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The map label for this gene is pyrC [H]

Identifier: 84624188

GI number: 84624188

Start: 2823362

End: 2824711

Strand: Direct

Name: pyrC [H]

Synonym: XOO_2531

Alternate gene names: 84624188

Gene position: 2823362-2824711 (Clockwise)

Preceding gene: 84624187

Following gene: 84624189

Centisome position: 57.15

GC content: 63.41

Gene sequence:

>1350_bases
ATGAGCCGAACCGTCATCGTCAATGCCCGCCTGGTCAATGAAGGCAAGGAATTCGACGCCGATCTTCTGATCGAGGGCGG
CCGTATCGCCAAGATCGACAGCAAGATCACCCCTGCCCCTGGCGATACCGTTGTGGACGCCGCCGGACGCTGGGTGCTGC
CGGGCATGATCGACGACCAGGTGCACTTCCGCGAACCCGGCCTGACCCACAAGGGCGACATCGCGACCGAATCCGGCGCC
GCTGTCGCTGGCGGCCTGACCAGCTTCATGGACATGCCCAACACCAACCCGCCGACCCTGGACGCCGCTGCGCTGCAGGC
CAAGTACGATGCCGCCGCCGGGCGCGCCTGGGCCAACTATGGCTTCTACATGGGCGCCAGCAACGACAACCTGGCTCACA
TCCAGTCGCTGGACCCCAAGACCGCACCGGGCATCAAGGTGTTCATGGGCGCGTCCACCGGCAACATGCTGGTCGATAAC
CCCGAAACGCTGGACGCTATCTTCCGCGACGCGCCGACGCCAATCATCACCCATTGCGAAGACACCCCGACCATCGACGC
GACGATGGAGCATTACAAGGAAAAGTATGGCGATGCGCTGACCCCGGAGATGCACCCGGACATCCGTTCGCGCGAGGCCT
GCCTGAAATCCTCGCAGCTGGCGGTGTCGCTGGCGCGCAAGCACAACACCCGCCTGCATGTACTACACATCTCCACCGCC
GACGAGCTGTCGCTGTTCGAAGCCGGCCCGCTGGTGGATTCGGACGGCAAACTGCGCAAGCGCATCACTGCCGAGACCTG
CATCCACTTCCTGCGTTTTGATCGCAGCGATTACGCGCGGCTGGGCAACCTGATCAAGTGCAATCCTGCGATCAAGGAGG
CCGAAGATCGTTTGGCACTGATCGATGCGCTGGCAGAAGACGTCATCGACGTGCTGGCCACCGACCACGCTCCGCACACC
TGGGAAGAAAAGCAGAAGCCGTATGCGCAGGCGCCTTCGGGCCTGCCGCTGGTGCAGTACGCGCTGGTCGCGGCACTGGA
GCTGGTGCACGAAGGCAAATTACCGATCACCCGCATCGTGCAAAAGTTCGCGCATGCACCAGCGCAATTGTTCGATGTGG
AAGAACGCGGCTTCCTGCGCGAAGGTTACTTCGCTGATCTGGTGATGATCGACAACACGCCGTTTACCGTGCAGCGCGAG
CAGGTGCTGTCCAAGTGCGGCTGGTCGCCGTTCGAGGGCACCACCTTCCGTTCGCGCATTGCCGCGACCTGGGTCAATGG
CCGGCAGGTGTGGGACGGCGAGCAGCTGGTGGGCAGCGCTGCCGGTCAGCGCCTGACCTTCGACCGCTGA

Upstream 100 bases:

>100_bases
GGCTCGGCCGCTGCCATCCCTTCCATCCAGGCGGGTTCGATCCGGTGCCCGATGCGCCCGCGTCGCCCTCTTCTTCCTGT
AGCTGCAAAGGACCCCATCC

Downstream 100 bases:

