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The map label for this gene is mazG [H]

Identifier: 84623350

GI number: 84623350

Start: 1862720

End: 1863739

Strand: Direct

Name: mazG [H]

Synonym: XOO_1693

Alternate gene names: 84623350

Gene position: 1862720-1863739 (Clockwise)

Preceding gene: 84623349

Following gene: 84623351

Centisome position: 37.71

GC content: 64.9

Gene sequence:

>1020_bases
ATGTCTCAGACCCCGCCCACCGGCGACATCCAGCAGCTGCTGCAGTTGATGGCGCGCCTGCGCGATCGCGAACACGGCTG
CCCCTGGGATGTGCAGCAGACCTTCGCCAGCATTGCGCCGTACACCATCGAAGAAGCCTACGAAGTGGCCGATGCGATCG
ACCGCAACGACTTGGCAGGCCTGCGCGACGAGTTGGGAGATTTGTTGCTGCAGGTGGTCTTCCATGCGCAAATGGCAGCC
GAGCAGGGGGCATTCGGCTTCGCCGACGTGGTCGCCACGCTCAGCGACAAACTGGTGCGCCGCCACCCGCATGTGTTCGC
TGCGCAACAGGTGCCCGATGCACAGGCGGTGAGCGTCAACTGGGAGCAGATCAAGCGCGAAGAACGTCGCGCTGCCGGCA
ACCAGGACGACTCCGCACTCGCCGGCGTCGCGCGTGGGCTCCCGGAATGGCAGCGCTCCACCAAACTGCAATCGCGTGCG
GCACGGGTCGGTTTCGATTGGCCTGGGCCAGTGCCGGTGCTGGAAAAATTGCAGGAAGAAATCGAAGAACTGCGTGTGGA
GTTCGCACGCGGCCCGGTGGCCGACAACCAGGCCCGGCTGGAAGACGAACTGGGCGATGTGTTGTTTGTTTGCGCCAATC
TGGCGCGGCATGCCGAGGTCGATGTCGGCGCCGCGCTGCGGCACGCCAATCTGAAGTTCGAACGCCGCTTCCGTGCGATG
GAAGCGCAGGCGCATGCGACCGGCACTGCCTTGAATGCGTTGTCGCTGAGCGAGCAGGAAGCGCTGTGGCAACAGGTCAA
ACGTAATGAGCGCAGTCGCGATGTGCAGGCTGGCGATGGTCCAGCCATCGCCAGTTCCGGGAGCGATGCACCGGCCTCGC
AAGCGCCTCTTCCCTGCGCACCGTCCGTGCACCACCCTGGCGCCTGTCACCGGGCAGTTGTCGGCCAAGTGGCCCACAGC
GCAGATGGCAATCACTCCGCCCTCGACAGCTCGGACTCCGACACGCCACGTTCCGCATGA

Upstream 100 bases:

>100_bases
TATGCCCGTTCGCCCTGCAGCACGCGATGACATCTGCTGTGCAGCGCGTGCGATAGGCCGCCGCTAGCGCACGCATTCTT
AAAGGTTCCAGGAATACACG

Downstream 100 bases:

>100_bases
ACCTCGCGCCGACCACGCTGTTGCTGTTTGCCGCGACGGCGCTCGCCGAGCTGGTCGGTTGCTACCTTCCTTATCTCTGG
CTGCGCAACGGCGGCAGCGT

Product: nucleoside triphosphate pyrophosphohydrolase

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MSQTPPTGDIQQLLQLMARLRDREHGCPWDVQQTFASIAPYTIEEAYEVADAIDRNDLAGLRDELGDLLLQVVFHAQMAA
EQGAFGFADVVATLSDKLVRRHPHVFAAQQVPDAQAVSVNWEQIKREERRAAGNQDDSALAGVARGLPEWQRSTKLQSRA
ARVGFDWPGPVPVLEKLQEEIEELRVEFARGPVADNQARLEDELGDVLFVCANLARHAEVDVGAALRHANLKFERRFRAM
EAQAHATGTALNALSLSEQEALWQQVKRNERSRDVQAGDGPAIASSGSDAPASQAPLPCAPSVHHPGACHRAVVGQVAHS
ADGNHSALDSSDSDTPRSA

Sequences:

>Translated_339_residues
MSQTPPTGDIQQLLQLMARLRDREHGCPWDVQQTFASIAPYTIEEAYEVADAIDRNDLAGLRDELGDLLLQVVFHAQMAA
EQGAFGFADVVATLSDKLVRRHPHVFAAQQVPDAQAVSVNWEQIKREERRAAGNQDDSALAGVARGLPEWQRSTKLQSRA
ARVGFDWPGPVPVLEKLQEEIEELRVEFARGPVADNQARLEDELGDVLFVCANLARHAEVDVGAALRHANLKFERRFRAM
EAQAHATGTALNALSLSEQEALWQQVKRNERSRDVQAGDGPAIASSGSDAPASQAPLPCAPSVHHPGACHRAVVGQVAHS
ADGNHSALDSSDSDTPRSA
>Mature_338_residues
SQTPPTGDIQQLLQLMARLRDREHGCPWDVQQTFASIAPYTIEEAYEVADAIDRNDLAGLRDELGDLLLQVVFHAQMAAE
QGAFGFADVVATLSDKLVRRHPHVFAAQQVPDAQAVSVNWEQIKREERRAAGNQDDSALAGVARGLPEWQRSTKLQSRAA
RVGFDWPGPVPVLEKLQEEIEELRVEFARGPVADNQARLEDELGDVLFVCANLARHAEVDVGAALRHANLKFERRFRAME
AQAHATGTALNALSLSEQEALWQQVKRNERSRDVQAGDGPAIASSGSDAPASQAPLPCAPSVHHPGACHRAVVGQVAHSA
DGNHSALDSSDSDTPRSA

Specific function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp p

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=261, Percent_Identity=54.4061302681992, Blast_Score=266, Evalue=1e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518
- InterPro:   IPR011551 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 36838; Mature: 36707

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQTPPTGDIQQLLQLMARLRDREHGCPWDVQQTFASIAPYTIEEAYEVADAIDRNDLAG
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHH
LRDELGDLLLQVVFHAQMAAEQGAFGFADVVATLSDKLVRRHPHVFAAQQVPDAQAVSVN
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEECCCCCCCCEEECC
WEQIKREERRAAGNQDDSALAGVARGLPEWQRSTKLQSRAARVGFDWPGPVPVLEKLQEE
HHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
IEELRVEFARGPVADNQARLEDELGDVLFVCANLARHAEVDVGAALRHANLKFERRFRAM
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHH
EAQAHATGTALNALSLSEQEALWQQVKRNERSRDVQAGDGPAIASSGSDAPASQAPLPCA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PSVHHPGACHRAVVGQVAHSADGNHSALDSSDSDTPRSA
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SQTPPTGDIQQLLQLMARLRDREHGCPWDVQQTFASIAPYTIEEAYEVADAIDRNDLAG
CCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHH
LRDELGDLLLQVVFHAQMAAEQGAFGFADVVATLSDKLVRRHPHVFAAQQVPDAQAVSVN
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEECCCCCCCCEEECC
WEQIKREERRAAGNQDDSALAGVARGLPEWQRSTKLQSRAARVGFDWPGPVPVLEKLQEE
HHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
IEELRVEFARGPVADNQARLEDELGDVLFVCANLARHAEVDVGAALRHANLKFERRFRAM
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHH
EAQAHATGTALNALSLSEQEALWQQVKRNERSRDVQAGDGPAIASSGSDAPASQAPLPCA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PSVHHPGACHRAVVGQVAHSADGNHSALDSSDSDTPRSA
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]