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The map label for this gene is pdxA

Identifier: 85058403

GI number: 85058403

Start: 746972

End: 747964

Strand: Reverse

Name: pdxA

Synonym: SG0425

Alternate gene names: 85058403

Gene position: 747964-746972 (Counterclockwise)

Preceding gene: 85058404

Following gene: 85058402

Centisome position: 17.93

GC content: 62.34

Gene sequence:

>993_bases
ATGGGCAGTAATCAACGCATTGTCATCACCCCCGGCGAACCCGCCGGGATTGGTCCGGACCTTGTCGCCGCGCTGGCCCA
GCAGGCGTGGCCGGTTGAACTGGTCATTTGCGCCGATCCCGCACTGCTGACGGCGCGGGCGCAGCAGCTTGGCCTGCCGC
TGCGGCTGCACTCCTATCGGCCTGAACAACCGGCTACCCCGCGGCCGGCCGGCGAGCTGACGGTGCTGGCCATTGATACG
CCGGCGCCGGTCGCCGCCGGTGAGCTCAACGTCGCCAACAGTCATTACGTGGTCGAAACGCTGGCCCGCGCCTGCGATAG
CTGTCTTAACGGTGAGTTCGCGGCGTTGCTCACGGGCCCGGTACATAAGGGCGTCATCAACGACGGTGGCCTACCATTCA
GCGGCCATACGGAATATTTCGCCCAGCGCAGCGGCCGCGAAAGGGTCGTGATGATGCTGGCCACCGAATCGCTGCGCGTC
GCATTGGCGACCACTCATTTGCCGCTGCTGGCGGTTCCGGGGGCCGTCACCCGCCAGTCCCTCGATGAAGTCATAACGAT
TCTGGTCCACGATCTGCAGCAGCAATTCGGCATCGCGCAGCCGTGCATCTACGTATGCGGGCTGAATCCCCACGCTGGCG
AAGGCGGCCATATGGGCCGGGAAGAAATCGAGGTGATAACGCCAGCCCTGGATACGCTGCGCGCCAAAGGTTATAATCTC
GTCGGTCCCCTGCCCGCCGATACCTTGTTTCAACCGAAATATCTGCAGCAGGCGGACGCGGTGCTGGCGATGTATCACGA
TCAGGGTCTGCCGGTACTGAAGTATCAGGGATTCGGCCGGGCGGTCAATATCACGCTGGGACTCCCCTTCATTCGTACCT
CCGTCGATCACGGCACCGCGCTGGAGCTGGCCGGATCGGGTCAGGCGGAGGCCGGCAGTATCAAAACGGCTCTTAATATC
GCCATCGACATGATAAAACATCGTAATGAATAA

Upstream 100 bases:

>100_bases
CGCGCCTACCGGCTGCTGTTTAACCGCAAGTTTGCTGAAGAGGCGCAAACCTGGATGCAGGAGCAGCGCGCGTCCGCTTA
CGTGAAAATCCTCGATAGCA

Downstream 100 bases:

>100_bases
CCGCGTACATCAGGGGCATCTGGCGCGCAAGCGTTTCGGCCAGAACTTTCTGCACGACAGCTCAATCATTGATGCTATTG
TTGCCGCCATTCATCCGCAG

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase

Number of amino acids: Translated: 330; Mature: 329

Protein sequence:

>330_residues
MGSNQRIVITPGEPAGIGPDLVAALAQQAWPVELVICADPALLTARAQQLGLPLRLHSYRPEQPATPRPAGELTVLAIDT
PAPVAAGELNVANSHYVVETLARACDSCLNGEFAALLTGPVHKGVINDGGLPFSGHTEYFAQRSGRERVVMMLATESLRV
ALATTHLPLLAVPGAVTRQSLDEVITILVHDLQQQFGIAQPCIYVCGLNPHAGEGGHMGREEIEVITPALDTLRAKGYNL
VGPLPADTLFQPKYLQQADAVLAMYHDQGLPVLKYQGFGRAVNITLGLPFIRTSVDHGTALELAGSGQAEAGSIKTALNI
AIDMIKHRNE

Sequences:

>Translated_330_residues
MGSNQRIVITPGEPAGIGPDLVAALAQQAWPVELVICADPALLTARAQQLGLPLRLHSYRPEQPATPRPAGELTVLAIDT
PAPVAAGELNVANSHYVVETLARACDSCLNGEFAALLTGPVHKGVINDGGLPFSGHTEYFAQRSGRERVVMMLATESLRV
ALATTHLPLLAVPGAVTRQSLDEVITILVHDLQQQFGIAQPCIYVCGLNPHAGEGGHMGREEIEVITPALDTLRAKGYNL
VGPLPADTLFQPKYLQQADAVLAMYHDQGLPVLKYQGFGRAVNITLGLPFIRTSVDHGTALELAGSGQAEAGSIKTALNI
AIDMIKHRNE
>Mature_329_residues
GSNQRIVITPGEPAGIGPDLVAALAQQAWPVELVICADPALLTARAQQLGLPLRLHSYRPEQPATPRPAGELTVLAIDTP
APVAAGELNVANSHYVVETLARACDSCLNGEFAALLTGPVHKGVINDGGLPFSGHTEYFAQRSGRERVVMMLATESLRVA
LATTHLPLLAVPGAVTRQSLDEVITILVHDLQQQFGIAQPCIYVCGLNPHAGEGGHMGREEIEVITPALDTLRAKGYNLV
GPLPADTLFQPKYLQQADAVLAMYHDQGLPVLKYQGFGRAVNITLGLPFIRTSVDHGTALELAGSGQAEAGSIKTALNIA
IDMIKHRNE

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family

Homologues:

Organism=Escherichia coli, GI1786237, Length=325, Percent_Identity=72.9230769230769, Blast_Score=478, Evalue=1e-136,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXA_SODGM (Q2NVX5)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_454105.1
- ProteinModelPortal:   Q2NVX5
- SMR:   Q2NVX5
- STRING:   Q2NVX5
- GeneID:   3867536
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG0425
- NMPDR:   fig|343509.6.peg.989
- eggNOG:   COG1995
- HOGENOM:   HBG451136
- OMA:   NPANAAY
- PhylomeDB:   Q2NVX5
- ProtClustDB:   PRK00232
- BioCyc:   SGLO343509:SG0425-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00536
- InterPro:   IPR005255
- TIGRFAMs:   TIGR00557

Pfam domain/function: PF04166 PdxA

EC number: =1.1.1.262

Molecular weight: Translated: 35036; Mature: 34905

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: BINDING 136-136 BINDING 137-137 BINDING 274-274 BINDING 283-283 BINDING 292-292

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSNQRIVITPGEPAGIGPDLVAALAQQAWPVELVICADPALLTARAQQLGLPLRLHSYR
CCCCCEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCEEECCCC
PEQPATPRPAGELTVLAIDTPAPVAAGELNVANSHYVVETLARACDSCLNGEFAALLTGP
CCCCCCCCCCCCEEEEEECCCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCEEEEEECC
VHKGVINDGGLPFSGHTEYFAQRSGRERVVMMLATESLRVALATTHLPLLAVPGAVTRQS
HHCCCCCCCCCCCCCCHHHHHHCCCCCEEEEEEECCCEEEEEEECCCCEEECCCHHHHHH
LDEVITILVHDLQQQFGIAQPCIYVCGLNPHAGEGGHMGREEIEVITPALDTLRAKGYNL
HHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCE
VGPLPADTLFQPKYLQQADAVLAMYHDQGLPVLKYQGFGRAVNITLGLPFIRTSVDHGTA
ECCCCCCCCCCCHHHHHHHHEEEEEECCCCCEEEECCCCCEEEEEECCCHHEECCCCCCE
LELAGSGQAEAGSIKTALNIAIDMIKHRNE
EEECCCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GSNQRIVITPGEPAGIGPDLVAALAQQAWPVELVICADPALLTARAQQLGLPLRLHSYR
CCCCEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCEEECCCC
PEQPATPRPAGELTVLAIDTPAPVAAGELNVANSHYVVETLARACDSCLNGEFAALLTGP
CCCCCCCCCCCCEEEEEECCCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCEEEEEECC
VHKGVINDGGLPFSGHTEYFAQRSGRERVVMMLATESLRVALATTHLPLLAVPGAVTRQS
HHCCCCCCCCCCCCCCHHHHHHCCCCCEEEEEEECCCEEEEEEECCCCEEECCCHHHHHH
LDEVITILVHDLQQQFGIAQPCIYVCGLNPHAGEGGHMGREEIEVITPALDTLRAKGYNL
HHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCE
VGPLPADTLFQPKYLQQADAVLAMYHDQGLPVLKYQGFGRAVNITLGLPFIRTSVDHGTA
ECCCCCCCCCCCHHHHHHHHEEEEEECCCCCEEEECCCCCEEEEEECCCHHEECCCCCCE
LELAGSGQAEAGSIKTALNIAIDMIKHRNE
EEECCCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA