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The map label for this gene is map [H]

Identifier: 84623531

GI number: 84623531

Start: 2065522

End: 2066298

Strand: Direct

Name: map [H]

Synonym: XOO_1874

Alternate gene names: 84623531

Gene position: 2065522-2066298 (Clockwise)

Preceding gene: 84623502

Following gene: 84623532

Centisome position: 41.81

GC content: 61.39

Gene sequence:

>777_bases
ATGAGCGTCAATCTAAAAACGAAAGAAGAAATCGAACTGATGCGCGTCGCCGGCCGCCTGGCCGCCGAAGTGCTCGATGT
CGTGGCCCGCTATGTCCAGCCGGGCGTGACCACTGCCGAGCTGGACCGCATCTGCCATGACCACATCGTCAACGTGCAGG
GCACCATTCCTGCCAACGTGGGCTACCGCGGCTTCCCCAAGAGCGTGTGTACTTCCGTCAACAACGTGATTTGTCACGGT
ATCCCGAGCGCCGCCAAGGTGTTGAAGGATGGCGACATCGTCAATATCGATGTCACCGTCATCAAGGATGGCTGGCACGG
CGACACCAGCCGCATGTATTACGTCGGCACGCCGTCGGTGATGGCCAAGCGTTTGGTCGACACCACCTATGAAGCGATGT
GGCGTGGGATCCGCGCGGTCAAGCCGGGCGCTACGCTGGGCGATGTGGGTCACGCCATCCAGAAGTTCGCCGAGTCCGAG
CGTTTCAGCGTGGTGCGCGATTACTGCGGCCATGGCATCGGCAAGGTCTACCACGACGAGCCGCAGGTGATGCATTACGG
CCGTCCAGGCGAAGGGCTGGTGCTCAAGCCGGGCATGACCTTCACCATCGAGCCGATGATCAACGAAGGCACCTATCACC
ATAAGACCCTGCCCGACGGCTGGACGGTGGTCACCAAGGACCGCAAGTTGTCCGCACAGTGGGAACACATGGTGGCGGTG
ACCGAAGACGGCGTGGATGTGCTGACGCTGTCGGCCAATTCGCCCGCGCCGGTATGA

Upstream 100 bases:

>100_bases
TTTTGCTGCACCGTCCGCTTGGCGCTGCACCGCTAATGTTCTGCAAAAAACGTCGGCGTGGATCGTTCAGATTCATGCCG
AATCGGCGATAATCGCGTTC

Downstream 100 bases:

>100_bases
CGGACGCGCCGGCGGAGCGACCCGACCCAAGCGTCGCCGGCGACGCGGACTGGGCCGCACAGGCCCGTCCGCTGCTGGTG
CATGCGGACATGCGGTTGCG

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MSVNLKTKEEIELMRVAGRLAAEVLDVVARYVQPGVTTAELDRICHDHIVNVQGTIPANVGYRGFPKSVCTSVNNVICHG
IPSAAKVLKDGDIVNIDVTVIKDGWHGDTSRMYYVGTPSVMAKRLVDTTYEAMWRGIRAVKPGATLGDVGHAIQKFAESE
RFSVVRDYCGHGIGKVYHDEPQVMHYGRPGEGLVLKPGMTFTIEPMINEGTYHHKTLPDGWTVVTKDRKLSAQWEHMVAV
TEDGVDVLTLSANSPAPV

Sequences:

>Translated_258_residues
MSVNLKTKEEIELMRVAGRLAAEVLDVVARYVQPGVTTAELDRICHDHIVNVQGTIPANVGYRGFPKSVCTSVNNVICHG
IPSAAKVLKDGDIVNIDVTVIKDGWHGDTSRMYYVGTPSVMAKRLVDTTYEAMWRGIRAVKPGATLGDVGHAIQKFAESE
RFSVVRDYCGHGIGKVYHDEPQVMHYGRPGEGLVLKPGMTFTIEPMINEGTYHHKTLPDGWTVVTKDRKLSAQWEHMVAV
TEDGVDVLTLSANSPAPV
>Mature_257_residues
SVNLKTKEEIELMRVAGRLAAEVLDVVARYVQPGVTTAELDRICHDHIVNVQGTIPANVGYRGFPKSVCTSVNNVICHGI
PSAAKVLKDGDIVNIDVTVIKDGWHGDTSRMYYVGTPSVMAKRLVDTTYEAMWRGIRAVKPGATLGDVGHAIQKFAESER
FSVVRDYCGHGIGKVYHDEPQVMHYGRPGEGLVLKPGMTFTIEPMINEGTYHHKTLPDGWTVVTKDRKLSAQWEHMVAVT
EDGVDVLTLSANSPAPV

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=256, Percent_Identity=48.4375, Blast_Score=246, Evalue=1e-65,
Organism=Homo sapiens, GI40385867, Length=248, Percent_Identity=41.1290322580645, Blast_Score=199, Evalue=3e-51,
Organism=Escherichia coli, GI1786364, Length=257, Percent_Identity=60.7003891050584, Blast_Score=341, Evalue=2e-95,
Organism=Escherichia coli, GI1788728, Length=213, Percent_Identity=25.8215962441315, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71996291, Length=248, Percent_Identity=45.5645161290323, Blast_Score=224, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6323273, Length=257, Percent_Identity=47.0817120622568, Blast_Score=238, Evalue=6e-64,
Organism=Drosophila melanogaster, GI21355531, Length=241, Percent_Identity=49.3775933609959, Blast_Score=231, Evalue=5e-61,
Organism=Drosophila melanogaster, GI24583427, Length=250, Percent_Identity=38.8, Blast_Score=197, Evalue=5e-51,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 28279; Mature: 28148

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVNLKTKEEIELMRVAGRLAAEVLDVVARYVQPGVTTAELDRICHDHIVNVQGTIPANV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEECCCCCCCCCC
GYRGFPKSVCTSVNNVICHGIPSAAKVLKDGDIVNIDVTVIKDGWHGDTSRMYYVGTPSV
CCCCCCHHHHHHHHHHEECCCCHHHHHHCCCCEEEEEEEEEECCCCCCCCEEEEEECHHH
MAKRLVDTTYEAMWRGIRAVKPGATLGDVGHAIQKFAESERFSVVRDYCGHGIGKVYHDE
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCC
PQVMHYGRPGEGLVLKPGMTFTIEPMINEGTYHHKTLPDGWTVVTKDRKLSAQWEHMVAV
CCEEECCCCCCCEEECCCCCEEEEEEECCCCCCCCCCCCCCEEEECCCCCCCCHHEEEEE
TEDGVDVLTLSANSPAPV
ECCCCEEEEEECCCCCCC
>Mature Secondary Structure 
SVNLKTKEEIELMRVAGRLAAEVLDVVARYVQPGVTTAELDRICHDHIVNVQGTIPANV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEECCCCCCCCCC
GYRGFPKSVCTSVNNVICHGIPSAAKVLKDGDIVNIDVTVIKDGWHGDTSRMYYVGTPSV
CCCCCCHHHHHHHHHHEECCCCHHHHHHCCCCEEEEEEEEEECCCCCCCCEEEEEECHHH
MAKRLVDTTYEAMWRGIRAVKPGATLGDVGHAIQKFAESERFSVVRDYCGHGIGKVYHDE
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCC
PQVMHYGRPGEGLVLKPGMTFTIEPMINEGTYHHKTLPDGWTVVTKDRKLSAQWEHMVAV
CCEEECCCCCCCEEECCCCCEEEEEEECCCCCCCCCCCCCCEEEECCCCCCCCHHEEEEE
TEDGVDVLTLSANSPAPV
ECCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]