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The map label for this gene is pth

Identifier: 84625060

GI number: 84625060

Start: 3864214

End: 3864798

Strand: Reverse

Name: pth

Synonym: XOO_3403

Alternate gene names: 84625060

Gene position: 3864798-3864214 (Counterclockwise)

Preceding gene: 84625061

Following gene: 84625059

Centisome position: 78.23

GC content: 62.91

Gene sequence:

>585_bases
ATGTCTGCACTCCGCCTGATCGTTGGACTCGGTAACCCGGGCCAGGAACACGCGCAAACCCGGCATAACGCCGGGTTTCG
TTTCGTCGATTCCCTCATCGAGCGCAGTGGCGCCCGCTGGGCATTGGACAGCAAGTTGTTCGGCGAGACCGCCAAGGTCG
ATATCGCAGGGCAGCCGGTCTGGCTGCTCAAGCCAGCCACCTTCATGAATCTCAGCGGCAAGTCGATCACCGCCGCATTG
CGGTTCTGGAAGATCGAGCCGGAGCACCTGCTCGTCGCCCATGACGAACTGGATCTGGCGCCCGGCACGGCGCGGCTCAA
GTTCGACGGTGGTCACGGCGGACAAAACGGTCTGCGCGACACCATTGGCCTGCTCGGGCATGGCAAATTTCACCGTCTGC
GCGTTGGAATTGGCCATCCCGGTCACAAGGACCGTGTGGTGCCCTGGGTGCTTGGACGGGCAGGGCGCGAGGATGACGCC
GCGATTGGCACTGCCATCGACGCCGCTATCGACGTGCTACCGCTGGCGATGGAAGGTCATTTCAGCGAGGCGATGAAACG
TCTGCACACCAGCAGGGATGCGTGA

Upstream 100 bases:

>100_bases
AGAAGACGCTGCCGGCGAAGAAGGCAGCGAAGGCGCCGAGACCAAGTAATCCGCCAGCCGATTCCTCGCATTGCGCGAGG
GATCGGCTGCGGTGACTGGC

Downstream 100 bases:

>100_bases
TTGGGGATTGGGGATTCGCGGCTGTGCAGCGCTACGAATCTCCAATCCCGAATCCCAAATCCCGGATGTGACCCATGGGT
ATCAAATGCGGCATCGTCGG

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 194; Mature: 193

Protein sequence:

>194_residues
MSALRLIVGLGNPGQEHAQTRHNAGFRFVDSLIERSGARWALDSKLFGETAKVDIAGQPVWLLKPATFMNLSGKSITAAL
RFWKIEPEHLLVAHDELDLAPGTARLKFDGGHGGQNGLRDTIGLLGHGKFHRLRVGIGHPGHKDRVVPWVLGRAGREDDA
AIGTAIDAAIDVLPLAMEGHFSEAMKRLHTSRDA

Sequences:

>Translated_194_residues
MSALRLIVGLGNPGQEHAQTRHNAGFRFVDSLIERSGARWALDSKLFGETAKVDIAGQPVWLLKPATFMNLSGKSITAAL
RFWKIEPEHLLVAHDELDLAPGTARLKFDGGHGGQNGLRDTIGLLGHGKFHRLRVGIGHPGHKDRVVPWVLGRAGREDDA
AIGTAIDAAIDVLPLAMEGHFSEAMKRLHTSRDA
>Mature_193_residues
SALRLIVGLGNPGQEHAQTRHNAGFRFVDSLIERSGARWALDSKLFGETAKVDIAGQPVWLLKPATFMNLSGKSITAALR
FWKIEPEHLLVAHDELDLAPGTARLKFDGGHGGQNGLRDTIGLLGHGKFHRLRVGIGHPGHKDRVVPWVLGRAGREDDAA
IGTAIDAAIDVLPLAMEGHFSEAMKRLHTSRDA

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=170, Percent_Identity=32.9411764705882, Blast_Score=89, Evalue=3e-18,
Organism=Escherichia coli, GI1787455, Length=190, Percent_Identity=50.5263157894737, Blast_Score=166, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6321983, Length=157, Percent_Identity=33.1210191082803, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_XANOM (Q2NZW9)

Other databases:

- EMBL:   AP008229
- RefSeq:   YP_452432.1
- ProteinModelPortal:   Q2NZW9
- SMR:   Q2NZW9
- STRING:   Q2NZW9
- GeneID:   3860015
- GenomeReviews:   AP008229_GR
- KEGG:   xom:XOO_3403
- eggNOG:   COG0193
- HOGENOM:   HBG610927
- OMA:   AMHRLHS
- PhylomeDB:   Q2NZW9
- ProtClustDB:   PRK05426
- BioCyc:   XORY342109:XOO3403-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 21038; Mature: 20907

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALRLIVGLGNPGQEHAQTRHNAGFRFVDSLIERSGARWALDSKLFGETAKVDIAGQPV
CCCEEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHCCCCEEECHHHCCCCEEEEECCCCE
WLLKPATFMNLSGKSITAALRFWKIEPEHLLVAHDELDLAPGTARLKFDGGHGGQNGLRD
EEECCCEEEECCCCHHEEEEEEEEECCCEEEEEECCCCCCCCCEEEEEECCCCCCCCHHH
TIGLLGHGKFHRLRVGIGHPGHKDRVVPWVLGRAGREDDAAIGTAIDAAIDVLPLAMEGH
HHHHHCCCCEEEEEEECCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
FSEAMKRLHTSRDA
HHHHHHHHHHCCCC
>Mature Secondary Structure 
SALRLIVGLGNPGQEHAQTRHNAGFRFVDSLIERSGARWALDSKLFGETAKVDIAGQPV
CCEEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHCCCCEEECHHHCCCCEEEEECCCCE
WLLKPATFMNLSGKSITAALRFWKIEPEHLLVAHDELDLAPGTARLKFDGGHGGQNGLRD
EEECCCEEEECCCCHHEEEEEEEEECCCEEEEEECCCCCCCCCEEEEEECCCCCCCCHHH
TIGLLGHGKFHRLRVGIGHPGHKDRVVPWVLGRAGREDDAAIGTAIDAAIDVLPLAMEGH
HHHHHCCCCEEEEEEECCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
FSEAMKRLHTSRDA
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA