Click here to switch to the map view.

The map label for this gene is hemB [H]

Identifier: 85059507

GI number: 85059507

Start: 2590366

End: 2591340

Strand: Reverse

Name: hemB [H]

Synonym: SG1529

Alternate gene names: 85059507

Gene position: 2591340-2590366 (Counterclockwise)

Preceding gene: 85059508

Following gene: 85059506

Centisome position: 62.13

GC content: 59.08

Gene sequence:

>975_bases
ATGTCCAGTGTTTATCCCGTTTCACGTCCACGCCGTTTGCGCCGTACCCCTGCTTTGCGCGCTCTGTTCCAGGAAACCGA
GGTACGGCTAAGCGATCTGGTACTGCCGATATTCGTCGAGGAGGAGGTCAGCGACTATGTGCCGGTGTCCGTCATGCCGG
GCGTGGTCAGGATACCGGAAGCACGCCTGGCTTTTGAAATCGAGCGCTATGCCAAAGCCGGCATTCAATCTGTCATGACC
TTCGGCATTTCCCATCACCTGGACGATACAGGTAGCGATACCTGGCAGGAGAATGGCTTGGTCGCGCGCATGGCGCGCAT
TTGTAAAGACACGGCGCCGGAAATGATTGTCATGTCCGACACCTGCTTTTGCGAATATACCACCCACGGTCATTGCGGCG
TGGTGCACGATAACGGGGTCGACAATGACGCCACACTTGTGAATTTGGGGCGTCAGGCGGTAGCGGCAGCGCGCGCCGGT
GCGGATTTTATTGCCCCGTCGGCGGCGATGGACGGGCAGGTGCAGGCGATACGCGCCGCGCTGGACGGCGCCGGCTTCAC
CGACACCGCCGTGATGGCGTATTCCACCAAGTTTGCCTCGGCCTTTTATGGTCCGTTTCGCGAAGCCGGGGGCACTGCCC
TGAAGGGTAACCGCAAAACCTATCAAATGAACCCGATGAACCGCCGCGAAGCGATACGGGAGTCGCTGTTGGATGAGCAG
GAGGGGGCCGATGCACTGATGGTAAAGCCGGCCGGCGCTTTTTTGGACACCATCCGCGATATCCGCGAGGCGGCCCATTT
GCCGCTGGCGGCGTATCAAGTAAGCGGCGAATACGCGATGATCAAATTTGCCGCTGCCGCCGGCGCCATTGACGAACGCC
AAATCGTGCGCGAAACCCTGGGCGCAATCAAGCGTGCCGGGGCGGATATTATTCTCAGCTATTTCACCCTGGATATTGCC
GAACAGGGTTTTTAA

Upstream 100 bases:

>100_bases
TGATTGCCCTGTTTTGTCCTGGCCGAGCCAAATGTCACGCGCATTTCCCCTGTCCGGTCATCTCGCCGCAATCGTAGCCT
CATTACCCGCAGGAGAAAAA

Downstream 100 bases:

>100_bases
TCCGTCAGTGTCCGGCGCGGTAACGTTTTACGGTGCCGCGCCGTCTGGCTTGCCTTCGCCTGCGGTATGGGGTTTGGCGG
TAGCGAGAGAGAGAAAAAGC

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MSSVYPVSRPRRLRRTPALRALFQETEVRLSDLVLPIFVEEEVSDYVPVSVMPGVVRIPEARLAFEIERYAKAGIQSVMT
FGISHHLDDTGSDTWQENGLVARMARICKDTAPEMIVMSDTCFCEYTTHGHCGVVHDNGVDNDATLVNLGRQAVAAARAG
ADFIAPSAAMDGQVQAIRAALDGAGFTDTAVMAYSTKFASAFYGPFREAGGTALKGNRKTYQMNPMNRREAIRESLLDEQ
EGADALMVKPAGAFLDTIRDIREAAHLPLAAYQVSGEYAMIKFAAAAGAIDERQIVRETLGAIKRAGADIILSYFTLDIA
EQGF

Sequences:

>Translated_324_residues
MSSVYPVSRPRRLRRTPALRALFQETEVRLSDLVLPIFVEEEVSDYVPVSVMPGVVRIPEARLAFEIERYAKAGIQSVMT
FGISHHLDDTGSDTWQENGLVARMARICKDTAPEMIVMSDTCFCEYTTHGHCGVVHDNGVDNDATLVNLGRQAVAAARAG
ADFIAPSAAMDGQVQAIRAALDGAGFTDTAVMAYSTKFASAFYGPFREAGGTALKGNRKTYQMNPMNRREAIRESLLDEQ
EGADALMVKPAGAFLDTIRDIREAAHLPLAAYQVSGEYAMIKFAAAAGAIDERQIVRETLGAIKRAGADIILSYFTLDIA
EQGF
>Mature_323_residues
SSVYPVSRPRRLRRTPALRALFQETEVRLSDLVLPIFVEEEVSDYVPVSVMPGVVRIPEARLAFEIERYAKAGIQSVMTF
GISHHLDDTGSDTWQENGLVARMARICKDTAPEMIVMSDTCFCEYTTHGHCGVVHDNGVDNDATLVNLGRQAVAAARAGA
DFIAPSAAMDGQVQAIRAALDGAGFTDTAVMAYSTKFASAFYGPFREAGGTALKGNRKTYQMNPMNRREAIRESLLDEQE
GADALMVKPAGAFLDTIRDIREAAHLPLAAYQVSGEYAMIKFAAAAGAIDERQIVRETLGAIKRAGADIILSYFTLDIAE
QGF

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=307, Percent_Identity=40.3908794788274, Blast_Score=219, Evalue=3e-57,
Organism=Escherichia coli, GI87081728, Length=316, Percent_Identity=76.2658227848101, Blast_Score=504, Evalue=1e-144,
Organism=Saccharomyces cerevisiae, GI6321398, Length=306, Percent_Identity=36.2745098039216, Blast_Score=197, Evalue=2e-51,
Organism=Drosophila melanogaster, GI21358291, Length=311, Percent_Identity=38.9067524115756, Blast_Score=211, Evalue=7e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 35248; Mature: 35117

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSVYPVSRPRRLRRTPALRALFQETEVRLSDLVLPIFVEEEVSDYVPVSVMPGVVRIPE
CCCCCCCCCCHHHHHCHHHHHHHHHHHHHHHHEEEEEEEEHHHHCCCCHHHCCCCEECCC
ARLAFEIERYAKAGIQSVMTFGISHHLDDTGSDTWQENGLVARMARICKDTAPEMIVMSD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCHHHHHHHHHHCCCCCEEEEEC
TCFCEYTTHGHCGVVHDNGVDNDATLVNLGRQAVAAARAGADFIAPSAAMDGQVQAIRAA
CEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCHHCCCCCCCCCHHHHHHHH
LDGAGFTDTAVMAYSTKFASAFYGPFREAGGTALKGNRKTYQMNPMNRREAIRESLLDEQ
HCCCCCCHHHHHHHHHHHHHHHHCHHHHCCCCEECCCCEEEEECCCHHHHHHHHHHHHHH
EGADALMVKPAGAFLDTIRDIREAAHLPLAAYQVSGEYAMIKFAAAAGAIDERQIVRETL
CCCCEEEECCCHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEEHHHHCCCHHHHHHHHHH
GAIKRAGADIILSYFTLDIAEQGF
HHHHHCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSVYPVSRPRRLRRTPALRALFQETEVRLSDLVLPIFVEEEVSDYVPVSVMPGVVRIPE
CCCCCCCCCHHHHHCHHHHHHHHHHHHHHHHEEEEEEEEHHHHCCCCHHHCCCCEECCC
ARLAFEIERYAKAGIQSVMTFGISHHLDDTGSDTWQENGLVARMARICKDTAPEMIVMSD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCHHHHHHHHHHCCCCCEEEEEC
TCFCEYTTHGHCGVVHDNGVDNDATLVNLGRQAVAAARAGADFIAPSAAMDGQVQAIRAA
CEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCHHCCCCCCCCCHHHHHHHH
LDGAGFTDTAVMAYSTKFASAFYGPFREAGGTALKGNRKTYQMNPMNRREAIRESLLDEQ
HCCCCCCHHHHHHHHHHHHHHHHCHHHHCCCCEECCCCEEEEECCCHHHHHHHHHHHHHH
EGADALMVKPAGAFLDTIRDIREAAHLPLAAYQVSGEYAMIKFAAAAGAIDERQIVRETL
CCCCEEEECCCHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEEHHHHCCCHHHHHHHHHH
GAIKRAGADIILSYFTLDIAEQGF
HHHHHCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2656410; 2464127; 9278503; 8439296; 10194344; 11444968; 11909869 [H]