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The map label for this gene is hutH [H]

Identifier: 84623935

GI number: 84623935

Start: 2535133

End: 2536674

Strand: Direct

Name: hutH [H]

Synonym: XOO_2278

Alternate gene names: 84623935

Gene position: 2535133-2536674 (Clockwise)

Preceding gene: 84623934

Following gene: 84623936

Centisome position: 51.32

GC content: 66.8

Gene sequence:

>1542_bases
ATGCCTGTTTCTGTTGTCTTGCAGCCCGGCCAGGTCACACTGACGCAATGGCGTGCGCTGTATCGCGGTGCCGAGGTCGC
AGTGGACGATGCATGCGCCGCTGCCGTGCTGCACAGCGCGCAAACGGTGGAGGCCATCGTTGCGCGTGGCGAGCCGGTGT
ATGGGGTCAATACCGGCTTCGGCAAGCTGGCCAGCGTACGCATCGAGCGGGAGGATCTGCAGACCCTGCAGCGTAATATC
GTGCTCTCGCATGCAGCCGGTGTCGGCGAGCCCACCCCGGTGCCGGTGGTGCGGCTGATGATGGCGCTCAAGCTCACCAG
CCTGGCCCAGGGCGCTTCCGGCGTGCAGCCGGACACGCTGGCACTGCTGGAAGCGATGCTGCGCCATGGCATCACCCCGG
TGGTGCCATGCCAGGGATCGGTGGGTGCCTCCGGCGATCTGGCGCCGCTGTCGCATCTGGCCGCGGTGATGATCGGCGTT
GGCGAAGCCTTCGTCGGCAACCAGCGCCTATCTGCTGCTGACGCACTGGCACAGGCGCAATTGCAGCCCCGCGTGCTGGG
CGCGAAAGAAGGCTTGGCGCTGCTCAATGGCACCCAGTTTTCCACCGCCTGCGCCCTGGCCGGTGTGTTTGAGATCGAAA
CCGTGTTGCAGGCCGCGCTGGTCGCCGGCGCGTTGTCGGTAGAAGCGGCCAAGGGCTCGGATACGCCCTTCGATGCGCGC
ATCCACGCATTGCGCGGGCAGCCGGGACAGATCGCCACCGCGGCGGCGTTGCGCGCCTTGATGACGGATTCGGCCATTCG
CGAATCGCATCGGCTTGGCGATGGGCGCGTGCAGGACCCGTACTGCCTGCGCTGCCAGCCACAGGTGATGGGAGCGGCGT
TGGACATCATGCGCCAGGCCGCGCGCACGCTGGAGATCGAAGCCAATGGCGTGTCCGATAACCCGCTGGTCTTCAGCGAT
ACCGGCGAAGCCTTGTCTGGTGGCAATTTCCACGCCGAGCCGGTGGCCTTCACCGCCGACATGCTGGCGATGGCGGTGTG
CGAAATCGGCTCGATCAGCGAACGCCGCACCGCCATGCTGGTGGACCCTGCCCTGTCCGGCCTGCCCGCCTTCCTCACCC
CGCGCCCGGGCTTGAACTCCGGCTTCATGATTCCGCAGGTCACCGCCGCGGCGCTGGTGTCGGAAAACAAACAGCGCGCG
TATCCGGCCAGCGTCGATTCGATTCCGACCTCGGCCAATCAGGAAGATCACGTGTCGATGGCCGCCCACGGTGCGCGCCG
TCTGCTGGCGATGGCAGAGAACGCCGCGCATGTGATCGGCATCGAACTGCTGGCCGCCGCACAAGGCTGCGATTTCCATG
CGCCGCTGCGCTCCAGCGCCGCACTGGAAGCCGCGCGTGCCCTGTTGCGCGCGCATGTACCAACACTGCAGGACGATCGC
TATTTCCATCCCGACATGTTGGCTGCCAGCGCCTTGGTACGCTCGGGCGCGCTGGCGCAGGCGGTGGCGATTGCGTTGCC
GGGCGTGGAGCACGACGTATGA

Upstream 100 bases:

>100_bases
TGGGACATCGATGCGCCGGCCGATCTGGTCTACCGCATGGGCTTCAACCCTCTTCATGCCCGCGTGTTGCGCGGGCATCT
TTGCTGAATCCGGAGTCGTC

Downstream 100 bases:

>100_bases
GTTGGCAGCTCTCATGCAGCGGGTCGATACCTACATCTTCGCAATCGCAACGGCAATCTTTCGCGATATCTCCAAGCACA
TGCGATGACGCGGCACGGCG

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 513; Mature: 512

Protein sequence:

>513_residues
MPVSVVLQPGQVTLTQWRALYRGAEVAVDDACAAAVLHSAQTVEAIVARGEPVYGVNTGFGKLASVRIEREDLQTLQRNI
VLSHAAGVGEPTPVPVVRLMMALKLTSLAQGASGVQPDTLALLEAMLRHGITPVVPCQGSVGASGDLAPLSHLAAVMIGV
GEAFVGNQRLSAADALAQAQLQPRVLGAKEGLALLNGTQFSTACALAGVFEIETVLQAALVAGALSVEAAKGSDTPFDAR
IHALRGQPGQIATAAALRALMTDSAIRESHRLGDGRVQDPYCLRCQPQVMGAALDIMRQAARTLEIEANGVSDNPLVFSD
TGEALSGGNFHAEPVAFTADMLAMAVCEIGSISERRTAMLVDPALSGLPAFLTPRPGLNSGFMIPQVTAAALVSENKQRA
YPASVDSIPTSANQEDHVSMAAHGARRLLAMAENAAHVIGIELLAAAQGCDFHAPLRSSAALEAARALLRAHVPTLQDDR
YFHPDMLAASALVRSGALAQAVAIALPGVEHDV

