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The map label for this gene is pyrC [H]

Identifier: 85059029

GI number: 85059029

Start: 1752474

End: 1753544

Strand: Reverse

Name: pyrC [H]

Synonym: SG1051

Alternate gene names: 85059029

Gene position: 1753544-1752474 (Counterclockwise)

Preceding gene: 85059030

Following gene: 85059028

Centisome position: 42.04

GC content: 56.02

Gene sequence:

>1071_bases
ATGACCGCACAGCCCGCAGTACTGAAAATTCGCCGGCCGGACGACTGGCATGTTCATTTGCGCGACGATGATATGTTGCG
CACTGTGCTGCCTTACACCAGCCGCCATTTTGGCCGGGCGATTATTATGCCCAACCTGACGACGACGCCCATTACGACAC
TCGGCCAGGCGATAGCCTATCGCGAACGTATTTTGGCTGCGCTGCCGGCGGGTCACCGGTTTACGCCACTGATGACCTGT
TATTTGACGGATTCGCTGGACAAGAAAACGCTGATTGACGGCCATCGCCAGGGAGTGTTTACCGCCGCCAAACTGTATCC
GGCCAATGCCACAACCAACTCTCAGCATGGCGTAACCAATATTGCCGCCATTTATCCCTTGTTTGACGCCATGCAGACCA
TCGGTATGCCGCTCCTTATTCACGGGGAAGTCACGGCGGCAGACATTGATATTTTCGATCGCGAGGCGCGCTTTATCGAA
CAAGTAATGACGCCGATTCGCCGCCAATTTCCGGCGCTGAAGATCGTGTTTGAACATATTACCACCAAAGAAGCCGCCGA
TTATGTGCTGGCCGGCGATAGGCATTTGGCCGCTACCCTTACCCCGCAGCATCTCATGTTCAACCGCAACCATATGCTGG
TGGGAGGAGTGCGTCCGCATCTCTACTGCTTGCCTATCCTGAAACGCAATGTACATCAGCAGGCATTGCGCGCGGCAGTG
GCCAGCGGTTGCGACCGTCTGTTCCTCGGTACCGATACCGCCCCTCACGCGCGCGGACGTAAAGAATCGGACTGCGGCTG
TGCCGGCATATTTAATGCACTCGCCGCTTTGCCGGCGTATGCTACGGTGTTTGAGGAAATCGGCGCGCTGGCACATTTTG
AAGCTTTTTGTTCGCTAAACGGTCCGCGCTTTTACGATCTGCCGCTTAACGATGATTTTATTACCCTGTACCGTGAACCC
CATCAGCAACCCGCGGCCATTCCTCTGACGGGCGGTGACGGCGAAACGCTGGTCCCCTTCCTTGCCGAGCAGACGCTCAA
TTGGACCGTGGTTGACGAAAGCGACCATTGA

Upstream 100 bases:

>100_bases
AAGAAATTAATGCAATAACTTCGCTTTACGCTTATTCTTGTACCCCGCCATGACAAGAAACGCACAACGACATTCCCCTG
CTCAACCGGAGTTCAACCCC

Downstream 100 bases:

>100_bases
CTCACCGCTCGGGCGCCGTTCGTCGCTCGCATAAAGCGTTGTCGGCATCCGGCGCCGGGGCAGACGCCCCGCCGCCTGTT
TGCCCTTTGTGCGAATGTAC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MTAQPAVLKIRRPDDWHVHLRDDDMLRTVLPYTSRHFGRAIIMPNLTTTPITTLGQAIAYRERILAALPAGHRFTPLMTC
YLTDSLDKKTLIDGHRQGVFTAAKLYPANATTNSQHGVTNIAAIYPLFDAMQTIGMPLLIHGEVTAADIDIFDREARFIE
QVMTPIRRQFPALKIVFEHITTKEAADYVLAGDRHLAATLTPQHLMFNRNHMLVGGVRPHLYCLPILKRNVHQQALRAAV
ASGCDRLFLGTDTAPHARGRKESDCGCAGIFNALAALPAYATVFEEIGALAHFEAFCSLNGPRFYDLPLNDDFITLYREP
HQQPAAIPLTGGDGETLVPFLAEQTLNWTVVDESDH

Sequences:

>Translated_356_residues
MTAQPAVLKIRRPDDWHVHLRDDDMLRTVLPYTSRHFGRAIIMPNLTTTPITTLGQAIAYRERILAALPAGHRFTPLMTC
YLTDSLDKKTLIDGHRQGVFTAAKLYPANATTNSQHGVTNIAAIYPLFDAMQTIGMPLLIHGEVTAADIDIFDREARFIE
QVMTPIRRQFPALKIVFEHITTKEAADYVLAGDRHLAATLTPQHLMFNRNHMLVGGVRPHLYCLPILKRNVHQQALRAAV
ASGCDRLFLGTDTAPHARGRKESDCGCAGIFNALAALPAYATVFEEIGALAHFEAFCSLNGPRFYDLPLNDDFITLYREP
HQQPAAIPLTGGDGETLVPFLAEQTLNWTVVDESDH
>Mature_355_residues
TAQPAVLKIRRPDDWHVHLRDDDMLRTVLPYTSRHFGRAIIMPNLTTTPITTLGQAIAYRERILAALPAGHRFTPLMTCY
LTDSLDKKTLIDGHRQGVFTAAKLYPANATTNSQHGVTNIAAIYPLFDAMQTIGMPLLIHGEVTAADIDIFDREARFIEQ
VMTPIRRQFPALKIVFEHITTKEAADYVLAGDRHLAATLTPQHLMFNRNHMLVGGVRPHLYCLPILKRNVHQQALRAAVA
SGCDRLFLGTDTAPHARGRKESDCGCAGIFNALAALPAYATVFEEIGALAHFEAFCSLNGPRFYDLPLNDDFITLYREPH
QQPAAIPLTGGDGETLVPFLAEQTLNWTVVDESDH

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787301, Length=350, Percent_Identity=71.7142857142857, Blast_Score=516, Evalue=1e-148,
Organism=Saccharomyces cerevisiae, GI6323452, Length=359, Percent_Identity=32.8690807799443, Blast_Score=155, Evalue=7e-39,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004721
- InterPro:   IPR002195 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 39554; Mature: 39423

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAQPAVLKIRRPDDWHVHLRDDDMLRTVLPYTSRHFGRAIIMPNLTTTPITTLGQAIAY
CCCCCCEEEEECCCCCEEEECCCHHHHHHHCHHHHHCCCEEEECCCCCCCHHHHHHHHHH
RERILAALPAGHRFTPLMTCYLTDSLDKKTLIDGHRQGVFTAAKLYPANATTNSQHGVTN
HHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHCCCCCCEEEEEEEEECCCCCCCCCCCHH
IAAIYPLFDAMQTIGMPLLIHGEVTAADIDIFDREARFIEQVMTPIRRQFPALKIVFEHI
HHHHHHHHHHHHHCCCCEEEECCEEEEEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
TTKEAADYVLAGDRHLAATLTPQHLMFNRNHMLVGGVRPHLYCLPILKRNVHQQALRAAV
HHHHHCCEEEECCCEEEEECCHHHHEECCCEEEEECCCCCEEEHHHHHHHHHHHHHHHHH
ASGCDRLFLGTDTAPHARGRKESDCGCAGIFNALAALPAYATVFEEIGALAHFEAFCSLN
HCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GPRFYDLPLNDDFITLYREPHQQPAAIPLTGGDGETLVPFLAEQTLNWTVVDESDH
CCEEEECCCCCCEEEEEECCCCCCCEEEEECCCCCCHHHHHHHCCCEEEEEECCCC
>Mature Secondary Structure 
TAQPAVLKIRRPDDWHVHLRDDDMLRTVLPYTSRHFGRAIIMPNLTTTPITTLGQAIAY
CCCCCEEEEECCCCCEEEECCCHHHHHHHCHHHHHCCCEEEECCCCCCCHHHHHHHHHH
RERILAALPAGHRFTPLMTCYLTDSLDKKTLIDGHRQGVFTAAKLYPANATTNSQHGVTN
HHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHCCCCCCEEEEEEEEECCCCCCCCCCCHH
IAAIYPLFDAMQTIGMPLLIHGEVTAADIDIFDREARFIEQVMTPIRRQFPALKIVFEHI
HHHHHHHHHHHHHCCCCEEEECCEEEEEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
TTKEAADYVLAGDRHLAATLTPQHLMFNRNHMLVGGVRPHLYCLPILKRNVHQQALRAAV
HHHHHCCEEEECCCEEEEECCHHHHEECCCEEEEECCCCCEEEHHHHHHHHHHHHHHHHH
ASGCDRLFLGTDTAPHARGRKESDCGCAGIFNALAALPAYATVFEEIGALAHFEAFCSLN
HCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GPRFYDLPLNDDFITLYREPHQQPAAIPLTGGDGETLVPFLAEQTLNWTVVDESDH
CCEEEECCCCCCEEEEEECCCCCCCEEEEECCCCCCHHHHHHHCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA