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The map label for this gene is msrA [H]

Identifier: 84625112

GI number: 84625112

Start: 3913576

End: 3914226

Strand: Reverse

Name: msrA [H]

Synonym: XOO_3455

Alternate gene names: 84625112

Gene position: 3914226-3913576 (Counterclockwise)

Preceding gene: 84625113

Following gene: 84625109

Centisome position: 79.23

GC content: 61.9

Gene sequence:

>651_bases
ATGCTGGGAATCGGCGCCTTCAAACAACGTATACCATGTCCGGGCGAGGCATTGCCCGGTCGCGAGCAAGCGCTGCCGCT
GCACAACACCCACCTGATCAACGGCCATCCGTTGCGCGGTGAGTTCACCGGCCTGGCCCAAGTGCAATTCGGGCTCGGTT
GCTTCTGGGGCGCGGAACGCAAGTTCTGGAAAGTGCCAGGGGTGTACACCACAGCAGCGGGTTACGCCGGCGGGCAGACG
CCGAACGCGACTTACTCGGAAGTGTGTTCTGGGCAAACCGGCCACACCGAAGCGGTGCTGGTGGTGTTCGACGAACAAGC
GGTGTCGTTCGAACACTTGCTGCGCACCTTCTGGGAAAGCCACGACCCGACCCAGGGCATGCAGCAAGGGAACGACGTCG
GTACGCAATATCGCTCGGCGATTTACTGCACCACACAGGCGCAATACGCCGCTGCGCTTGCCAGCCGCGATGCGTATCAG
CAACAGCTGACCGCAGCCGGATATGGCGCAATCACCACGGAGATCGGTTTTCCGGCGCCGACGTTCTACTACGCCGAAGA
CGATCACCAGCAATATCTCGCCAAGCATCCCAATGGCTATTGCGGGCTTGGCGGCACGGGAGTGAGCTGCCCGATCGGGC
TGGATGCCTGA

Upstream 100 bases:

>100_bases
AGTAATGCGGTGCAGGCGACATGCGCTGGCCGGGCAGGCTTGAAAGCGGCTCCGGCCGGCGCCATCCAGCAGGCAATCCT
CACGATTGCGGAGTTGCACC

Downstream 100 bases:

>100_bases
AGGAAAGGCGGGCCGGATTGAAGCGCTGTCGTCCACGTGATCGTGGCAGCGCGCCGATGGCCAACAGGGACCGGCAGCGT
TATCACGATCACGCGGCGCA

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MLGIGAFKQRIPCPGEALPGREQALPLHNTHLINGHPLRGEFTGLAQVQFGLGCFWGAERKFWKVPGVYTTAAGYAGGQT
PNATYSEVCSGQTGHTEAVLVVFDEQAVSFEHLLRTFWESHDPTQGMQQGNDVGTQYRSAIYCTTQAQYAAALASRDAYQ
QQLTAAGYGAITTEIGFPAPTFYYAEDDHQQYLAKHPNGYCGLGGTGVSCPIGLDA

Sequences:

>Translated_216_residues
MLGIGAFKQRIPCPGEALPGREQALPLHNTHLINGHPLRGEFTGLAQVQFGLGCFWGAERKFWKVPGVYTTAAGYAGGQT
PNATYSEVCSGQTGHTEAVLVVFDEQAVSFEHLLRTFWESHDPTQGMQQGNDVGTQYRSAIYCTTQAQYAAALASRDAYQ
QQLTAAGYGAITTEIGFPAPTFYYAEDDHQQYLAKHPNGYCGLGGTGVSCPIGLDA
>Mature_216_residues
MLGIGAFKQRIPCPGEALPGREQALPLHNTHLINGHPLRGEFTGLAQVQFGLGCFWGAERKFWKVPGVYTTAAGYAGGQT
PNATYSEVCSGQTGHTEAVLVVFDEQAVSFEHLLRTFWESHDPTQGMQQGNDVGTQYRSAIYCTTQAQYAAALASRDAYQ
QQLTAAGYGAITTEIGFPAPTFYYAEDDHQQYLAKHPNGYCGLGGTGVSCPIGLDA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=213, Percent_Identity=57.7464788732394, Blast_Score=250, Evalue=6e-67,
Organism=Homo sapiens, GI208609995, Length=186, Percent_Identity=60.752688172043, Blast_Score=231, Evalue=2e-61,
Organism=Homo sapiens, GI208609993, Length=212, Percent_Identity=45.2830188679245, Blast_Score=171, Evalue=4e-43,
Organism=Escherichia coli, GI1790665, Length=191, Percent_Identity=56.5445026178011, Blast_Score=220, Evalue=6e-59,
Organism=Caenorhabditis elegans, GI17533973, Length=148, Percent_Identity=35.1351351351351, Blast_Score=84, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6320881, Length=161, Percent_Identity=31.055900621118, Blast_Score=86, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24664627, Length=160, Percent_Identity=34.375, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24664631, Length=160, Percent_Identity=34.375, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45553131, Length=141, Percent_Identity=35.4609929078014, Blast_Score=70, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 23257; Mature: 23257

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGIGAFKQRIPCPGEALPGREQALPLHNTHLINGHPLRGEFTGLAQVQFGLGCFWGAER
CCCCCCHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCEEEEEECCEEEECCCC
KFWKVPGVYTTAAGYAGGQTPNATYSEVCSGQTGHTEAVLVVFDEQAVSFEHLLRTFWES
CEEECCCEEEECCCCCCCCCCCCCHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHC
HDPTQGMQQGNDVGTQYRSAIYCTTQAQYAAALASRDAYQQQLTAAGYGAITTEIGFPAP
CCCHHHHHCCCHHHHHHCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
TFYYAEDDHQQYLAKHPNGYCGLGGTGVSCPIGLDA
EEEECCCHHHHHHHHCCCCEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MLGIGAFKQRIPCPGEALPGREQALPLHNTHLINGHPLRGEFTGLAQVQFGLGCFWGAER
CCCCCCHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCEEEEEECCEEEECCCC
KFWKVPGVYTTAAGYAGGQTPNATYSEVCSGQTGHTEAVLVVFDEQAVSFEHLLRTFWES
CEEECCCEEEECCCCCCCCCCCCCHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHC
HDPTQGMQQGNDVGTQYRSAIYCTTQAQYAAALASRDAYQQQLTAAGYGAITTEIGFPAP
CCCHHHHHCCCHHHHHHCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
TFYYAEDDHQQYLAKHPNGYCGLGGTGVSCPIGLDA
EEEECCCHHHHHHHHCCCCEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]