>100_bases
TGCGCGCAGCCCTGTTGGGCGCCTGGTTAATCCTGGCACACGTATCGCTGGTCACCGACCGCGACGACGCGCAAACAGCC
GCCGCGGCGGATGTCGTGTT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MSRTVIVNARLVNEGKEFDADLLIEGGRIAKIDSKITPAPGDTVVDAAGRWVLPGMIDDQVHFREPGLTHKGDIATESGA
AVAGGLTSFMDMPNTNPPTLDAAALQAKYDAAAGRAWANYGFYMGASNDNLAHIQSLDPKTAPGIKVFMGASTGNMLVDN
PETLDAIFRDAPTPIITHCEDTPTIDATMEHYKEKYGDALTPEMHPDIRSREACLKSSQLAVSLARKHNTRLHVLHISTA
DELSLFEAGPLVDSDGKLRKRITAETCIHFLRFDRSDYARLGNLIKCNPAIKEAEDRLALIDALAEDVIDVLATDHAPHT
WEEKQKPYAQAPSGLPLVQYALVAALELVHEGKLPITRIVQKFAHAPAQLFDVEERGFLREGYFADLVMIDNTPFTVQRE
QVLSKCGWSPFEGTTFRSRIAATWVNGRQVWDGEQLVGSAAGQRLTFDR

Sequences:

>Translated_449_residues
MSRTVIVNARLVNEGKEFDADLLIEGGRIAKIDSKITPAPGDTVVDAAGRWVLPGMIDDQVHFREPGLTHKGDIATESGA
AVAGGLTSFMDMPNTNPPTLDAAALQAKYDAAAGRAWANYGFYMGASNDNLAHIQSLDPKTAPGIKVFMGASTGNMLVDN
PETLDAIFRDAPTPIITHCEDTPTIDATMEHYKEKYGDALTPEMHPDIRSREACLKSSQLAVSLARKHNTRLHVLHISTA
DELSLFEAGPLVDSDGKLRKRITAETCIHFLRFDRSDYARLGNLIKCNPAIKEAEDRLALIDALAEDVIDVLATDHAPHT
WEEKQKPYAQAPSGLPLVQYALVAALELVHEGKLPITRIVQKFAHAPAQLFDVEERGFLREGYFADLVMIDNTPFTVQRE
QVLSKCGWSPFEGTTFRSRIAATWVNGRQVWDGEQLVGSAAGQRLTFDR
>Mature_448_residues
SRTVIVNARLVNEGKEFDADLLIEGGRIAKIDSKITPAPGDTVVDAAGRWVLPGMIDDQVHFREPGLTHKGDIATESGAA
VAGGLTSFMDMPNTNPPTLDAAALQAKYDAAAGRAWANYGFYMGASNDNLAHIQSLDPKTAPGIKVFMGASTGNMLVDNP
ETLDAIFRDAPTPIITHCEDTPTIDATMEHYKEKYGDALTPEMHPDIRSREACLKSSQLAVSLARKHNTRLHVLHISTAD
ELSLFEAGPLVDSDGKLRKRITAETCIHFLRFDRSDYARLGNLIKCNPAIKEAEDRLALIDALAEDVIDVLATDHAPHTW
EEKQKPYAQAPSGLPLVQYALVAALELVHEGKLPITRIVQKFAHAPAQLFDVEERGFLREGYFADLVMIDNTPFTVQREQ
VLSKCGWSPFEGTTFRSRIAATWVNGRQVWDGEQLVGSAAGQRLTFDR

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=396, Percent_Identity=29.040404040404, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI19923821, Length=417, Percent_Identity=22.7817745803357, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1786722, Length=449, Percent_Identity=27.1714922048998, Blast_Score=161, Evalue=8e-41,
Organism=Escherichia coli, GI87082175, Length=460, Percent_Identity=24.7826086956522, Blast_Score=108, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI193204318, Length=387, Percent_Identity=29.9741602067183, Blast_Score=159, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI71989490, Length=458, Percent_Identity=25.764192139738, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17539558, Length=464, Percent_Identity=25.2155172413793, Blast_Score=94, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6322218, Length=450, Percent_Identity=26, Blast_Score=116, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24642586, Length=398, Percent_Identity=30.4020100502513, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI18859883, Length=443, Percent_Identity=25.9593679458239, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI221377917, Length=458, Percent_Identity=25.764192139738, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17137462, Length=458, Percent_Identity=26.2008733624454, Blast_Score=82, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 49239; Mature: 49108

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRTVIVNARLVNEGKEFDADLLIEGGRIAKIDSKITPAPGDTVVDAAGRWVLPGMIDDQ
CCCEEEEEEEEECCCCCCCCEEEEECCEEEEECCCCCCCCCCCEECCCCCEECCCCCCCC
VHFREPGLTHKGDIATESGAAVAGGLTSFMDMPNTNPPTLDAAALQAKYDAAAGRAWANY
EEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCHHHCC
GFYMGASNDNLAHIQSLDPKTAPGIKVFMGASTGNMLVDNPETLDAIFRDAPTPIITHCE
CEEEECCCCCCEEEECCCCCCCCCEEEEEECCCCCEEECCHHHHHHHHHCCCCCEEECCC
DTPTIDATMEHYKEKYGDALTPEMHPDIRSREACLKSSQLAVSLARKHNTRLHVLHISTA
CCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCC
DELSLFEAGPLVDSDGKLRKRITAETCIHFLRFDRSDYARLGNLIKCNPAIKEAEDRLAL
CHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCEEECCCHHHHHHHHHHH
IDALAEDVIDVLATDHAPHTWEEKQKPYAQAPSGLPLVQYALVAALELVHEGKLPITRIV
HHHHHHHHHHHHHCCCCCCCHHHHCCCHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHH
QKFAHAPAQLFDVEERGFLREGYFADLVMIDNTPFTVQREQVLSKCGWSPFEGTTFRSRI
HHHHCCCHHHEECHHCCCCCCCCEEEEEEECCCCCEEEHHHHHHHCCCCCCCCCHHHHHH
AATWVNGRQVWDGEQLVGSAAGQRLTFDR
HEEEECCCEECCHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SRTVIVNARLVNEGKEFDADLLIEGGRIAKIDSKITPAPGDTVVDAAGRWVLPGMIDDQ
CCEEEEEEEEECCCCCCCCEEEEECCEEEEECCCCCCCCCCCEECCCCCEECCCCCCCC
VHFREPGLTHKGDIATESGAAVAGGLTSFMDMPNTNPPTLDAAALQAKYDAAAGRAWANY
EEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCHHHCC
GFYMGASNDNLAHIQSLDPKTAPGIKVFMGASTGNMLVDNPETLDAIFRDAPTPIITHCE
CEEEECCCCCCEEEECCCCCCCCCEEEEEECCCCCEEECCHHHHHHHHHCCCCCEEECCC
DTPTIDATMEHYKEKYGDALTPEMHPDIRSREACLKSSQLAVSLARKHNTRLHVLHISTA
CCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCC
DELSLFEAGPLVDSDGKLRKRITAETCIHFLRFDRSDYARLGNLIKCNPAIKEAEDRLAL
CHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCEEECCCHHHHHHHHHHH
IDALAEDVIDVLATDHAPHTWEEKQKPYAQAPSGLPLVQYALVAALELVHEGKLPITRIV
HHHHHHHHHHHHHCCCCCCCHHHHCCCHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHH
QKFAHAPAQLFDVEERGFLREGYFADLVMIDNTPFTVQREQVLSKCGWSPFEGTTFRSRI
HHHHCCCHHHEECHHCCCCCCCCEEEEEEECCCCCEEEHHHHHHHCCCCCCCCCHHHHHH
AATWVNGRQVWDGEQLVGSAAGQRLTFDR
HEEEECCCEECCHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463; 7929010 [H]