Click here to switch to the map view.

The map label for this gene is serS

Identifier: 84623645

GI number: 84623645

Start: 2192781

End: 2194130

Strand: Direct

Name: serS

Synonym: XOO_1988

Alternate gene names: 84623645

Gene position: 2192781-2194130 (Clockwise)

Preceding gene: 84623639

Following gene: 84623648

Centisome position: 44.39

GC content: 59.78

Gene sequence:

>1350_bases
ATGCTAGATCCGGCCCTGCTTCGCCAACACCCCGCCGACCTTGCCGAGCGCCTGCGCAGCACGCGCGGTTTCGCACTGGA
CACAGCTAAGCTGGAGTCCCTGGAGAGCGAGCGCAAGCATATGCAGGTGCGTACGCAGGAACTGCAGAGCCTTCGCAATT
CCAAATCCAAGGCGATCGGGCAGGCTAAGGCCAAGGGCGAGGATGTCGCCGCGCTGATGGCCGAGGTGGCCGGTGTCGGC
GATGAACTTTTGCACTCTCATGGCAGACTGACGGTCGTTCAGCACGAGTTGGAAAAGATTTACGCGGTAATTCCCAACCT
GCCGCATGCAGACGTGCCTCTTGGGAAAAGTGAGGCTGACAACGTCGAGCAATCGCGTTGGGGCACGCCGCGCCAGTTCG
ATTTCCCGGTTAAGGATCATGTGGAGCTTGGGGCGCCCAACGGCTGGCTGGATGGGGAAACCGCAGTCAAGTTGTCGGGT
GCACGTTTCACCGTATTGCGCGGTCCGATTGCGCGCCTGCATCGCGCGCTGGCGCAGTTCATGCTTGACCTACACGTCGG
TGAGCATGGCTACGAGGAAACCAACGTGCCTCTATTGGTCAATGCTGACTCAATGCGCGGCACAGGGCAGTTGCCAAAAT
TCGAGGATGATCTCTTCAGAATTTACGAAAACGAATATGAAGGTCATACCGACGAAGAGACCGGTGAAAGTTTTTATACG
CCTACAGGCGGGGTAGATCCCGATCCTGCTTACTATCTCATTCCCACCTCCGAAGTGCCGCTGACCAATATCGTGCGCGA
CGAGATCATCGATGCCGAGCGTCTGCCGCTGCGCATGACCGCACATTCGATGTGTTTCCGTGCCGAAGCGGGCAGCGGCG
GCCGCGATACGCGCGGCATGATCCGCCAGCACCAATTCGAAAAAGTGGAGCTGGTCACTGCCTGCGCGCCGGAAGACAGC
GACGCCGAACATCAGCGCATGACGCGTTGCGCCGAAGTGGTGTTGGAGCAACTCGGCCTGCCGTATCGCAAGGTGTTGCT
GTGCACGGGAGATATGGGTTTTTCCGCGATCAAGACCTACGATCTGGAGGTCTGGTTGCCGTCGCAGAACACTTATCGCG
AAATTTCGTCGTGCTCCAATTGCGGCGATTTCCAGGCGCGGCGCATGCAGGCGCGCTGGCGCAACCCGGTCAGCGGCAAG
CTGGAACTGCTGCACACGCTCAACGGCTCCGGCACTGCTGTGGGCCGCGCGATGATCGCGGTGATGGAGAACTACCAGAA
CGCCGATGGGTCGATCGATGTGCCGCAGGTGCTGCGTCCTTACATGGGCGGCATCGAGCGGATCGGCTGA

Upstream 100 bases:

>100_bases
GAAGAATCGCCGTAATTCTGGCATAGCCGCAGTGAATTGATCGCAGCAGATGGCGGAACAGGCGATAATCTTGCGCTATC
CCACTGACGCACATATTCCG

Downstream 100 bases:

>100_bases
GAGCAGCTAACAAACTACTGCGCAGCCGTCAGGCGGGCGTGGCCGTTACTCGGTGCGGCATGTGGTGCTCGTACACTCCG
GTTCCCGCCCGCCGTCCGCA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MLDPALLRQHPADLAERLRSTRGFALDTAKLESLESERKHMQVRTQELQSLRNSKSKAIGQAKAKGEDVAALMAEVAGVG
DELLHSHGRLTVVQHELEKIYAVIPNLPHADVPLGKSEADNVEQSRWGTPRQFDFPVKDHVELGAPNGWLDGETAVKLSG
ARFTVLRGPIARLHRALAQFMLDLHVGEHGYEETNVPLLVNADSMRGTGQLPKFEDDLFRIYENEYEGHTDEETGESFYT
PTGGVDPDPAYYLIPTSEVPLTNIVRDEIIDAERLPLRMTAHSMCFRAEAGSGGRDTRGMIRQHQFEKVELVTACAPEDS
DAEHQRMTRCAEVVLEQLGLPYRKVLLCTGDMGFSAIKTYDLEVWLPSQNTYREISSCSNCGDFQARRMQARWRNPVSGK
LELLHTLNGSGTAVGRAMIAVMENYQNADGSIDVPQVLRPYMGGIERIG

Sequences:

>Translated_449_residues
MLDPALLRQHPADLAERLRSTRGFALDTAKLESLESERKHMQVRTQELQSLRNSKSKAIGQAKAKGEDVAALMAEVAGVG
DELLHSHGRLTVVQHELEKIYAVIPNLPHADVPLGKSEADNVEQSRWGTPRQFDFPVKDHVELGAPNGWLDGETAVKLSG
ARFTVLRGPIARLHRALAQFMLDLHVGEHGYEETNVPLLVNADSMRGTGQLPKFEDDLFRIYENEYEGHTDEETGESFYT
PTGGVDPDPAYYLIPTSEVPLTNIVRDEIIDAERLPLRMTAHSMCFRAEAGSGGRDTRGMIRQHQFEKVELVTACAPEDS
DAEHQRMTRCAEVVLEQLGLPYRKVLLCTGDMGFSAIKTYDLEVWLPSQNTYREISSCSNCGDFQARRMQARWRNPVSGK
LELLHTLNGSGTAVGRAMIAVMENYQNADGSIDVPQVLRPYMGGIERIG
>Mature_449_residues
MLDPALLRQHPADLAERLRSTRGFALDTAKLESLESERKHMQVRTQELQSLRNSKSKAIGQAKAKGEDVAALMAEVAGVG
DELLHSHGRLTVVQHELEKIYAVIPNLPHADVPLGKSEADNVEQSRWGTPRQFDFPVKDHVELGAPNGWLDGETAVKLSG
ARFTVLRGPIARLHRALAQFMLDLHVGEHGYEETNVPLLVNADSMRGTGQLPKFEDDLFRIYENEYEGHTDEETGESFYT
PTGGVDPDPAYYLIPTSEVPLTNIVRDEIIDAERLPLRMTAHSMCFRAEAGSGGRDTRGMIRQHQFEKVELVTACAPEDS
DAEHQRMTRCAEVVLEQLGLPYRKVLLCTGDMGFSAIKTYDLEVWLPSQNTYREISSCSNCGDFQARRMQARWRNPVSGK
LELLHTLNGSGTAVGRAMIAVMENYQNADGSIDVPQVLRPYMGGIERIG

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=474, Percent_Identity=31.2236286919831, Blast_Score=208, Evalue=1e-53,
Organism=Homo sapiens, GI225579074, Length=452, Percent_Identity=28.0973451327434, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI8923421, Length=450, Percent_Identity=27.5555555555556, Blast_Score=160, Evalue=2e-39,
Organism=Escherichia coli, GI1787120, Length=449, Percent_Identity=60.1336302895323, Blast_Score=535, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI17539260, Length=486, Percent_Identity=31.0699588477366, Blast_Score=211, Evalue=7e-55,
Organism=Caenorhabditis elegans, GI17542084, Length=338, Percent_Identity=26.9230769230769, Blast_Score=135, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6320226, Length=417, Percent_Identity=31.1750599520384, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6321799, Length=390, Percent_Identity=28.7179487179487, Blast_Score=177, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24581334, Length=452, Percent_Identity=29.4247787610619, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI17737985, Length=357, Percent_Identity=31.6526610644258, Blast_Score=166, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_XANOM (Q2P3Y4)

Other databases:

- EMBL:   AP008229
- RefSeq:   YP_451017.1
- ProteinModelPortal:   Q2P3Y4
- SMR:   Q2P3Y4
- STRING:   Q2P3Y4
- GeneID:   3860682
- GenomeReviews:   AP008229_GR
- KEGG:   xom:XOO_1988
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   AHWDLGP
- PhylomeDB:   Q2P3Y4
- ProtClustDB:   PRK05431
- BioCyc:   XORY342109:XOO1988-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 49960; Mature: 49960

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 310-310 BINDING 410-410

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDPALLRQHPADLAERLRSTRGFALDTAKLESLESERKHMQVRTQELQSLRNSKSKAIG
CCCHHHHHCCHHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAKAKGEDVAALMAEVAGVGDELLHSHGRLTVVQHELEKIYAVIPNLPHADVPLGKSEAD
HHHCCCHHHHHHHHHHHCCCHHHHHCCCCEEEHHHHHHHHHHHCCCCCCCCCCCCCCCCC
NVEQSRWGTPRQFDFPVKDHVELGAPNGWLDGETAVKLSGARFTVLRGPIARLHRALAQF
CCHHHHCCCCCCCCCCCHHCCEECCCCCCCCCCCEEEECCCEEEEECCHHHHHHHHHHHH
MLDLHVGEHGYEETNVPLLVNADSMRGTGQLPKFEDDLFRIYENEYEGHTDEETGESFYT
HHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEC
PTGGVDPDPAYYLIPTSEVPLTNIVRDEIIDAERLPLRMTAHSMCFRAEAGSGGRDTRGM
CCCCCCCCCCEEEEECCCCCHHHHHHHHHCCHHCCCEEEHHHHHHEEECCCCCCCHHHHH
IRQHQFEKVELVTACAPEDSDAEHQRMTRCAEVVLEQLGLPYRKVLLCTGDMGFSAIKTY
HHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEEEE
DLEVWLPSQNTYREISSCSNCGDFQARRMQARWRNPVSGKLELLHTLNGSGTAVGRAMIA
EEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHEEEECCCCCHHHHHHHHH
VMENYQNADGSIDVPQVLRPYMGGIERIG
HHHHHCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLDPALLRQHPADLAERLRSTRGFALDTAKLESLESERKHMQVRTQELQSLRNSKSKAIG
CCCHHHHHCCHHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAKAKGEDVAALMAEVAGVGDELLHSHGRLTVVQHELEKIYAVIPNLPHADVPLGKSEAD
HHHCCCHHHHHHHHHHHCCCHHHHHCCCCEEEHHHHHHHHHHHCCCCCCCCCCCCCCCCC
NVEQSRWGTPRQFDFPVKDHVELGAPNGWLDGETAVKLSGARFTVLRGPIARLHRALAQF
CCHHHHCCCCCCCCCCCHHCCEECCCCCCCCCCCEEEECCCEEEEECCHHHHHHHHHHHH
MLDLHVGEHGYEETNVPLLVNADSMRGTGQLPKFEDDLFRIYENEYEGHTDEETGESFYT
HHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEC
PTGGVDPDPAYYLIPTSEVPLTNIVRDEIIDAERLPLRMTAHSMCFRAEAGSGGRDTRGM
CCCCCCCCCCEEEEECCCCCHHHHHHHHHCCHHCCCEEEHHHHHHEEECCCCCCCHHHHH
IRQHQFEKVELVTACAPEDSDAEHQRMTRCAEVVLEQLGLPYRKVLLCTGDMGFSAIKTY
HHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEEEE
DLEVWLPSQNTYREISSCSNCGDFQARRMQARWRNPVSGKLELLHTLNGSGTAVGRAMIA
EEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHEEEECCCCCHHHHHHHHH
VMENYQNADGSIDVPQVLRPYMGGIERIG
HHHHHCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA