Click here to switch to the map view.

The map label for this gene is thrC [H]

Identifier: 84623768

GI number: 84623768

Start: 2337690

End: 2338994

Strand: Direct

Name: thrC [H]

Synonym: XOO_2111

Alternate gene names: 84623768

Gene position: 2337690-2338994 (Clockwise)

Preceding gene: 84623766

Following gene: 84623769

Centisome position: 47.32

GC content: 68.58

Gene sequence:

>1305_bases
ATGTTCATCTCCACCCGTGGCGGTGCCCCCGCCGCAAGCCTGAGCCAGGCCATTGCCGCCGGGCTGGCGCCCGATGGCGG
CCTCTACGTGCCACAGACCCTGCCACCTGCCCGTACGCTGATTGCGGGCGCCGGCCTTGCCGACACCGCCACTGCGCTAT
TGCAGCCATTTTTCGAGGGCGATGCACTGGCGGCAGAACTCTCTGCCATCTGTGCCGAGGCCTTCGATTTCCCGGCGCCA
TTGGTGGCCTTGGGTACGCCGGGCGATTACGCGCTGGAGCTGTTTCATGGCCCCACCGCCGCATTCAAGGATTTCGGTGC
GCGTTTCCTGGCGGCCTGCCTGACCCGCCTGCGCCGTGCCGAAGACCGCCCGCTCACCATCCTGGTCGCCACCTCCGGCG
ACACCGGTGCCGCCGTGGCCGCTGCGTTCCATCGGCAGCCTGGCCTGCGTGTGGTGGTGCTCTACCCGGACGGCCGCGTG
TCGCCACGCCAGGCGCATCAGCTGGGGTGTTTCGGCGACAACATTCAGGCCCTGCGTGTGGCCGGCTCGTTCGACGACTG
CCAGGCGATGGTCAAACAGGCCTTGAACGATGCCGCGTTGCAGACGCAGGTGCCGCTGAGTTCGGCCAACAGCATCAGCC
TGGGCCGGCTGCTGCCGCAGATGAGTTACTACGCGCATGCCGCGCTGCAGCACCATGCGGCGTGGGGCGACGTGCTCAAC
CTGGTGGTGCCCACCGGCAACCTGGGCAACGCGCTGGCGGCGATCATCGCGCGCGCGCTCGGGGTGCCATTAGGCCGCAT
CGCGCTGGCCTCCAACGCCAACCATGTCTTGCCGGACTATTTCGCTGGCGACGCGTACGCGCCGCAGCCCAGCGTGGCCA
CGCTGGCCAATGCGATGGACGTGGGCGCGCCGAGCAATTTCGAGCGGCTGCGTTGGCTCTACAACGGCGACGATGCCGCC
TTGCGCGAGGAATTCCGTGCGTTGTCGGTGGACGACGCAGCGATTCGCCACACCGTGCAGCAGCGTTTCGCGCGCTATGG
CGAGGTGCATTGCCCGCATACCGCCACCGCGGTGCATGTGCTTGAACAACTGCGTGCCGAGGGCGCGGAGGGCGGCACCG
GCGATTGGGCGGTGGCGGCCACGGCGCATCCGGCCAAGTTCGAAGGCGTGGTGGAGCCATTGATCGGCCGGACGGTGGAG
GTTCCGCCGGCGCTGGCCGCGCTGCTGCAGCGCCCAGCGCAAGCCGAAGCACTGGCGGCGGACTATGCGGCTTTCCGGCA
GCGTCTGCTTGCGGATGCGACCTGA

Upstream 100 bases:

>100_bases
TTCGGCCGAATGCCGGTGCAAGCCGACGCCCGGCTAAGTCACACGCGGCATCGCTTGTCATGGGTGCCGCCCAGCCTTCG
CTTTATTTGGAGTCACACTG

Downstream 100 bases:

>100_bases
CCCAACGCGTTCAGGCACTCGGGGTTGGAAAGTGGCCTGCATGGGGCTATTTCTAGGCAGCTGCGGCCCCGTTGTGGCGC
CGCGTCTGCTGTGGGTTGTT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MFISTRGGAPAASLSQAIAAGLAPDGGLYVPQTLPPARTLIAGAGLADTATALLQPFFEGDALAAELSAICAEAFDFPAP
LVALGTPGDYALELFHGPTAAFKDFGARFLAACLTRLRRAEDRPLTILVATSGDTGAAVAAAFHRQPGLRVVVLYPDGRV
SPRQAHQLGCFGDNIQALRVAGSFDDCQAMVKQALNDAALQTQVPLSSANSISLGRLLPQMSYYAHAALQHHAAWGDVLN
LVVPTGNLGNALAAIIARALGVPLGRIALASNANHVLPDYFAGDAYAPQPSVATLANAMDVGAPSNFERLRWLYNGDDAA
LREEFRALSVDDAAIRHTVQQRFARYGEVHCPHTATAVHVLEQLRAEGAEGGTGDWAVAATAHPAKFEGVVEPLIGRTVE
VPPALAALLQRPAQAEALAADYAAFRQRLLADAT

Sequences:

>Translated_434_residues
MFISTRGGAPAASLSQAIAAGLAPDGGLYVPQTLPPARTLIAGAGLADTATALLQPFFEGDALAAELSAICAEAFDFPAP
LVALGTPGDYALELFHGPTAAFKDFGARFLAACLTRLRRAEDRPLTILVATSGDTGAAVAAAFHRQPGLRVVVLYPDGRV
SPRQAHQLGCFGDNIQALRVAGSFDDCQAMVKQALNDAALQTQVPLSSANSISLGRLLPQMSYYAHAALQHHAAWGDVLN
LVVPTGNLGNALAAIIARALGVPLGRIALASNANHVLPDYFAGDAYAPQPSVATLANAMDVGAPSNFERLRWLYNGDDAA
LREEFRALSVDDAAIRHTVQQRFARYGEVHCPHTATAVHVLEQLRAEGAEGGTGDWAVAATAHPAKFEGVVEPLIGRTVE
VPPALAALLQRPAQAEALAADYAAFRQRLLADAT
>Mature_434_residues
MFISTRGGAPAASLSQAIAAGLAPDGGLYVPQTLPPARTLIAGAGLADTATALLQPFFEGDALAAELSAICAEAFDFPAP
LVALGTPGDYALELFHGPTAAFKDFGARFLAACLTRLRRAEDRPLTILVATSGDTGAAVAAAFHRQPGLRVVVLYPDGRV
SPRQAHQLGCFGDNIQALRVAGSFDDCQAMVKQALNDAALQTQVPLSSANSISLGRLLPQMSYYAHAALQHHAAWGDVLN
LVVPTGNLGNALAAIIARALGVPLGRIALASNANHVLPDYFAGDAYAPQPSVATLANAMDVGAPSNFERLRWLYNGDDAA
LREEFRALSVDDAAIRHTVQQRFARYGEVHCPHTATAVHVLEQLRAEGAEGGTGDWAVAATAHPAKFEGVVEPLIGRTVE
VPPALAALLQRPAQAEALAADYAAFRQRLLADAT

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=505, Percent_Identity=31.4851485148515, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI149193323, Length=401, Percent_Identity=30.6733167082294, Blast_Score=157, Evalue=2e-38,
Organism=Escherichia coli, GI1786185, Length=421, Percent_Identity=38.9548693586698, Blast_Score=260, Evalue=1e-70,
Organism=Saccharomyces cerevisiae, GI6319901, Length=451, Percent_Identity=31.4855875831486, Blast_Score=203, Evalue=3e-53,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 45368; Mature: 45368

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFISTRGGAPAASLSQAIAAGLAPDGGLYVPQTLPPARTLIAGAGLADTATALLQPFFEG
CEECCCCCCCHHHHHHHHHHCCCCCCCEECCCCCCCHHHHHHCCCCHHHHHHHHHHHHCC
DALAAELSAICAEAFDFPAPLVALGTPGDYALELFHGPTAAFKDFGARFLAACLTRLRRA
CHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCC
EDRPLTILVATSGDTGAAVAAAFHRQPGLRVVVLYPDGRVSPRQAHQLGCFGDNIQALRV
CCCCEEEEEEECCCCCHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHCCCCCCCCEEEEE
AGSFDDCQAMVKQALNDAALQTQVPLSSANSISLGRLLPQMSYYAHAALQHHAAWGDVLN
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHE
LVVPTGNLGNALAAIIARALGVPLGRIALASNANHVLPDYFAGDAYAPQPSVATLANAMD
EEECCCCCHHHHHHHHHHHHCCCHHHEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
VGAPSNFERLRWLYNGDDAALREEFRALSVDDAAIRHTVQQRFARYGEVHCPHTATAVHV
CCCCCCHHHHHEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LEQLRAEGAEGGTGDWAVAATAHPAKFEGVVEPLIGRTVEVPPALAALLQRPAQAEALAA
HHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHH
DYAAFRQRLLADAT
HHHHHHHHHHHCCC
>Mature Secondary Structure
MFISTRGGAPAASLSQAIAAGLAPDGGLYVPQTLPPARTLIAGAGLADTATALLQPFFEG
CEECCCCCCCHHHHHHHHHHCCCCCCCEECCCCCCCHHHHHHCCCCHHHHHHHHHHHHCC
DALAAELSAICAEAFDFPAPLVALGTPGDYALELFHGPTAAFKDFGARFLAACLTRLRRA
CHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCC
EDRPLTILVATSGDTGAAVAAAFHRQPGLRVVVLYPDGRVSPRQAHQLGCFGDNIQALRV
CCCCEEEEEEECCCCCHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHCCCCCCCCEEEEE
AGSFDDCQAMVKQALNDAALQTQVPLSSANSISLGRLLPQMSYYAHAALQHHAAWGDVLN
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHE
LVVPTGNLGNALAAIIARALGVPLGRIALASNANHVLPDYFAGDAYAPQPSVATLANAMD
EEECCCCCHHHHHHHHHHHHCCCHHHEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
VGAPSNFERLRWLYNGDDAALREEFRALSVDDAAIRHTVQQRFARYGEVHCPHTATAVHV
CCCCCCHHHHHEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LEQLRAEGAEGGTGDWAVAATAHPAKFEGVVEPLIGRTVEVPPALAALLQRPAQAEALAA
HHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHH
DYAAFRQRLLADAT
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]