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The map label for this gene is tyrA [C]

Identifier: 84489877

GI number: 84489877

Start: 1222849

End: 1224183

Strand: Direct

Name: tyrA [C]

Synonym: Msp_1083

Alternate gene names: 84489877

Gene position: 1222849-1224183 (Clockwise)

Preceding gene: 84489876

Following gene: 84489878

Centisome position: 69.19

GC content: 28.54

Gene sequence:

>1335_bases
ATGACTTGTGAGAATAATAATATAAATATTACAATTATTGGAGGTTCAAGGGGACTTGGTAAATGGATTGCAAATGAACT
TCATAAAGATAATTTTAATGTTAAAATCACAAGTCGTAATAGAAGTTCTGGTGAAAAAATAGCACATAAAATGGGAGTAA
AATATGATGATGATAATATTGAAGCAATAGCTGATGCTAATATTATCATATTCAGTGTTCCTATTGAATATATGGTTGAT
ACAATCAAAGAAGTTGCACCATATGCTCCTAAAGATTCATTACTCATGGATGTAACCTCTGTAAAAACTGAACCTGCAGA
AGCATTAAGTAAGTATGCTCCAGAAGATACTTATATTCTTCCATGTCATCCAATGTTTGGACCACGTATTCCCTCTCTTG
ATGGACAAGTTGTTATATTAACACCAATTGAAGATAGATGTAGATTGTGGTATGATAAGATAGTATATTACTTAAAAAAT
AAAGATGCTAATCTTGTTATAAGTACACCTCAAGAACATGATAAAATCATGAGTGTTGTTCAAGGTTTAACTCATTTTTC
CTATATTAGTATCGCTTCAACAATAAGACGTTTAGGAATAAGTGTTAAAAAATCTCGTGAATTTGCAAGTCCAGTATATA
GTTTAATGTTAGATATGATAAGTCGTATTGTATCACAAAATCCATACTTATATTATTCTATTCAAAAATCAAATAAACAA
ACAGCTATTTCTAGAAAGACACTGATTGAAGAGAGTAATAGATTAGCTAAGTTAATTGATGATGATATGGAAGAGGAATT
TGTATATGATATGAGTGAATCTGCAAAACATTTAGATGAATTTGAAGAAGCATTAGGTCGTTCAGATAAGGCAATAAGTG
TCCTAACCCATGATTTTAATTATATTAAAGAATCTATTGGATGTGAAATAGGTTTTGAACATCAATATTCAAAAAAAATA
CATATAGGTGTAGTTGAATCTGTAAATGCCACTACTGTTACATTACGTGATTTAAAAAACAATAGAATAACACTTAAAAT
ATCCAATATTAATATATTAACTGAAAATGAGATTTATGAATGGAAGAAAAATAACCTTCCAATACATGAATATGATGTTT
CTATTATATTCCCAGATACATGTAGTGAAGACATATTACTTTCAATGTTTAGTCAAATTAAACCTGTTATAGATGTGAAT
ATAAAAGATGTTTATAATGGAAAACAGATAGATGATGGTTTTATGAGTATAACGTTCCATTATAGTGTTTTTAATAGTGA
AGAAAGAGAGGTTGTTGAAGAATATCTAAGAGGCATTGGTGGAAAAATTAGATAA

Upstream 100 bases:

>100_bases
TAAATTTCATAGATTTAAGTCATACATCTACTTTTTTTTAAATAAAATTATAAAGAAAAAACTACAGAGTAGTAGTAATA
AATAAATTGAGGATAATGAT

Downstream 100 bases:

>100_bases
TAATTCCATTAATTTCTTTTAAAAAAAAATATTTTACTTGTTTTTACTTTGTTAAGTTTGAAAAAATTCTTTTTTAAAGT
CTTTTTATAATATAATAATT

Product: prephenate dehydrogenase

Products: 4-hydroxyphenylpyruvate; CO2; NADH

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MTCENNNINITIIGGSRGLGKWIANELHKDNFNVKITSRNRSSGEKIAHKMGVKYDDDNIEAIADANIIIFSVPIEYMVD
TIKEVAPYAPKDSLLMDVTSVKTEPAEALSKYAPEDTYILPCHPMFGPRIPSLDGQVVILTPIEDRCRLWYDKIVYYLKN
KDANLVISTPQEHDKIMSVVQGLTHFSYISIASTIRRLGISVKKSREFASPVYSLMLDMISRIVSQNPYLYYSIQKSNKQ
TAISRKTLIEESNRLAKLIDDDMEEEFVYDMSESAKHLDEFEEALGRSDKAISVLTHDFNYIKESIGCEIGFEHQYSKKI
HIGVVESVNATTVTLRDLKNNRITLKISNINILTENEIYEWKKNNLPIHEYDVSIIFPDTCSEDILLSMFSQIKPVIDVN
IKDVYNGKQIDDGFMSITFHYSVFNSEEREVVEEYLRGIGGKIR

Sequences:

>Translated_444_residues
MTCENNNINITIIGGSRGLGKWIANELHKDNFNVKITSRNRSSGEKIAHKMGVKYDDDNIEAIADANIIIFSVPIEYMVD
TIKEVAPYAPKDSLLMDVTSVKTEPAEALSKYAPEDTYILPCHPMFGPRIPSLDGQVVILTPIEDRCRLWYDKIVYYLKN
KDANLVISTPQEHDKIMSVVQGLTHFSYISIASTIRRLGISVKKSREFASPVYSLMLDMISRIVSQNPYLYYSIQKSNKQ
TAISRKTLIEESNRLAKLIDDDMEEEFVYDMSESAKHLDEFEEALGRSDKAISVLTHDFNYIKESIGCEIGFEHQYSKKI
HIGVVESVNATTVTLRDLKNNRITLKISNINILTENEIYEWKKNNLPIHEYDVSIIFPDTCSEDILLSMFSQIKPVIDVN
IKDVYNGKQIDDGFMSITFHYSVFNSEEREVVEEYLRGIGGKIR
>Mature_443_residues
TCENNNINITIIGGSRGLGKWIANELHKDNFNVKITSRNRSSGEKIAHKMGVKYDDDNIEAIADANIIIFSVPIEYMVDT
IKEVAPYAPKDSLLMDVTSVKTEPAEALSKYAPEDTYILPCHPMFGPRIPSLDGQVVILTPIEDRCRLWYDKIVYYLKNK
DANLVISTPQEHDKIMSVVQGLTHFSYISIASTIRRLGISVKKSREFASPVYSLMLDMISRIVSQNPYLYYSIQKSNKQT
AISRKTLIEESNRLAKLIDDDMEEEFVYDMSESAKHLDEFEEALGRSDKAISVLTHDFNYIKESIGCEIGFEHQYSKKIH
IGVVESVNATTVTLRDLKNNRITLKISNINILTENEIYEWKKNNLPIHEYDVSIIFPDTCSEDILLSMFSQIKPVIDVNI
KDVYNGKQIDDGFMSITFHYSVFNSEEREVVEEYLRGIGGKIR

Specific function: Tyrosine biosynthesis [C]

COG id: COG0287

COG function: function code E; Prephenate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate/arogenate dehydrogenase domain [H]

Homologues:

Organism=Escherichia coli, GI1788952, Length=231, Percent_Identity=28.5714285714286, Blast_Score=99, Evalue=4e-22,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR005121
- InterPro:   IPR008299
- InterPro:   IPR003099 [H]

Pfam domain/function: PF03147 FDX-ACB; PF02153 PDH [H]

EC number: 1.3.1.12

Molecular weight: Translated: 50684; Mature: 50553

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTCENNNINITIIGGSRGLGKWIANELHKDNFNVKITSRNRSSGEKIAHKMGVKYDDDNI
CCCCCCCEEEEEEECCCCHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHCCEECCCCC
EAIADANIIIFSVPIEYMVDTIKEVAPYAPKDSLLMDVTSVKTEPAEALSKYAPEDTYIL
EEEECCCEEEEECCHHHHHHHHHHHCCCCCCCCEEEEHHHCCCCHHHHHHHHCCCCCEEE
PCHPMFGPRIPSLDGQVVILTPIEDRCRLWYDKIVYYLKNKDANLVISTPQEHDKIMSVV
ECCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHEEEECCCCEEEEECCHHHHHHHHHH
QGLTHFSYISIASTIRRLGISVKKSREFASPVYSLMLDMISRIVSQNPYLYYSIQKSNKQ
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCH
TAISRKTLIEESNRLAKLIDDDMEEEFVYDMSESAKHLDEFEEALGRSDKAISVLTHDFN
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHH
YIKESIGCEIGFEHQYSKKIHIGVVESVNATTVTLRDLKNNRITLKISNINILTENEIYE
HHHHHHCCEECCCCCCCCEEEEEEEECCCCEEEEEEECCCCEEEEEEECEEEEECCCHHH
WKKNNLPIHEYDVSIIFPDTCSEDILLSMFSQIKPVIDVNIKDVYNGKQIDDGFMSITFH
HHCCCCCEEEEEEEEEECCCCCHHHHHHHHHHCCCEEEEEEHHCCCCCCCCCCEEEEEEE
YSVFNSEEREVVEEYLRGIGGKIR
EEECCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TCENNNINITIIGGSRGLGKWIANELHKDNFNVKITSRNRSSGEKIAHKMGVKYDDDNI
CCCCCCEEEEEEECCCCHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHCCEECCCCC
EAIADANIIIFSVPIEYMVDTIKEVAPYAPKDSLLMDVTSVKTEPAEALSKYAPEDTYIL
EEEECCCEEEEECCHHHHHHHHHHHCCCCCCCCEEEEHHHCCCCHHHHHHHHCCCCCEEE
PCHPMFGPRIPSLDGQVVILTPIEDRCRLWYDKIVYYLKNKDANLVISTPQEHDKIMSVV
ECCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHEEEECCCCEEEEECCHHHHHHHHHH
QGLTHFSYISIASTIRRLGISVKKSREFASPVYSLMLDMISRIVSQNPYLYYSIQKSNKQ
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCH
TAISRKTLIEESNRLAKLIDDDMEEEFVYDMSESAKHLDEFEEALGRSDKAISVLTHDFN
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHH
YIKESIGCEIGFEHQYSKKIHIGVVESVNATTVTLRDLKNNRITLKISNINILTENEIYE
HHHHHHCCEECCCCCCCCEEEEEEEECCCCEEEEEEECCCCEEEEEEECEEEEECCCHHH
WKKNNLPIHEYDVSIIFPDTCSEDILLSMFSQIKPVIDVNIKDVYNGKQIDDGFMSITFH
HHCCCCCEEEEEEEEEECCCCCHHHHHHHHHHCCCEEEEEEHHCCCCCCCCCCEEEEEEE
YSVFNSEEREVVEEYLRGIGGKIR
EEECCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: prephenate; NAD+

Specific reaction: prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]