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The map label for this gene is cyoB [H]

Identifier: 84623173

GI number: 84623173

Start: 1660954

End: 1662954

Strand: Direct

Name: cyoB [H]

Synonym: XOO_1516

Alternate gene names: 84623173

Gene position: 1660954-1662954 (Clockwise)

Preceding gene: 84623172

Following gene: 84623174

Centisome position: 33.62

GC content: 60.62

Gene sequence:

>2001_bases
ATGCTAGGCAAACTTACCATTGATGCAGTTCCATACCACGAGCCGATCATCATGGTCGCTCTGGGTGGTGGCGGGCTGCT
CGGCCTGCTCATCGCGGCCGCCATCACCAAGTACAAGCTGTGGGGCTATCTGTGGAAAGAGTGGTTCACCTCGGTCGATC
ACAAGCGCATCGGCGTGATGTACATCATCGTGGCGCTGGTCATGCTGCTGCGCGGCTTCGCCGATGCGGCGATGATGCGC
ACCCAGCAGGCGCTGGTCGGCAACGGTGGCGAAGGTGTGTTTCCTCCGCATCACTACGACCAGATCTTTACCGCGCATGG
CGTGATCATGATCTTCTTCATGGCCATGCCGTTCATGACCGGCCTGTTGAACCTGATCGTGCCGCTGCAGATCGGCGCAC
GCGACGTGGCGTTCCCGTTTCTGAACTCGCTGAGTTTCTGGCTGTTCGTGGCCGGTGCGGCGTTGATCAACATCTCGCTG
GGTGTCGGCGAGTTCGCGCAGACCGGTTGGCTGGCGTATCCGCCCTTGTCGGGGCTGGAATACAGTCCGGGGGTCGGCGT
CGATTACTACATCTGGGCGTTGCAGATCTCCGGATTGGGCACCTTGCTGACCGGCGTCAACTTCTTCGTGACGATCCTGC
GGATGCGCGCGCCGGGCATGACCCTGATGCGCATGCCGGTCTTCACCTGGACTGCGCTGATCACCAACATCCTGATCATC
GCCGCGTTCCCGATCCTGACCGTGGCGCTGGCGCTGCTGGGTGCCGACCGTTACCTGGGCACGCACTTCTTCACCAACGG
CGGTGGCGGCAACGCCATGATGTACGTCAACCTGATCTGGATCTGGGGTCACCCGGAGGTCTACATCCTGATCCTGCCGG
CGTTCGGCATCTTCTCCGAGTTGATTGCCACCTACAGCCGCAAGCGTCTGTTCGGCTACACCTCGATGGTCTACGCCACC
TCGTGCATCGGCGTGCTGTCGTTCGTGGTGTGGTTGCACCACTTCTTCACCATGGGCTCGGGTGCCAATGTCAATGCCTT
CTTCGGTATCACGACGATGATCATCTCGATTCCGACCGGCGTGAAGATCTTCAACTGGCTGTTCACCATGTTCCGCGGCC
GTGTGCACGTGACCGCGCCGGTGCTGTGGACGATCGGCTTCATCATCACCTTCAGCATCGGCGGCATGACCGGCGTGATG
CTGGCGATTCCGGCCGTGGACTTCGTGCTGCACAACAGCCTGTTCCTGATCGCGCACTTCCATAATGTGATCATCGGTGG
CGTGGTGTTCGGTTACTTGGCCGGTCTGACCTACTGGTTTCCGAAGGCCTTCGGTTTCAAGCTCAACGAAAAGCTGGGCA
AGGCCTCGTTCTGGTGCTGGATCATCGGTTTCTTTGTGGCCTTCATGCCGCTGTACGTGCTCGGCTTCATGGGCATGACC
CGCCGCATGAACACCTACAACCATCCCGAGTGGGCGCCGTGGCTGTATGTGGCTGCGGTGGGTGCTGCGATCATCGGCAT
GGGTATCTTCCTGAACCTGCTGCAGATCGCTTACAGCGTGTGGAAGCGCAAGGACCACATGGACTACACCGGCGACCCGT
GGGATGGCCGTACGCTGGAATGGGCGACTTCGTCGCCGCCTCCGTTCTACAACTTCGCCGTGCTGCCGCACATCGACGAC
CGCGACCAGTTCTGGGCCGACAAGCAGAACGGCAAGGGCTGGGTGCGTCCTTCGAAGTACGAAGCCATCCACATGCCGCG
CAACACCGCTGCAGGCGTCTACATCGGTGCCTTCAGCGTGCTGATGGGCTTCGGTCTGATCTGGCACATCTGGTGGCTGG
CCATCATCGGCCTGGTGGGCATGATCGGCAGCTTCATTGCGCGTACGTTCGATGACGACATCGATTACTGGGTGCCGGCC
GACGAAGTGGAGCGCATCGAAAACGCACGCTTCGCCCTGCTCGAACAGCAACAGGCGGCGCAGGCCGCGAAGGTGGTATG
A

Upstream 100 bases:

>100_bases
TCGACAAATACATGAATGGTCCCGGCCACAGTAAAGGCCACGGCGACCATCAGGCATCGGCTATGGAGCCGGTCGCCATG
TGCACTTCTGGAGACAAGTG

Downstream 100 bases:

>100_bases
CCATGGCTTCTTCGACCACGCTTGACCACGCCGCCCATGCGGGCGGCCATGATCACGACCACGAACATCACGACGGCGGC
GGCAATACCGTCTTCGGGTT

Product: cytochrome O ubiquinol oxidase subunit I

Products: Ubiquinone-8; H2O. [C]

Alternate protein names: Cytochrome o subunit 1; Cytochrome o ubiquinol oxidase subunit 1; Oxidase BO(3) subunit 1; Ubiquinol oxidase chain A; Ubiquinol oxidase polypeptide I [H]

Number of amino acids: Translated: 666; Mature: 666

Protein sequence:

>666_residues
MLGKLTIDAVPYHEPIIMVALGGGGLLGLLIAAAITKYKLWGYLWKEWFTSVDHKRIGVMYIIVALVMLLRGFADAAMMR
TQQALVGNGGEGVFPPHHYDQIFTAHGVIMIFFMAMPFMTGLLNLIVPLQIGARDVAFPFLNSLSFWLFVAGAALINISL
GVGEFAQTGWLAYPPLSGLEYSPGVGVDYYIWALQISGLGTLLTGVNFFVTILRMRAPGMTLMRMPVFTWTALITNILII
AAFPILTVALALLGADRYLGTHFFTNGGGGNAMMYVNLIWIWGHPEVYILILPAFGIFSELIATYSRKRLFGYTSMVYAT
SCIGVLSFVVWLHHFFTMGSGANVNAFFGITTMIISIPTGVKIFNWLFTMFRGRVHVTAPVLWTIGFIITFSIGGMTGVM
LAIPAVDFVLHNSLFLIAHFHNVIIGGVVFGYLAGLTYWFPKAFGFKLNEKLGKASFWCWIIGFFVAFMPLYVLGFMGMT
RRMNTYNHPEWAPWLYVAAVGAAIIGMGIFLNLLQIAYSVWKRKDHMDYTGDPWDGRTLEWATSSPPPFYNFAVLPHIDD
RDQFWADKQNGKGWVRPSKYEAIHMPRNTAAGVYIGAFSVLMGFGLIWHIWWLAIIGLVGMIGSFIARTFDDDIDYWVPA
DEVERIENARFALLEQQQAAQAAKVV

Sequences:

>Translated_666_residues
MLGKLTIDAVPYHEPIIMVALGGGGLLGLLIAAAITKYKLWGYLWKEWFTSVDHKRIGVMYIIVALVMLLRGFADAAMMR
TQQALVGNGGEGVFPPHHYDQIFTAHGVIMIFFMAMPFMTGLLNLIVPLQIGARDVAFPFLNSLSFWLFVAGAALINISL
GVGEFAQTGWLAYPPLSGLEYSPGVGVDYYIWALQISGLGTLLTGVNFFVTILRMRAPGMTLMRMPVFTWTALITNILII
AAFPILTVALALLGADRYLGTHFFTNGGGGNAMMYVNLIWIWGHPEVYILILPAFGIFSELIATYSRKRLFGYTSMVYAT
SCIGVLSFVVWLHHFFTMGSGANVNAFFGITTMIISIPTGVKIFNWLFTMFRGRVHVTAPVLWTIGFIITFSIGGMTGVM
LAIPAVDFVLHNSLFLIAHFHNVIIGGVVFGYLAGLTYWFPKAFGFKLNEKLGKASFWCWIIGFFVAFMPLYVLGFMGMT
RRMNTYNHPEWAPWLYVAAVGAAIIGMGIFLNLLQIAYSVWKRKDHMDYTGDPWDGRTLEWATSSPPPFYNFAVLPHIDD
RDQFWADKQNGKGWVRPSKYEAIHMPRNTAAGVYIGAFSVLMGFGLIWHIWWLAIIGLVGMIGSFIARTFDDDIDYWVPA
DEVERIENARFALLEQQQAAQAAKVV
>Mature_666_residues
MLGKLTIDAVPYHEPIIMVALGGGGLLGLLIAAAITKYKLWGYLWKEWFTSVDHKRIGVMYIIVALVMLLRGFADAAMMR
TQQALVGNGGEGVFPPHHYDQIFTAHGVIMIFFMAMPFMTGLLNLIVPLQIGARDVAFPFLNSLSFWLFVAGAALINISL
GVGEFAQTGWLAYPPLSGLEYSPGVGVDYYIWALQISGLGTLLTGVNFFVTILRMRAPGMTLMRMPVFTWTALITNILII
AAFPILTVALALLGADRYLGTHFFTNGGGGNAMMYVNLIWIWGHPEVYILILPAFGIFSELIATYSRKRLFGYTSMVYAT
SCIGVLSFVVWLHHFFTMGSGANVNAFFGITTMIISIPTGVKIFNWLFTMFRGRVHVTAPVLWTIGFIITFSIGGMTGVM
LAIPAVDFVLHNSLFLIAHFHNVIIGGVVFGYLAGLTYWFPKAFGFKLNEKLGKASFWCWIIGFFVAFMPLYVLGFMGMT
RRMNTYNHPEWAPWLYVAAVGAAIIGMGIFLNLLQIAYSVWKRKDHMDYTGDPWDGRTLEWATSSPPPFYNFAVLPHIDD
RDQFWADKQNGKGWVRPSKYEAIHMPRNTAAGVYIGAFSVLMGFGLIWHIWWLAIIGLVGMIGSFIARTFDDDIDYWVPA
DEVERIENARFALLEQQQAAQAAKVV

Specific function: Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain that predominates when cells are grown at high aeration. This ubiquinol oxidase shows proton pump activity across the membrane in addition to the electron transfer [H]

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=509, Percent_Identity=39.8821218074656, Blast_Score=348, Evalue=1e-95,
Organism=Escherichia coli, GI1786634, Length=656, Percent_Identity=69.969512195122, Blast_Score=969, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6226519, Length=472, Percent_Identity=40.6779661016949, Blast_Score=348, Evalue=1e-96,
Organism=Saccharomyces cerevisiae, GI6226524, Length=331, Percent_Identity=41.3897280966767, Blast_Score=248, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6226523, Length=249, Percent_Identity=34.136546184739, Blast_Score=132, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014207 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: 1.10.3.- [C]

