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The map label for this gene is hutU [H]

Identifier: 84623937

GI number: 84623937

Start: 2537727

End: 2539394

Strand: Direct

Name: hutU [H]

Synonym: XOO_2280

Alternate gene names: 84623937

Gene position: 2537727-2539394 (Clockwise)

Preceding gene: 84623936

Following gene: 84623938

Centisome position: 51.37

GC content: 65.89

Gene sequence:

>1668_bases
ATGACCCGTCACGATGCAAGCCGCGTCATCCGCGCCGCCACCGGCACCACGCTCACCGCCAAGAGCTGGCTCACCGAAGC
GCCGCTGCGCATGTTGATGAACAACCTGGACCTGGACGTGGCCGAGCGCCCGCAGGAACTGGTGGTGTACGGCGGCATTG
GCCGTGCCGCGCGCGATTGGGAATCCTTCGATGCCATCATCGCTGCGCTCACCCGTCTTGACGACGACCAGACCCTGCTG
GTGCAGTCCGGCAAACCGGTGGGCGTGTTCCGCACCCACGCCGATGCACCGCGCGTGCTGATCGCCAATTCCAACCTGGT
GCCGCGCTGGGCCACCTGGGACCACTTCAATGAACTCGATCAAAAGGGCTTGGCCATGTATGGCCAGATGACCGCCGGCA
GCTGGATCTACATCGGCGCGCAAGGCATCGTGCAGGGCACCTACGAAACCTTCGTGGAAATGGGCCGCCAGCACTACGCC
GGCAACCTGGCCGGCAAGTGGTTGTTCACCGGCGGGCTTGGCGGCATGGGCGGCGCGCAACCGCTGGCCGCGGTGATGGC
CGGCGCCTCATGCCTGGCGGTGGAGTGCCGCAAGAGCAGCATCGACATGCGCCTGCGCACCGGCTATCTCGATACCTGGA
CCGATTCGCTGGATGAAGCGCTGCGCTTGATCGAAGACTCGTGCACCGCGAAAAAACCGCTGTCGGTCGGCCTGCTCGGC
AATGTCGCCGACATGCTGGACGAACTGCTGCTGCGCGGGATCAAGCCGGATCTGTTGACCGACCAGACCTCGGCGCACGA
TCCGGTCAACGGCTACCTGCCGCAGGGCTGGAGCGTGGACGAATGGGACGACAAGCGCGTCAGCGCACCGAAGGAAGTGG
AAGCCGCCGCGCGCGATTCGATGGCCAACCACATCCGCGCCATGCTCACTTTCCATGCGCTGGGCGTGCCCACCGTGGAC
TACGGCAACAACCTGCGCCAGATGGCGCTGGAAGCCGGCATCGATAACGCATTCGATTTCCCCGGCTTCGTACCCGCCTA
CATCCGCCCGCTGTTTTGTCGCGGTATTGGCCCGTTCCGCTGGGTCGCGCTCAGTGGCGACCCGGACGATATCGCCAAGA
CCGACGCCAAGGTCAAGGAACTCATTCCCGACGATGCGCACCTGCATCGCTGGCTCGACATGGCGGCCGAAAAGATCGCC
TTCCAGGGCCTGCCCGCGCGCATCTGCTGGGTGGGCCTGGGCGACCGCCACCGGCTGGGCCTGGCCTTCAATGCCATGGT
CCGCAGCGGCGAACTGAAGGCGCCGGTGGTGATCGGCCGCGACCATCTGGATTCCGGCAGCGTGGCCTCGCCCAATCGCG
AAACCGAAGCGATGGCCGACGGCTCGGACGCGGTTTCCGACTGGCCGCTGCTCAACGCCCTGCTCAACACCGCCAGCGGC
GCCACCTGGGTATCGCTGCACCACGGCGGCGGCGTCGGCATGGGGTTCTCGCAACACGCCGGCATGGTCATCGTCTGCGA
TGGCAGCGAGGCCGCCGACAAGCGCCTGGAACGCGTGCTCTGGAACGACCCGGCCACCGGCGTGATGCGCCACGCCGATG
CCGGTTACGCCATTGCAACCGATTGCGCCAAGGAAAAAGGGCTGGATTTGCCTGGAATTTTGGGCTGA

Upstream 100 bases:

>100_bases
GTGCTACGCCATGTACTGCTGGCCTGCCTGCAGTTCGCCAACACCCCCTCTTCCGACGCCGCGCCGCCTGCGGCCACCCG
CTGATTGCAAGGAACCCGGC

Downstream 100 bases:

>100_bases
TACCTCAACCTGGCCCATGACACGCATGCATCCACTGGGCCTTACACACCAATTCGGGATACACACATGCGCTGCCGGTT
AGCTCCCGAGTTCGGCGTAG

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 555; Mature: 554

Protein sequence:

>555_residues
MTRHDASRVIRAATGTTLTAKSWLTEAPLRMLMNNLDLDVAERPQELVVYGGIGRAARDWESFDAIIAALTRLDDDQTLL
VQSGKPVGVFRTHADAPRVLIANSNLVPRWATWDHFNELDQKGLAMYGQMTAGSWIYIGAQGIVQGTYETFVEMGRQHYA
GNLAGKWLFTGGLGGMGGAQPLAAVMAGASCLAVECRKSSIDMRLRTGYLDTWTDSLDEALRLIEDSCTAKKPLSVGLLG
NVADMLDELLLRGIKPDLLTDQTSAHDPVNGYLPQGWSVDEWDDKRVSAPKEVEAAARDSMANHIRAMLTFHALGVPTVD
YGNNLRQMALEAGIDNAFDFPGFVPAYIRPLFCRGIGPFRWVALSGDPDDIAKTDAKVKELIPDDAHLHRWLDMAAEKIA
FQGLPARICWVGLGDRHRLGLAFNAMVRSGELKAPVVIGRDHLDSGSVASPNRETEAMADGSDAVSDWPLLNALLNTASG
ATWVSLHHGGGVGMGFSQHAGMVIVCDGSEAADKRLERVLWNDPATGVMRHADAGYAIATDCAKEKGLDLPGILG

Sequences:

>Translated_555_residues
MTRHDASRVIRAATGTTLTAKSWLTEAPLRMLMNNLDLDVAERPQELVVYGGIGRAARDWESFDAIIAALTRLDDDQTLL
VQSGKPVGVFRTHADAPRVLIANSNLVPRWATWDHFNELDQKGLAMYGQMTAGSWIYIGAQGIVQGTYETFVEMGRQHYA
GNLAGKWLFTGGLGGMGGAQPLAAVMAGASCLAVECRKSSIDMRLRTGYLDTWTDSLDEALRLIEDSCTAKKPLSVGLLG
NVADMLDELLLRGIKPDLLTDQTSAHDPVNGYLPQGWSVDEWDDKRVSAPKEVEAAARDSMANHIRAMLTFHALGVPTVD
YGNNLRQMALEAGIDNAFDFPGFVPAYIRPLFCRGIGPFRWVALSGDPDDIAKTDAKVKELIPDDAHLHRWLDMAAEKIA
FQGLPARICWVGLGDRHRLGLAFNAMVRSGELKAPVVIGRDHLDSGSVASPNRETEAMADGSDAVSDWPLLNALLNTASG
ATWVSLHHGGGVGMGFSQHAGMVIVCDGSEAADKRLERVLWNDPATGVMRHADAGYAIATDCAKEKGLDLPGILG
>Mature_554_residues
TRHDASRVIRAATGTTLTAKSWLTEAPLRMLMNNLDLDVAERPQELVVYGGIGRAARDWESFDAIIAALTRLDDDQTLLV
QSGKPVGVFRTHADAPRVLIANSNLVPRWATWDHFNELDQKGLAMYGQMTAGSWIYIGAQGIVQGTYETFVEMGRQHYAG
NLAGKWLFTGGLGGMGGAQPLAAVMAGASCLAVECRKSSIDMRLRTGYLDTWTDSLDEALRLIEDSCTAKKPLSVGLLGN
VADMLDELLLRGIKPDLLTDQTSAHDPVNGYLPQGWSVDEWDDKRVSAPKEVEAAARDSMANHIRAMLTFHALGVPTVDY
GNNLRQMALEAGIDNAFDFPGFVPAYIRPLFCRGIGPFRWVALSGDPDDIAKTDAKVKELIPDDAHLHRWLDMAAEKIAF
QGLPARICWVGLGDRHRLGLAFNAMVRSGELKAPVVIGRDHLDSGSVASPNRETEAMADGSDAVSDWPLLNALLNTASGA
TWVSLHHGGGVGMGFSQHAGMVIVCDGSEAADKRLERVLWNDPATGVMRHADAGYAIATDCAKEKGLDLPGILG

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=569, Percent_Identity=35.3251318101933, Blast_Score=313, Evalue=3e-85,
Organism=Homo sapiens, GI260306182, Length=638, Percent_Identity=32.4451410658307, Blast_Score=286, Evalue=4e-77,
Organism=Caenorhabditis elegans, GI71997891, Length=552, Percent_Identity=35.8695652173913, Blast_Score=323, Evalue=1e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 60008; Mature: 59877

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRHDASRVIRAATGTTLTAKSWLTEAPLRMLMNNLDLDVAERPQELVVYGGIGRAARDW
CCCCCHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHCCCCHHCCCCEEEEECCCCCHHHHH
ESFDAIIAALTRLDDDQTLLVQSGKPVGVFRTHADAPRVLIANSNLVPRWATWDHFNELD
HHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCEEEEECCCCCCCCCCHHHHHHHH
QKGLAMYGQMTAGSWIYIGAQGIVQGTYETFVEMGRQHYAGNLAGKWLFTGGLGGMGGAQ
HHHHHEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHH
PLAAVMAGASCLAVECRKSSIDMRLRTGYLDTWTDSLDEALRLIEDSCTAKKPLSVGLLG
HHHHHHCCCHHEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEHHH
NVADMLDELLLRGIKPDLLTDQTSAHDPVNGYLPQGWSVDEWDDKRVSAPKEVEAAARDS
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
MANHIRAMLTFHALGVPTVDYGNNLRQMALEAGIDNAFDFPGFVPAYIRPLFCRGIGPFR
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCEE
WVALSGDPDDIAKTDAKVKELIPDDAHLHRWLDMAAEKIAFQGLPARICWVGLGDRHRLG
EEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCC
LAFNAMVRSGELKAPVVIGRDHLDSGSVASPNRETEAMADGSDAVSDWPLLNALLNTASG
CEEEHHHCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHCCCC
ATWVSLHHGGGVGMGFSQHAGMVIVCDGSEAADKRLERVLWNDPATGVMRHADAGYAIAT
CEEEEEECCCCCCCCHHCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEH
DCAKEKGLDLPGILG
HHHHHCCCCCCCCCC
>Mature Secondary Structure 
TRHDASRVIRAATGTTLTAKSWLTEAPLRMLMNNLDLDVAERPQELVVYGGIGRAARDW
CCCCHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHCCCCHHCCCCEEEEECCCCCHHHHH
ESFDAIIAALTRLDDDQTLLVQSGKPVGVFRTHADAPRVLIANSNLVPRWATWDHFNELD
HHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCEEEEECCCCCCCCCCHHHHHHHH
QKGLAMYGQMTAGSWIYIGAQGIVQGTYETFVEMGRQHYAGNLAGKWLFTGGLGGMGGAQ
HHHHHEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHH
PLAAVMAGASCLAVECRKSSIDMRLRTGYLDTWTDSLDEALRLIEDSCTAKKPLSVGLLG
HHHHHHCCCHHEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEHHH
NVADMLDELLLRGIKPDLLTDQTSAHDPVNGYLPQGWSVDEWDDKRVSAPKEVEAAARDS
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
MANHIRAMLTFHALGVPTVDYGNNLRQMALEAGIDNAFDFPGFVPAYIRPLFCRGIGPFR
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCEE
WVALSGDPDDIAKTDAKVKELIPDDAHLHRWLDMAAEKIAFQGLPARICWVGLGDRHRLG
EEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCC
LAFNAMVRSGELKAPVVIGRDHLDSGSVASPNRETEAMADGSDAVSDWPLLNALLNTASG
CEEEHHHCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHCCCC
ATWVSLHHGGGVGMGFSQHAGMVIVCDGSEAADKRLERVLWNDPATGVMRHADAGYAIAT
CEEEEEECCCCCCCCHHCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEH
DCAKEKGLDLPGILG
HHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]