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The map label for this gene is guaB [H]

Identifier: 84623719

GI number: 84623719

Start: 2281185

End: 2282642

Strand: Direct

Name: guaB [H]

Synonym: XOO_2062

Alternate gene names: 84623719

Gene position: 2281185-2282642 (Clockwise)

Preceding gene: 84623718

Following gene: 84623720

Centisome position: 46.18

GC content: 63.51

Gene sequence:

>1458_bases
ATGCTACGCATCCAGGCTGAAGCTCTTACCTACGACGACGTTTCGCTCGTCCCCGCTCATTCGATCGTCCTGCCCAAGGA
CGTCAGCCTGGAAACCCGGCTGACGCGCGACCTGCGCCTGAAACTGCCGATTCTGTCGGCGGCAATGGACACAGTGACCG
AACACCGTCTTGCGGTGGCCATGGCCCAGCTGGGCGGCATCGGCATCATCCACAAGAATCTGACCCCGCAGCAGCAATCC
GGCGAAGTGGCGCGGGTCAAGAAGTTCGAATCCGGTGTGATCACCGAGCCGTTCACCGTCCGCCCGGACACGACCATCGG
TGAAGTGCTGGCACTGACGCGCGCGCGCAACATCTCCGGCGTGCCGGTGGTCGACGGCAGTGAACTGGTCGGTATCGTCA
CCAGCCGCGACATGCGCTTCGAAAAGAAGCTCGACGATCCGGTCCGCCACATCATGACCAAGAAGGATCGCCTGATCACC
GTGCGCGAAGGCGCCAGCGATGAGGAAGTGCTCGAGCTGCTGCATCGCAATCGCATCGAAAAGGTCTTGGTGGTCAACCA
CAGCTTCGAGCTGCGCGGCCTGATCACGGTCAAGGACATCCAGAAGAAGACCGACAACCCGAATGCCGCCAAGGACAGCG
CCAAGCGCTTGCTGGTGGGCGCGGCGGTGGGTGTGGGCGGCGATACCGAACAGCGTATCGAACTGCTTGCCGCAGCTGGC
GTGGACGTGGTTATCGTCGATACTGCGCATGGTCATTCGCAGGGCGTGATCGATCGCGTGGCGTGGGTCAAGAAGACTTA
TCCGCAGCTGCAGGTGATCGGCGGCAACATCGTCACCGGCGATGCCGCGCTGGCGTTGATGGACGCCGGTGCCGACGCAG
TCAAGGTTGGCGTGGGTCCTGGTTCGATCTGCACCACGCGTGTGGTTGCTGGCGTGGGCGTGCCGCAGATCACGGCGGTG
GACATGGTGGCCGAAGCGCTGCAGGACCGCATTCCGTTGATTGCCGATGGCGGCATCCGCTATTCCGGCGACATCGGCAA
GGCGTTGGTGGCCGGTGCGTCCACGGTGATGGTCGGTGGCCTGTTGGCCGGTACCGAAGAAGCACCGGGCGAAGTCGAAC
TGTTCCAGGGCCGTAGCTACAAGAGCTACCGCGGCATGGGCAGCCTGGGTGCGATGGAGAAGGGGTCCAAGGACCGCTAT
TTCCAGGACGCCTCCGATGCCGACAAGCTGGTTCCCGAAGGCATCGAGGGGCGCGTGCCGTATCGCGGCCCGGTCGGCGG
CATCATCCATCAGCTCATCGGCGGCTTGCGCGCGACCATGGGGTATGTGGGCTGCGCCACCATCGAAGACATGCGCAGCA
AGCCCAAGTTCGTCAAGATCACGGGCGCCGGCCAGCGCGAAAGCCACGTGCACGACGTGCAGATCACCAAAGAGCCACCG
AACTATCGCGCCGGGTAA

Upstream 100 bases:

>100_bases
GACGGTGCAAGGCGGCGCTGTTGCGACTCCCCAATCCCGACTCCCCAATCCCCGTCCCAATGCGTTAAAATGCCGCGCTT
CCCCAAACTCGGGTCCGCCG

Downstream 100 bases:

>100_bases
ACCAGCGCGCGGGAGTGGGGATTCGGCATTCGGGATTCGCAAGAGCCTACCGCGTCCTCATCCGGCAACGGTTGTGGCGT
GTGTTCTTGCGAATCTCCAA

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MLRIQAEALTYDDVSLVPAHSIVLPKDVSLETRLTRDLRLKLPILSAAMDTVTEHRLAVAMAQLGGIGIIHKNLTPQQQS
GEVARVKKFESGVITEPFTVRPDTTIGEVLALTRARNISGVPVVDGSELVGIVTSRDMRFEKKLDDPVRHIMTKKDRLIT
VREGASDEEVLELLHRNRIEKVLVVNHSFELRGLITVKDIQKKTDNPNAAKDSAKRLLVGAAVGVGGDTEQRIELLAAAG
VDVVIVDTAHGHSQGVIDRVAWVKKTYPQLQVIGGNIVTGDAALALMDAGADAVKVGVGPGSICTTRVVAGVGVPQITAV
DMVAEALQDRIPLIADGGIRYSGDIGKALVAGASTVMVGGLLAGTEEAPGEVELFQGRSYKSYRGMGSLGAMEKGSKDRY
FQDASDADKLVPEGIEGRVPYRGPVGGIIHQLIGGLRATMGYVGCATIEDMRSKPKFVKITGAGQRESHVHDVQITKEPP
NYRAG

Sequences:

>Translated_485_residues
MLRIQAEALTYDDVSLVPAHSIVLPKDVSLETRLTRDLRLKLPILSAAMDTVTEHRLAVAMAQLGGIGIIHKNLTPQQQS
GEVARVKKFESGVITEPFTVRPDTTIGEVLALTRARNISGVPVVDGSELVGIVTSRDMRFEKKLDDPVRHIMTKKDRLIT
VREGASDEEVLELLHRNRIEKVLVVNHSFELRGLITVKDIQKKTDNPNAAKDSAKRLLVGAAVGVGGDTEQRIELLAAAG
VDVVIVDTAHGHSQGVIDRVAWVKKTYPQLQVIGGNIVTGDAALALMDAGADAVKVGVGPGSICTTRVVAGVGVPQITAV
DMVAEALQDRIPLIADGGIRYSGDIGKALVAGASTVMVGGLLAGTEEAPGEVELFQGRSYKSYRGMGSLGAMEKGSKDRY
FQDASDADKLVPEGIEGRVPYRGPVGGIIHQLIGGLRATMGYVGCATIEDMRSKPKFVKITGAGQRESHVHDVQITKEPP
NYRAG
>Mature_485_residues
MLRIQAEALTYDDVSLVPAHSIVLPKDVSLETRLTRDLRLKLPILSAAMDTVTEHRLAVAMAQLGGIGIIHKNLTPQQQS
GEVARVKKFESGVITEPFTVRPDTTIGEVLALTRARNISGVPVVDGSELVGIVTSRDMRFEKKLDDPVRHIMTKKDRLIT
VREGASDEEVLELLHRNRIEKVLVVNHSFELRGLITVKDIQKKTDNPNAAKDSAKRLLVGAAVGVGGDTEQRIELLAAAG
VDVVIVDTAHGHSQGVIDRVAWVKKTYPQLQVIGGNIVTGDAALALMDAGADAVKVGVGPGSICTTRVVAGVGVPQITAV
DMVAEALQDRIPLIADGGIRYSGDIGKALVAGASTVMVGGLLAGTEEAPGEVELFQGRSYKSYRGMGSLGAMEKGSKDRY
FQDASDADKLVPEGIEGRVPYRGPVGGIIHQLIGGLRATMGYVGCATIEDMRSKPKFVKITGAGQRESHVHDVQITKEPP
NYRAG

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=485, Percent_Identity=44.1237113402062, Blast_Score=360, Evalue=2e-99,
Organism=Homo sapiens, GI156616279, Length=485, Percent_Identity=44.1237113402062, Blast_Score=359, Evalue=3e-99,
Organism=Homo sapiens, GI34328928, Length=485, Percent_Identity=44.1237113402062, Blast_Score=359, Evalue=3e-99,
Organism=Homo sapiens, GI66933016, Length=483, Percent_Identity=43.064182194617, Blast_Score=359, Evalue=4e-99,
Organism=Homo sapiens, GI34328930, Length=485, Percent_Identity=44.1237113402062, Blast_Score=358, Evalue=4e-99,
Organism=Homo sapiens, GI217035152, Length=474, Percent_Identity=44.0928270042194, Blast_Score=349, Evalue=3e-96,
Organism=Homo sapiens, GI217035148, Length=485, Percent_Identity=43.5051546391753, Blast_Score=348, Evalue=5e-96,
Organism=Homo sapiens, GI217035150, Length=485, Percent_Identity=41.2371134020619, Blast_Score=316, Evalue=3e-86,
Organism=Homo sapiens, GI50541954, Length=246, Percent_Identity=38.6178861788618, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI50541952, Length=246, Percent_Identity=38.6178861788618, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI50541948, Length=246, Percent_Identity=38.6178861788618, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI50541956, Length=246, Percent_Identity=38.6178861788618, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI156104880, Length=261, Percent_Identity=36.3984674329502, Blast_Score=158, Evalue=1e-38,
Organism=Escherichia coli, GI1788855, Length=487, Percent_Identity=62.6283367556468, Blast_Score=566, Evalue=1e-163,
Organism=Escherichia coli, GI1786293, Length=267, Percent_Identity=34.0823970037453, Blast_Score=149, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI71994385, Length=499, Percent_Identity=39.2785571142285, Blast_Score=304, Evalue=6e-83,
Organism=Caenorhabditis elegans, GI71994389, Length=421, Percent_Identity=41.3301662707838, Blast_Score=285, Evalue=4e-77,
Organism=Caenorhabditis elegans, GI17560440, Length=255, Percent_Identity=33.3333333333333, Blast_Score=157, Evalue=9e-39,
Organism=Saccharomyces cerevisiae, GI6322012, Length=483, Percent_Identity=39.7515527950311, Blast_Score=332, Evalue=1e-91,
Organism=Saccharomyces cerevisiae, GI6323585, Length=487, Percent_Identity=39.4250513347023, Blast_Score=329, Evalue=5e-91,
Organism=Saccharomyces cerevisiae, GI6323464, Length=483, Percent_Identity=39.7515527950311, Blast_Score=317, Evalue=2e-87,
Organism=Saccharomyces cerevisiae, GI6319352, Length=338, Percent_Identity=39.6449704142012, Blast_Score=241, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6319353, Length=141, Percent_Identity=38.2978723404255, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24641071, Length=481, Percent_Identity=41.7879417879418, Blast_Score=343, Evalue=1e-94,
Organism=Drosophila melanogaster, GI24641073, Length=481, Percent_Identity=41.7879417879418, Blast_Score=343, Evalue=1e-94,
Organism=Drosophila melanogaster, GI28571163, Length=439, Percent_Identity=42.5968109339408, Blast_Score=313, Evalue=1e-85,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51766; Mature: 51766

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRIQAEALTYDDVSLVPAHSIVLPKDVSLETRLTRDLRLKLPILSAAMDTVTEHRLAVA
CEEEEEEEEEECCCEECCCCEEECCCCCCHHHHHCCCEEEECHHHHHHHHHHHHHHHHHH
MAQLGGIGIIHKNLTPQQQSGEVARVKKFESGVITEPFTVRPDTTIGEVLALTRARNISG
HHHHCCEEEEECCCCCCCCCCCHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHCCCCC
VPVVDGSELVGIVTSRDMRFEKKLDDPVRHIMTKKDRLITVREGASDEEVLELLHRNRIE
CEEECCCCEEEEEECCCCHHHHHCCHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCC
KVLVVNHSFELRGLITVKDIQKKTDNPNAAKDSAKRLLVGAAVGVGGDTEQRIELLAAAG
EEEEEECCEEEEEEEEEHHHHHHCCCCCHHHHHHHHEEEEEEECCCCCHHHHHHHHHHCC
VDVVIVDTAHGHSQGVIDRVAWVKKTYPQLQVIGGNIVTGDAALALMDAGADAVKVGVGP
CCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEECCEEEECCCEEEEEECCCCEEEEECCC
GSICTTRVVAGVGVPQITAVDMVAEALQDRIPLIADGGIRYSGDIGKALVAGASTVMVGG
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEECCCEEECCCHHHHHHHCCHHHHHHH
LLAGTEEAPGEVELFQGRSYKSYRGMGSLGAMEKGSKDRYFQDASDADKLVPEGIEGRVP
EEECCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCC
YRGPVGGIIHQLIGGLRATMGYVGCATIEDMRSKPKFVKITGAGQRESHVHDVQITKEPP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEECCCC
NYRAG
CCCCC
>Mature Secondary Structure
MLRIQAEALTYDDVSLVPAHSIVLPKDVSLETRLTRDLRLKLPILSAAMDTVTEHRLAVA
CEEEEEEEEEECCCEECCCCEEECCCCCCHHHHHCCCEEEECHHHHHHHHHHHHHHHHHH
MAQLGGIGIIHKNLTPQQQSGEVARVKKFESGVITEPFTVRPDTTIGEVLALTRARNISG
HHHHCCEEEEECCCCCCCCCCCHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHCCCCC
VPVVDGSELVGIVTSRDMRFEKKLDDPVRHIMTKKDRLITVREGASDEEVLELLHRNRIE
CEEECCCCEEEEEECCCCHHHHHCCHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCC
KVLVVNHSFELRGLITVKDIQKKTDNPNAAKDSAKRLLVGAAVGVGGDTEQRIELLAAAG
EEEEEECCEEEEEEEEEHHHHHHCCCCCHHHHHHHHEEEEEEECCCCCHHHHHHHHHHCC
VDVVIVDTAHGHSQGVIDRVAWVKKTYPQLQVIGGNIVTGDAALALMDAGADAVKVGVGP
CCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEECCEEEECCCEEEEEECCCCEEEEECCC
GSICTTRVVAGVGVPQITAVDMVAEALQDRIPLIADGGIRYSGDIGKALVAGASTVMVGG
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEECCCEEECCCHHHHHHHCCHHHHHHH
LLAGTEEAPGEVELFQGRSYKSYRGMGSLGAMEKGSKDRYFQDASDADKLVPEGIEGRVP
EEECCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCC
YRGPVGGIIHQLIGGLRATMGYVGCATIEDMRSKPKFVKITGAGQRESHVHDVQITKEPP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEECCCC
NYRAG
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA