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The map label for this gene is thiD [H]

Identifier: 84624437

GI number: 84624437

Start: 3129510

End: 3130319

Strand: Direct

Name: thiD [H]

Synonym: XOO_2780

Alternate gene names: 84624437

Gene position: 3129510-3130319 (Clockwise)

Preceding gene: 84624436

Following gene: 84624438

Centisome position: 63.35

GC content: 65.68

Gene sequence:

>810_bases
ATGACCACGCCCAGCACGCTGTCTGCATTGACCATCGCCGGTTCCGATTCCGGCGGTGGCGCCGGTATCCAGGCCGACCT
CAAGACCTTCGCCGCACACCGCGTGCACGGGTTGTCGGCAATCGCCGCATTGACCGCACAACACACTCGCGCCGTCACCG
CCGTGCATATCCCGCCACTGCCGTTTCTGCAGGCGCAGGTGGATGCCTGCTTCGCCGATTTCGAGATCCAGGCGGTCAAG
CTCGGCATGCTGTCCAATGCCGCCGTCATCCATTGCGTGGCCGATCTGCTCGAACGGCATCGCCCACCATTCGTCGTGCT
CGATCCGGTGATGGTGTCCACCAGTGGCGCACGCCTGCTCGAAGATGCCGCGCTGGATGCGCTGCGCACGCGTCTGCTGC
CGCTGGCCACGCTGATCACGCCCAATACGCACGAAGCCGAGCTACTGATCGGCCGCCGCGTCGACAGCGCCGATAGCGCC
GAACGCGCCACCGCCGCCCTGCTCGATCTGGGCGCGAATGCGGTGCTGCTCAAGGGCGGACATCTGCATGAAGGCGCGCG
TGTACTCGATCGCTTCGATGACGGCGTGACCCAGGATGTGTTCATGCATCCGCGCCTGCAGGTGGATGCGCATGGCACCG
GCTGCAGCCTGTCGGCGGCGATTGCCGCGCAGCTGTGTCAGGGCCTGTCGTTGCTCAATGCCTGCGAAGCGGCCATCGAT
TACGTTGCACGCGCCATCTGCCTCGGCCAACGTCCCGGCCATAGCGATGTACTGGTGCTCGACCACTTCGGCGCAGCACC
CAGCGCATGA

Upstream 100 bases:

>100_bases
GAACGCGATACGGTGACGCTGTTGTCGCGATGGACCGGCGCAACGTGGTGTCGACACACCGATTCTGCACAGCCGCAATC
CGGCAGTGCAGAATCGGCAG

Downstream 100 bases:

>100_bases
GCGTGCAGACCGATACCTTGCTCGCCAGCGCTGCAGATGGACACCGATGGCAGGTGATTCGCTGCGCGCCACCGCAACCA
ACGGCCACCCTGCTGTGACT

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MTTPSTLSALTIAGSDSGGGAGIQADLKTFAAHRVHGLSAIAALTAQHTRAVTAVHIPPLPFLQAQVDACFADFEIQAVK
LGMLSNAAVIHCVADLLERHRPPFVVLDPVMVSTSGARLLEDAALDALRTRLLPLATLITPNTHEAELLIGRRVDSADSA
ERATAALLDLGANAVLLKGGHLHEGARVLDRFDDGVTQDVFMHPRLQVDAHGTGCSLSAAIAAQLCQGLSLLNACEAAID
YVARAICLGQRPGHSDVLVLDHFGAAPSA

Sequences:

>Translated_269_residues
MTTPSTLSALTIAGSDSGGGAGIQADLKTFAAHRVHGLSAIAALTAQHTRAVTAVHIPPLPFLQAQVDACFADFEIQAVK
LGMLSNAAVIHCVADLLERHRPPFVVLDPVMVSTSGARLLEDAALDALRTRLLPLATLITPNTHEAELLIGRRVDSADSA
ERATAALLDLGANAVLLKGGHLHEGARVLDRFDDGVTQDVFMHPRLQVDAHGTGCSLSAAIAAQLCQGLSLLNACEAAID
YVARAICLGQRPGHSDVLVLDHFGAAPSA
>Mature_268_residues
TTPSTLSALTIAGSDSGGGAGIQADLKTFAAHRVHGLSAIAALTAQHTRAVTAVHIPPLPFLQAQVDACFADFEIQAVKL
GMLSNAAVIHCVADLLERHRPPFVVLDPVMVSTSGARLLEDAALDALRTRLLPLATLITPNTHEAELLIGRRVDSADSAE
RATAALLDLGANAVLLKGGHLHEGARVLDRFDDGVTQDVFMHPRLQVDAHGTGCSLSAAIAAQLCQGLSLLNACEAAIDY
VARAICLGQRPGHSDVLVLDHFGAAPSA

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=242, Percent_Identity=41.3223140495868, Blast_Score=160, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6325378, Length=254, Percent_Identity=31.1023622047244, Blast_Score=115, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6324997, Length=254, Percent_Identity=34.6456692913386, Blast_Score=112, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6324517, Length=254, Percent_Identity=33.0708661417323, Blast_Score=110, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 27997; Mature: 27866

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPSTLSALTIAGSDSGGGAGIQADLKTFAAHRVHGLSAIAALTAQHTRAVTAVHIPPL
CCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCC
PFLQAQVDACFADFEIQAVKLGMLSNAAVIHCVADLLERHRPPFVVLDPVMVSTSGARLL
CHHHHHHHHHHHCCEEEEEEECHHCCHHHHHHHHHHHHHCCCCEEEECCEEECCCCHHHH
EDAALDALRTRLLPLATLITPNTHEAELLIGRRVDSADSAERATAALLDLGANAVLLKGG
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECC
HLHEGARVLDRFDDGVTQDVFMHPRLQVDAHGTGCSLSAAIAAQLCQGLSLLNACEAAID
CCCHHHHHHHHHCCCCCHHHEECCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
YVARAICLGQRPGHSDVLVLDHFGAAPSA
HHHHHHHHCCCCCCCCEEEEECCCCCCCC
>Mature Secondary Structure 
TTPSTLSALTIAGSDSGGGAGIQADLKTFAAHRVHGLSAIAALTAQHTRAVTAVHIPPL
CCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCC
PFLQAQVDACFADFEIQAVKLGMLSNAAVIHCVADLLERHRPPFVVLDPVMVSTSGARLL
CHHHHHHHHHHHCCEEEEEEECHHCCHHHHHHHHHHHHHCCCCEEEECCEEECCCCHHHH
EDAALDALRTRLLPLATLITPNTHEAELLIGRRVDSADSAERATAALLDLGANAVLLKGG
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECC
HLHEGARVLDRFDDGVTQDVFMHPRLQVDAHGTGCSLSAAIAAQLCQGLSLLNACEAAID
CCCHHHHHHHHHCCCCCHHHEECCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
YVARAICLGQRPGHSDVLVLDHFGAAPSA
HHHHHHHHCCCCCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481431; 8246891 [H]