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The map label for this gene is aqpM1

Identifier: 84489797

GI number: 84489797

Start: 1146881

End: 1147615

Strand: Direct

Name: aqpM1

Synonym: Msp_0998

Alternate gene names: 84489797

Gene position: 1146881-1147615 (Clockwise)

Preceding gene: 84489792

Following gene: 84489798

Centisome position: 64.89

GC content: 35.24

Gene sequence:

>735_bases
ATGACTGATATGAAAAAAATAATGGCTGAAATCGTTGGTACATTTATTCTTGTATTCTTTGGTACAGCATCAGTTGTATT
AACATTATTTATCAATGATGGACAGACATTCCCAAGTATATATAATATTGGAATTACACTGCCTGATTGGATTGGAATTG
GTTTAGCATTTGGTCTTGCATTAGTAGTTGCAATACATGCACTAGGTCCTATATCAGGGGCACATTTTAACCCTGCAGTA
ACTATAGGATTATGGGCAGGTAAAAAATTCCCAGGAAAAGATGTAATACCTTATGTAATTGCACAATTTATAGGAGCAAT
CATAGCTTCTGCTGCATTACTTGCAATTTCCGGTCCAAAAGCATCCACCATTGGAGCTTTAGGAGGAGTTGGACCATTTG
GAGATATTTCAATAATAGGAATGTTCATTGTAGAATTCCTTGGTACAGCACTATTGATGTATGTAATTATGGCTACAGCT
GTAGATAAAAATGCACCATCTATTGATGCAGCTTTAGATATAGGTTTAGTATTAGCAGGTATTGTTATTGCATTAGGTAA
CTTCACAGGTTGTGGAATTAACCCAGCTCGTGCATTCTCACCAATGCTTTTCAACTTCTTTGTAAGTGGAGCAAACGCAT
TTATATACTATCCTATTTACTTCATTGCACCTATTGTAGGAGCAATTGTAGCAGTATACTTATATGACTACTTCCATAAA
GAAATAGGATACTAA

Upstream 100 bases:

>100_bases
TTGGAAGTAGACAAAGGTGAAATAGAACATGTACTTCTTTGTAGAATTATATGTATCTATTATTTCTTTACTCAACATAA
AAAATATGGAGAAAATCAAA

Downstream 100 bases:

>100_bases
TATTATAGAAATTGTAATAATACAATTTTCTTTTATTACAATTTTTTTATTAAACTAACTTTTTTTAAATTAATTTAACT
TATTATCATTATACTATAAT

Product: AqpM1

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MTDMKKIMAEIVGTFILVFFGTASVVLTLFINDGQTFPSIYNIGITLPDWIGIGLAFGLALVVAIHALGPISGAHFNPAV
TIGLWAGKKFPGKDVIPYVIAQFIGAIIASAALLAISGPKASTIGALGGVGPFGDISIIGMFIVEFLGTALLMYVIMATA
VDKNAPSIDAALDIGLVLAGIVIALGNFTGCGINPARAFSPMLFNFFVSGANAFIYYPIYFIAPIVGAIVAVYLYDYFHK
EIGY

Sequences:

>Translated_244_residues
MTDMKKIMAEIVGTFILVFFGTASVVLTLFINDGQTFPSIYNIGITLPDWIGIGLAFGLALVVAIHALGPISGAHFNPAV
TIGLWAGKKFPGKDVIPYVIAQFIGAIIASAALLAISGPKASTIGALGGVGPFGDISIIGMFIVEFLGTALLMYVIMATA
VDKNAPSIDAALDIGLVLAGIVIALGNFTGCGINPARAFSPMLFNFFVSGANAFIYYPIYFIAPIVGAIVAVYLYDYFHK
EIGY
>Mature_243_residues
TDMKKIMAEIVGTFILVFFGTASVVLTLFINDGQTFPSIYNIGITLPDWIGIGLAFGLALVVAIHALGPISGAHFNPAVT
IGLWAGKKFPGKDVIPYVIAQFIGAIIASAALLAISGPKASTIGALGGVGPFGDISIIGMFIVEFLGTALLMYVIMATAV
DKNAPSIDAALDIGLVLAGIVIALGNFTGCGINPARAFSPMLFNFFVSGANAFIYYPIYFIAPIVGAIVAVYLYDYFHKE
IGY

Specific function: Channel that permits osmotically driven movement of water in both directions [H]

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI37694062, Length=237, Percent_Identity=32.9113924050633, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI4502183, Length=242, Percent_Identity=32.6446280991736, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI4502179, Length=236, Percent_Identity=32.6271186440678, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI4755125, Length=236, Percent_Identity=32.2033898305085, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI4502181, Length=191, Percent_Identity=33.5078534031414, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI4826645, Length=258, Percent_Identity=29.0697674418605, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4502187, Length=246, Percent_Identity=27.2357723577236, Blast_Score=84, Evalue=8e-17,
Organism=Homo sapiens, GI6912506, Length=239, Percent_Identity=29.2887029288703, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI157266307, Length=264, Percent_Identity=28.030303030303, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI22538420, Length=257, Percent_Identity=24.9027237354086, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI86792455, Length=235, Percent_Identity=29.7872340425532, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI45446752, Length=225, Percent_Identity=28.8888888888889, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI310133356, Length=188, Percent_Identity=28.1914893617021, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI310114181, Length=188, Percent_Identity=28.1914893617021, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1787101, Length=208, Percent_Identity=40.8653846153846, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1790362, Length=256, Percent_Identity=31.25, Blast_Score=91, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI71994009, Length=255, Percent_Identity=34.1176470588235, Blast_Score=110, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI32564052, Length=252, Percent_Identity=30.952380952381, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17533613, Length=252, Percent_Identity=30.952380952381, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17531431, Length=249, Percent_Identity=26.5060240963855, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17531429, Length=249, Percent_Identity=26.5060240963855, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71993722, Length=244, Percent_Identity=28.2786885245902, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71992966, Length=251, Percent_Identity=25.4980079681275, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17544068, Length=258, Percent_Identity=27.906976744186, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17558372, Length=245, Percent_Identity=27.3469387755102, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6321054, Length=215, Percent_Identity=32.5581395348837, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24762344, Length=245, Percent_Identity=29.7959183673469, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24762346, Length=245, Percent_Identity=29.7959183673469, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24762348, Length=245, Percent_Identity=29.7959183673469, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI20130305, Length=245, Percent_Identity=29.7959183673469, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI45550503, Length=255, Percent_Identity=25.0980392156863, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24762342, Length=198, Percent_Identity=30.3030303030303, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24652747, Length=248, Percent_Identity=28.6290322580645, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI45551084, Length=248, Percent_Identity=28.6290322580645, Blast_Score=71, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 25568; Mature: 25436

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDMKKIMAEIVGTFILVFFGTASVVLTLFINDGQTFPSIYNIGITLPDWIGIGLAFGLA
CCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHCCCCCCHHHHHHHHHHHHH
LVVAIHALGPISGAHFNPAVTIGLWAGKKFPGKDVIPYVIAQFIGAIIASAALLAISGPK
HHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
ASTIGALGGVGPFGDISIIGMFIVEFLGTALLMYVIMATAVDKNAPSIDAALDIGLVLAG
CHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
IVIALGNFTGCGINPARAFSPMLFNFFVSGANAFIYYPIYFIAPIVGAIVAVYLYDYFHK
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHH
EIGY
HHCC
>Mature Secondary Structure 
TDMKKIMAEIVGTFILVFFGTASVVLTLFINDGQTFPSIYNIGITLPDWIGIGLAFGLA
CHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHCCCCCCHHHHHHHHHHHHH
LVVAIHALGPISGAHFNPAVTIGLWAGKKFPGKDVIPYVIAQFIGAIIASAALLAISGPK
HHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
ASTIGALGGVGPFGDISIIGMFIVEFLGTALLMYVIMATAVDKNAPSIDAALDIGLVLAG
CHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
IVIALGNFTGCGINPARAFSPMLFNFFVSGANAFIYYPIYFIAPIVGAIVAVYLYDYFHK
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHH
EIGY
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]