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The map label for this gene is mdtG [H]

Identifier: 85057997

GI number: 85057997

Start: 35597

End: 36805

Strand: Reverse

Name: mdtG [H]

Synonym: SG0019

Alternate gene names: 85057997

Gene position: 36805-35597 (Counterclockwise)

Preceding gene: 85058005

Following gene: 85057995

Centisome position: 0.88

GC content: 57.65

Gene sequence:

>1209_bases
ATGGAAGCCTGGAAGGTCAATATTATATCGGTCTGGCTGGGATGCTTTTTTACCGGCCTGGCGATGAGCCAAATCCTGCC
TTTTTTGCCGCTGTATGTGGAACAACTCGGCGTCCGCTCGCACGAATCTCTCAGCCTTTGGTCCGGTATGGTGTTCAGCG
CCACCTTTTTAGTGTCGGCCATCGTGTCGCCCCTGTGGGGCAGTATGGCGGACCGCCGCGGGCGCAAGCTGATGCTTCTG
CGCGCCTCGCTTGGTATGGCGGTAGTGATAGCCCTGCAGGCTTTCGTCACCAGCGTCTGGCAATTGCTGTTGCTGCGCGC
GTTGATGGGGCTGACCTCGGGGTATGTTCCCAACGCCATGGCGCTGGTGGCGTCGCAGGTGCCGCGGGATAAGAGCGGCT
GGGCGTTCGCCATACTGTCGACCGGCCAGGTTTCCGGGGTGATTATCGGTCCACTGCTCGGCGGTTTTATGGCCGACCAT
CTCGGTCTGCGGGTGGTCTTTCTTATCACCGCCGCGCTGATGACCGTCAGTTTCCTCATTACGCTTGTGTTAATCAAAGA
ACGAGTGGTGACGGTAAAAAAGGCCGATCAACTGCACGGACGGGCAGTATTCGCCGCGCTACCCTACCCACGGTTGATTC
TGACGCTGTTTGTCACCACCATGATGATTCAGCTGACCAACAGTTCCATCAGCCCGATCTTGACCTTATTTATTAAAGAG
CTCTCTAGCGACCATGATAACTTGGCGTTCATTAGCGGTGCGATTGCCGCGGTGCCGGGGGTGTCGGCGCTGCTGGCCGC
TCCGCGCCTTGGCCGCTTAGGGGATCGTATTGGTACGGCGCGCGTGCTGATGACGGCGTTAGGCTGCCTGATTGCGCTGT
TTTGCATCATGGCGCTGGTCAGAACGCCGCTACAGCTGGGAATATTACGCTTTTTAATGGGATTTGCCGAAGGGGCGTTG
ATGCCGGCGGTGCAGACGCTGCTGGTAAAATACTCAAGCGATCAGGTCACCGGTCGCGTTTTTGGCTACAACCAGTCGTT
TATGTATCTGGGAAATGTTGCCGGCCCGCTGGTGGGCTCCAGCATTTCGGCATTGCTGGGCTTTCGCTGGGTCTTTATCG
CCACCGCCGCTCTGGTGCTGATCAACACCTGGCAGTTGCATGCCGGGATACACAAACTTAGCGTCGCGCGCGAGCGGAAA
TCCGTCTAA

Upstream 100 bases:

>100_bases
CGGTTAAAAACGCCGGGGCGGGCAATTTTCGATAGGGCAGCTTGAGCAAGGATGGTACCCTATATTCCCACCTCACTTTT
GCTCGGTGTAAGTACTGACT

Downstream 100 bases:

>100_bases
GGACAACAGCTTAGATCCACGGATAATGACCACCCATTTGGACCACCATGACCCCAGCACATACGGCGATGAAAAATAGA
AAGACTAGCAGAATTCGGGT

Product: putative transport protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MEAWKVNIISVWLGCFFTGLAMSQILPFLPLYVEQLGVRSHESLSLWSGMVFSATFLVSAIVSPLWGSMADRRGRKLMLL
RASLGMAVVIALQAFVTSVWQLLLLRALMGLTSGYVPNAMALVASQVPRDKSGWAFAILSTGQVSGVIIGPLLGGFMADH
LGLRVVFLITAALMTVSFLITLVLIKERVVTVKKADQLHGRAVFAALPYPRLILTLFVTTMMIQLTNSSISPILTLFIKE
LSSDHDNLAFISGAIAAVPGVSALLAAPRLGRLGDRIGTARVLMTALGCLIALFCIMALVRTPLQLGILRFLMGFAEGAL
MPAVQTLLVKYSSDQVTGRVFGYNQSFMYLGNVAGPLVGSSISALLGFRWVFIATAALVLINTWQLHAGIHKLSVARERK
SV

Sequences:

>Translated_402_residues
MEAWKVNIISVWLGCFFTGLAMSQILPFLPLYVEQLGVRSHESLSLWSGMVFSATFLVSAIVSPLWGSMADRRGRKLMLL
RASLGMAVVIALQAFVTSVWQLLLLRALMGLTSGYVPNAMALVASQVPRDKSGWAFAILSTGQVSGVIIGPLLGGFMADH
LGLRVVFLITAALMTVSFLITLVLIKERVVTVKKADQLHGRAVFAALPYPRLILTLFVTTMMIQLTNSSISPILTLFIKE
LSSDHDNLAFISGAIAAVPGVSALLAAPRLGRLGDRIGTARVLMTALGCLIALFCIMALVRTPLQLGILRFLMGFAEGAL
MPAVQTLLVKYSSDQVTGRVFGYNQSFMYLGNVAGPLVGSSISALLGFRWVFIATAALVLINTWQLHAGIHKLSVARERK
SV
>Mature_402_residues
MEAWKVNIISVWLGCFFTGLAMSQILPFLPLYVEQLGVRSHESLSLWSGMVFSATFLVSAIVSPLWGSMADRRGRKLMLL
RASLGMAVVIALQAFVTSVWQLLLLRALMGLTSGYVPNAMALVASQVPRDKSGWAFAILSTGQVSGVIIGPLLGGFMADH
LGLRVVFLITAALMTVSFLITLVLIKERVVTVKKADQLHGRAVFAALPYPRLILTLFVTTMMIQLTNSSISPILTLFIKE
LSSDHDNLAFISGAIAAVPGVSALLAAPRLGRLGDRIGTARVLMTALGCLIALFCIMALVRTPLQLGILRFLMGFAEGAL
MPAVQTLLVKYSSDQVTGRVFGYNQSFMYLGNVAGPLVGSSISALLGFRWVFIATAALVLINTWQLHAGIHKLSVARERK
SV

Specific function: Confers resistance to fosfomycin and deoxycholate [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787291, Length=379, Percent_Identity=59.3667546174143, Blast_Score=444, Evalue=1e-126,
Organism=Escherichia coli, GI87082404, Length=401, Percent_Identity=23.6907730673317, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI62471713, Length=365, Percent_Identity=25.2054794520548, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI62471717, Length=365, Percent_Identity=25.2054794520548, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI62471715, Length=365, Percent_Identity=25.2054794520548, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43364; Mature: 43364

Theoretical pI: Translated: 10.99; Mature: 10.99

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAWKVNIISVWLGCFFTGLAMSQILPFLPLYVEQLGVRSHESLSLWSGMVFSATFLVSA
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
IVSPLWGSMADRRGRKLMLLRASLGMAVVIALQAFVTSVWQLLLLRALMGLTSGYVPNAM
HHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
ALVASQVPRDKSGWAFAILSTGQVSGVIIGPLLGGFMADHLGLRVVFLITAALMTVSFLI
HHHHHHCCCCCCCCEEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLVLIKERVVTVKKADQLHGRAVFAALPYPRLILTLFVTTMMIQLTNSSISPILTLFIKE
HHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LSSDHDNLAFISGAIAAVPGVSALLAAPRLGRLGDRIGTARVLMTALGCLIALFCIMALV
HCCCCCCHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RTPLQLGILRFLMGFAEGALMPAVQTLLVKYSSDQVTGRVFGYNQSFMYLGNVAGPLVGS
HCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEECCCCHHEECCHHHHHHHH
SISALLGFRWVFIATAALVLINTWQLHAGIHKLSVARERKSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEAWKVNIISVWLGCFFTGLAMSQILPFLPLYVEQLGVRSHESLSLWSGMVFSATFLVSA
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
IVSPLWGSMADRRGRKLMLLRASLGMAVVIALQAFVTSVWQLLLLRALMGLTSGYVPNAM
HHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
ALVASQVPRDKSGWAFAILSTGQVSGVIIGPLLGGFMADHLGLRVVFLITAALMTVSFLI
HHHHHHCCCCCCCCEEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLVLIKERVVTVKKADQLHGRAVFAALPYPRLILTLFVTTMMIQLTNSSISPILTLFIKE
HHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LSSDHDNLAFISGAIAAVPGVSALLAAPRLGRLGDRIGTARVLMTALGCLIALFCIMALV
HCCCCCCHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RTPLQLGILRFLMGFAEGALMPAVQTLLVKYSSDQVTGRVFGYNQSFMYLGNVAGPLVGS
HCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEECCCCHHEECCHHHHHHHH
SISALLGFRWVFIATAALVLINTWQLHAGIHKLSVARERKSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA