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The map label for this gene is fabG2 [H]

Identifier: 84624411

GI number: 84624411

Start: 3106006

End: 3106776

Strand: Direct

Name: fabG2 [H]

Synonym: XOO_2754

Alternate gene names: 84624411

Gene position: 3106006-3106776 (Clockwise)

Preceding gene: 84624410

Following gene: 84624412

Centisome position: 62.87

GC content: 67.7

Gene sequence:

>771_bases
ATGCAGCCCTCTTCTGTTCTTGCCATCGTCACCGGCGGCGTGTCCGGCCTCGGTCTGGCTGTTGCACAGCGTCTCGTTGC
CGACGGCGGCAAGGTCGCCTTATTCGACGTCAACGCCGACAAGGCCGACGCAGCGCTGGCGCTGCTCGGTGCCGGCAACG
CGCATTACCTCGCCACCGATGTCACCGACGAAGCGCAGGTGGCCGCGCAGGTGGCGAAGGCTGCGCAAGCGCTGGGCGGG
CTCAACCTGGTGGTGAATTGCGCCGGCATCCTGGGCGCCGGCCGCGTGCTGGGCAAGGAAGCGCCGATGCCGTTGGCCAC
CTTCCGTAGCACCGTGCTGGTGAATCTGGTCGGCAGCTTCAATGTGGCCAAGGCCGCGGCCGATGTGATGCAACACAACC
CCGCCGGCGATGACGGCGAGCGCGGCGTGATCGTCAACACCGCCTCGGTGGCCGCGTTCGAGGGCCAGATCGGCCAGGCG
GCATACGCCGCCAGCAAGGGTGGCGTGGTCGGCATGACCTTGCCGATGGCACGCGAACTCGCACGCTTCGGTATCCGCGT
CATGACGATCGCACCGGGCGTGTTCTGGACCCCGATGGTCGACGGCATGCCCGAAGCCGTGCAGCAATCGCTGGCCGCCT
CCATCCCGTTCCCCTCGCGCCTGGGCCAGCCCGACGAATACGCCGACACCGTCGCCTTCATCCTGCGCAACCGCTACCTC
AATGGCGAAGTGATTCGTCTGGACGGCGGCGTGCGGTTGGCGCCCAAGTAG

Upstream 100 bases:

>100_bases
CGCGATCGCGCAAGGGCTTCGGCTAGAATTGACGACCGCTTCGCCGATCGTTCGCTGGCCGGTCTGCACCGGCCTTCAAC
GTGACTCAGGGAATCACCGC

Downstream 100 bases:

>100_bases
CCGGGATTGGTCAGTGGCATTGGGGATTGGGAACAGCAAATGACTGCCGCACCCTCCCCGCCTCCTGCAATTGTGCTTTT
ACCAATCCCGAATCCCCAAT

Product: 3-hydroxyacyl-CoA dehydrogenase type II

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MQPSSVLAIVTGGVSGLGLAVAQRLVADGGKVALFDVNADKADAALALLGAGNAHYLATDVTDEAQVAAQVAKAAQALGG
LNLVVNCAGILGAGRVLGKEAPMPLATFRSTVLVNLVGSFNVAKAAADVMQHNPAGDDGERGVIVNTASVAAFEGQIGQA
AYAASKGGVVGMTLPMARELARFGIRVMTIAPGVFWTPMVDGMPEAVQQSLAASIPFPSRLGQPDEYADTVAFILRNRYL
NGEVIRLDGGVRLAPK

Sequences:

>Translated_256_residues
MQPSSVLAIVTGGVSGLGLAVAQRLVADGGKVALFDVNADKADAALALLGAGNAHYLATDVTDEAQVAAQVAKAAQALGG
LNLVVNCAGILGAGRVLGKEAPMPLATFRSTVLVNLVGSFNVAKAAADVMQHNPAGDDGERGVIVNTASVAAFEGQIGQA
AYAASKGGVVGMTLPMARELARFGIRVMTIAPGVFWTPMVDGMPEAVQQSLAASIPFPSRLGQPDEYADTVAFILRNRYL
NGEVIRLDGGVRLAPK
>Mature_256_residues
MQPSSVLAIVTGGVSGLGLAVAQRLVADGGKVALFDVNADKADAALALLGAGNAHYLATDVTDEAQVAAQVAKAAQALGG
LNLVVNCAGILGAGRVLGKEAPMPLATFRSTVLVNLVGSFNVAKAAADVMQHNPAGDDGERGVIVNTASVAAFEGQIGQA
AYAASKGGVVGMTLPMARELARFGIRVMTIAPGVFWTPMVDGMPEAVQQSLAASIPFPSRLGQPDEYADTVAFILRNRYL
NGEVIRLDGGVRLAPK

