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The map label for this gene is ccmA

Identifier: 85059615

GI number: 85059615

Start: 2796575

End: 2797210

Strand: Reverse

Name: ccmA

Synonym: SG1637

Alternate gene names: 85059615

Gene position: 2797210-2796575 (Counterclockwise)

Preceding gene: 85059619

Following gene: 85059614

Centisome position: 67.06

GC content: 57.39

Gene sequence:

>636_bases
TTGGCAATTCACAATCTGGCCTGTGTCCGCGATGAGCGGCAATTATTTAGCGGATTGAACGAGGAATTTGCTCCCGGCGA
TGGGGTGCAAATTGAGGGATCGAACGGTGCCGGCAAAACGTTGCTATTGCGGATTTTGGCCGGGCTGACGCCGCCGGATG
CGGGTGAGATACGCTGGCGTCAGCGCCCGCTGCGTCAGTGCCGCAGCGACTATTATCGTGAGCTGGTTTATATCGGCCAT
CGGGCGGCAATTAAGCCTGTTCTGACGCCCCGGGAAAATCTAACTTTTTATCAAGGGATTACCGGTCTACGCAATGATTA
CGCCATTTATCGGGCGCTGGAGCAGGTCGGACTGCTGGGATATGAGGACGTGCGCGCGGCGGGGTTGTCGGCAGGGCAGC
AGCAGCGTATCGCTCTGGCCAGGCTGTGGCTGACGTCGGCCTCGCTGTGGATTCTGGATGAGCCGCTTACGGCTATCGAC
CATCAGGGCGCCCAGGCGCTTGTCAGGTTATTTGAGCAGCATTGTGCCACCGGCGGAATGGTGATTATGACAACTCATCA
ACCGCTGCCGGCTTCACGTTATCGGATGCGCAAGGTTGCTTTGCGTATGGCCGAGGCAACGTCATGTTTTGGTTAG

Upstream 100 bases:

>100_bases
ATCGTTCATTGGCCGTGAATCGCGTCGGCGCGTAAGTGTTTTCCGTGGCGCCCCGTGATAGGAAGCGAACCATTGTTAAT
AAAGAGTTTAATGTCCAACG

Downstream 100 bases:

>100_bases
TGCTACGCCGTGAGCTGCGGCTGGCGCGGCGTCAGGGCAATGAGCTGGTGAATCCGCTGTGGTTCTTTCTAATTGTCATT
ACCTTGTTCCCATTGGGAAT

Product: heme exporter protein A

Products: NA

Alternate protein names: Heme exporter protein A

Number of amino acids: Translated: 211; Mature: 210

Protein sequence:

>211_residues
MAIHNLACVRDERQLFSGLNEEFAPGDGVQIEGSNGAGKTLLLRILAGLTPPDAGEIRWRQRPLRQCRSDYYRELVYIGH
RAAIKPVLTPRENLTFYQGITGLRNDYAIYRALEQVGLLGYEDVRAAGLSAGQQQRIALARLWLTSASLWILDEPLTAID
HQGAQALVRLFEQHCATGGMVIMTTHQPLPASRYRMRKVALRMAEATSCFG

Sequences:

>Translated_211_residues
MAIHNLACVRDERQLFSGLNEEFAPGDGVQIEGSNGAGKTLLLRILAGLTPPDAGEIRWRQRPLRQCRSDYYRELVYIGH
RAAIKPVLTPRENLTFYQGITGLRNDYAIYRALEQVGLLGYEDVRAAGLSAGQQQRIALARLWLTSASLWILDEPLTAID
HQGAQALVRLFEQHCATGGMVIMTTHQPLPASRYRMRKVALRMAEATSCFG
>Mature_210_residues
AIHNLACVRDERQLFSGLNEEFAPGDGVQIEGSNGAGKTLLLRILAGLTPPDAGEIRWRQRPLRQCRSDYYRELVYIGHR
AAIKPVLTPRENLTFYQGITGLRNDYAIYRALEQVGLLGYEDVRAAGLSAGQQQRIALARLWLTSASLWILDEPLTAIDH
QGAQALVRLFEQHCATGGMVIMTTHQPLPASRYRMRKVALRMAEATSCFG

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain

Homologues:

Organism=Homo sapiens, GI27436953, Length=211, Percent_Identity=28.436018957346, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI62526033, Length=204, Percent_Identity=28.4313725490196, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI105990541, Length=192, Percent_Identity=27.6041666666667, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI21536376, Length=194, Percent_Identity=27.8350515463918, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI9961250, Length=189, Percent_Identity=27.5132275132275, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI4505771, Length=189, Percent_Identity=27.5132275132275, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI9961252, Length=189, Percent_Identity=27.5132275132275, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI150417984, Length=173, Percent_Identity=28.9017341040462, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI87082064, Length=202, Percent_Identity=52.970297029703, Blast_Score=187, Evalue=4e-49,
Organism=Escherichia coli, GI1789873, Length=196, Percent_Identity=30.1020408163265, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787105, Length=203, Percent_Identity=27.5862068965517, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1790544, Length=223, Percent_Identity=28.2511210762332, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1787089, Length=226, Percent_Identity=26.1061946902655, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI87081834, Length=195, Percent_Identity=27.1794871794872, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI87081709, Length=149, Percent_Identity=31.5436241610738, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1787772, Length=191, Percent_Identity=31.9371727748691, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1788761, Length=211, Percent_Identity=29.8578199052133, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1789891, Length=201, Percent_Identity=28.8557213930348, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI87081791, Length=165, Percent_Identity=30.3030303030303, Blast_Score=67, Evalue=7e-13,
Organism=Escherichia coli, GI1788165, Length=173, Percent_Identity=29.4797687861272, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786703, Length=191, Percent_Identity=28.2722513089005, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786872, Length=163, Percent_Identity=29.4478527607362, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788225, Length=202, Percent_Identity=28.7128712871287, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI87081782, Length=157, Percent_Identity=28.0254777070064, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1787164, Length=181, Percent_Identity=30.939226519337, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786319, Length=176, Percent_Identity=26.1363636363636, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787370, Length=163, Percent_Identity=29.4478527607362, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1790467, Length=177, Percent_Identity=26.5536723163842, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1786345, Length=216, Percent_Identity=29.6296296296296, Blast_Score=61, Evalue=5e-11,
Organism=Escherichia coli, GI1786563, Length=175, Percent_Identity=28.5714285714286, Blast_Score=60, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI115533608, Length=193, Percent_Identity=29.5336787564767, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17558664, Length=192, Percent_Identity=27.6041666666667, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323217, Length=207, Percent_Identity=27.536231884058, Blast_Score=66, Evalue=5e-12,
Organism=Drosophila melanogaster, GI19920532, Length=183, Percent_Identity=27.8688524590164, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24580930, Length=183, Percent_Identity=27.8688524590164, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI28574744, Length=188, Percent_Identity=28.7234042553192, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585091, Length=186, Percent_Identity=33.8709677419355, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28574533, Length=186, Percent_Identity=26.8817204301075, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI116007184, Length=170, Percent_Identity=25.8823529411765, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221500365, Length=170, Percent_Identity=25.8823529411765, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45552199, Length=227, Percent_Identity=26.431718061674, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24581407, Length=227, Percent_Identity=26.431718061674, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCMA_SODGM (Q2NSG3)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_455317.1
- ProteinModelPortal:   Q2NSG3
- STRING:   Q2NSG3
- GeneID:   3867160
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG1637
- NMPDR:   fig|343509.6.peg.3482
- eggNOG:   COG4133
- HOGENOM:   HBG758042
- OMA:   ARLWHND
- PhylomeDB:   Q2NSG3
- BioCyc:   SGLO343509:SG1637-MONOMER
- HAMAP:   MF_01707
- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR005895
- InterPro:   IPR003593
- PANTHER:   PTHR19222:SF5
- SMART:   SM00382
- TIGRFAMs:   TIGR01189

Pfam domain/function: PF00005 ABC_tran

EC number: =3.6.3.41

Molecular weight: Translated: 23521; Mature: 23390

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: PS00211 ABC_TRANSPORTER_1; PS50893 ABC_TRANSPORTER_2; PS51243 CCMA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIHNLACVRDERQLFSGLNEEFAPGDGVQIEGSNGAGKTLLLRILAGLTPPDAGEIRWR
CCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHH
QRPLRQCRSDYYRELVYIGHRAAIKPVLTPRENLTFYQGITGLRNDYAIYRALEQVGLLG
HHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCC
YEDVRAAGLSAGQQQRIALARLWLTSASLWILDEPLTAIDHQGAQALVRLFEQHCATGGM
HHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEECCCHHHHCCCCHHHHHHHHHHHCCCCCE
VIMTTHQPLPASRYRMRKVALRMAEATSCFG
EEEEECCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AIHNLACVRDERQLFSGLNEEFAPGDGVQIEGSNGAGKTLLLRILAGLTPPDAGEIRWR
CCCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHH
QRPLRQCRSDYYRELVYIGHRAAIKPVLTPRENLTFYQGITGLRNDYAIYRALEQVGLLG
HHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCC
YEDVRAAGLSAGQQQRIALARLWLTSASLWILDEPLTAIDHQGAQALVRLFEQHCATGGM
HHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEECCCHHHHCCCCHHHHHHHHHHHCCCCCE
VIMTTHQPLPASRYRMRKVALRMAEATSCFG
EEEEECCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA