCCCCCCCHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA