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The map label for this gene is pncB

Identifier: 85058994

GI number: 85058994

Start: 1679311

End: 1680519

Strand: Reverse

Name: pncB

Synonym: SG1016

Alternate gene names: 85058994

Gene position: 1680519-1679311 (Counterclockwise)

Preceding gene: 85058997

Following gene: 85058993

Centisome position: 40.29

GC content: 54.59

Gene sequence:

>1209_bases
GTGAATGTTGCCACCGATCCGATTTTAACGTCGATACTCGATACTGATGCCTACAAATTCCATATGCAGCAGGCCGTGTT
CCACCGTTACCACGACGTCATGGTAAGCGCGAAATTTCGCTGCCGGGGATACGAGTTGCTTGGCGAATACGCCGCCGACA
TCAGTGCGCAGGTCGACATGATGCGTGGCTTGCAATTGAATGACGATGAATTTACCTATCTGCGCGGTCTGCCGTTTTTC
CAGAGTGATTACCTTAATTGTCTGCGCCAGTTCCGCTTTGACCCAAGTCAGGTTCGGATACGCAATCATCACGGCAAACT
TGATATTCGCATCACCGGTCCCTGGCGCGACGTTATTTTGTGGGAAGTGCCGCTGCTTGCGGTCATAAGCGAAGTCGTGC
ACCACCGCCGTTCGCCACAGGTAACGACGGCAGACGCAGTAGCGCGACTGCGGCAAAAGCTGCTCCATTTTCGCCGCATC
AGCGAAGATTTGGACACCTCCCGTTTCCGGCTGATGGATTTCGGTACCCGGCGGCGTTTCTCGCGTCAGGTGCAGTTTGA
AGTTATCGCCGAATTGCAGCGGGAATTTCCTTATCTTATCGGTACCAGCAATTACCAGTTGGCGCGGGAACGGGGCTTGC
CGCCGATTGGTACCCAGGCGCATGAATGGTTTCAGGCCCATCAGCAGATCAGCCCGGATCTGGCGAATAGCCAGAGCGCC
GCGCTGCAGGCCTGGCTGGACGAATACCCCGACAGGTTAGGGATCGCTCTTACCGATTGTATTACCATGGATGCGTTTTT
GCGCGACTTCGGGCCGTCTTTCGCCCGTGCCTACCAGGGCATGCGCCACGATTCAGGCGATCCGGTAGAATGGGGCGAGA
AGGCGATTGCGCATTATCAGCAGCTGGGTATCGATCCGCTCACCAAAACGCTGGTGTTCTCAGACAGCCTCGATTTTGAT
AAGGCCTTCATGCTTTATCGTCATTTCTGGCAGCGCATCAACCTGGTGTTTGGCATCGGCACGCGGCTGACGTGCGATAT
CCCCGGCATTAAGCCGCTTAACATCGTTATCAAACTGGTGAAATGCAACGGTAAACCGGTGGCTAAGCTGTCGGACAGCC
CCGGCAAAATCATGTGTCATGATAAAGCCTTTGTCCGCGCCTTACGTAAAGCGTTTGATGTGCCACTGGTGGTGAAAAAG
GCCAGTTGA

Upstream 100 bases:

>100_bases
CCTGATGTGACTACACTGATAGGATAACCGCGGCTTTTCATGGCCGTTACCCCTTTATCCGACTGAGAACACATGTCGTA
AGAGGATGCTTGAACGCACC

Downstream 100 bases:

>100_bases
ACTAGCGCCAGGGCGCGAATACGCCTCCCCCTTTCCCGCGATTTGTCATGACCGTCCTGCAGTGGTCATGACACCGCCGC
CGTTTCCTTCGCGCAATAAT

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MNVATDPILTSILDTDAYKFHMQQAVFHRYHDVMVSAKFRCRGYELLGEYAADISAQVDMMRGLQLNDDEFTYLRGLPFF
QSDYLNCLRQFRFDPSQVRIRNHHGKLDIRITGPWRDVILWEVPLLAVISEVVHHRRSPQVTTADAVARLRQKLLHFRRI
SEDLDTSRFRLMDFGTRRRFSRQVQFEVIAELQREFPYLIGTSNYQLARERGLPPIGTQAHEWFQAHQQISPDLANSQSA
ALQAWLDEYPDRLGIALTDCITMDAFLRDFGPSFARAYQGMRHDSGDPVEWGEKAIAHYQQLGIDPLTKTLVFSDSLDFD
KAFMLYRHFWQRINLVFGIGTRLTCDIPGIKPLNIVIKLVKCNGKPVAKLSDSPGKIMCHDKAFVRALRKAFDVPLVVKK
AS

Sequences:

