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The map label for this gene is strD [H]

Identifier: 83721342

GI number: 83721342

Start: 652857

End: 653576

Strand: Reverse

Name: strD [H]

Synonym: BTH_I0573

Alternate gene names: 83721342

Gene position: 653576-652857 (Counterclockwise)

Preceding gene: 83719266

Following gene: 83719871

Centisome position: 17.16

GC content: 72.36

Gene sequence:

>720_bases
ATGACGCACACACTCGATACGGCGATGATCTTCGCCGCCGGGCGCGGCGAACGGATGCGCCCGCTCACCGACACGACGCC
CAAGCCGCTCCTCGCGGCGGGCGGCAAGCCGCTGATCGTCTGGCAGATCGAGCGGCTCGCCGCGGCGGGCATCCGCACGA
TCGTCGTCAACCATGCGTGGCTCGGCGCGCAGATCGAGGCCGCGCTCGGCGACGGCTCGCGCTGGGGCGTGCGGCTCCTG
TATTCCGCCGAGCGCGAAGCGCTCGAGACGGCGGGCGGAATCGCGCAGGCGCTGCCGCTCATCGAGGGCGGCGGCGGACC
GAAGGTGTTCGTCGGCGTATCGGGCGACATCTACACCGGCTTCGACTATGCCGCGCTGTCGGCCCGCGCGAGCGCGCTCG
CCGGCGCGCCCGAGCCCAGCATGCACCTCGTGATGGTGCCCAACCCGCCGTTTCATCCGGCGGGCGATTTCACGCTCGGC
GACGACGGCCTGCTATCGCTCGACGGCGCGCCGCGCGCGACGTTCGGCAACATCGGGCTCTACGACACGCGGATGTTCCG
CGATCTGCCGGCCGGGACACGCCGCGCGCTCACGCCCTATTACCGCGAGACGATCGCCGCGCGCCGCGCGACGGGCGAGC
TCTACAGCGGCGCATGGGAGAACGTCGGCACGCCCGCGCAACTGGGCGAGCTCGACGCCGCGCTGAAGGCTGCTCGCTGA

Upstream 100 bases:

>100_bases
CGTCGCGCTGCGCTACCGGCCGCTCGCGCCGTTCGCCAGGCTCCTCGACGATCTCGAAGACAAGACGGCCGAAGTCGGCT
ACACGTTCTGAATCCGAACG

Downstream 100 bases:

>100_bases
GAGCGTCGGTCCGGCAGCGCGCCGAGCGGGATCGTCGACGAATTTCAGGCCAATCCGGCGAGCGCGCGATCGTGCCGTTT
CGTGCCGTTTCGTGCCGTTT

Product: nucleotidyltransferase family protein

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 239; Mature: 238

Protein sequence:

>239_residues
MTHTLDTAMIFAAGRGERMRPLTDTTPKPLLAAGGKPLIVWQIERLAAAGIRTIVVNHAWLGAQIEAALGDGSRWGVRLL
YSAEREALETAGGIAQALPLIEGGGGPKVFVGVSGDIYTGFDYAALSARASALAGAPEPSMHLVMVPNPPFHPAGDFTLG
DDGLLSLDGAPRATFGNIGLYDTRMFRDLPAGTRRALTPYYRETIAARRATGELYSGAWENVGTPAQLGELDAALKAAR

Sequences:

>Translated_239_residues
MTHTLDTAMIFAAGRGERMRPLTDTTPKPLLAAGGKPLIVWQIERLAAAGIRTIVVNHAWLGAQIEAALGDGSRWGVRLL
YSAEREALETAGGIAQALPLIEGGGGPKVFVGVSGDIYTGFDYAALSARASALAGAPEPSMHLVMVPNPPFHPAGDFTLG
DDGLLSLDGAPRATFGNIGLYDTRMFRDLPAGTRRALTPYYRETIAARRATGELYSGAWENVGTPAQLGELDAALKAAR
>Mature_238_residues
THTLDTAMIFAAGRGERMRPLTDTTPKPLLAAGGKPLIVWQIERLAAAGIRTIVVNHAWLGAQIEAALGDGSRWGVRLLY
SAEREALETAGGIAQALPLIEGGGGPKVFVGVSGDIYTGFDYAALSARASALAGAPEPSMHLVMVPNPPFHPAGDFTLGD
DGLLSLDGAPRATFGNIGLYDTRMFRDLPAGTRRALTPYYRETIAARRATGELYSGAWENVGTPAQLGELDAALKAAR

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=120, Percent_Identity=35, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI11761619, Length=120, Percent_Identity=35, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI133931050, Length=239, Percent_Identity=27.1966527196653, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320148, Length=236, Percent_Identity=28.3898305084746, Blast_Score=69, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21355443, Length=120, Percent_Identity=35, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24644084, Length=120, Percent_Identity=35, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 25168; Mature: 25037

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHTLDTAMIFAAGRGERMRPLTDTTPKPLLAAGGKPLIVWQIERLAAAGIRTIVVNHAW
CCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHCCCCEEEEEEEHHHHHCCEEEEEEECCC
LGAQIEAALGDGSRWGVRLLYSAEREALETAGGIAQALPLIEGGGGPKVFVGVSGDIYTG
CCEEEEEECCCCCCCEEEEEEHHHHHHHHHHCCHHHHHHEEECCCCCEEEEEECCCEECC
FDYAALSARASALAGAPEPSMHLVMVPNPPFHPAGDFTLGDDGLLSLDGAPRATFGNIGL
CCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCEECCCCEEEECCCCCCEECCCCC
YDTRMFRDLPAGTRRALTPYYRETIAARRATGELYSGAWENVGTPAQLGELDAALKAAR
HHHHHHHHCCCCCHHHCCHHHHHHHHHHHHCCHHHCCHHHCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
THTLDTAMIFAAGRGERMRPLTDTTPKPLLAAGGKPLIVWQIERLAAAGIRTIVVNHAW
CCCCCEEEEEECCCCCCCCCCCCCCCCCHHHCCCCEEEEEEEHHHHHCCEEEEEEECCC
LGAQIEAALGDGSRWGVRLLYSAEREALETAGGIAQALPLIEGGGGPKVFVGVSGDIYTG
CCEEEEEECCCCCCCEEEEEEHHHHHHHHHHCCHHHHHHEEECCCCCEEEEEECCCEECC
FDYAALSARASALAGAPEPSMHLVMVPNPPFHPAGDFTLGDDGLLSLDGAPRATFGNIGL
CCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCEECCCCEEEECCCCCCEECCCCC
YDTRMFRDLPAGTRRALTPYYRETIAARRATGELYSGAWENVGTPAQLGELDAALKAAR
HHHHHHHHCCCCCHHHCCHHHHHHHHHHHHCCHHHCCHHHCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]