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The map label for this gene is estA [H]

Identifier: 83721624

GI number: 83721624

Start: 2734117

End: 2735076

Strand: Reverse

Name: estA [H]

Synonym: BTH_I2404

Alternate gene names: 83721624

Gene position: 2735076-2734117 (Counterclockwise)

Preceding gene: 83720251

Following gene: 83721407

Centisome position: 71.8

GC content: 69.06

Gene sequence:

>960_bases
GTGCGGGCTGCGTCGGCCGCATCGATCAGGAAACGGCGGCGAACACGCCGGCGCGATGCGCGGGCCGTTCACGCGGGCCG
CTCGCGCGATCATGCGCAGGCGGGGCCGCGAGGCGGACGGCAAGGTCGCCGAGACAGCGACACGCGTCACGAGCGCGTCA
CGACGTGTCACGAAACGCGGCCGCCCGTTGCGCGTGCAAGCGGCTGCCGGTCATCCCGATGTGCGATCATCGACGCGTTT
TCTTCCGATCCCCCATCTGAACGGAGCCCCAGCATGCTTGACGAAACGCCGACGATCGAAATCGAGACCGGCCCGAACCC
CGCGTTCGCGGTGATCCTGATGCACGGCCTCGGCGCCGACGCGAACGATTTCGTGCCGCTCGTCCCTGAGTTGCGGATCG
CGAACGGCCCGGCGGTGCGCTTCGTGTTCCCGAACGCGCCCGAGATCGCGGTCACCGCGAACAACGGCTACATGATGCGC
GCGTGGTACGACATCCTGTCGTTCGAAGGCGTGAACCGGCAGGTCGACGAAGCGGGAATCGACGCATCGTGCGCGGCCGT
GCGAAGCCTGATCGCCGAGCAGAACCGGCGCGGCATCCCGACATCGCGGATCTTCGTCGCGGGCTTCTCGCAGGGCGGCG
CGATGACGTATTCGGCGGGGTTCACGCATCCGGACGCGCTCGCGGGGCTGATCGTGCTGTCCGGCTACGTGCCTTCGCCG
CGCTTCATCGACGCGCGGCTCGCCGGCGCGAATCGCACGACGCCGATCTTCGCCGCGCACGGCACGGACGACGACATCCT
GCCGATCCGCCTGGGCGAGGCCGCCCGCGATTTCGCGCGCGAGAAAGGCGCGAGCGTCGACTGGCACGCGTATCCGATGC
CGCATGCGGTGTGCATCGAGGAAATCGACGCGCTGCGAAGGTGGCTGCATGCGCGGATCGCCGCGCTGCAAGCGGCATGA

Upstream 100 bases:

>100_bases
CGCGCACGCATGGGGCGCGGCGCTCGTCACGCCGCAGGCGCTCGAGCGCGGGGGCGGATGAACGACGCGCCGACGGTTGC
ATGCGAGGCGGCGGTGCGGT

Downstream 100 bases:

>100_bases
CCCGTCCGCCGTCGCGCCTCGTTCCACGCGTGGCCGGCTTGCTTGCCGTCCGGCGCCTCGGGTGGCGAGCACCGCGAACG
GCGGCTCACCTGTCGCGCGT

Product: carboxylesterase

Products: NA

Alternate protein names: Esterase I [H]

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MRAASAASIRKRRRTRRRDARAVHAGRSRDHAQAGPRGGRQGRRDSDTRHERVTTCHETRPPVARASGCRSSRCAIIDAF
SSDPPSERSPSMLDETPTIEIETGPNPAFAVILMHGLGADANDFVPLVPELRIANGPAVRFVFPNAPEIAVTANNGYMMR
AWYDILSFEGVNRQVDEAGIDASCAAVRSLIAEQNRRGIPTSRIFVAGFSQGGAMTYSAGFTHPDALAGLIVLSGYVPSP
RFIDARLAGANRTTPIFAAHGTDDDILPIRLGEAARDFAREKGASVDWHAYPMPHAVCIEEIDALRRWLHARIAALQAA

Sequences:

>Translated_319_residues
MRAASAASIRKRRRTRRRDARAVHAGRSRDHAQAGPRGGRQGRRDSDTRHERVTTCHETRPPVARASGCRSSRCAIIDAF
SSDPPSERSPSMLDETPTIEIETGPNPAFAVILMHGLGADANDFVPLVPELRIANGPAVRFVFPNAPEIAVTANNGYMMR
AWYDILSFEGVNRQVDEAGIDASCAAVRSLIAEQNRRGIPTSRIFVAGFSQGGAMTYSAGFTHPDALAGLIVLSGYVPSP
RFIDARLAGANRTTPIFAAHGTDDDILPIRLGEAARDFAREKGASVDWHAYPMPHAVCIEEIDALRRWLHARIAALQAA
>Mature_319_residues
MRAASAASIRKRRRTRRRDARAVHAGRSRDHAQAGPRGGRQGRRDSDTRHERVTTCHETRPPVARASGCRSSRCAIIDAF
SSDPPSERSPSMLDETPTIEIETGPNPAFAVILMHGLGADANDFVPLVPELRIANGPAVRFVFPNAPEIAVTANNGYMMR
AWYDILSFEGVNRQVDEAGIDASCAAVRSLIAEQNRRGIPTSRIFVAGFSQGGAMTYSAGFTHPDALAGLIVLSGYVPSP
RFIDARLAGANRTTPIFAAHGTDDDILPIRLGEAARDFAREKGASVDWHAYPMPHAVCIEEIDALRRWLHARIAALQAA

Specific function: Hydrolyzes carboxylic ester bonds with relatively broad substrate specificity [H]

COG id: COG0400

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase 2 family [H]

Homologues:

Organism=Homo sapiens, GI9966764, Length=203, Percent_Identity=32.512315270936, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI5453722, Length=204, Percent_Identity=30.3921568627451, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI20270341, Length=209, Percent_Identity=23.9234449760766, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17508057, Length=206, Percent_Identity=35.4368932038835, Blast_Score=125, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6323147, Length=211, Percent_Identity=31.7535545023697, Blast_Score=120, Evalue=2e-28,
Organism=Drosophila melanogaster, GI45553055, Length=208, Percent_Identity=28.3653846153846, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI45553057, Length=208, Percent_Identity=28.3653846153846, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21357257, Length=208, Percent_Identity=28.3653846153846, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI161078179, Length=224, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003140 [H]

Pfam domain/function: PF02230 Abhydrolase_2 [H]

EC number: =3.1.1.1 [H]

Molecular weight: Translated: 34623; Mature: 34623

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAASAASIRKRRRTRRRDARAVHAGRSRDHAQAGPRGGRQGRRDSDTRHERVTTCHETR
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHCCC
PPVARASGCRSSRCAIIDAFSSDPPSERSPSMLDETPTIEIETGPNPAFAVILMHGLGAD
CCHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEEECCCCC
ANDFVPLVPELRIANGPAVRFVFPNAPEIAVTANNGYMMRAWYDILSFEGVNRQVDEAGI
CCCCCCCCCCEEECCCCEEEEECCCCCEEEEECCCCEEEHHHHHHHHHCCCCCHHHHCCC
DASCAAVRSLIAEQNRRGIPTSRIFVAGFSQGGAMTYSAGFTHPDALAGLIVLSGYVPSP
CHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCEEEEECCCCCHHHHHHHHHHCCCCCCC
RFIDARLAGANRTTPIFAAHGTDDDILPIRLGEAARDFAREKGASVDWHAYPMPHAVCIE
CEEEEEECCCCCCCEEEEECCCCCCEEEEEECHHHHHHHHHCCCCCCEECCCCCHHHHHH
EIDALRRWLHARIAALQAA
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRAASAASIRKRRRTRRRDARAVHAGRSRDHAQAGPRGGRQGRRDSDTRHERVTTCHETR
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHCCC
PPVARASGCRSSRCAIIDAFSSDPPSERSPSMLDETPTIEIETGPNPAFAVILMHGLGAD
CCHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEEECCCCC
ANDFVPLVPELRIANGPAVRFVFPNAPEIAVTANNGYMMRAWYDILSFEGVNRQVDEAGI
CCCCCCCCCCEEECCCCEEEEECCCCCEEEEECCCCEEEHHHHHHHHHCCCCCHHHHCCC
DASCAAVRSLIAEQNRRGIPTSRIFVAGFSQGGAMTYSAGFTHPDALAGLIVLSGYVPSP
CHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCEEEEECCCCCHHHHHHHHHHCCCCCCC
RFIDARLAGANRTTPIFAAHGTDDDILPIRLGEAARDFAREKGASVDWHAYPMPHAVCIE
CEEEEEECCCCCCCEEEEECCCCCCEEEEEECHHHHHHHHHCCCCCCEECCCCCHHHHHH
EIDALRRWLHARIAALQAA
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA