Click here to switch to the map view.

The map label for this gene is lysA

Identifier: 84490355

GI number: 84490355

Start: 1757393

End: 1758682

Strand: Direct

Name: lysA

Synonym: Msp_1578

Alternate gene names: 84490355

Gene position: 1757393-1758682 (Clockwise)

Preceding gene: 84490347

Following gene: 84490356

Centisome position: 99.43

GC content: 31.78

Gene sequence:

>1290_bases
ATGCCATATGATTTTAATTTAAAAAAAGAAAATAATCATCTCATTATTGGAAATATAGATGCTAACGAACTTGCTGAAAA
ATATAAAACACCATTATATGTGATAGATGAAGAAAAAGTTAGAAATAATTATAATAAATTATACACTGCATTTAATAGTA
AATATGAAGATCTTCACATGTGTTATGCTGCAAAAGCAAATACAAACCTAGCAGTAATGAAAATATTAGAAGATGAAGGA
AGTTACATTGATGCCGTATCTCCCGGTGAAATATACACTGCACTTCTTGCAGGATTTACACCAGAAAGAATAGTATTTAC
TGGAAACAACGTAACAAATGAAGAACTAGAATATGCACATAAAACTGGAGTTACAATAAATCTTGACAGTATTTCTGCAC
TTGAAAGATTAAGTACCATTGAAGGAACTAAAGGAAAAGAAATATCCATAAGAGTTAACCCGATGGTAGAAGCAGGACAT
CATGAACACTGTATTACTGGTGGTCCAAAAAGTAAATTTGGAATAAAAGAAGAAGAAGCTGTTGAAGTATATCAAAAAGC
TATTGATTTAGGATTTAAACCTATAGGAATGCACTCCCACATAGGTTCTGAAATTCTTGAATCTGAACCATTCATGTTAG
CTGTTGAAACAATGATGGATATTGCTGGAAAAGTTCATAAAGAAGTAGGAGTAGACTTTAAATTCCTAGATTTTGGTGGA
GGATTTGGTATCCCATATGAACCAACAGAAAATGAATTAGACCTAGAAACATTCACAACAGACATAATTAAATTATTTAA
ATCAAAATTAGAAGAATATGATATGGGAAAACCTGCAATGTACATAGAACCAGGAAGATTCTTAGTAGGTAATGCTGAAG
TACTCCTTACGAGAGTAAATACTATAAAAGAAAGTTATCGTAAATTTGCTGGTGTAGACTGTGGATTTGGAACATTACTT
AGACCTACAATGTATGGTTCATACCACCACATAGTTGTTGCAAATAAAATTAATGAAGAAAATGTGGAAGAAATTGATAT
TGCAGGAAACTTATGTGAATCAGGAGATTTATTTGCAAGAGACAGACCTATGCCTAAACTTGAAGAAGGAGACTTACTTG
CAATATTAAATGCTGGAGCATATGCATACAGTATGGCTTCACAATACAATTCAAGACCTAGACCTGCAGAAGTTCTTGTA
AACAAAGACGAAGTAGATGTAATTAGAAGAAGAGAAGAATTCAGTGACTTATTTAATGGTCAAAAAATTCCTACAAGGTT
ATTAAAATGA

Upstream 100 bases:

>100_bases
TATAAAATTTATACTTTTAAAAAAGAACTTTTTTTGATTATATAGAATATTATATAACTTTTTTTTAAAATATAAACTAA
CTACAATAGGAATCAATAAA

Downstream 100 bases:

>100_bases
TTAAAGAAATAGAATTTACTAAAATGCATGCACTTGGTAATGATTATATTGTAATTAATGAAACAGAAACTGAAGTTATT
CCTGAAGAAGCAAAAAACAA

Product: hypothetical protein

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MPYDFNLKKENNHLIIGNIDANELAEKYKTPLYVIDEEKVRNNYNKLYTAFNSKYEDLHMCYAAKANTNLAVMKILEDEG
SYIDAVSPGEIYTALLAGFTPERIVFTGNNVTNEELEYAHKTGVTINLDSISALERLSTIEGTKGKEISIRVNPMVEAGH
HEHCITGGPKSKFGIKEEEAVEVYQKAIDLGFKPIGMHSHIGSEILESEPFMLAVETMMDIAGKVHKEVGVDFKFLDFGG
GFGIPYEPTENELDLETFTTDIIKLFKSKLEEYDMGKPAMYIEPGRFLVGNAEVLLTRVNTIKESYRKFAGVDCGFGTLL
RPTMYGSYHHIVVANKINEENVEEIDIAGNLCESGDLFARDRPMPKLEEGDLLAILNAGAYAYSMASQYNSRPRPAEVLV
NKDEVDVIRRREEFSDLFNGQKIPTRLLK

Sequences:

>Translated_429_residues
MPYDFNLKKENNHLIIGNIDANELAEKYKTPLYVIDEEKVRNNYNKLYTAFNSKYEDLHMCYAAKANTNLAVMKILEDEG
SYIDAVSPGEIYTALLAGFTPERIVFTGNNVTNEELEYAHKTGVTINLDSISALERLSTIEGTKGKEISIRVNPMVEAGH
HEHCITGGPKSKFGIKEEEAVEVYQKAIDLGFKPIGMHSHIGSEILESEPFMLAVETMMDIAGKVHKEVGVDFKFLDFGG
GFGIPYEPTENELDLETFTTDIIKLFKSKLEEYDMGKPAMYIEPGRFLVGNAEVLLTRVNTIKESYRKFAGVDCGFGTLL
RPTMYGSYHHIVVANKINEENVEEIDIAGNLCESGDLFARDRPMPKLEEGDLLAILNAGAYAYSMASQYNSRPRPAEVLV
NKDEVDVIRRREEFSDLFNGQKIPTRLLK
>Mature_428_residues
PYDFNLKKENNHLIIGNIDANELAEKYKTPLYVIDEEKVRNNYNKLYTAFNSKYEDLHMCYAAKANTNLAVMKILEDEGS
YIDAVSPGEIYTALLAGFTPERIVFTGNNVTNEELEYAHKTGVTINLDSISALERLSTIEGTKGKEISIRVNPMVEAGHH
EHCITGGPKSKFGIKEEEAVEVYQKAIDLGFKPIGMHSHIGSEILESEPFMLAVETMMDIAGKVHKEVGVDFKFLDFGGG
FGIPYEPTENELDLETFTTDIIKLFKSKLEEYDMGKPAMYIEPGRFLVGNAEVLLTRVNTIKESYRKFAGVDCGFGTLLR
PTMYGSYHHIVVANKINEENVEEIDIAGNLCESGDLFARDRPMPKLEEGDLLAILNAGAYAYSMASQYNSRPRPAEVLVN
KDEVDVIRRREEFSDLFNGQKIPTRLLK

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=356, Percent_Identity=24.1573033707865, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1789203, Length=415, Percent_Identity=33.0120481927711, Blast_Score=211, Evalue=7e-56,
Organism=Caenorhabditis elegans, GI17562780, Length=363, Percent_Identity=23.1404958677686, Blast_Score=73, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6322664, Length=377, Percent_Identity=24.4031830238727, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24586472, Length=346, Percent_Identity=26.878612716763, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24586474, Length=341, Percent_Identity=28.1524926686217, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 48199; Mature: 48068

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00878 ODR_DC_2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYDFNLKKENNHLIIGNIDANELAEKYKTPLYVIDEEKVRNNYNKLYTAFNSKYEDLHM
CCCCCCEEECCCEEEEECCCHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHCCCCCCEEE
CYAAKANTNLAVMKILEDEGSYIDAVSPGEIYTALLAGFTPERIVFTGNNVTNEELEYAH
EEEECCCCCEEEEEEEECCCCEEECCCCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHH
KTGVTINLDSISALERLSTIEGTKGKEISIRVNPMVEAGHHEHCITGGPKSKFGIKEEEA
HCCCEEEEHHHHHHHHHHHCCCCCCCEEEEEECCEEECCCCCCCCCCCCCCCCCCCHHHH
VEVYQKAIDLGFKPIGMHSHIGSEILESEPFMLAVETMMDIAGKVHKEVGVDFKFLDFGG
HHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCCCEEEEECCC
GFGIPYEPTENELDLETFTTDIIKLFKSKLEEYDMGKPAMYIEPGRFLVGNAEVLLTRVN
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEECCHHEEEHHHH
TIKESYRKFAGVDCGFGTLLRPTMYGSYHHIVVANKINEENVEEIDIAGNLCESGDLFAR
HHHHHHHHHCCCCCCCHHHHCHHHCCCEEEEEEEECCCCCCCCEEECCCCCCCCCCCEEC
DRPMPKLEEGDLLAILNAGAYAYSMASQYNSRPRPAEVLVNKDEVDVIRRREEFSDLFNG
CCCCCCCCCCCEEEEEECCHHHHHHHHHHCCCCCCHHEEECCCHHHHHHHHHHHHHHHCC
QKIPTRLLK
CCCHHHHCC
>Mature Secondary Structure 
PYDFNLKKENNHLIIGNIDANELAEKYKTPLYVIDEEKVRNNYNKLYTAFNSKYEDLHM
CCCCCEEECCCEEEEECCCHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHCCCCCCEEE
CYAAKANTNLAVMKILEDEGSYIDAVSPGEIYTALLAGFTPERIVFTGNNVTNEELEYAH
EEEECCCCCEEEEEEEECCCCEEECCCCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHH
KTGVTINLDSISALERLSTIEGTKGKEISIRVNPMVEAGHHEHCITGGPKSKFGIKEEEA
HCCCEEEEHHHHHHHHHHHCCCCCCCEEEEEECCEEECCCCCCCCCCCCCCCCCCCHHHH
VEVYQKAIDLGFKPIGMHSHIGSEILESEPFMLAVETMMDIAGKVHKEVGVDFKFLDFGG
HHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCCCEEEEECCC
GFGIPYEPTENELDLETFTTDIIKLFKSKLEEYDMGKPAMYIEPGRFLVGNAEVLLTRVN
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEECCHHEEEHHHH
TIKESYRKFAGVDCGFGTLLRPTMYGSYHHIVVANKINEENVEEIDIAGNLCESGDLFAR
HHHHHHHHHCCCCCCCHHHHCHHHCCCEEEEEEEECCCCCCCCEEECCCCCCCCCCCEEC
DRPMPKLEEGDLLAILNAGAYAYSMASQYNSRPRPAEVLVNKDEVDVIRRREEFSDLFNG
CCCCCCCCCCCEEEEEECCHHHHHHHHHHCCCCCCHHEEECCCHHHHHHHHHHHHHHHCC
QKIPTRLLK
CCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]