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The map label for this gene is pth

Identifier: 84489948

GI number: 84489948

Start: 1328107

End: 1328445

Strand: Direct

Name: pth

Synonym: Msp_1156

Alternate gene names: 84489948

Gene position: 1328107-1328445 (Clockwise)

Preceding gene: 84489947

Following gene: 84489949

Centisome position: 75.14

GC content: 33.33

Gene sequence:

>339_bases
ATGAAACAAGTTATAATTATGAGAACAGATCTTAAAATGGGAAAAGGAAAAATTGCTGCCCAAGCATGTCATGCTAGTTT
AAATTGTTATAAGAATGCCGATAAATCAAGACTCAGAGCATGGGAACTTAGTGGACAGAAAAAGGTTGTTCTTAAAGTAT
CTTCTGAGAAAGAATTATTAGAACTTAATAGCATTGTAAAAGAGACTGATCTTCCACATTCATTAATTACTGATGCTGGT
CATACACAGATTGAACCTTCTACAAGAACTTGTTTAGGAATTGGTCCAGGGTCTGATGAAGAGATTGACAAGTTAACTGG
TCATCTAAAATTATTATAG

Upstream 100 bases:

>100_bases
GTACGTGTAATAATACCAGGTATGGAGTTATTTAGTGTTGATTCATCACGTGTGGGTAATAGACTAAAACCTAAGGACTT
AATAATATAGGAAGGATTAG

Downstream 100 bases:

>100_bases
AAGGTATGTTATGGTAACTGTTGTTAAAATAGGTGGAAGTTTATTTCCAGAGCATGTTAATAGGTTATGTGAATGTTTTA
AAAAATCTAAGGAAAAAATT

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 112; Mature: 112

Protein sequence:

>112_residues
MKQVIIMRTDLKMGKGKIAAQACHASLNCYKNADKSRLRAWELSGQKKVVLKVSSEKELLELNSIVKETDLPHSLITDAG
HTQIEPSTRTCLGIGPGSDEEIDKLTGHLKLL

Sequences:

>Translated_112_residues
MKQVIIMRTDLKMGKGKIAAQACHASLNCYKNADKSRLRAWELSGQKKVVLKVSSEKELLELNSIVKETDLPHSLITDAG
HTQIEPSTRTCLGIGPGSDEEIDKLTGHLKLL
>Mature_112_residues
MKQVIIMRTDLKMGKGKIAAQACHASLNCYKNADKSRLRAWELSGQKKVVLKVSSEKELLELNSIVKETDLPHSLITDAG
HTQIEPSTRTCLGIGPGSDEEIDKLTGHLKLL

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG1990

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH2 family [H]

Homologues:

Organism=Homo sapiens, GI7706351, Length=113, Percent_Identity=50.4424778761062, Blast_Score=110, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17558188, Length=116, Percent_Identity=43.1034482758621, Blast_Score=89, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6319414, Length=120, Percent_Identity=36.6666666666667, Blast_Score=82, Evalue=2e-17,
Organism=Drosophila melanogaster, GI281376919, Length=115, Percent_Identity=45.2173913043478, Blast_Score=103, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24644665, Length=115, Percent_Identity=45.2173913043478, Blast_Score=103, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24646438, Length=117, Percent_Identity=42.7350427350427, Blast_Score=98, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002833 [H]

Pfam domain/function: PF01981 PTH2 [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 12324; Mature: 12324

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQVIIMRTDLKMGKGKIAAQACHASLNCYKNADKSRLRAWELSGQKKVVLKVSSEKELL
CCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCHHHEEEECCCCEEEEEEECCCHHHH
ELNSIVKETDLPHSLITDAGHTQIEPSTRTCLGIGPGSDEEIDKLTGHLKLL
HHHHHHHHCCCCHHHHCCCCCCEECCCCCEEEEECCCCCHHHHHHHCCEECC
>Mature Secondary Structure
MKQVIIMRTDLKMGKGKIAAQACHASLNCYKNADKSRLRAWELSGQKKVVLKVSSEKELL
CCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCHHHEEEECCCCEEEEEEECCCHHHH
ELNSIVKETDLPHSLITDAGHTQIEPSTRTCLGIGPGSDEEIDKLTGHLKLL
HHHHHHHHCCCCHHHHCCCCCCEECCCCCEEEEECCCCCHHHHHHHCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]