Click here to switch to the map view.

The map label for this gene is acsA [H]

Identifier: 84625937

GI number: 84625937

Start: 4838661

End: 4840604

Strand: Reverse

Name: acsA [H]

Synonym: XOO_4280

Alternate gene names: 84625937

Gene position: 4840604-4838661 (Counterclockwise)

Preceding gene: 84625942

Following gene: 84625936

Centisome position: 97.98

GC content: 64.66

Gene sequence:

>1944_bases
ATGGCTGATGTTTATCCCGTCGATCCCGCGTTCGCCGCCGATGCGCGCGTGACGCGCGAGCAGTACGCCGCGCTGTACCG
CGAATCGATCGAACACCCTGAGCAATTCTGGGGCAAGGCCGCGCAGCGGTTGGAATGGTTCAAGCAACCCACCCAGGTCA
AGGACGTCAGCTACGCGCTGGACGACTTCCATATCCGCTGGTTCGGCGATGGCGAGCTCAACGCCAGCGTCAACTGCCTG
GACCGCCAGTTGGCCACACGCGGCGACAAGACCGCGCTGCTGTTCGAACCCGACAGCCCGGACGCGGCGTCGTACCCGGT
CACCTATCGCCAGTTGTATGAGCGCGTCTGCAAGCTTGGCAATGCGCTGCGCAACCTGGGCGTCAAGAAAGGCGACCGGG
TCACCATCTATCTGCCGATGATCGTCGATGCGGCGGTGGCCATGCTCGCCTGCGCGCGCATCGGGGCGGTGCACTCGGTG
GTGTTCGGCGGCTTTGCCGCCAACTCCATCGCCGACCGCGTGATCGATTGCCAGAGCAAGCTGATCATCACCGCCGACGA
AGGCCTGCGTGGCGGCAAGAAGATTCCGCTCAAGGCCAACGTCGATGCAGCGCTGAAGATTCCCGGCACCAACACGATCG
AAACCGTGCTGGTGGTGCGTCACACCGGTGGCGCAGTGGAGATGCAGGCACCGCGCGATCGCTGGTTCCATGACGTGGTC
GACGGCCAACCGGCCGAATGCGAACCCGAGCGGATGAACGCGGAAGACCCGCTCTTCATCCTCTATACATCCGGCTCCAC
CGGCAAACCCAAGGGCGTGCTGCACACCACTGCCGGCTACCTGCTGTTTGCCAGCTACACGCACGAAGTGGTGTTCGACC
TGCGCGAGGACGACATCTACTGGTGCACCGCCGACGTGGGCTGGGTCACCGGCCATAGCTACATCGTCTACGGCCCGCTC
GCCAACGGCGCCACCGCGGTGATGTTCGAAGGCGTGCCCAACTACCCGAACGTGTCGCGCTTCTGGGAAGTGATCGACAA
GCACCAGGTCACCATCTTCTACACCGCGCCTACTGCGATTCGCGCGTTGATGCGCGACGGTGCGGAACCGGTCAAGAAGA
CCTCGCGCAAGAGCCTGCGCCTGCTGGGCAGCGTCGGCGAGCCGATCAATCCGGAAGCCTGGCGCTGGTACTACGACGTG
GTTGGCGACAGCCGCTGCCCGATCGTGGACACCTGGTGGCAGACCGAAACCGGCGGCATCCTGATCTCGCCGCTGGCCGG
CGCGGTCGATCTCAAGCCGGGCTCGGCCACCCTGCCGTTCTTCGGCGTGCAGCCAGCGCTGGTGGATGCCGAAGGCAAGA
TCCTGGAAGGCGCCACCGAAGGCAATCTGGTGCTGCTGGATTCCTGGCCGGGCCAGATGCGTAGCGTCTACGGCGACCAT
CAGCGCTTTATCGATACCTACTTCCGCACCTATCCGGGCAGCTACTTCACCGGCGACGGTTGTCGCCGCGATGCCGACGG
CTACTACTGGATCACCGGCCGCGTGGATGACGTGATCAACGTGTCGGGCCACCGCATCGGCACCGCCGAAGTGGAAAGCG
CGCTGGTCTCGCACCCCAAGGTCGCCGAAGCGGCCGTGGTCGGCTTTCCGCACGACGTCAAGGGCCAGGGCATCTATGCC
TACGTCACCCTGATCGCCGGCGAGACTCCGAGCGACGAACTGCACAAGGAACTGGTGAGCTGGGTGCGCAAGGAGATCGG
CCCGATCGCCTCGCCCGATCACCTGCAGTGGGCTCCCGGCCTGCCCAAGACCCGCTCGGGCAAGATCATGCGCCGCATCC
TGCGCAAGATCGCCGAAAACGCCCCGGACCAGTTGGGCGACACCTCGACCTTAGCTGATCCATCGGTGGTGGATTCGCTG
GTCAATGAGCGGTTGACGCGCTGA

