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The map label for this gene is cobB [H]

Identifier: 84625753

GI number: 84625753

Start: 4619800

End: 4620681

Strand: Reverse

Name: cobB [H]

Synonym: XOO_4096

Alternate gene names: 84625753

Gene position: 4620681-4619800 (Counterclockwise)

Preceding gene: 84625755

Following gene: 84625752

Centisome position: 93.53

GC content: 67.12

Gene sequence:

>882_bases
ATGACTGCTGTCCCCGCCCACGACGACCACGCGCTGCAGGACTTCATCGAGCGCCATCAGCGCCTGTTCGTGCTCACCGG
TGCCGGTTGCAGCACCGATTCGGGCATTCCCGATTATCGGGATCTGCAAGGCGGCTGGAAGCGTCCGCAGCCGGTGACGT
TTCAGGCCTTTATGGGCGAGCTGTCCACGCGGCAGCGCTATTGGGCGCGCAGCCTGGTCGGTTGGCCGCGGTTCGGCCTG
GCGCAACCCAACGCCACCCATCACGCGCTCGCTGCGCTGGAAGCGCGCGGCCAGTTGGAAGTGCTGCTCACCCAGAACGT
GGATCGCCTGCATCAGGCCGCCGGCAGCCAGGCGGTGATCGATCTGCATGGGCGGCTGGATGTGGTGCGCTGCATGGGCT
GCGAACGCCGCATGCCACGTACCGAATTTCAACTGTTGCTCGAGCAGGCCAATCCGGGCTGGGCAGCGCGTGAGGCCGCG
CAAGCGCCCGATGGCGATGCCGATCTGGACGATGTGGCCTTCGAGCATTTCGTGGTGCCGCCGTGCCCGGTGTGCGGTGG
CGTGCTCAAGCCGGACGTGGTGTTTTTCGGCGAGAACGTGCCGCGCGAGCGGGTGGAGCGCGCATTCGCGCACCTGCAGG
CGGCCGATGCGGTGCTGGTGGTGGGGTCGTCGCTGATGGTGTATTCCGGCTTCCGGTTCGTGCAGACCGCCGCGCGCAAT
GGCTTGCCGATTGCCGCGCTCAACGTCGGGCACACGCGTGCGGACGAACTGCTGACGTTGAAGGTGGAGCAGTCGTGCGC
GCAGGCGCTGGCGTTCCTGCACGGGTCGACGGACCTGCTGCGTGCACGTCGCGTCAATGACGCCAGTGCGCGTTCTGCAT
GA

Upstream 100 bases:

>100_bases
GCTATTGCGCGCGCGCCGATCCGGCCGCCGACGTTGCGTCGTAGCGGGCGAACGACGCGCTGCCGGTGCACAGTGCTCCC
ATCGTTTCCGGAATTGCCAG

Downstream 100 bases:

>100_bases
CGCAGCGATCCATCGCAGCGGTTGTGCCGGCGCGCGCAGCGCAGTGCAATAGGCACCCATGTCAGCTGTGGATGCCGCTT
TGAGCCAGTTGTTCTCTCCC

Product: NAD-dependent deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MTAVPAHDDHALQDFIERHQRLFVLTGAGCSTDSGIPDYRDLQGGWKRPQPVTFQAFMGELSTRQRYWARSLVGWPRFGL
AQPNATHHALAALEARGQLEVLLTQNVDRLHQAAGSQAVIDLHGRLDVVRCMGCERRMPRTEFQLLLEQANPGWAAREAA
QAPDGDADLDDVAFEHFVVPPCPVCGGVLKPDVVFFGENVPRERVERAFAHLQAADAVLVVGSSLMVYSGFRFVQTAARN
GLPIAALNVGHTRADELLTLKVEQSCAQALAFLHGSTDLLRARRVNDASARSA

Sequences:

>Translated_293_residues
MTAVPAHDDHALQDFIERHQRLFVLTGAGCSTDSGIPDYRDLQGGWKRPQPVTFQAFMGELSTRQRYWARSLVGWPRFGL
AQPNATHHALAALEARGQLEVLLTQNVDRLHQAAGSQAVIDLHGRLDVVRCMGCERRMPRTEFQLLLEQANPGWAAREAA
QAPDGDADLDDVAFEHFVVPPCPVCGGVLKPDVVFFGENVPRERVERAFAHLQAADAVLVVGSSLMVYSGFRFVQTAARN
GLPIAALNVGHTRADELLTLKVEQSCAQALAFLHGSTDLLRARRVNDASARSA
>Mature_292_residues
TAVPAHDDHALQDFIERHQRLFVLTGAGCSTDSGIPDYRDLQGGWKRPQPVTFQAFMGELSTRQRYWARSLVGWPRFGLA
QPNATHHALAALEARGQLEVLLTQNVDRLHQAAGSQAVIDLHGRLDVVRCMGCERRMPRTEFQLLLEQANPGWAAREAAQ
APDGDADLDDVAFEHFVVPPCPVCGGVLKPDVVFFGENVPRERVERAFAHLQAADAVLVVGSSLMVYSGFRFVQTAARNG
LPIAALNVGHTRADELLTLKVEQSCAQALAFLHGSTDLLRARRVNDASARSA

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI6912662, Length=265, Percent_Identity=47.5471698113208, Blast_Score=242, Evalue=3e-64,
Organism=Homo sapiens, GI6912664, Length=277, Percent_Identity=29.6028880866426, Blast_Score=118, Evalue=6e-27,
Organism=Homo sapiens, GI13787215, Length=261, Percent_Identity=30.6513409961686, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI300795542, Length=285, Percent_Identity=28.0701754385965, Blast_Score=115, Evalue=6e-26,
Organism=Escherichia coli, GI308199517, Length=235, Percent_Identity=32.3404255319149, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71990482, Length=271, Percent_Identity=42.0664206642066, Blast_Score=218, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI71990487, Length=273, Percent_Identity=41.7582417582418, Blast_Score=213, Evalue=7e-56,
Organism=Caenorhabditis elegans, GI17567771, Length=256, Percent_Identity=39.84375, Blast_Score=201, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI17541892, Length=228, Percent_Identity=28.0701754385965, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI28571445, Length=279, Percent_Identity=43.7275985663082, Blast_Score=228, Evalue=5e-60,
Organism=Drosophila melanogaster, GI28571443, Length=217, Percent_Identity=44.7004608294931, Blast_Score=195, Evalue=4e-50,
Organism=Drosophila melanogaster, GI28571441, Length=217, Percent_Identity=44.7004608294931, Blast_Score=195, Evalue=4e-50,
Organism=Drosophila melanogaster, GI17137536, Length=237, Percent_Identity=29.535864978903, Blast_Score=92, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 32106; Mature: 31975

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAVPAHDDHALQDFIERHQRLFVLTGAGCSTDSGIPDYRDLQGGWKRPQPVTFQAFMGE
CCCCCCCCCHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHHCCCCCCCCCEEHHHHHHH
LSTRQRYWARSLVGWPRFGLAQPNATHHALAALEARGQLEVLLTQNVDRLHQAAGSQAVI
HHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHCCCCEEE
DLHGRLDVVRCMGCERRMPRTEFQLLLEQANPGWAAREAAQAPDGDADLDDVAFEHFVVP
EECCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCHHHHHHHHCCCC
PCPVCGGVLKPDVVFFGENVPRERVERAFAHLQAADAVLVVGSSLMVYSGFRFVQTAARN
CCHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCEECCCHHHHHHCHHHHHHHHCC
GLPIAALNVGHTRADELLTLKVEQSCAQALAFLHGSTDLLRARRVNDASARSA
CCCEEEEECCCCCCCCEEEEHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TAVPAHDDHALQDFIERHQRLFVLTGAGCSTDSGIPDYRDLQGGWKRPQPVTFQAFMGE
CCCCCCCCHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHHCCCCCCCCCEEHHHHHHH
LSTRQRYWARSLVGWPRFGLAQPNATHHALAALEARGQLEVLLTQNVDRLHQAAGSQAVI
HHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHCCCCEEE
DLHGRLDVVRCMGCERRMPRTEFQLLLEQANPGWAAREAAQAPDGDADLDDVAFEHFVVP
EECCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCHHHHHHHHCCCC
PCPVCGGVLKPDVVFFGENVPRERVERAFAHLQAADAVLVVGSSLMVYSGFRFVQTAARN
CCHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCEECCCHHHHHHCHHHHHHHHCC
GLPIAALNVGHTRADELLTLKVEQSCAQALAFLHGSTDLLRARRVNDASARSA
CCCEEEEECCCCCCCCEEEEHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]