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The map label for this gene is galK [H]

Identifier: 85058873

GI number: 85058873

Start: 1455438

End: 1456112

Strand: Reverse

Name: galK [H]

Synonym: SG0895

Alternate gene names: 85058873

Gene position: 1456112-1455438 (Counterclockwise)

Preceding gene: 85058874

Following gene: 85058872

Centisome position: 34.91

GC content: 54.22

Gene sequence:

>675_bases
ATGAGTTTACAAAACACCACTGCAACCGTTTTTCGCGACGCCTTTGGTTATGCCCCTGTCCTGACGGTCAAGGCACCCGG
CCGGTTCAATCTTATTGGCGAACACACCGATTATAACGACGGTTTTGTACTGCCCTGCGCCATCGATTACGAGACGGTCA
TAAGCTGCGCCCGCCGCGACGATCGCAAAATTTGGATTATTGCCGTGGACTATGACCGCCAGCACGATATTTTTTCTCTG
GATGAGCCAATTTTGTCCCATGCCGATCAGCAATGGTCCAATTATGTGCGCGGCGTGGTAAAACATTTACAGCGCCGAGA
CGGGAATTTTGGCGGCGCCGACCTGGTTATTAGCGGCAACGTTCCCAAAGGGGCGGGCCTGAGTTCGTCTGCCGCGCTGG
AAGTAGCGGTGGGCAAAGCGTTGCAATCGCTCTATCACCTGTCGGTGGATAACGTAGCGCTGGCGCTTAATGGTCAGGAA
GCGGAAAATCAGTTTGTCGGTTGTAACTGCGGCATAATGGATCAGTTAATTTCGGCGTTGGGCAAAGACAATCACGCCTT
ATTGATCGACTGCCGCACGCTGGGGCACCCGCGCGGTGCCGATGCCGATGCCGATGCCGATGCCGATGCCGATGCCGGAC
AATATCGCAGTGGTTATCGTCAACTCCAACGTTAA

Upstream 100 bases:

>100_bases
AAATGCTGGCGGAAACCCAGCGCGACTTGACCTCAGAACAAGCCGCCGAACGCCTGCGGGCGGTCAGCGAGAATCATTTT
CGGCAATCTGGAGCCTCACG

Downstream 100 bases:

>100_bases
ACGTGGCTTGGTGGACAGCGAATATAACGCCCGCCGCCAGCAATGCGAAACCGGCGCGCGCTTTTTCGCGGTGGAAAAAT
TGCGCGATGTGGCGCTGGAT

Product: putative galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 224; Mature: 223

Protein sequence:

>224_residues
MSLQNTTATVFRDAFGYAPVLTVKAPGRFNLIGEHTDYNDGFVLPCAIDYETVISCARRDDRKIWIIAVDYDRQHDIFSL
DEPILSHADQQWSNYVRGVVKHLQRRDGNFGGADLVISGNVPKGAGLSSSAALEVAVGKALQSLYHLSVDNVALALNGQE
AENQFVGCNCGIMDQLISALGKDNHALLIDCRTLGHPRGADADADADADADAGQYRSGYRQLQR

Sequences:

>Translated_224_residues
MSLQNTTATVFRDAFGYAPVLTVKAPGRFNLIGEHTDYNDGFVLPCAIDYETVISCARRDDRKIWIIAVDYDRQHDIFSL
DEPILSHADQQWSNYVRGVVKHLQRRDGNFGGADLVISGNVPKGAGLSSSAALEVAVGKALQSLYHLSVDNVALALNGQE
AENQFVGCNCGIMDQLISALGKDNHALLIDCRTLGHPRGADADADADADADAGQYRSGYRQLQR
>Mature_223_residues
SLQNTTATVFRDAFGYAPVLTVKAPGRFNLIGEHTDYNDGFVLPCAIDYETVISCARRDDRKIWIIAVDYDRQHDIFSLD
EPILSHADQQWSNYVRGVVKHLQRRDGNFGGADLVISGNVPKGAGLSSSAALEVAVGKALQSLYHLSVDNVALALNGQEA
ENQFVGCNCGIMDQLISALGKDNHALLIDCRTLGHPRGADADADADADADAGQYRSGYRQLQR

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=189, Percent_Identity=44.4444444444444, Blast_Score=146, Evalue=1e-35,
Organism=Homo sapiens, GI4503897, Length=188, Percent_Identity=30.3191489361702, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI48527957, Length=188, Percent_Identity=30.3191489361702, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI1786972, Length=195, Percent_Identity=72.8205128205128, Blast_Score=308, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI71989053, Length=202, Percent_Identity=32.1782178217822, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6319494, Length=203, Percent_Identity=30.5418719211823, Blast_Score=89, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6320212, Length=199, Percent_Identity=28.1407035175879, Blast_Score=75, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24661292, Length=190, Percent_Identity=31.5789473684211, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21355577, Length=190, Percent_Identity=31.5789473684211, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24661285, Length=190, Percent_Identity=31.5789473684211, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 24366; Mature: 24235

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLQNTTATVFRDAFGYAPVLTVKAPGRFNLIGEHTDYNDGFVLPCAIDYETVISCARRD
CCCCCHHHHHHHHHCCCCEEEEEECCCCEEEEECCCCCCCCEEEEEECCHHHHHHHHCCC
DRKIWIIAVDYDRQHDIFSLDEPILSHADQQWSNYVRGVVKHLQRRDGNFGGADLVISGN
CCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
VPKGAGLSSSAALEVAVGKALQSLYHLSVDNVALALNGQEAENQFVGCNCGIMDQLISAL
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEECCCCCHHHHHHHHH
GKDNHALLIDCRTLGHPRGADADADADADADAGQYRSGYRQLQR
CCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SLQNTTATVFRDAFGYAPVLTVKAPGRFNLIGEHTDYNDGFVLPCAIDYETVISCARRD
CCCCHHHHHHHHHCCCCEEEEEECCCCEEEEECCCCCCCCEEEEEECCHHHHHHHHCCC
DRKIWIIAVDYDRQHDIFSLDEPILSHADQQWSNYVRGVVKHLQRRDGNFGGADLVISGN
CCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
VPKGAGLSSSAALEVAVGKALQSLYHLSVDNVALALNGQEAENQFVGCNCGIMDQLISAL
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEECCCCCHHHHHHHHH
GKDNHALLIDCRTLGHPRGADADADADADADAGQYRSGYRQLQR
CCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA