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The map label for this gene is dtd

Identifier: 84489585

GI number: 84489585

Start: 914148

End: 914594

Strand: Direct

Name: dtd

Synonym: Msp_0781

Alternate gene names: 84489585

Gene position: 914148-914594 (Clockwise)

Preceding gene: 84489581

Following gene: 84489586

Centisome position: 51.72

GC content: 28.41

Gene sequence:

>447_bases
ATGAAATTAGTAGTACAAAGAGTTACAAGTGCAAAGGTAGAGGTAAATAATAACATTGTAGGAAAAATAGGTAAGGGATA
CCTAGTGCTATTAGGCATTAAAAAAACAGATACTAAAAAAGAAGCAGATTATATGATAAATAAATTAATGAAACTAAGGG
TATTTGAAGATGAAGAAAATAAAATGAATCTATCAATACAAGACATTGATGGTGAAATACTTCTAATTCCACAGTTTACA
TTATATGGTGATGTTACCCATAACAACAGACCATCATTTTCAAATGCCATGAAACCCACTGATGCTAAAAAACTTTTTGA
ATACTGCTGTAATGAATGTGAAAAGAAAGTACATACTCAGAAAGGAGAATTTGGTGCATTTATGGATGTTAATTTAGTAA
ATAATGGACCTGTAACTATAATAATAGAAAAAGAATATAATAGCTAA

Upstream 100 bases:

>100_bases
TTACACTAATGGAAGTAGAATTATATAAACTTACAAATAAAAATAATTATATAAATCAAATAAAAAAGTGCTTTTTTAAA
AAAATAGAAGAGGATAATAA

Downstream 100 bases:

>100_bases
AGAAAGTGTAATTATGAAAATGGACATTAATATTGATGCTGAATTACAAAGAAGAGCAAGAGCAGTATGTAGAAAGGTTA
GTGGTCTAACACTAGCTAGT

Product: D-tyrosyl-tRNA(Tyr) deacylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 148; Mature: 148

Protein sequence:

>148_residues
MKLVVQRVTSAKVEVNNNIVGKIGKGYLVLLGIKKTDTKKEADYMINKLMKLRVFEDEENKMNLSIQDIDGEILLIPQFT
LYGDVTHNNRPSFSNAMKPTDAKKLFEYCCNECEKKVHTQKGEFGAFMDVNLVNNGPVTIIIEKEYNS

Sequences:

>Translated_148_residues
MKLVVQRVTSAKVEVNNNIVGKIGKGYLVLLGIKKTDTKKEADYMINKLMKLRVFEDEENKMNLSIQDIDGEILLIPQFT
LYGDVTHNNRPSFSNAMKPTDAKKLFEYCCNECEKKVHTQKGEFGAFMDVNLVNNGPVTIIIEKEYNS
>Mature_148_residues
MKLVVQRVTSAKVEVNNNIVGKIGKGYLVLLGIKKTDTKKEADYMINKLMKLRVFEDEENKMNLSIQDIDGEILLIPQFT
LYGDVTHNNRPSFSNAMKPTDAKKLFEYCCNECEKKVHTQKGEFGAFMDVNLVNNGPVTIIIEKEYNS

Specific function: Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine

COG id: COG1490

COG function: function code J; D-Tyr-tRNAtyr deacylase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DTD family

Homologues:

Organism=Homo sapiens, GI30795227, Length=147, Percent_Identity=42.8571428571429, Blast_Score=107, Evalue=5e-24,
Organism=Escherichia coli, GI1790320, Length=144, Percent_Identity=41.6666666666667, Blast_Score=131, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI115533292, Length=148, Percent_Identity=42.5675675675676, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319982, Length=149, Percent_Identity=38.255033557047, Blast_Score=103, Evalue=1e-23,
Organism=Drosophila melanogaster, GI281361569, Length=146, Percent_Identity=40.4109589041096, Blast_Score=115, Evalue=8e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DTD_METST (Q2NG79)

Other databases:

- EMBL:   CP000102
- RefSeq:   YP_447817.1
- HSSP:   O66742
- ProteinModelPortal:   Q2NG79
- SMR:   Q2NG79
- STRING:   Q2NG79
- GeneID:   3856017
- GenomeReviews:   CP000102_GR
- KEGG:   mst:Msp_0781
- NMPDR:   fig|339860.6.peg.752
- eggNOG:   COG1490
- HOGENOM:   HBG286048
- OMA:   MKAVIQR
- PhylomeDB:   Q2NG79
- ProtClustDB:   PRK05273
- BioCyc:   MSTA339860:MSP_0781-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00518
- InterPro:   IPR003732
- Gene3D:   G3DSA:3.50.80.10
- PANTHER:   PTHR10472
- TIGRFAMs:   TIGR00256

Pfam domain/function: PF02580 Tyr_Deacylase; SSF69500 DTyrtRNA_deacyls

EC number: NA

Molecular weight: Translated: 16837; Mature: 16837

Theoretical pI: Translated: 8.04; Mature: 8.04

Prosite motif: NA

Important sites: ACT_SITE 80-80

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLVVQRVTSAKVEVNNNIVGKIGKGYLVLLGIKKTDTKKEADYMINKLMKLRVFEDEEN
CCCEEEECCCCEEEECCCEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHEEEEEECCCC
KMNLSIQDIDGEILLIPQFTLYGDVTHNNRPSFSNAMKPTDAKKLFEYCCNECEKKVHTQ
EEEEEEEECCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
KGEFGAFMDVNLVNNGPVTIIIEKEYNS
CCCCCEEEEEEEECCCCEEEEEEECCCC
>Mature Secondary Structure
MKLVVQRVTSAKVEVNNNIVGKIGKGYLVLLGIKKTDTKKEADYMINKLMKLRVFEDEEN
CCCEEEECCCCEEEECCCEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHEEEEEECCCC
KMNLSIQDIDGEILLIPQFTLYGDVTHNNRPSFSNAMKPTDAKKLFEYCCNECEKKVHTQ
EEEEEEEECCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
KGEFGAFMDVNLVNNGPVTIIIEKEYNS
CCCCCEEEEEEEECCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA