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The map label for this gene is trpC

Identifier: 84489866

GI number: 84489866

Start: 1212361

End: 1213152

Strand: Direct

Name: trpC

Synonym: Msp_1072

Alternate gene names: 84489866

Gene position: 1212361-1213152 (Clockwise)

Preceding gene: 84489865

Following gene: 84489867

Centisome position: 68.6

GC content: 25.38

Gene sequence:

>792_bases
ATGAATGTTATAGATAGAATAATAGAAAATAAAAAAGTAACACTCACACAAACTAAAAAACAAAAACCCCTAGAAAAACT
TAAAGAAGAGGCAATTGACATAGTTTCTACAAAAACAAAGTTATTTAGATTTCAAGAAAAACTAAAAAATAAAACAACAC
AACTCATTGCAGAATACAAACCTGCAAGTCCATCAAAAGGAAATATCAGTACATTAAAAGCAGAAGATGTTATTCCAATA
TATGATAAAAATAACGTAGACATGATGTCAATTTTAACTGAAGAAACATACTTTAAAAGTAATCTAAAAAATTTTAACAT
AGCAAACAACTTAACAAACAAACCATTACTTAGAAAAGATTTTATTATAGATGAATACATGATCTATGAAGCTGCTGTTA
ATAATGCTAGTGGAATATTATTAATAAGTGGAATCTGTCCTAATATAGAAGAATATTTGAATATTTCTAGAAATCTTGGA
TTAGATGCAGTAGTTGAATGTCATACATTAGAGGATATTGAATCTGTAGTAGATTATAACCCTGAAATTATTGGTATAAA
CAATAGAAATCTAGATGATTTTACTATTAATCTTAAAACAACAAAAGAATTAAAAAAATATGTTCCAAACTACTTAATAT
CAGAAAGTGGAGTAAAAACCATAGAAGATGCTAAAAAATTAAAGGAATATGGAGCAGATGGTATTTTAATAGGAACAAGT
ATCCTACAAAACAACACAGAAAAAGAAATTGAAAAATTTATTGAAAACCTAATTAACGTCCTAAAAAAATAA

Upstream 100 bases:

>100_bases
TTATCCAACCTATGGTATTCAATTTCATCCAGAATCAATTGGAAGTTCATATGGTGATACTATAATCAAAAATTTCTTAA
GTATTAATGGATGATCTAAT

Downstream 100 bases:

>100_bases
AAAGAAGGTATTGAATATGACACCTAAGATAAAAGTATGTGGTATAACAAATAGAGATGATTTAAAGAAAATTGAAAAAT
TAAATGTTAACCACGTAGGT

Product: hypothetical protein

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MNVIDRIIENKKVTLTQTKKQKPLEKLKEEAIDIVSTKTKLFRFQEKLKNKTTQLIAEYKPASPSKGNISTLKAEDVIPI
YDKNNVDMMSILTEETYFKSNLKNFNIANNLTNKPLLRKDFIIDEYMIYEAAVNNASGILLISGICPNIEEYLNISRNLG
LDAVVECHTLEDIESVVDYNPEIIGINNRNLDDFTINLKTTKELKKYVPNYLISESGVKTIEDAKKLKEYGADGILIGTS
ILQNNTEKEIEKFIENLINVLKK

Sequences:

>Translated_263_residues
MNVIDRIIENKKVTLTQTKKQKPLEKLKEEAIDIVSTKTKLFRFQEKLKNKTTQLIAEYKPASPSKGNISTLKAEDVIPI
YDKNNVDMMSILTEETYFKSNLKNFNIANNLTNKPLLRKDFIIDEYMIYEAAVNNASGILLISGICPNIEEYLNISRNLG
LDAVVECHTLEDIESVVDYNPEIIGINNRNLDDFTINLKTTKELKKYVPNYLISESGVKTIEDAKKLKEYGADGILIGTS
ILQNNTEKEIEKFIENLINVLKK
>Mature_263_residues
MNVIDRIIENKKVTLTQTKKQKPLEKLKEEAIDIVSTKTKLFRFQEKLKNKTTQLIAEYKPASPSKGNISTLKAEDVIPI
YDKNNVDMMSILTEETYFKSNLKNFNIANNLTNKPLLRKDFIIDEYMIYEAAVNNASGILLISGICPNIEEYLNISRNLG
LDAVVECHTLEDIESVVDYNPEIIGINNRNLDDFTINLKTTKELKKYVPNYLISESGVKTIEDAKKLKEYGADGILIGTS
ILQNNTEKEIEKFIENLINVLKK

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=248, Percent_Identity=30.6451612903226, Blast_Score=119, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6322638, Length=222, Percent_Identity=31.981981981982, Blast_Score=107, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 29981; Mature: 29981

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVIDRIIENKKVTLTQTKKQKPLEKLKEEAIDIVSTKTKLFRFQEKLKNKTTQLIAEYK
CCHHHHHHCCCCEEEECCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PASPSKGNISTLKAEDVIPIYDKNNVDMMSILTEETYFKSNLKNFNIANNLTNKPLLRKD
CCCCCCCCEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHH
FIIDEYMIYEAAVNNASGILLISGICPNIEEYLNISRNLGLDAVVECHTLEDIESVVDYN
HHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC
PEIIGINNRNLDDFTINLKTTKELKKYVPNYLISESGVKTIEDAKKLKEYGADGILIGTS
CCEEECCCCCCCEEEEEECCHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHCCCCEEEEHH
ILQNNTEKEIEKFIENLINVLKK
HHHCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNVIDRIIENKKVTLTQTKKQKPLEKLKEEAIDIVSTKTKLFRFQEKLKNKTTQLIAEYK
CCHHHHHHCCCCEEEECCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PASPSKGNISTLKAEDVIPIYDKNNVDMMSILTEETYFKSNLKNFNIANNLTNKPLLRKD
CCCCCCCCEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHH
FIIDEYMIYEAAVNNASGILLISGICPNIEEYLNISRNLGLDAVVECHTLEDIESVVDYN
HHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC
PEIIGINNRNLDDFTINLKTTKELKKYVPNYLISESGVKTIEDAKKLKEYGADGILIGTS
CCEEECCCCCCCEEEEEECCHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHCCCCEEEEHH
ILQNNTEKEIEKFIENLINVLKK
HHHCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]