Upstream 100 bases:

>100_bases
GCCGTTGGCCGTCGGGACAGAATGGATGCGGCACACTGATTGTCTACCGAGGGAAGCCGTAACGCCCTCTTCCGACAAGT
TCATCGCAAGTGAGGGTGCC

Downstream 100 bases:

>100_bases
AAGGCCGGGATTGGGCATTCGGGATTGGCTGAGGAGCGGGGATTGGGGATTCGCAGAAGCGGGTTGCCAGTACCTGGTCA
TCTCTCTCCTCAACCATGCA

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 647; Mature: 646

Protein sequence:

>647_residues
MADVYPVDPAFAADARVTREQYAALYRESIEHPEQFWGKAAQRLEWFKQPTQVKDVSYALDDFHIRWFGDGELNASVNCL
DRQLATRGDKTALLFEPDSPDAASYPVTYRQLYERVCKLGNALRNLGVKKGDRVTIYLPMIVDAAVAMLACARIGAVHSV
VFGGFAANSIADRVIDCQSKLIITADEGLRGGKKIPLKANVDAALKIPGTNTIETVLVVRHTGGAVEMQAPRDRWFHDVV
DGQPAECEPERMNAEDPLFILYTSGSTGKPKGVLHTTAGYLLFASYTHEVVFDLREDDIYWCTADVGWVTGHSYIVYGPL
ANGATAVMFEGVPNYPNVSRFWEVIDKHQVTIFYTAPTAIRALMRDGAEPVKKTSRKSLRLLGSVGEPINPEAWRWYYDV
VGDSRCPIVDTWWQTETGGILISPLAGAVDLKPGSATLPFFGVQPALVDAEGKILEGATEGNLVLLDSWPGQMRSVYGDH
QRFIDTYFRTYPGSYFTGDGCRRDADGYYWITGRVDDVINVSGHRIGTAEVESALVSHPKVAEAAVVGFPHDVKGQGIYA
YVTLIAGETPSDELHKELVSWVRKEIGPIASPDHLQWAPGLPKTRSGKIMRRILRKIAENAPDQLGDTSTLADPSVVDSL
VNERLTR

Sequences:

>Translated_647_residues
MADVYPVDPAFAADARVTREQYAALYRESIEHPEQFWGKAAQRLEWFKQPTQVKDVSYALDDFHIRWFGDGELNASVNCL
DRQLATRGDKTALLFEPDSPDAASYPVTYRQLYERVCKLGNALRNLGVKKGDRVTIYLPMIVDAAVAMLACARIGAVHSV
VFGGFAANSIADRVIDCQSKLIITADEGLRGGKKIPLKANVDAALKIPGTNTIETVLVVRHTGGAVEMQAPRDRWFHDVV
DGQPAECEPERMNAEDPLFILYTSGSTGKPKGVLHTTAGYLLFASYTHEVVFDLREDDIYWCTADVGWVTGHSYIVYGPL
ANGATAVMFEGVPNYPNVSRFWEVIDKHQVTIFYTAPTAIRALMRDGAEPVKKTSRKSLRLLGSVGEPINPEAWRWYYDV
VGDSRCPIVDTWWQTETGGILISPLAGAVDLKPGSATLPFFGVQPALVDAEGKILEGATEGNLVLLDSWPGQMRSVYGDH
QRFIDTYFRTYPGSYFTGDGCRRDADGYYWITGRVDDVINVSGHRIGTAEVESALVSHPKVAEAAVVGFPHDVKGQGIYA
YVTLIAGETPSDELHKELVSWVRKEIGPIASPDHLQWAPGLPKTRSGKIMRRILRKIAENAPDQLGDTSTLADPSVVDSL
VNERLTR
>Mature_646_residues
ADVYPVDPAFAADARVTREQYAALYRESIEHPEQFWGKAAQRLEWFKQPTQVKDVSYALDDFHIRWFGDGELNASVNCLD
RQLATRGDKTALLFEPDSPDAASYPVTYRQLYERVCKLGNALRNLGVKKGDRVTIYLPMIVDAAVAMLACARIGAVHSVV
FGGFAANSIADRVIDCQSKLIITADEGLRGGKKIPLKANVDAALKIPGTNTIETVLVVRHTGGAVEMQAPRDRWFHDVVD
GQPAECEPERMNAEDPLFILYTSGSTGKPKGVLHTTAGYLLFASYTHEVVFDLREDDIYWCTADVGWVTGHSYIVYGPLA
NGATAVMFEGVPNYPNVSRFWEVIDKHQVTIFYTAPTAIRALMRDGAEPVKKTSRKSLRLLGSVGEPINPEAWRWYYDVV
GDSRCPIVDTWWQTETGGILISPLAGAVDLKPGSATLPFFGVQPALVDAEGKILEGATEGNLVLLDSWPGQMRSVYGDHQ
RFIDTYFRTYPGSYFTGDGCRRDADGYYWITGRVDDVINVSGHRIGTAEVESALVSHPKVAEAAVVGFPHDVKGQGIYAY
VTLIAGETPSDELHKELVSWVRKEIGPIASPDHLQWAPGLPKTRSGKIMRRILRKIAENAPDQLGDTSTLADPSVVDSLV
NERLTR