Sequences:

>Translated_513_residues
MPVSVVLQPGQVTLTQWRALYRGAEVAVDDACAAAVLHSAQTVEAIVARGEPVYGVNTGFGKLASVRIEREDLQTLQRNI
VLSHAAGVGEPTPVPVVRLMMALKLTSLAQGASGVQPDTLALLEAMLRHGITPVVPCQGSVGASGDLAPLSHLAAVMIGV
GEAFVGNQRLSAADALAQAQLQPRVLGAKEGLALLNGTQFSTACALAGVFEIETVLQAALVAGALSVEAAKGSDTPFDAR
IHALRGQPGQIATAAALRALMTDSAIRESHRLGDGRVQDPYCLRCQPQVMGAALDIMRQAARTLEIEANGVSDNPLVFSD
TGEALSGGNFHAEPVAFTADMLAMAVCEIGSISERRTAMLVDPALSGLPAFLTPRPGLNSGFMIPQVTAAALVSENKQRA
YPASVDSIPTSANQEDHVSMAAHGARRLLAMAENAAHVIGIELLAAAQGCDFHAPLRSSAALEAARALLRAHVPTLQDDR
YFHPDMLAASALVRSGALAQAVAIALPGVEHDV
>Mature_512_residues
PVSVVLQPGQVTLTQWRALYRGAEVAVDDACAAAVLHSAQTVEAIVARGEPVYGVNTGFGKLASVRIEREDLQTLQRNIV
LSHAAGVGEPTPVPVVRLMMALKLTSLAQGASGVQPDTLALLEAMLRHGITPVVPCQGSVGASGDLAPLSHLAAVMIGVG
EAFVGNQRLSAADALAQAQLQPRVLGAKEGLALLNGTQFSTACALAGVFEIETVLQAALVAGALSVEAAKGSDTPFDARI
HALRGQPGQIATAAALRALMTDSAIRESHRLGDGRVQDPYCLRCQPQVMGAALDIMRQAARTLEIEANGVSDNPLVFSDT
GEALSGGNFHAEPVAFTADMLAMAVCEIGSISERRTAMLVDPALSGLPAFLTPRPGLNSGFMIPQVTAAALVSENKQRAY
PASVDSIPTSANQEDHVSMAAHGARRLLAMAENAAHVIGIELLAAAQGCDFHAPLRSSAALEAARALLRAHVPTLQDDRY
FHPDMLAASALVRSGALAQAVAIALPGVEHDV

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=481, Percent_Identity=44.2827442827443, Blast_Score=369, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17567831, Length=473, Percent_Identity=43.7632135306554, Blast_Score=341, Evalue=4e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 53209; Mature: 53077

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00488 PAL_HISTIDASE ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVSVVLQPGQVTLTQWRALYRGAEVAVDDACAAAVLHSAQTVEAIVARGEPVYGVNTGF
CCEEEEECCCCEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCC
GKLASVRIEREDLQTLQRNIVLSHAAGVGEPTPVPVVRLMMALKLTSLAQGASGVQPDTL
CCCEEEEECHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHH
ALLEAMLRHGITPVVPCQGSVGASGDLAPLSHLAAVMIGVGEAFVGNQRLSAADALAQAQ
HHHHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHH
LQPRVLGAKEGLALLNGTQFSTACALAGVFEIETVLQAALVAGALSVEAAKGSDTPFDAR
CCCHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHH
IHALRGQPGQIATAAALRALMTDSAIRESHRLGDGRVQDPYCLRCQPQVMGAALDIMRQA
HHEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHHHH
ARTLEIEANGVSDNPLVFSDTGEALSGGNFHAEPVAFTADMLAMAVCEIGSISERRTAML
HHEEEEEECCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEE
VDPALSGLPAFLTPRPGLNSGFMIPQVTAAALVSENKQRAYPASVDSIPTSANQEDHVSM
ECHHHCCCCCEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHH
AAHGARRLLAMAENAAHVIGIELLAAAQGCDFHAPLRSSAALEAARALLRAHVPTLQDDR
HHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
YFHPDMLAASALVRSGALAQAVAIALPGVEHDV
CCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PVSVVLQPGQVTLTQWRALYRGAEVAVDDACAAAVLHSAQTVEAIVARGEPVYGVNTGF
CEEEEECCCCEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCC
GKLASVRIEREDLQTLQRNIVLSHAAGVGEPTPVPVVRLMMALKLTSLAQGASGVQPDTL
CCCEEEEECHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHH
ALLEAMLRHGITPVVPCQGSVGASGDLAPLSHLAAVMIGVGEAFVGNQRLSAADALAQAQ
HHHHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHH
LQPRVLGAKEGLALLNGTQFSTACALAGVFEIETVLQAALVAGALSVEAAKGSDTPFDAR
CCCHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHH
IHALRGQPGQIATAAALRALMTDSAIRESHRLGDGRVQDPYCLRCQPQVMGAALDIMRQA
HHEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHHHH
ARTLEIEANGVSDNPLVFSDTGEALSGGNFHAEPVAFTADMLAMAVCEIGSISERRTAML
HHEEEEEECCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEE
VDPALSGLPAFLTPRPGLNSGFMIPQVTAAALVSENKQRAYPASVDSIPTSANQEDHVSM
ECHHHCCCCCEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHH
AAHGARRLLAMAENAAHVIGIELLAAAQGCDFHAPLRSSAALEAARALLRAHVPTLQDDR
HHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
YFHPDMLAASALVRSGALAQAVAIALPGVEHDV
CCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]