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The map label for this gene is rnc [H]

Identifier: 84623408

GI number: 84623408

Start: 1935528

End: 1936208

Strand: Direct

Name: rnc [H]

Synonym: XOO_1751

Alternate gene names: 84623408

Gene position: 1935528-1936208 (Clockwise)

Preceding gene: 84623407

Following gene: 84623409

Centisome position: 39.18

GC content: 63.58

Gene sequence:

>681_bases
GTGTCGAATAGAATCTTCCAACGCGGTGATCCGATCGGGCATGCATTTGCCGATCCGGATCTGCTCGCCCAGGCGCTGCG
GCATCGCAGCGCCGGGACGCCGCACAACGAGCGGCTGGAATTTCTCGGCGACGGCATCGTCAATCTGCTGGTCGCCGAGG
CGCTGTATCAACGTTGGCCCAAGGCCGATGAAGGCGCATTGACCCGCGCGCGGGCCGAACTCGTACGCGAAGGCGCGCTG
GCAGTGATCGGACGTACGTTGAACCTCGGCGAGCGCCTCACGCTGGGTCCAGGTGAGTTGAAGTCCGGTGGTCATCGGCG
CGATTCGATCCTGGCCGATGCTGTCGAAGCGATTGTCGCGGCCATCTACCTGGACTGCGGTTTCGAGCGTTGCCGTGCGG
TGGTGCTGCCGTGGTTCGAAGCCTCGCTGGCGGCATTGCCGGTTGGCAAGGCAGAAAAAGATCCCAAGACCCGGCTGCAG
GAATGGCTGCAGGCGCGCCAGCTGCCGCTGCCCAATTACGCTCTGATCAGTGAGAGCGGCGATGAGCATGCCAAGCAGTT
CCATGTCGCCTGCATTCTGGAGCAGCCCGTCGCCCGCGCCGAGGGCCAGGGCACCTCGCGTCGTCTTGCCGAGCAACAGG
CGGCGACTCTTGTCATCGCACAACTGGATTCAAGAATGTGA

Upstream 100 bases:

>100_bases
GGCTGGCGGATGAAAGTCAACTACGAAGTCCGCCGCGAGCTGGTTGGCAATCTGGATGTGGTTGGCAAGTTCGATACGGC
ACAGGATTTGACGAAGCGCG

Downstream 100 bases:

>100_bases
GCGTAACCTCGTCCCCCCACCGCAGCGGTAGCGTTGCCGTGATCGGCCGGCCCAACGTCGGCAAGTCCACCCTGACCAAT
GCCCTGGTCGGCGCGAAGGT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MSNRIFQRGDPIGHAFADPDLLAQALRHRSAGTPHNERLEFLGDGIVNLLVAEALYQRWPKADEGALTRARAELVREGAL
AVIGRTLNLGERLTLGPGELKSGGHRRDSILADAVEAIVAAIYLDCGFERCRAVVLPWFEASLAALPVGKAEKDPKTRLQ
EWLQARQLPLPNYALISESGDEHAKQFHVACILEQPVARAEGQGTSRRLAEQQAATLVIAQLDSRM

Sequences:

>Translated_226_residues
MSNRIFQRGDPIGHAFADPDLLAQALRHRSAGTPHNERLEFLGDGIVNLLVAEALYQRWPKADEGALTRARAELVREGAL
AVIGRTLNLGERLTLGPGELKSGGHRRDSILADAVEAIVAAIYLDCGFERCRAVVLPWFEASLAALPVGKAEKDPKTRLQ
EWLQARQLPLPNYALISESGDEHAKQFHVACILEQPVARAEGQGTSRRLAEQQAATLVIAQLDSRM
>Mature_225_residues
SNRIFQRGDPIGHAFADPDLLAQALRHRSAGTPHNERLEFLGDGIVNLLVAEALYQRWPKADEGALTRARAELVREGALA
VIGRTLNLGERLTLGPGELKSGGHRRDSILADAVEAIVAAIYLDCGFERCRAVVLPWFEASLAALPVGKAEKDPKTRLQE
WLQARQLPLPNYALISESGDEHAKQFHVACILEQPVARAEGQGTSRRLAEQQAATLVIAQLDSRM

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=216, Percent_Identity=29.6296296296296, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI155030236, Length=216, Percent_Identity=29.6296296296296, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1788920, Length=200, Percent_Identity=49.5, Blast_Score=204, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI17506883, Length=227, Percent_Identity=30.3964757709251, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI193202651, Length=227, Percent_Identity=30.3964757709251, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17137682, Length=219, Percent_Identity=29.2237442922374, Blast_Score=78, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 24740; Mature: 24608

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNRIFQRGDPIGHAFADPDLLAQALRHRSAGTPHNERLEFLGDGIVNLLVAEALYQRWP
CCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
KADEGALTRARAELVREGALAVIGRTLNLGERLTLGPGELKSGGHRRDSILADAVEAIVA
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHCCCCCHHHHHHHHHHHHHHH
AIYLDCGFERCRAVVLPWFEASLAALPVGKAEKDPKTRLQEWLQARQLPLPNYALISESG
HHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCC
DEHAKQFHVACILEQPVARAEGQGTSRRLAEQQAATLVIAQLDSRM
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SNRIFQRGDPIGHAFADPDLLAQALRHRSAGTPHNERLEFLGDGIVNLLVAEALYQRWP
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
KADEGALTRARAELVREGALAVIGRTLNLGERLTLGPGELKSGGHRRDSILADAVEAIVA
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHCCCCCHHHHHHHHHHHHHHH
AIYLDCGFERCRAVVLPWFEASLAALPVGKAEKDPKTRLQEWLQARQLPLPNYALISESG
HHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCC
DEHAKQFHVACILEQPVARAEGQGTSRRLAEQQAATLVIAQLDSRM
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]