Click here to switch to the map view.

The map label for this gene is acdA [H]

Identifier: 84625780

GI number: 84625780

Start: 4650405

End: 4651568

Strand: Reverse

Name: acdA [H]

Synonym: XOO_4123

Alternate gene names: 84625780

Gene position: 4651568-4650405 (Counterclockwise)

Preceding gene: 84625783

Following gene: 84625779

Centisome position: 94.16

GC content: 64.78

Gene sequence:

>1164_bases
ATGCATGTGCCGTCCCTGAACTTCGAGCTTGGCGAAGAGATCGATCTGCTGCGCGAAAGCGTGGCCGCCTTCGCCAACCA
CCATATCGCCCCGCTGGCCGCGGCAGCCGATCACGATAATGTGTTTCCCACGCAGTTATGGCGCCTGTTCGGCGAGCAGG
GCCTGCTCGGCCTGACCGTCGAAGAAGCATACGGCGGCAGCGGCATGGGCTACCTGGCGCATGTGGTGGCGATGGAAGAG
ATCTCGCGCGCCGGCGGTGCGATCGGGCTGTCGTACGGCGCGCATTCCAACCTGTGCCTCAATCAACTGCGCAAGAACGC
CAGCCCCGAACAGAAACAGCGCTACCTGCCCAAACTATGCAGCGGCGAGCATGTAGGCGCACTGGCGATGAGCGAGGCCG
GCTCCGGCTCGGACGTGGTGTCGATGAAGCTGCGCGCCGATGCGCGCGGCGACCGCTACGTGCTCAACGGCAGCAAGATG
TGGATCACCAACGGCCCGGATGCCGACGTACTGGTGGTGTACGCCAAGACCGACCCCGACGCGGGCGCGCGCGGTATTAC
CGCCTTCATCATCGAAAAGGGCATGCCGGGCTTTTCCACCGCACAGAAGCTGGACAAGCTGGGCATGCGCGGCTCTAACA
CTTGCGAACTGGTCTTCAGCGATTGCGAAGTGCCTGCAGAGAACGTGTTGGGCACGCTCAACGGCGGCGTGCGCGTGCTG
ATGTCCGGGCTGGATTTCGAACGCGTGGTGCTGGCGGGCGGCCCGCTCGGGCTAATGGCCGCGGCGATGGATGTGGCGCT
GCCCTACGTGCACGAGCGTAAGCAGTTCGGCGAGCCGATCGGCAACTTCCAGTTGATGCAGGCCAAGCTCGCCGACATGT
ACGTGGGGCTCAATGCCTGCCGTGCGTATGTGTATGCGGTAGCGCGCGCCTGCGATGCCGGGTGCACCACCCGCCAGGAC
GCCGCTGGCGCCATTTTGTATGCCGCCGAAAAAGCGACCTGGCTCACCGGCCAGGCGATCCAGGTGCTCGGCGGCAACGG
CTACATCAACGACTACCCCACCGGCCGCTTGTGGCGCGATGCCAAGCTGTACGAGATTGGCGCGGGCACCTCGGAAATCC
GCCGCATGCTGATCGGCCGCGAGTTGTTCGAACGCACCGCCTGA

Upstream 100 bases:

>100_bases
TTTAGTTCACTTTTTTGTTGCGGACCGCTAGTCTGGTCCTATCCGCCGCGCGGCCCGCCCGCTCCCACCCGGCACATTCC
GATCCCTGTGGAGTTGTCGC

Downstream 100 bases:

>100_bases
CGGAGTCACCATGAGCGTGATCGATAGCCAGCTACAGGTCAGCAGCGAAAGTTTCCAACACAACGCCGCTGCGATGCGTG
CGGTGATCGACGACCTGCGC

Product: acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MHVPSLNFELGEEIDLLRESVAAFANHHIAPLAAAADHDNVFPTQLWRLFGEQGLLGLTVEEAYGGSGMGYLAHVVAMEE
ISRAGGAIGLSYGAHSNLCLNQLRKNASPEQKQRYLPKLCSGEHVGALAMSEAGSGSDVVSMKLRADARGDRYVLNGSKM
WITNGPDADVLVVYAKTDPDAGARGITAFIIEKGMPGFSTAQKLDKLGMRGSNTCELVFSDCEVPAENVLGTLNGGVRVL
MSGLDFERVVLAGGPLGLMAAAMDVALPYVHERKQFGEPIGNFQLMQAKLADMYVGLNACRAYVYAVARACDAGCTTRQD
AAGAILYAAEKATWLTGQAIQVLGGNGYINDYPTGRLWRDAKLYEIGAGTSEIRRMLIGRELFERTA

Sequences:

>Translated_387_residues
MHVPSLNFELGEEIDLLRESVAAFANHHIAPLAAAADHDNVFPTQLWRLFGEQGLLGLTVEEAYGGSGMGYLAHVVAMEE
ISRAGGAIGLSYGAHSNLCLNQLRKNASPEQKQRYLPKLCSGEHVGALAMSEAGSGSDVVSMKLRADARGDRYVLNGSKM
WITNGPDADVLVVYAKTDPDAGARGITAFIIEKGMPGFSTAQKLDKLGMRGSNTCELVFSDCEVPAENVLGTLNGGVRVL
MSGLDFERVVLAGGPLGLMAAAMDVALPYVHERKQFGEPIGNFQLMQAKLADMYVGLNACRAYVYAVARACDAGCTTRQD
AAGAILYAAEKATWLTGQAIQVLGGNGYINDYPTGRLWRDAKLYEIGAGTSEIRRMLIGRELFERTA
>Mature_387_residues
MHVPSLNFELGEEIDLLRESVAAFANHHIAPLAAAADHDNVFPTQLWRLFGEQGLLGLTVEEAYGGSGMGYLAHVVAMEE
ISRAGGAIGLSYGAHSNLCLNQLRKNASPEQKQRYLPKLCSGEHVGALAMSEAGSGSDVVSMKLRADARGDRYVLNGSKM
WITNGPDADVLVVYAKTDPDAGARGITAFIIEKGMPGFSTAQKLDKLGMRGSNTCELVFSDCEVPAENVLGTLNGGVRVL
MSGLDFERVVLAGGPLGLMAAAMDVALPYVHERKQFGEPIGNFQLMQAKLADMYVGLNACRAYVYAVARACDAGCTTRQD
AAGAILYAAEKATWLTGQAIQVLGGNGYINDYPTGRLWRDAKLYEIGAGTSEIRRMLIGRELFERTA

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=375, Percent_Identity=64.5333333333333, Blast_Score=502, Evalue=1e-142,
Organism=Homo sapiens, GI226958414, Length=370, Percent_Identity=63.5135135135135, Blast_Score=482, Evalue=1e-136,
Organism=Homo sapiens, GI4557233, Length=383, Percent_Identity=39.4255874673629, Blast_Score=283, Evalue=2e-76,
Organism=Homo sapiens, GI4501859, Length=382, Percent_Identity=36.3874345549738, Blast_Score=266, Evalue=2e-71,
Organism=Homo sapiens, GI187960098, Length=385, Percent_Identity=35.0649350649351, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI4557231, Length=385, Percent_Identity=35.0649350649351, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI21361497, Length=357, Percent_Identity=37.2549019607843, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI4501857, Length=372, Percent_Identity=32.258064516129, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI7656849, Length=385, Percent_Identity=32.7272727272727, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI76496475, Length=389, Percent_Identity=34.9614395886889, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI4557235, Length=389, Percent_Identity=34.9614395886889, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI4503943, Length=392, Percent_Identity=32.1428571428571, Blast_Score=168, Evalue=9e-42,
Organism=Homo sapiens, GI7669494, Length=362, Percent_Identity=33.1491712707182, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI48976061, Length=278, Percent_Identity=25.1798561151079, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI211971008, Length=278, Percent_Identity=25.1798561151079, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI218563752, Length=232, Percent_Identity=26.2931034482759, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI38505218, Length=277, Percent_Identity=22.0216606498195, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786223, Length=381, Percent_Identity=28.6089238845144, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI87081958, Length=382, Percent_Identity=29.0575916230367, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI87082384, Length=258, Percent_Identity=29.4573643410853, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87081702, Length=272, Percent_Identity=24.6323529411765, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17538396, Length=377, Percent_Identity=63.395225464191, Blast_Score=500, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI17508101, Length=379, Percent_Identity=33.7730870712401, Blast_Score=235, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI17569725, Length=382, Percent_Identity=35.3403141361257, Blast_Score=235, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI17506239, Length=378, Percent_Identity=33.0687830687831, Blast_Score=234, Evalue=5e-62,
Organism=Caenorhabditis elegans, GI17570075, Length=385, Percent_Identity=34.5454545454545, Blast_Score=229, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI17534899, Length=389, Percent_Identity=33.9331619537275, Blast_Score=225, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI71990804, Length=280, Percent_Identity=38.5714285714286, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17533517, Length=378, Percent_Identity=32.010582010582, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI71985184, Length=355, Percent_Identity=32.6760563380282, Blast_Score=178, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=35.036496350365, Blast_Score=174, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=34.1991341991342, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17505929, Length=368, Percent_Identity=30.1630434782609, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17534353, Length=383, Percent_Identity=29.5039164490862, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17551932, Length=372, Percent_Identity=29.0322580645161, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71985192, Length=295, Percent_Identity=32.5423728813559, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17531909, Length=239, Percent_Identity=30.1255230125523, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI86563383, Length=281, Percent_Identity=28.1138790035587, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI86563381, Length=281, Percent_Identity=28.1138790035587, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21355753, Length=381, Percent_Identity=64.0419947506562, Blast_Score=484, Evalue=1e-137,
Organism=Drosophila melanogaster, GI21356377, Length=378, Percent_Identity=39.4179894179894, Blast_Score=286, Evalue=1e-77,
Organism=Drosophila melanogaster, GI24646207, Length=369, Percent_Identity=38.7533875338753, Blast_Score=273, Evalue=2e-73,
Organism=Drosophila melanogaster, GI24666513, Length=377, Percent_Identity=36.0742705570292, Blast_Score=261, Evalue=8e-70,
Organism=Drosophila melanogaster, GI24660351, Length=381, Percent_Identity=35.4330708661417, Blast_Score=224, Evalue=5e-59,
Organism=Drosophila melanogaster, GI281363737, Length=353, Percent_Identity=34.5609065155807, Blast_Score=208, Evalue=5e-54,
Organism=Drosophila melanogaster, GI19920834, Length=386, Percent_Identity=30.3108808290155, Blast_Score=161, Evalue=9e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 41455; Mature: 41455

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHVPSLNFELGEEIDLLRESVAAFANHHIAPLAAAADHDNVFPTQLWRLFGEQGLLGLTV
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHCCCCCEEEEE
EEAYGGSGMGYLAHVVAMEEISRAGGAIGLSYGAHSNLCLNQLRKNASPEQKQRYLPKLC
ECCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHC
SGEHVGALAMSEAGSGSDVVSMKLRADARGDRYVLNGSKMWITNGPDADVLVVYAKTDPD
CCCCCCEEEECCCCCCCCEEEEEEEECCCCCEEEECCCEEEEECCCCCCEEEEEEECCCC
AGARGITAFIIEKGMPGFSTAQKLDKLGMRGSNTCELVFSDCEVPAENVLGTLNGGVRVL
CCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHCCCCHHHH
MSGLDFERVVLAGGPLGLMAAAMDVALPYVHERKQFGEPIGNFQLMQAKLADMYVGLNAC
HCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
RAYVYAVARACDAGCTTRQDAAGAILYAAEKATWLTGQAIQVLGGNGYINDYPTGRLWRD
HHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCEEECCCEEEEECCCCCCCCCCCCCEECC
AKLYEIGAGTSEIRRMLIGRELFERTA
CEEEEECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHVPSLNFELGEEIDLLRESVAAFANHHIAPLAAAADHDNVFPTQLWRLFGEQGLLGLTV
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHCCCCCEEEEE
EEAYGGSGMGYLAHVVAMEEISRAGGAIGLSYGAHSNLCLNQLRKNASPEQKQRYLPKLC
ECCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHC
SGEHVGALAMSEAGSGSDVVSMKLRADARGDRYVLNGSKMWITNGPDADVLVVYAKTDPD
CCCCCCEEEECCCCCCCCEEEEEEEECCCCCEEEECCCEEEEECCCCCCEEEEEEECCCC
AGARGITAFIIEKGMPGFSTAQKLDKLGMRGSNTCELVFSDCEVPAENVLGTLNGGVRVL
CCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHCCCCHHHH
MSGLDFERVVLAGGPLGLMAAAMDVALPYVHERKQFGEPIGNFQLMQAKLADMYVGLNAC
HCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
RAYVYAVARACDAGCTTRQDAAGAILYAAEKATWLTGQAIQVLGGNGYINDYPTGRLWRD
HHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCEEECCCEEEEECCCCCCCCCCCCCEECC
AKLYEIGAGTSEIRRMLIGRELFERTA
CEEEEECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]