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=252, Percent_Identity=51.5873015873016, Blast_Score=238, Evalue=3e-63,
Organism=Homo sapiens, GI83715985, Length=252, Percent_Identity=48.015873015873, Blast_Score=213, Evalue=1e-55,
Organism=Homo sapiens, GI15277342, Length=260, Percent_Identity=36.5384615384615, Blast_Score=127, Evalue=8e-30,
Organism=Homo sapiens, GI40254992, Length=244, Percent_Identity=34.8360655737705, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI31542939, Length=242, Percent_Identity=28.099173553719, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI5031737, Length=250, Percent_Identity=28.8, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI32483357, Length=250, Percent_Identity=27.2, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI59889578, Length=216, Percent_Identity=27.3148148148148, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI10190704, Length=259, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI19923817, Length=262, Percent_Identity=26.3358778625954, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI33667109, Length=194, Percent_Identity=30.4123711340206, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1787335, Length=255, Percent_Identity=31.3725490196078, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI87082100, Length=257, Percent_Identity=30.7392996108949, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI2367175, Length=252, Percent_Identity=33.3333333333333, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1790717, Length=255, Percent_Identity=28.6274509803922, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787905, Length=249, Percent_Identity=30.5220883534137, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1789057, Length=265, Percent_Identity=28.3018867924528, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87082160, Length=249, Percent_Identity=28.1124497991968, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1789378, Length=259, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1788459, Length=259, Percent_Identity=30.1158301158301, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1786812, Length=262, Percent_Identity=30.5343511450382, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789208, Length=251, Percent_Identity=28.2868525896414, Blast_Score=68, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17538182, Length=251, Percent_Identity=45.8167330677291, Blast_Score=206, Evalue=8e-54,
Organism=Caenorhabditis elegans, GI25147288, Length=254, Percent_Identity=32.6771653543307, Blast_Score=120, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17555706, Length=253, Percent_Identity=33.596837944664, Blast_Score=110, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI17561402, Length=260, Percent_Identity=33.0769230769231, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17560676, Length=252, Percent_Identity=26.984126984127, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562906, Length=271, Percent_Identity=27.6752767527675, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17568967, Length=196, Percent_Identity=30.1020408163265, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17559104, Length=266, Percent_Identity=25.187969924812, Blast_Score=64, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6322861, Length=202, Percent_Identity=30.6930693069307, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324126, Length=257, Percent_Identity=26.8482490272374, Blast_Score=66, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17737361, Length=251, Percent_Identity=50.199203187251, Blast_Score=232, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24639444, Length=249, Percent_Identity=37.3493975903614, Blast_Score=136, Evalue=1e-32,
Organism=Drosophila melanogaster, GI21355319, Length=251, Percent_Identity=30.2788844621514, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24665243, Length=205, Percent_Identity=30.2439024390244, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI221331218, Length=205, Percent_Identity=30.2439024390244, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24665247, Length=206, Percent_Identity=30.5825242718447, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI23397609, Length=265, Percent_Identity=30.188679245283, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI221331216, Length=206, Percent_Identity=30.5825242718447, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI28571526, Length=252, Percent_Identity=30.1587301587302, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24663911, Length=238, Percent_Identity=26.4705882352941, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 26091; Mature: 26091

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPSSVLAIVTGGVSGLGLAVAQRLVADGGKVALFDVNADKADAALALLGAGNAHYLATD
CCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEECCCCEEEEEC
VTDEAQVAAQVAKAAQALGGLNLVVNCAGILGAGRVLGKEAPMPLATFRSTVLVNLVGSF
CCHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHCCC
NVAKAAADVMQHNPAGDDGERGVIVNTASVAAFEGQIGQAAYAASKGGVVGMTLPMAREL
HHHHHHHHHHHCCCCCCCCCCCEEEEECCEEEECCCCCHHHHHHCCCCEEEEEHHHHHHH
ARFGIRVMTIAPGVFWTPMVDGMPEAVQQSLAASIPFPSRLGQPDEYADTVAFILRNRYL
HHCCEEEEEECCCCEECCHHCCCHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHCCC
NGEVIRLDGGVRLAPK
CCEEEEECCCEEECCC
>Mature Secondary Structure
MQPSSVLAIVTGGVSGLGLAVAQRLVADGGKVALFDVNADKADAALALLGAGNAHYLATD
CCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEECCCCEEEEEC
VTDEAQVAAQVAKAAQALGGLNLVVNCAGILGAGRVLGKEAPMPLATFRSTVLVNLVGSF
CCHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHCCC
NVAKAAADVMQHNPAGDDGERGVIVNTASVAAFEGQIGQAAYAASKGGVVGMTLPMAREL
HHHHHHHHHHHCCCCCCCCCCCEEEEECCEEEECCCCCHHHHHHCCCCEEEEEHHHHHHH
ARFGIRVMTIAPGVFWTPMVDGMPEAVQQSLAASIPFPSRLGQPDEYADTVAFILRNRYL
HHCCEEEEEECCCCEECCHHCCCHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHCCC
NGEVIRLDGGVRLAPK
CCEEEEECCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]