Molecular weight: Translated: 74269; Mature: 74269

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGKLTIDAVPYHEPIIMVALGGGGLLGLLIAAAITKYKLWGYLWKEWFTSVDHKRIGVM
CCCCEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
YIIVALVMLLRGFADAAMMRTQQALVGNGGEGVFPPHHYDQIFTAHGVIMIFFMAMPFMT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GLLNLIVPLQIGARDVAFPFLNSLSFWLFVAGAALINISLGVGEFAQTGWLAYPPLSGLE
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHCCCEECCCCCCCC
YSPGVGVDYYIWALQISGLGTLLTGVNFFVTILRMRAPGMTLMRMPVFTWTALITNILII
CCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
AAFPILTVALALLGADRYLGTHFFTNGGGGNAMMYVNLIWIWGHPEVYILILPAFGIFSE
HHHHHHHHHHHHHCCHHHHCCCEEECCCCCCEEEEEEEEEEECCCCEEEEEECHHHHHHH
LIATYSRKRLFGYTSMVYATSCIGVLSFVVWLHHFFTMGSGANVNAFFGITTMIISIPTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCC
VKIFNWLFTMFRGRVHVTAPVLWTIGFIITFSIGGMTGVMLAIPAVDFVLHNSLFLIAHF
HHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHH
HNVIIGGVVFGYLAGLTYWFPKAFGFKLNEKLGKASFWCWIIGFFVAFMPLYVLGFMGMT
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RRMNTYNHPEWAPWLYVAAVGAAIIGMGIFLNLLQIAYSVWKRKDHMDYTGDPWDGRTLE
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEE
WATSSPPPFYNFAVLPHIDDRDQFWADKQNGKGWVRPSKYEAIHMPRNTAAGVYIGAFSV
ECCCCCCCCCEEEEECCCCCCHHHCCCCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHH
LMGFGLIWHIWWLAIIGLVGMIGSFIARTFDDDIDYWVPADEVERIENARFALLEQQQAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
QAAKVV
HHHCCC
>Mature Secondary Structure
MLGKLTIDAVPYHEPIIMVALGGGGLLGLLIAAAITKYKLWGYLWKEWFTSVDHKRIGVM
CCCCEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
YIIVALVMLLRGFADAAMMRTQQALVGNGGEGVFPPHHYDQIFTAHGVIMIFFMAMPFMT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GLLNLIVPLQIGARDVAFPFLNSLSFWLFVAGAALINISLGVGEFAQTGWLAYPPLSGLE
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHCCCEECCCCCCCC
YSPGVGVDYYIWALQISGLGTLLTGVNFFVTILRMRAPGMTLMRMPVFTWTALITNILII
CCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
AAFPILTVALALLGADRYLGTHFFTNGGGGNAMMYVNLIWIWGHPEVYILILPAFGIFSE
HHHHHHHHHHHHHCCHHHHCCCEEECCCCCCEEEEEEEEEEECCCCEEEEEECHHHHHHH
LIATYSRKRLFGYTSMVYATSCIGVLSFVVWLHHFFTMGSGANVNAFFGITTMIISIPTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCC
VKIFNWLFTMFRGRVHVTAPVLWTIGFIITFSIGGMTGVMLAIPAVDFVLHNSLFLIAHF
HHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHH
HNVIIGGVVFGYLAGLTYWFPKAFGFKLNEKLGKASFWCWIIGFFVAFMPLYVLGFMGMT
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RRMNTYNHPEWAPWLYVAAVGAAIIGMGIFLNLLQIAYSVWKRKDHMDYTGDPWDGRTLE
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEE
WATSSPPPFYNFAVLPHIDDRDQFWADKQNGKGWVRPSKYEAIHMPRNTAAGVYIGAFSV
ECCCCCCCCCEEEEECCCCCCHHHCCCCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHH
LMGFGLIWHIWWLAIIGLVGMIGSFIARTFDDDIDYWVPADEVERIENARFALLEQQQAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
QAAKVV
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Protoheme IX (Heme B55 and B562); Copper B. [C]

Metal ions: Fe; Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Ubiquinol-8; O(2) [C]

Specific reaction: Ubiquinol-8 + O(2) = Ubiquinone-8 + H2O. [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]