>Translated_402_residues
MNVATDPILTSILDTDAYKFHMQQAVFHRYHDVMVSAKFRCRGYELLGEYAADISAQVDMMRGLQLNDDEFTYLRGLPFF
QSDYLNCLRQFRFDPSQVRIRNHHGKLDIRITGPWRDVILWEVPLLAVISEVVHHRRSPQVTTADAVARLRQKLLHFRRI
SEDLDTSRFRLMDFGTRRRFSRQVQFEVIAELQREFPYLIGTSNYQLARERGLPPIGTQAHEWFQAHQQISPDLANSQSA
ALQAWLDEYPDRLGIALTDCITMDAFLRDFGPSFARAYQGMRHDSGDPVEWGEKAIAHYQQLGIDPLTKTLVFSDSLDFD
KAFMLYRHFWQRINLVFGIGTRLTCDIPGIKPLNIVIKLVKCNGKPVAKLSDSPGKIMCHDKAFVRALRKAFDVPLVVKK
AS
>Mature_402_residues
MNVATDPILTSILDTDAYKFHMQQAVFHRYHDVMVSAKFRCRGYELLGEYAADISAQVDMMRGLQLNDDEFTYLRGLPFF
QSDYLNCLRQFRFDPSQVRIRNHHGKLDIRITGPWRDVILWEVPLLAVISEVVHHRRSPQVTTADAVARLRQKLLHFRRI
SEDLDTSRFRLMDFGTRRRFSRQVQFEVIAELQREFPYLIGTSNYQLARERGLPPIGTQAHEWFQAHQQISPDLANSQSA
ALQAWLDEYPDRLGIALTDCITMDAFLRDFGPSFARAYQGMRHDSGDPVEWGEKAIAHYQQLGIDPLTKTLVFSDSLDFD
KAFMLYRHFWQRINLVFGIGTRLTCDIPGIKPLNIVIKLVKCNGKPVAKLSDSPGKIMCHDKAFVRALRKAFDVPLVVKK
AS

Specific function: NAD biosynthesis; nicotinamide to NaMN; second step. [C]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family

Homologues:

Organism=Escherichia coli, GI1787162, Length=402, Percent_Identity=70.3980099502487, Blast_Score=586, Evalue=1e-169,
Organism=Saccharomyces cerevisiae, GI6324783, Length=418, Percent_Identity=33.7320574162679, Blast_Score=216, Evalue=7e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PNCB_SODGM (Q2NU84)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_454696.1
- HSSP:   P39683
- ProteinModelPortal:   Q2NU84
- SMR:   Q2NU84
- STRING:   Q2NU84
- GeneID:   3866380
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG1016
- NMPDR:   fig|343509.6.peg.2101
- eggNOG:   COG1488
- HOGENOM:   HBG325503
- OMA:   GNTFYGK
- PhylomeDB:   Q2NU84
- ProtClustDB:   PRK05321
- BioCyc:   SGLO343509:SG1016-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00570
- InterPro:   IPR006406
- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR002638
- PANTHER:   PTHR11098:SF1
- PIRSF:   PIRSF000484
- TIGRFAMs:   TIGR01514

Pfam domain/function: PF04095 NAPRTase; SSF51690 Q_phspho_trans

EC number: =2.4.2.11

Molecular weight: Translated: 46362; Mature: 46362

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVATDPILTSILDTDAYKFHMQQAVFHRYHDVMVSAKFRCRGYELLGEYAADISAQVDM
CCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MRGLQLNDDEFTYLRGLPFFQSDYLNCLRQFRFDPSQVRIRNHHGKLDIRITGPWRDVIL
HHCCCCCCCCCHHEECCCCHHHHHHHHHHHHCCCHHHEEEEECCCEEEEEEECCHHHHHH
WEVPLLAVISEVVHHRRSPQVTTADAVARLRQKLLHFRRISEDLDTSRFRLMDFGTRRRF
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
SRQVQFEVIAELQREFPYLIGTSNYQLARERGLPPIGTQAHEWFQAHQQISPDLANSQSA
HHHHHHHHHHHHHHHCCEEEECCCCHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCHHH
ALQAWLDEYPDRLGIALTDCITMDAFLRDFGPSFARAYQGMRHDSGDPVEWGEKAIAHYQ
HHHHHHHHCCHHHCHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
QLGIDPLTKTLVFSDSLDFDKAFMLYRHFWQRINLVFGIGTRLTCDIPGIKPLNIVIKLV
HHCCCHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHEECCCEEEECCCCCCHHHHHEEEE
KCNGKPVAKLSDSPGKIMCHDKAFVRALRKAFDVPLVVKKAS
ECCCCCCEEECCCCCEEEECCHHHHHHHHHHCCCCEEEEECC
>Mature Secondary Structure
MNVATDPILTSILDTDAYKFHMQQAVFHRYHDVMVSAKFRCRGYELLGEYAADISAQVDM
CCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MRGLQLNDDEFTYLRGLPFFQSDYLNCLRQFRFDPSQVRIRNHHGKLDIRITGPWRDVIL
HHCCCCCCCCCHHEECCCCHHHHHHHHHHHHCCCHHHEEEEECCCEEEEEEECCHHHHHH
WEVPLLAVISEVVHHRRSPQVTTADAVARLRQKLLHFRRISEDLDTSRFRLMDFGTRRRF
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
SRQVQFEVIAELQREFPYLIGTSNYQLARERGLPPIGTQAHEWFQAHQQISPDLANSQSA
HHHHHHHHHHHHHHHCCEEEECCCCHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCHHH
ALQAWLDEYPDRLGIALTDCITMDAFLRDFGPSFARAYQGMRHDSGDPVEWGEKAIAHYQ
HHHHHHHHCCHHHCHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
QLGIDPLTKTLVFSDSLDFDKAFMLYRHFWQRINLVFGIGTRLTCDIPGIKPLNIVIKLV
HHCCCHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHEECCCEEEECCCCCCHHHHHEEEE
KCNGKPVAKLSDSPGKIMCHDKAFVRALRKAFDVPLVVKKAS
ECCCCCCEEECCCCCEEEECCHHHHHHHHHHCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA