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The map label for this gene is aqpM2

Identifier: 84490028

GI number: 84490028

Start: 1409972

End: 1410721

Strand: Direct

Name: aqpM2

Synonym: Msp_1240

Alternate gene names: 84490028

Gene position: 1409972-1410721 (Clockwise)

Preceding gene: 84490027

Following gene: 84490029

Centisome position: 79.78

GC content: 34.0

Gene sequence:

>750_bases
ATGACTGAATTTAGAAAGATACTAAGTGAAGTTATAGGTACCTATACTCTCGTATTTTTTGGTACTCTATCAGTAGTAGT
AACATTATTAATAGCCCAAGGAGTAGAAACTACAAACATATTTAACATAGGAATTGGAGCATTAGGTGGAGTGGGTGATT
GGTTATCCATAGGTTTTGCATTTGCAATGCCACTAATAGCAGCAATATATGCTTTTGCTAGGATATCTGGAGCCCATTTT
AATCCTGCTGTAACTATTGGATTATGGTCTATAAAGAAATTTCCTACAAAGGATGTTATACCATACATAGTTTCACAAAT
AATAGGATCATTACTTGCTACTTTTACAATAGTAGCTATACTTGGTAAACAAGCATCAACTATAGGTGTTCTTGGATCTG
TAGCACCTTTTGGTGATGTTACATTACTTGGAGTGTTTATTGCTGAATTTTTAGGTACATTTCTATTAATGTATGCAATT
ATGGCTGTGGCAGTTGATAAAAATGCACAACCTGGATTTGCTGCATTGATAATTGGACTTGTAATTCTAGGAATCGTTGT
TGCTATAGGTAATATAAGTGGATCTGGTATTAATCCAGCTCGTTCACTAACACCAATGATTGGAAATCTTATAGTGGCAG
GTACTCCTATAGACCTATTAGTTCTAGCTGTGTATATTATTGCCCCAATTTTAGGAGCAATATGTGGTGCTCAATTATAT
GAATACTTGTATAAAGAGATTGGATATTAA

Upstream 100 bases:

>100_bases
TAAAAAACGATATATATCTAATATAATTAACATAAGAAAATCATTTTAAGAAAAATAAAAATAATGTAGAAATATTATAA
AACACGGAGGCTGTATAATT

Downstream 100 bases:

>100_bases
AACTAAAAATATTATGAGTATTTGAGTTTTAAGAACTTATTTACTCATATCCCTCCTTTTAGCATTTTTTTTAACATGAA
TTAAAAATATTCTATTTTCA

Product: AqpM2

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MTEFRKILSEVIGTYTLVFFGTLSVVVTLLIAQGVETTNIFNIGIGALGGVGDWLSIGFAFAMPLIAAIYAFARISGAHF
NPAVTIGLWSIKKFPTKDVIPYIVSQIIGSLLATFTIVAILGKQASTIGVLGSVAPFGDVTLLGVFIAEFLGTFLLMYAI
MAVAVDKNAQPGFAALIIGLVILGIVVAIGNISGSGINPARSLTPMIGNLIVAGTPIDLLVLAVYIIAPILGAICGAQLY
EYLYKEIGY

Sequences:

>Translated_249_residues
MTEFRKILSEVIGTYTLVFFGTLSVVVTLLIAQGVETTNIFNIGIGALGGVGDWLSIGFAFAMPLIAAIYAFARISGAHF
NPAVTIGLWSIKKFPTKDVIPYIVSQIIGSLLATFTIVAILGKQASTIGVLGSVAPFGDVTLLGVFIAEFLGTFLLMYAI
MAVAVDKNAQPGFAALIIGLVILGIVVAIGNISGSGINPARSLTPMIGNLIVAGTPIDLLVLAVYIIAPILGAICGAQLY
EYLYKEIGY
>Mature_248_residues
TEFRKILSEVIGTYTLVFFGTLSVVVTLLIAQGVETTNIFNIGIGALGGVGDWLSIGFAFAMPLIAAIYAFARISGAHFN
PAVTIGLWSIKKFPTKDVIPYIVSQIIGSLLATFTIVAILGKQASTIGVLGSVAPFGDVTLLGVFIAEFLGTFLLMYAIM
AVAVDKNAQPGFAALIIGLVILGIVVAIGNISGSGINPARSLTPMIGNLIVAGTPIDLLVLAVYIIAPILGAICGAQLYE
YLYKEIGY

Specific function: Channel that permits osmotically driven movement of water in both directions [H]

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI4502187, Length=256, Percent_Identity=31.640625, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI4826645, Length=260, Percent_Identity=27.6923076923077, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4755125, Length=194, Percent_Identity=29.8969072164948, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI4502181, Length=194, Percent_Identity=29.8969072164948, Blast_Score=72, Evalue=4e-13,
Organism=Escherichia coli, GI1787101, Length=209, Percent_Identity=33.9712918660287, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790362, Length=264, Percent_Identity=32.5757575757576, Blast_Score=86, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71994009, Length=256, Percent_Identity=30.46875, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71993722, Length=249, Percent_Identity=30.1204819277108, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17533613, Length=257, Percent_Identity=27.2373540856031, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI32564052, Length=257, Percent_Identity=27.2373540856031, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17531429, Length=254, Percent_Identity=24.8031496062992, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17531431, Length=254, Percent_Identity=24.8031496062992, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17558372, Length=214, Percent_Identity=28.5046728971963, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71992966, Length=259, Percent_Identity=25.4826254826255, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17544068, Length=261, Percent_Identity=27.2030651340996, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6321054, Length=221, Percent_Identity=33.0316742081448, Blast_Score=85, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 26033; Mature: 25901

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEFRKILSEVIGTYTLVFFGTLSVVVTLLIAQGVETTNIFNIGIGALGGVGDWLSIGFA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHCCHHHHHHHHHH
FAMPLIAAIYAFARISGAHFNPAVTIGLWSIKKFPTKDVIPYIVSQIIGSLLATFTIVAI
HHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LGKQASTIGVLGSVAPFGDVTLLGVFIAEFLGTFLLMYAIMAVAVDKNAQPGFAALIIGL
HHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
VILGIVVAIGNISGSGINPARSLTPMIGNLIVAGTPIDLLVLAVYIIAPILGAICGAQLY
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EYLYKEIGY
HHHHHHHCC
>Mature Secondary Structure 
TEFRKILSEVIGTYTLVFFGTLSVVVTLLIAQGVETTNIFNIGIGALGGVGDWLSIGFA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHCCHHHHHHHHHH
FAMPLIAAIYAFARISGAHFNPAVTIGLWSIKKFPTKDVIPYIVSQIIGSLLATFTIVAI
HHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LGKQASTIGVLGSVAPFGDVTLLGVFIAEFLGTFLLMYAIMAVAVDKNAQPGFAALIIGL
HHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
VILGIVVAIGNISGSGINPARSLTPMIGNLIVAGTPIDLLVLAVYIIAPILGAICGAQLY
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EYLYKEIGY
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]