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The map label for this gene is tatD [H]

Identifier: 84489773

GI number: 84489773

Start: 1116659

End: 1117441

Strand: Direct

Name: tatD [H]

Synonym: Msp_0974

Alternate gene names: 84489773

Gene position: 1116659-1117441 (Clockwise)

Preceding gene: 84489772

Following gene: 84489774

Centisome position: 63.18

GC content: 30.52

Gene sequence:

>783_bases
ATGGAACTTATAGATATTGGATTAAATCTAATGCATAAATCATATGATAAAGATAGAATTGATGTTATTAATGAAGCCAA
AAAAGTAAATGTAACAAAAGCCATAATAACTGGAAGTAGTATTCAATCAAGTATTCAAGCTACAGAATATGCATTAAAAT
ACCCTAACCTCTATGCAACATGTGGAGTACATCCCCATGATGCAAAAACATGTGATGAAAACACAATAGACACACTACAT
AAACTAGCAAAAAATGACTGTGTTGTTGCAATTGGTGAATGTGGTCTTGATTACAATAGAAACTACTCTCCCCAAAACAT
ACAACGTAAATGGTTTGAAAAACAAGTAGAACTAGCAGAAAAATTAGATATGCCCCTATTTTTACATGACAGAGAATCCT
ATGATGATTTTGCAAAAATACTCAGAAAACACAAAAAAATGGCTAAACAATCAGTAGTTCATTGTTTTACTGGAACAAAA
TATGAAGCTGAAGATTACCTTGATTTAGGCTGTTATATTGGTATTACCGGATGGATCTGTGATGAACGTAGAAACAGTGA
CTTACTCAAAGCTATTAAAGTAATACCTCCAGAAAAATTAATGATAGAAACTGATGGTCCATTCTTACTTCCAAGAGATT
TTGAAAAAAAACCTAAAAAAAATAGAAACGAACCAAAATATCTACCACATATCCTAAAAAGAATAGCAAAAGAAATGAAT
ATAGAACCAGAAACACTAGCAAAAGAAGTTACACATAACACAAAAGAATTCTTTAGAATATAA

Upstream 100 bases:

>100_bases
TAGAAGACGATGTTAAACTATGTCAATTAATTAATGAAATTAATGAAGTACCAATATACAAAAATAATGAAATAACAAAA
CTATAATATAGGAGAATACA

Downstream 100 bases:

>100_bases
CAAAAAGAGGATAAAAGATTAAAATGGAAACTATCTACTGTGCAAACTGTGGACATAAAAACAATATTTCAACTGATACT
TGTGAAAAATGTGGTGAAAT

Product: Mg-dependent DNase

Products: NA

Alternate protein names: DNase tatD [H]

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MELIDIGLNLMHKSYDKDRIDVINEAKKVNVTKAIITGSSIQSSIQATEYALKYPNLYATCGVHPHDAKTCDENTIDTLH
KLAKNDCVVAIGECGLDYNRNYSPQNIQRKWFEKQVELAEKLDMPLFLHDRESYDDFAKILRKHKKMAKQSVVHCFTGTK
YEAEDYLDLGCYIGITGWICDERRNSDLLKAIKVIPPEKLMIETDGPFLLPRDFEKKPKKNRNEPKYLPHILKRIAKEMN
IEPETLAKEVTHNTKEFFRI

Sequences:

>Translated_260_residues
MELIDIGLNLMHKSYDKDRIDVINEAKKVNVTKAIITGSSIQSSIQATEYALKYPNLYATCGVHPHDAKTCDENTIDTLH
KLAKNDCVVAIGECGLDYNRNYSPQNIQRKWFEKQVELAEKLDMPLFLHDRESYDDFAKILRKHKKMAKQSVVHCFTGTK
YEAEDYLDLGCYIGITGWICDERRNSDLLKAIKVIPPEKLMIETDGPFLLPRDFEKKPKKNRNEPKYLPHILKRIAKEMN
IEPETLAKEVTHNTKEFFRI
>Mature_260_residues
MELIDIGLNLMHKSYDKDRIDVINEAKKVNVTKAIITGSSIQSSIQATEYALKYPNLYATCGVHPHDAKTCDENTIDTLH
KLAKNDCVVAIGECGLDYNRNYSPQNIQRKWFEKQVELAEKLDMPLFLHDRESYDDFAKILRKHKKMAKQSVVHCFTGTK
YEAEDYLDLGCYIGITGWICDERRNSDLLKAIKVIPPEKLMIETDGPFLLPRDFEKKPKKNRNEPKYLPHILKRIAKEMN
IEPETLAKEVTHNTKEFFRI

Specific function: Shows DNase activity [H]

COG id: COG0084

COG function: function code L; Mg-dependent DNase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tatD DNase family [H]

Homologues:

Organism=Homo sapiens, GI14042943, Length=293, Percent_Identity=35.1535836177474, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI225903439, Length=249, Percent_Identity=36.144578313253, Blast_Score=134, Evalue=7e-32,
Organism=Homo sapiens, GI225903424, Length=163, Percent_Identity=32.5153374233129, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI110349730, Length=269, Percent_Identity=25.2788104089219, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI110349734, Length=269, Percent_Identity=25.2788104089219, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI226061853, Length=276, Percent_Identity=25.3623188405797, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI226061595, Length=229, Percent_Identity=25.3275109170306, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI48994985, Length=258, Percent_Identity=43.7984496124031, Blast_Score=233, Evalue=9e-63,
Organism=Escherichia coli, GI1787342, Length=258, Percent_Identity=31.0077519379845, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI87082439, Length=262, Percent_Identity=27.4809160305344, Blast_Score=103, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17559024, Length=281, Percent_Identity=41.6370106761566, Blast_Score=225, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17565396, Length=221, Percent_Identity=30.7692307692308, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17543026, Length=219, Percent_Identity=26.9406392694064, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71980746, Length=272, Percent_Identity=23.8970588235294, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24648690, Length=281, Percent_Identity=33.0960854092527, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI221330018, Length=299, Percent_Identity=31.1036789297659, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24586117, Length=268, Percent_Identity=31.7164179104478, Blast_Score=108, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015992
- InterPro:   IPR001130
- InterPro:   IPR018228
- InterPro:   IPR012278 [H]

Pfam domain/function: PF01026 TatD_DNase [H]

EC number: 3.1.21.-

Molecular weight: Translated: 30118; Mature: 30118

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: PS01091 TATD_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELIDIGLNLMHKSYDKDRIDVINEAKKVNVTKAIITGSSIQSSIQATEYALKYPNLYAT
CCHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHEEECHHHHHHHHHHHHHHCCCCEEEE
CGVHPHDAKTCDENTIDTLHKLAKNDCVVAIGECGLDYNRNYSPQNIQRKWFEKQVELAE
CCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHH
KLDMPLFLHDRESYDDFAKILRKHKKMAKQSVVHCFTGTKYEAEDYLDLGCYIGITGWIC
HCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCHHEEE
DERRNSDLLKAIKVIPPEKLMIETDGPFLLPRDFEKKPKKNRNEPKYLPHILKRIAKEMN
CCCCCHHHHHHHHCCCCCCEEEECCCCEECCCCCHHCCCCCCCCCHHHHHHHHHHHHHCC
IEPETLAKEVTHNTKEFFRI
CCHHHHHHHHHHCHHHHHCC
>Mature Secondary Structure
MELIDIGLNLMHKSYDKDRIDVINEAKKVNVTKAIITGSSIQSSIQATEYALKYPNLYAT
CCHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHEEECHHHHHHHHHHHHHHCCCCEEEE
CGVHPHDAKTCDENTIDTLHKLAKNDCVVAIGECGLDYNRNYSPQNIQRKWFEKQVELAE
CCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHH
KLDMPLFLHDRESYDDFAKILRKHKKMAKQSVVHCFTGTKYEAEDYLDLGCYIGITGWIC
HCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCHHEEE
DERRNSDLLKAIKVIPPEKLMIETDGPFLLPRDFEKKPKKNRNEPKYLPHILKRIAKEMN
CCCCCHHHHHHHHCCCCCCEEEECCCCEECCCCCHHCCCCCCCCCHHHHHHHHHHHHHCC
IEPETLAKEVTHNTKEFFRI
CCHHHHHHHHHHCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Mg [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1584020; 9649434; 1379743; 9278503; 10747959 [H]