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=667, Percent_Identity=53.2233883058471, Blast_Score=697, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=680, Percent_Identity=52.0588235294118, Blast_Score=692, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=626, Percent_Identity=49.6805111821086, Blast_Score=624, Evalue=1e-179,
Organism=Homo sapiens, GI13375727, Length=627, Percent_Identity=37.0015948963317, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI31982927, Length=646, Percent_Identity=25.6965944272446, Blast_Score=195, Evalue=1e-49,
Organism=Homo sapiens, GI42544132, Length=521, Percent_Identity=29.9424184261036, Blast_Score=187, Evalue=4e-47,
Organism=Homo sapiens, GI38505220, Length=516, Percent_Identity=29.8449612403101, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI115511026, Length=518, Percent_Identity=27.6061776061776, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI122937307, Length=513, Percent_Identity=28.2651072124756, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI58082049, Length=512, Percent_Identity=25.390625, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI157311624, Length=514, Percent_Identity=25.2918287937743, Blast_Score=139, Evalue=8e-33,
Organism=Homo sapiens, GI157311622, Length=514, Percent_Identity=25.2918287937743, Blast_Score=139, Evalue=8e-33,
Organism=Homo sapiens, GI187761345, Length=547, Percent_Identity=28.5191956124314, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI187761343, Length=547, Percent_Identity=28.5191956124314, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI195947378, Length=427, Percent_Identity=25.9953161592506, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI42544134, Length=328, Percent_Identity=26.8292682926829, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1790505, Length=637, Percent_Identity=62.0094191522763, Blast_Score=844, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=631, Percent_Identity=36.7670364500792, Blast_Score=390, Evalue=1e-109,
Organism=Escherichia coli, GI221142682, Length=542, Percent_Identity=23.4317343173432, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI145693145, Length=542, Percent_Identity=24.5387453874539, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1788107, Length=561, Percent_Identity=23.5294117647059, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI1786810, Length=521, Percent_Identity=22.4568138195777, Blast_Score=82, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI71983001, Length=660, Percent_Identity=50, Blast_Score=625, Evalue=1e-179,
Organism=Caenorhabditis elegans, GI71982997, Length=660, Percent_Identity=50, Blast_Score=624, Evalue=1e-179,
Organism=Caenorhabditis elegans, GI17569507, Length=645, Percent_Identity=23.4108527131783, Blast_Score=142, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17538037, Length=545, Percent_Identity=23.8532110091743, Blast_Score=98, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI32563687, Length=558, Percent_Identity=22.5806451612903, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17558820, Length=546, Percent_Identity=23.4432234432234, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17557194, Length=550, Percent_Identity=24, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323182, Length=639, Percent_Identity=49.1392801251956, Blast_Score=622, Evalue=1e-179,
Organism=Saccharomyces cerevisiae, GI6319264, Length=642, Percent_Identity=48.5981308411215, Blast_Score=588, Evalue=1e-169,
Organism=Saccharomyces cerevisiae, GI6319699, Length=371, Percent_Identity=25.6064690026954, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24667955, Length=660, Percent_Identity=53.030303030303, Blast_Score=702, Evalue=0.0,
Organism=Drosophila melanogaster, GI62472339, Length=562, Percent_Identity=57.4733096085409, Blast_Score=656, Evalue=0.0,
Organism=Drosophila melanogaster, GI24667959, Length=520, Percent_Identity=58.0769230769231, Blast_Score=610, Evalue=1e-175,
Organism=Drosophila melanogaster, GI21355225, Length=634, Percent_Identity=35.6466876971609, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI21355181, Length=547, Percent_Identity=23.400365630713, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI18859661, Length=521, Percent_Identity=24.9520153550864, Blast_Score=96, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24656500, Length=546, Percent_Identity=24.1758241758242, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24581924, Length=530, Percent_Identity=22.2641509433962, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 71367; Mature: 71235

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADVYPVDPAFAADARVTREQYAALYRESIEHPEQFWGKAAQRLEWFKQPTQVKDVSYAL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHEEE
DDFHIRWFGDGELNASVNCLDRQLATRGDKTALLFEPDSPDAASYPVTYRQLYERVCKLG
CCEEEEEEECCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
NALRNLGVKKGDRVTIYLPMIVDAAVAMLACARIGAVHSVVFGGFAANSIADRVIDCQSK
HHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
LIITADEGLRGGKKIPLKANVDAALKIPGTNTIETVLVVRHTGGAVEMQAPRDRWFHDVV
EEEEECCCCCCCCCCCEEECCCEEEECCCCCCEEEEEEEEECCCEEEECCCHHHHHHHHH
DGQPAECEPERMNAEDPLFILYTSGSTGKPKGVLHTTAGYLLFASYTHEVVFDLREDDIY
CCCCCCCCHHHCCCCCCEEEEEECCCCCCCCCEEEECCCEEEEECCCEEEEEEECCCCEE
WCTADVGWVTGHSYIVYGPLANGATAVMFEGVPNYPNVSRFWEVIDKHQVTIFYTAPTAI
EEECCCCEEECCCEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHCCCEEEEEECHHHH
RALMRDGAEPVKKTSRKSLRLLGSVGEPINPEAWRWYYDVVGDSRCPIVDTWWQTETGGI
HHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCEEECCCCCCCCCE
LISPLAGAVDLKPGSATLPFFGVQPALVDAEGKILEGATEGNLVLLDSWPGQMRSVYGDH
EEECCCCEEEECCCCCCCCEECCCCEEECCCCCEEECCCCCCEEEEECCCHHHHHHHHHH
QRFIDTYFRTYPGSYFTGDGCRRDADGYYWITGRVDDVINVSGHRIGTAEVESALVSHPK
HHHHHHHHHHCCCCEECCCCCCCCCCCEEEEECCCCCEEECCCCCCCHHHHHHHHHCCCC
VAEAAVVGFPHDVKGQGIYAYVTLIAGETPSDELHKELVSWVRKEIGPIASPDHLQWAPG
HHHEEEECCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCEECCC
LPKTRSGKIMRRILRKIAENAPDQLGDTSTLADPSVVDSLVNERLTR
CCCCCCCHHHHHHHHHHHHCCCHHCCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
ADVYPVDPAFAADARVTREQYAALYRESIEHPEQFWGKAAQRLEWFKQPTQVKDVSYAL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHEEE
DDFHIRWFGDGELNASVNCLDRQLATRGDKTALLFEPDSPDAASYPVTYRQLYERVCKLG
CCEEEEEEECCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
NALRNLGVKKGDRVTIYLPMIVDAAVAMLACARIGAVHSVVFGGFAANSIADRVIDCQSK
HHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
LIITADEGLRGGKKIPLKANVDAALKIPGTNTIETVLVVRHTGGAVEMQAPRDRWFHDVV
EEEEECCCCCCCCCCCEEECCCEEEECCCCCCEEEEEEEEECCCEEEECCCHHHHHHHHH
DGQPAECEPERMNAEDPLFILYTSGSTGKPKGVLHTTAGYLLFASYTHEVVFDLREDDIY
CCCCCCCCHHHCCCCCCEEEEEECCCCCCCCCEEEECCCEEEEECCCEEEEEEECCCCEE
WCTADVGWVTGHSYIVYGPLANGATAVMFEGVPNYPNVSRFWEVIDKHQVTIFYTAPTAI
EEECCCCEEECCCEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHCCCEEEEEECHHHH
RALMRDGAEPVKKTSRKSLRLLGSVGEPINPEAWRWYYDVVGDSRCPIVDTWWQTETGGI
HHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCEEECCCCCCCCCE
LISPLAGAVDLKPGSATLPFFGVQPALVDAEGKILEGATEGNLVLLDSWPGQMRSVYGDH
EEECCCCEEEECCCCCCCCEECCCCEEECCCCCEEECCCCCCEEEEECCCHHHHHHHHHH
QRFIDTYFRTYPGSYFTGDGCRRDADGYYWITGRVDDVINVSGHRIGTAEVESALVSHPK
HHHHHHHHHHCCCCEECCCCCCCCCCCEEEEECCCCCEEECCCCCCCHHHHHHHHHCCCC
VAEAAVVGFPHDVKGQGIYAYVTLIAGETPSDELHKELVSWVRKEIGPIASPDHLQWAPG
HHHEEEECCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCEECCC
LPKTRSGKIMRRILRKIAENAPDQLGDTSTLADPSVVDSLVNERLTR
CCCCCCCHHHHHHHHHHHHCCCHHCCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]