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The map label for this gene is hisI [H]

Identifier: 84623782

GI number: 84623782

Start: 2350980

End: 2351600

Strand: Direct

Name: hisI [H]

Synonym: XOO_2125

Alternate gene names: 84623782

Gene position: 2350980-2351600 (Clockwise)

Preceding gene: 84623781

Following gene: 84623783

Centisome position: 47.59

GC content: 64.09

Gene sequence:

>621_bases
ATGGGCAGTAACGACGTGGCAACGGGCGACGCGCTCGTAACGTTGGATTGGAGCAAGGGCGACGGCCTGTTGCCGGTGAT
CGTGCAGGACGCCGACAATTTGCGCGTGTTGATGCTGGGCTACATGAATGCCGAAGCGTTGGCCGCCACCCAACAGCGTG
GTGAAGTCACCTTCTTCAGCCGCAGCAAGCAGCGCTTGTGGACCAAGGGCGAGAGCTCGGGGAACGTGTTGCGCGTGGTA
TCGATCGAGACCGATTGCGATGCCGACACACTGCTGGTGCAGGCACGTCCGCATGGCCCCACCTGCCATCTTGGCCGCAC
CAGCTGTTTTCCCAGTGCGCCCGGGCAGTTCCTGGGTAGCCTGGATGCGCTGGTGGCCGAGCGCGAGCGCGAACGCCCGC
ACGGTAGCTACACCAGCAAGCTGTTCGAGCAAGGCATCCGCCGCATCGCGCAGAAGGTAGGCGAGGAGGGCGTGGAAACC
GCGCTGGCCGGTGTGGTGCAGGGCAATGACGCGTTGCTCGGCGAATCGGCCGATCTGCTGTATCACCTGATCGTGCTGCT
GCGCGCACGTGGCTTGGGTCTTGGCGATGCGGTGGCGTTGCTGGAATCGCGGCACACGTAA

Upstream 100 bases:

>100_bases
GATGTGGATGGCGCACTGGCAGCGAGCGTGTTTCATAGCGGTGCGATTCCGATTCCGGAACTCAAGCAATTTTTGCGCGC
GCAACAGATCGAGGTACGCG

Downstream 100 bases:

>100_bases
CGTGGTCGGGTAGGAGCGCACCCGGGCGCGCCGGGCGTCCTTGGGAATGCCCCGTCGCGCCCCGGTGCGCTCCTAGGGAT
GTGCGGTCATGCCTTCCAAC

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MGSNDVATGDALVTLDWSKGDGLLPVIVQDADNLRVLMLGYMNAEALAATQQRGEVTFFSRSKQRLWTKGESSGNVLRVV
SIETDCDADTLLVQARPHGPTCHLGRTSCFPSAPGQFLGSLDALVAERERERPHGSYTSKLFEQGIRRIAQKVGEEGVET
ALAGVVQGNDALLGESADLLYHLIVLLRARGLGLGDAVALLESRHT

Sequences:

>Translated_206_residues
MGSNDVATGDALVTLDWSKGDGLLPVIVQDADNLRVLMLGYMNAEALAATQQRGEVTFFSRSKQRLWTKGESSGNVLRVV
SIETDCDADTLLVQARPHGPTCHLGRTSCFPSAPGQFLGSLDALVAERERERPHGSYTSKLFEQGIRRIAQKVGEEGVET
ALAGVVQGNDALLGESADLLYHLIVLLRARGLGLGDAVALLESRHT
>Mature_205_residues
GSNDVATGDALVTLDWSKGDGLLPVIVQDADNLRVLMLGYMNAEALAATQQRGEVTFFSRSKQRLWTKGESSGNVLRVVS
IETDCDADTLLVQARPHGPTCHLGRTSCFPSAPGQFLGSLDALVAERERERPHGSYTSKLFEQGIRRIAQKVGEEGVETA
LAGVVQGNDALLGESADLLYHLIVLLRARGLGLGDAVALLESRHT

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=193, Percent_Identity=60.1036269430052, Blast_Score=227, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6319819, Length=207, Percent_Identity=33.3333333333333, Blast_Score=94, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 22111; Mature: 21980

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSNDVATGDALVTLDWSKGDGLLPVIVQDADNLRVLMLGYMNAEALAATQQRGEVTFFS
CCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCEEEEEEECCCHHHHHHHHHCCCEEEEE
RSKQRLWTKGESSGNVLRVVSIETDCDADTLLVQARPHGPTCHLGRTSCFPSAPGQFLGS
CCHHHHHCCCCCCCCEEEEEEEECCCCCCEEEEEECCCCCEEECCCCCCCCCCCHHHHHH
LDALVAERERERPHGSYTSKLFEQGIRRIAQKVGEEGVETALAGVVQGNDALLGESADLL
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCHHHH
YHLIVLLRARGLGLGDAVALLESRHT
HHHHHHHHHCCCCCHHHHHHHHCCCC
>Mature Secondary Structure 
GSNDVATGDALVTLDWSKGDGLLPVIVQDADNLRVLMLGYMNAEALAATQQRGEVTFFS
CCCCCCCCCEEEEEEECCCCCEEEEEEECCCCEEEEEEECCCHHHHHHHHHCCCEEEEE
RSKQRLWTKGESSGNVLRVVSIETDCDADTLLVQARPHGPTCHLGRTSCFPSAPGQFLGS
CCHHHHHCCCCCCCCEEEEEEEECCCCCCEEEEEECCCCCEEECCCCCCCCCCCHHHHHH
LDALVAERERERPHGSYTSKLFEQGIRRIAQKVGEEGVETALAGVVQGNDALLGESADLL
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCHHHH
YHLIVLLRARGLGLGDAVALLESRHT
HHHHHHHHHCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]