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The map label for this gene is rmlD [H]

Identifier: 84489910

GI number: 84489910

Start: 1287266

End: 1288126

Strand: Direct

Name: rmlD [H]

Synonym: Msp_1116

Alternate gene names: 84489910

Gene position: 1287266-1288126 (Clockwise)

Preceding gene: 84489904

Following gene: 84489912

Centisome position: 72.83

GC content: 28.8

Gene sequence:

>861_bases
ATGAAATTCTTTATAACAGGTGGTAGTGGTTTACTTGGTGAAAGATTAGCCACAATAGCAAGTAATGATGATGAGATTGT
ATTATCACATAATTCAAATCCAACAAAAAACACTATAAAATGTGATATTACAGATAAAAATGAAGTTGAAAAAGTAATAA
ATAAAAATAAACCAGACACTATAGTTCATTGTGCTGCTATGACAGATGTAGATTTATGTGAAGATGAAATAGACATAGCT
TATAGAATTAATAGTGATGGAACAAGAAATATGGCCCAAGCTGCTGAAAATATTGGTGCTAAAATTATATATGTATCAAC
AGACTTTGTATTTGATGGAGATAAAGGTTACTATAGTGAAGATGATGAAGTAAATCCCCTTGGAATCTATGCAAAATCTA
AATATGATGGAGAAGTTCAATTAAAAAAATACAGTACTAACTGGGCAATTGCACGTGTAAGTGTATTGTATGGATGGCAT
AAAAAAGCAAACTTCACAACATGGGTTATAAATCAACTACGTAGTAATAATTCAATAAATATTGTAACTGATCAAATTAA
CTCACCAACCTATGCAGATAATGCTGGTGAAGCTATATTTGAAATAGCAAAACAAGATAAAAATGGTATTTATCATACAG
CAGGTAATGATAGAATAAATAGATTTGATTTTACACAGAAAATTGCCGAAGCATTTAATTTAAATAAGGATTTAATTAAT
CCAACAACAAGTGATAAATTCATTCAAAAAGCACCAAGACCAAGAGATTCTTCCTTGAATGTTAATAAAATTAAAAAAGA
ATTGGGTTTTACTATGGAAACATGTAGTGAATCATTAGAAAGAATGGCTAATTGTAAATAA

Upstream 100 bases:

>100_bases
AATAGTTAAGTCAACAATGACTTATCAAAGGGCTAAAAATATATTACTAGTATTAATAACTACCTAAAAAACATATATTT
AAAAGAAGTAATAGTTTAAT

Downstream 100 bases:

>100_bases
GATGGATTTTTTTCATCTTATACTATAAAGTCATTAACTATTTATAAATAGAAGAAGTCACTCTCAGAAGTTCAGTGGAT
ATAACTTTTCATATTTTTTA

Product: dTDP-4-dehydrorhamnose reductase

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MKFFITGGSGLLGERLATIASNDDEIVLSHNSNPTKNTIKCDITDKNEVEKVINKNKPDTIVHCAAMTDVDLCEDEIDIA
YRINSDGTRNMAQAAENIGAKIIYVSTDFVFDGDKGYYSEDDEVNPLGIYAKSKYDGEVQLKKYSTNWAIARVSVLYGWH
KKANFTTWVINQLRSNNSINIVTDQINSPTYADNAGEAIFEIAKQDKNGIYHTAGNDRINRFDFTQKIAEAFNLNKDLIN
PTTSDKFIQKAPRPRDSSLNVNKIKKELGFTMETCSESLERMANCK

Sequences:

>Translated_286_residues
MKFFITGGSGLLGERLATIASNDDEIVLSHNSNPTKNTIKCDITDKNEVEKVINKNKPDTIVHCAAMTDVDLCEDEIDIA
YRINSDGTRNMAQAAENIGAKIIYVSTDFVFDGDKGYYSEDDEVNPLGIYAKSKYDGEVQLKKYSTNWAIARVSVLYGWH
KKANFTTWVINQLRSNNSINIVTDQINSPTYADNAGEAIFEIAKQDKNGIYHTAGNDRINRFDFTQKIAEAFNLNKDLIN
PTTSDKFIQKAPRPRDSSLNVNKIKKELGFTMETCSESLERMANCK
>Mature_286_residues
MKFFITGGSGLLGERLATIASNDDEIVLSHNSNPTKNTIKCDITDKNEVEKVINKNKPDTIVHCAAMTDVDLCEDEIDIA
YRINSDGTRNMAQAAENIGAKIIYVSTDFVFDGDKGYYSEDDEVNPLGIYAKSKYDGEVQLKKYSTNWAIARVSVLYGWH
KKANFTTWVINQLRSNNSINIVTDQINSPTYADNAGEAIFEIAKQDKNGIYHTAGNDRINRFDFTQKIAEAFNLNKDLIN
PTTSDKFIQKAPRPRDSSLNVNKIKKELGFTMETCSESLERMANCK

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N-acetylglucosamine-L-rhamnose disaccharide, which connects the galacta

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI11034825, Length=282, Percent_Identity=30.4964539007092, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI33519455, Length=282, Percent_Identity=30.4964539007092, Blast_Score=136, Evalue=2e-32,
Organism=Escherichia coli, GI1788352, Length=256, Percent_Identity=29.6875, Blast_Score=111, Evalue=7e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 32079; Mature: 32079

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFFITGGSGLLGERLATIASNDDEIVLSHNSNPTKNTIKCDITDKNEVEKVINKNKPDT
CEEEEECCCCHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCHHHHHHHHCCCCCCC
IVHCAAMTDVDLCEDEIDIAYRINSDGTRNMAQAAENIGAKIIYVSTDFVFDGDKGYYSE
EEEEEECCCCHHCCCCEEEEEEECCCCCHHHHHHHHHCCEEEEEEEEEEEEECCCCCCCC
DDEVNPLGIYAKSKYDGEVQLKKYSTNWAIARVSVLYGWHKKANFTTWVINQLRSNNSIN
CCCCCCEEEEEECCCCCEEEEEEECCCEEEEEEEEEECCCCCCCCHHHHHHHHHCCCCEE
IVTDQINSPTYADNAGEAIFEIAKQDKNGIYHTAGNDRINRFDFTQKIAEAFNLNKDLIN
EEEECCCCCCCCCCCHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHCCCHHHCC
PTTSDKFIQKAPRPRDSSLNVNKIKKELGFTMETCSESLERMANCK
CCCCHHHHHHCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKFFITGGSGLLGERLATIASNDDEIVLSHNSNPTKNTIKCDITDKNEVEKVINKNKPDT
CEEEEECCCCHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCHHHHHHHHCCCCCCC
IVHCAAMTDVDLCEDEIDIAYRINSDGTRNMAQAAENIGAKIIYVSTDFVFDGDKGYYSE
EEEEEECCCCHHCCCCEEEEEEECCCCCHHHHHHHHHCCEEEEEEEEEEEEECCCCCCCC
DDEVNPLGIYAKSKYDGEVQLKKYSTNWAIARVSVLYGWHKKANFTTWVINQLRSNNSIN
CCCCCCEEEEEECCCCCEEEEEEECCCEEEEEEEEEECCCCCCCCHHHHHHHHHCCCCEE
IVTDQINSPTYADNAGEAIFEIAKQDKNGIYHTAGNDRINRFDFTQKIAEAFNLNKDLIN
EEEECCCCCCCCCCCHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHCCCHHHCC
PTTSDKFIQKAPRPRDSSLNVNKIKKELGFTMETCSESLERMANCK
CCCCHHHHHHCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA