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The map label for this gene is ribA

Identifier: 85059388

GI number: 85059388

Start: 2340601

End: 2341200

Strand: Reverse

Name: ribA

Synonym: SG1410

Alternate gene names: 85059388

Gene position: 2341200-2340601 (Counterclockwise)

Preceding gene: 85059394

Following gene: 85059385

Centisome position: 56.13

GC content: 58.5

Gene sequence:

>600_bases
ATGCAGCTTAAACGTGTGGCAGAAGCCAAACTGCCGACACCCTGGGATGATTTCCTGATGGTGGGATTCGAGGAAATCGC
CACCGGGCACGACCATCTGGCGCTGGTGTACGGCGATATCACCGGGCCGGCGCCGGTGCTGGCGCGTGTCCATTCCGAAT
GCCTCACTGGCGATGCTCTGTTCAGCCTGCGCTGCGATTGCGGCTTTCAACTGGAGGCGGCGCTCAGCCACATCGCCGAA
GAAGGCCGCGGTATTTTGCTCTACCATCGTCAGGAAGGCCGTAATATCGGCCTGTTGAACAAGATTCGCGCCTACGCCCT
GCAGGACAAAGGCGCCGATACGGTCGAGGCCAACCATCAGCTGGGCTTTGCCGCCGACGAGCGGGATTTCACCCTGTGCG
CCGATATGTTCAAACTGCTGGGCGTTGAAACGGTACGTCTGTTGACCAACAATCCCAAAAAGGTCGAGATTTTGACCGAG
GCAGGCATCCATATCAGCGAGCGGGTGCCGCTAATAGTGGGCCGCAACCCCAAAAACGCCCGCTATCTAGATACCAAGGC
CGCCAAAATGGGGCATTTGCTTAACGGCCCCGCCGAATAA

Upstream 100 bases:

>100_bases
CCAGAGAGGATTCCGATCGGCGCGCCTTCATGTGCTGGTGCTGGTCAAACGGCGCGCCAAGCAGTAGGATGCGCGTCATT
CTTAGGTTTTGGAGAGCAAC

Downstream 100 bases:

>100_bases
GTGCCGGTCGGATCATTGCTCCCCCTGCGCGGCCAGGCTGTATGAGGTCCTGTCGGCGCGGCCCCGCCCGTTTCGACAGT
TCGTCCTCTTATATCGGTTC

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II [H]

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MQLKRVAEAKLPTPWDDFLMVGFEEIATGHDHLALVYGDITGPAPVLARVHSECLTGDALFSLRCDCGFQLEAALSHIAE
EGRGILLYHRQEGRNIGLLNKIRAYALQDKGADTVEANHQLGFAADERDFTLCADMFKLLGVETVRLLTNNPKKVEILTE
AGIHISERVPLIVGRNPKNARYLDTKAAKMGHLLNGPAE

Sequences:

>Translated_199_residues
MQLKRVAEAKLPTPWDDFLMVGFEEIATGHDHLALVYGDITGPAPVLARVHSECLTGDALFSLRCDCGFQLEAALSHIAE
EGRGILLYHRQEGRNIGLLNKIRAYALQDKGADTVEANHQLGFAADERDFTLCADMFKLLGVETVRLLTNNPKKVEILTE
AGIHISERVPLIVGRNPKNARYLDTKAAKMGHLLNGPAE
>Mature_199_residues
MQLKRVAEAKLPTPWDDFLMVGFEEIATGHDHLALVYGDITGPAPVLARVHSECLTGDALFSLRCDCGFQLEAALSHIAE
EGRGILLYHRQEGRNIGLLNKIRAYALQDKGADTVEANHQLGFAADERDFTLCADMFKLLGVETVRLLTNNPKKVEILTE
AGIHISERVPLIVGRNPKNARYLDTKAAKMGHLLNGPAE

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=195, Percent_Identity=90.7692307692308, Blast_Score=365, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6319438, Length=173, Percent_Identity=43.9306358381503, Blast_Score=124, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000926 [H]

Pfam domain/function: PF00925 GTP_cyclohydro2 [H]

EC number: =3.5.4.25 [H]

Molecular weight: Translated: 21896; Mature: 21896

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00626 RCC1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLKRVAEAKLPTPWDDFLMVGFEEIATGHDHLALVYGDITGPAPVLARVHSECLTGDAL
CCCCHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCE
FSLRCDCGFQLEAALSHIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDKGADTVEANHQ
EEEECCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCEECCCC
LGFAADERDFTLCADMFKLLGVETVRLLTNNPKKVEILTEAGIHISERVPLIVGRNPKNA
CCCCCCCCCHHHHHHHHHHHCHHHEEEECCCCCEEEEEECCCCEECCCCCEEEECCCCCC
RYLDTKAAKMGHLLNGPAE
EEECHHHHHHHHCCCCCCC
>Mature Secondary Structure
MQLKRVAEAKLPTPWDDFLMVGFEEIATGHDHLALVYGDITGPAPVLARVHSECLTGDAL
CCCCHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCE
FSLRCDCGFQLEAALSHIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDKGADTVEANHQ
EEEECCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCEECCCC
LGFAADERDFTLCADMFKLLGVETVRLLTNNPKKVEILTEAGIHISERVPLIVGRNPKNA
CCCCCCCCCHHHHHHHHHHHCHHHEEEECCCCCEEEEEECCCCEECCCCCEEEECCCCCC
RYLDTKAAKMGHLLNGPAE
EEECHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA