Click here to switch to the map view.

The map label for this gene is upp [H]

Identifier: 84624022

GI number: 84624022

Start: 2626549

End: 2627181

Strand: Direct

Name: upp [H]

Synonym: XOO_2365

Alternate gene names: 84624022

Gene position: 2626549-2627181 (Clockwise)

Preceding gene: 84624017

Following gene: 84624023

Centisome position: 53.17

GC content: 66.03

Gene sequence:

>633_bases
ATGAACATCGTCGAAGTCCGCCACCCCCTGGTCCAGCACAAGATCGGCCTGCTGCGCGACGCCTCCTTGAGCACCAAGGG
CTTCCGCGAGCTGGTCACCGAACTGGGCACGCTGCTGGCCTACGAGGCCACTGCCAATCTGGAGACCGAATCGCACACCC
AGCCGGGCTGGGCCGGTCCGGTTAACGTGCAGCGCATTGCCGGCGCCAAGATCACCCTGGTCCCGATCCTGCGTGCCGGC
CTGGGCATGTTGCCGGGCGTGCTGGCATTGATTCCCACCGCGCGCGTGAGCGTGGTCGGCTTGCAGCGCGATGAAGAGAC
CTTGCAGCCGGTGCCTTACTTCGAACGCCTTACCGGCCGCCTGGAAGAACGCGATGCCCTCATCCTGGACCCGATGCTGG
CCACCGGCGGCACCCTGATTGCCACCATCGACATGCTCAAGCGCGCCGGCGCGCGGCGCATCAAAGGCATTTTTCTGGTC
GCCGCACCGGAAGGCCTCAAGGCGCTGGAAGCGGTGCATCCGGACGTGGAGGTCTACACCGCCGCCATCGACGACCACCT
CAACGACAAGGGCTACATCCTGCCCGGCCTGGGCGATGCAGGCGATCGGATCTTTGGCACGCGGGTCGAGTGA

Upstream 100 bases:

>100_bases
TTTCACTGACATGACATCTGCGTTCGCGATCACGCCCAATGTATGGCGACACACCGCGCGGCTGCGGCACACTGCGCCCT
TCGCCAGCCTGTCGCTACCC

Downstream 100 bases:

>100_bases
GCGCGCCAACTTGGAGCGGCTAACACAACGTCGCGAGGGCTGCCGGGTGGGCGCGGACGGCGCGCTCAGAAGCGGAGTGT
ACGCGTGGTACATGCCGATT

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MNIVEVRHPLVQHKIGLLRDASLSTKGFRELVTELGTLLAYEATANLETESHTQPGWAGPVNVQRIAGAKITLVPILRAG
LGMLPGVLALIPTARVSVVGLQRDEETLQPVPYFERLTGRLEERDALILDPMLATGGTLIATIDMLKRAGARRIKGIFLV
AAPEGLKALEAVHPDVEVYTAAIDDHLNDKGYILPGLGDAGDRIFGTRVE

Sequences:

>Translated_210_residues
MNIVEVRHPLVQHKIGLLRDASLSTKGFRELVTELGTLLAYEATANLETESHTQPGWAGPVNVQRIAGAKITLVPILRAG
LGMLPGVLALIPTARVSVVGLQRDEETLQPVPYFERLTGRLEERDALILDPMLATGGTLIATIDMLKRAGARRIKGIFLV
AAPEGLKALEAVHPDVEVYTAAIDDHLNDKGYILPGLGDAGDRIFGTRVE
>Mature_210_residues
MNIVEVRHPLVQHKIGLLRDASLSTKGFRELVTELGTLLAYEATANLETESHTQPGWAGPVNVQRIAGAKITLVPILRAG
LGMLPGVLALIPTARVSVVGLQRDEETLQPVPYFERLTGRLEERDALILDPMLATGGTLIATIDMLKRAGARRIKGIFLV
AAPEGLKALEAVHPDVEVYTAAIDDHLNDKGYILPGLGDAGDRIFGTRVE

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=144, Percent_Identity=31.9444444444444, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI57863312, Length=144, Percent_Identity=31.9444444444444, Blast_Score=72, Evalue=3e-13,
Organism=Escherichia coli, GI87082118, Length=208, Percent_Identity=65.8653846153846, Blast_Score=292, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI17539892, Length=205, Percent_Identity=24.390243902439, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17539894, Length=205, Percent_Identity=24.390243902439, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321920, Length=158, Percent_Identity=36.0759493670886, Blast_Score=103, Evalue=2e-23,
Organism=Drosophila melanogaster, GI45550449, Length=146, Percent_Identity=30.8219178082192, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI28573516, Length=146, Percent_Identity=30.8219178082192, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI28573514, Length=146, Percent_Identity=30.8219178082192, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI28573512, Length=146, Percent_Identity=30.8219178082192, Blast_Score=74, Evalue=8e-14,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 22653; Mature: 22653

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIVEVRHPLVQHKIGLLRDASLSTKGFRELVTELGTLLAYEATANLETESHTQPGWAGP
CCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
VNVQRIAGAKITLVPILRAGLGMLPGVLALIPTARVSVVGLQRDEETLQPVPYFERLTGR
CCHHHHCCCEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHCCCCCHHHHHHCC
LEERDALILDPMLATGGTLIATIDMLKRAGARRIKGIFLVAAPEGLKALEAVHPDVEVYT
HHHCCEEEECCHHHCCCHHHHHHHHHHHCCHHHCCEEEEEECCCHHHHHHHHCCCHHEEE
AAIDDHLNDKGYILPGLGDAGDRIFGTRVE
EHHHHCCCCCCEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNIVEVRHPLVQHKIGLLRDASLSTKGFRELVTELGTLLAYEATANLETESHTQPGWAGP
CCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
VNVQRIAGAKITLVPILRAGLGMLPGVLALIPTARVSVVGLQRDEETLQPVPYFERLTGR
CCHHHHCCCEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHCCCCCHHHHHHCC
LEERDALILDPMLATGGTLIATIDMLKRAGARRIKGIFLVAAPEGLKALEAVHPDVEVYT
HHHCCEEEECCHHHCCCHHHHHHHHHHHCCHHHCCEEEEEECCCHHHHHHHHCCCHHEEE
AAIDDHLNDKGYILPGLGDAGDRIFGTRVE
EHHHHCCCCCCEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]