Click here to switch to the map view.

The map label for this gene is fucA [C]

Identifier: 83721235

GI number: 83721235

Start: 918030

End: 918812

Strand: Reverse

Name: fucA [C]

Synonym: BTH_I0804

Alternate gene names: 83721235

Gene position: 918812-918030 (Counterclockwise)

Preceding gene: 83719798

Following gene: 83719202

Centisome position: 24.12

GC content: 66.54

Gene sequence:

>783_bases
ATGGTCGACACATTGAAGATGGGCAAGGCCGAGCTCGTCGCGCTCGCGCAGCGGCGGCTCGACAACGAAATCAAGGACAG
CGGATGGACCGCGCGCGAAAAGCTCGCGCTCACGTGCCGGATTCTGTTCGACGACGGGCATGACTCCGGCCTCGCCGGGC
AGATCACGTGCCGCGCCGACACGCCGAACACGTACTACACGCAGCGCCTCGGACTCGGTTTCGACGAGATCGCCGAATCG
AACCTGCTGCAGGTCAATCAGGATATCGAAGTGATCGTCGGCCAGGGCATTCCGAACCCGGCGAACCGCTTCCACACATG
GATCTATCGCGCGCGTCCGGACGTCAACTGCATCATCCACACGCATCCGGCGCACGTCGCCGCGCTATCGATGCTCGAGA
CGCCGCTCGTCGTGTCGCACATGGACACCTGTCCGCTCTACGACGATTGCGCGTTCCTGAAGGACTGGCCGGGCGTGCCC
GTCGGCAACGAGGAAGGCGAGATCATCTCGAACGCGCTCGGCGCCAAGCGCGCGATCCTGCTGTCCCATCACGGCCAGCT
CGTCGTCGGCAAGACGATCGAAGAGGCCTGCATGCTCGCGATCCTGATCGAGCGCGCGGCGCGGCTGCAACTGCTCGCGA
TGGCCGCGGGCGCGATCGAGCCGATTCCGCCCGCGCTCGCGACCGACGCGCGCGACTGGATCTCGACGCCCAAGCGCGAC
GCGGTGACGTTCGCGTACTACGCGCGCCGCGCGCTGCGCCATCACCCCGACTGCCTCGGCTGA

Upstream 100 bases:

>100_bases
ATCTCATGACACTTCGTGTCATATAATCGACCTTGTGTTTTGCGTGCGGCGCAGCGCCGCATCGCACACATCGCACATTC
GTTCACGACTTGGAGGCTGC

Downstream 100 bases:

>100_bases
TCCGCCGAGGCGCCCGCGCGTCGGGCCGGCGACAAGCCGCCGACGCACCGACCACAACGAACATTCGGAGCACCCCAACT
CATGTCCCACGCATTGCAAG

Product: class II aldolase/adducin domain-containing protein

Products: Dihydroxyacetone phosphate; L-Lactaldehyde [C]

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MVDTLKMGKAELVALAQRRLDNEIKDSGWTAREKLALTCRILFDDGHDSGLAGQITCRADTPNTYYTQRLGLGFDEIAES
NLLQVNQDIEVIVGQGIPNPANRFHTWIYRARPDVNCIIHTHPAHVAALSMLETPLVVSHMDTCPLYDDCAFLKDWPGVP
VGNEEGEIISNALGAKRAILLSHHGQLVVGKTIEEACMLAILIERAARLQLLAMAAGAIEPIPPALATDARDWISTPKRD
AVTFAYYARRALRHHPDCLG

Sequences:

>Translated_260_residues
MVDTLKMGKAELVALAQRRLDNEIKDSGWTAREKLALTCRILFDDGHDSGLAGQITCRADTPNTYYTQRLGLGFDEIAES
NLLQVNQDIEVIVGQGIPNPANRFHTWIYRARPDVNCIIHTHPAHVAALSMLETPLVVSHMDTCPLYDDCAFLKDWPGVP
VGNEEGEIISNALGAKRAILLSHHGQLVVGKTIEEACMLAILIERAARLQLLAMAAGAIEPIPPALATDARDWISTPKRD
AVTFAYYARRALRHHPDCLG
>Mature_260_residues
MVDTLKMGKAELVALAQRRLDNEIKDSGWTAREKLALTCRILFDDGHDSGLAGQITCRADTPNTYYTQRLGLGFDEIAES
NLLQVNQDIEVIVGQGIPNPANRFHTWIYRARPDVNCIIHTHPAHVAALSMLETPLVVSHMDTCPLYDDCAFLKDWPGVP
VGNEEGEIISNALGAKRAILLSHHGQLVVGKTIEEACMLAILIERAARLQLLAMAAGAIEPIPPALATDARDWISTPKRD
AVTFAYYARRALRHHPDCLG

Specific function: Fucose metabolism; third step. [C]

COG id: COG0235

COG function: function code G; Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldolase class II family [H]

Homologues:

Organism=Homo sapiens, GI29826325, Length=193, Percent_Identity=27.979274611399, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI29826323, Length=193, Percent_Identity=27.979274611399, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI29826321, Length=193, Percent_Identity=27.979274611399, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI9951927, Length=177, Percent_Identity=31.0734463276836, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI62912453, Length=177, Percent_Identity=31.0734463276836, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI9943848, Length=177, Percent_Identity=31.0734463276836, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI29826319, Length=193, Percent_Identity=27.979274611399, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1789164, Length=200, Percent_Identity=28, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71989550, Length=224, Percent_Identity=30.3571428571429, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71989560, Length=224, Percent_Identity=30.3571428571429, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71989541, Length=224, Percent_Identity=30.3571428571429, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71989555, Length=224, Percent_Identity=30.3571428571429, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71989544, Length=224, Percent_Identity=30.3571428571429, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI115533218, Length=198, Percent_Identity=25.7575757575758, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI115533216, Length=221, Percent_Identity=24.4343891402715, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI281363755, Length=192, Percent_Identity=32.8125, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI281363751, Length=192, Percent_Identity=32.8125, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24655690, Length=192, Percent_Identity=32.8125, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24655685, Length=192, Percent_Identity=32.8125, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI281363761, Length=192, Percent_Identity=32.8125, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI281363759, Length=192, Percent_Identity=32.8125, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI281363753, Length=192, Percent_Identity=32.8125, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI281363763, Length=192, Percent_Identity=32.8125, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI281363757, Length=192, Percent_Identity=32.8125, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17136738, Length=192, Percent_Identity=32.8125, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001303 [H]

Pfam domain/function: PF00596 Aldolase_II [H]

EC number: 4.1.2.17 [C]

Molecular weight: Translated: 28607; Mature: 28607

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDTLKMGKAELVALAQRRLDNEIKDSGWTAREKLALTCRILFDDGHDSGLAGQITCRAD
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHEEEEEEEEEEECCCCCCCEEEEEEECC
TPNTYYTQRLGLGFDEIAESNLLQVNQDIEVIVGQGIPNPANRFHTWIYRARPDVNCIIH
CCCCHHHHHHCCCHHHHHCCCCEEECCCEEEEEECCCCCHHHHHEEEEEECCCCCEEEEE
THPAHVAALSMLETPLVVSHMDTCPLYDDCAFLKDWPGVPVGNEEGEIISNALGAKRAIL
ECCHHHHHHHHHHCCHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHCCCEEEE
LSHHGQLVVGKTIEEACMLAILIERAARLQLLAMAAGAIEPIPPALATDARDWISTPKRD
EECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCHHHHCCCCCH
AVTFAYYARRALRHHPDCLG
HHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MVDTLKMGKAELVALAQRRLDNEIKDSGWTAREKLALTCRILFDDGHDSGLAGQITCRAD
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHEEEEEEEEEEECCCCCCCEEEEEEECC
TPNTYYTQRLGLGFDEIAESNLLQVNQDIEVIVGQGIPNPANRFHTWIYRARPDVNCIIH
CCCCHHHHHHCCCHHHHHCCCCEEECCCEEEEEECCCCCHHHHHEEEEEECCCCCEEEEE
THPAHVAALSMLETPLVVSHMDTCPLYDDCAFLKDWPGVPVGNEEGEIISNALGAKRAIL
ECCHHHHHHHHHHCCHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHCCCEEEE
LSHHGQLVVGKTIEEACMLAILIERAARLQLLAMAAGAIEPIPPALATDARDWISTPKRD
EECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCHHHHCCCCCH
AVTFAYYARRALRHHPDCLG
HHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Ca2+; Co2+; Mg2+; Mn2+; Zn2+ [C]

Kcat value (1/min): 19.3 [C]

Specific activity: 21.0

Km value (mM): 0.7 {L-fuculose} [C]

Substrates: L-Fuculose 1-phosphate [C]

Specific reaction: L-Fuculose 1-phosphate <==> Dihydroxyacetone phosphate + L-Lactaldehyde [C]

General reaction: Elimination of an aldehyde C-C bond; Cleavage [C]

Inhibitor: EDTA; Phosphoglycolohydroxamate [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]