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The map label for this gene is glxR [H]

Identifier: 83721180

GI number: 83721180

Start: 2350725

End: 2351672

Strand: Direct

Name: glxR [H]

Synonym: BTH_I2076

Alternate gene names: 83721180

Gene position: 2350725-2351672 (Clockwise)

Preceding gene: 83719602

Following gene: 83719942

Centisome position: 61.71

GC content: 71.1

Gene sequence:

>948_bases
GTGATAGGTATGATGGGCGGCAACTTCAACCGGTATTCGAACGAGAGGAAAGGGGAAGACGTGGACGTAGGATTTTGCGG
TCCGGGGTTGATGGGCGCGCCGATGATCCGGCATCTGCTGTCGGCGGGCCATCGGGTGCATGTATGGAACCGCACGCGCG
CGAAGGCCGATGCGCTCGCCGCGCACGGCGCGCAGGTCGTCGACACGCCGGCCGAGCTTGCCGCGCGCGCGCAGACGGTG
ATGCTGTGCGTGCTCGATGCGCAAGCGGTTGGCGACGTCGTGTTCGGCGCATCCGGCGTGCTCGCGGGCGACGCCGCCGC
GCGCTGTGTGACGCGCATCGTCGATCATTCGAGCATACCGCCCGCGGCGACGCGCGCGTATGCGGCGCGCGCGGCGGCGC
TTGGCGCGAGTTGGGTCGACGCACCCGTGTCGGGCGGCGTGCCGGGCGCCGAGGCGGGCACGCTCGCGGTGATGGCGGGT
GGCGCGCAGGCGGATGTCGACGCAGTGCGCGGGCTGATCGGCGCGTACGCATCGCGCGTCACGCATCTCGGCGATGCGGG
CGCGGGGCAGACGGCGAAGCTCTGCAATCAGGCGATCGTGACGGCGAGCGTCACGGCGATCGCGGAGGCAGTGGGGCTCG
CGCAGGCGAGCGGCATCGATGCGGCGCGCCTTGCCGAAGCGCTCGCGGGCGGCTGGGCGGATTCCGTGCTGCTGCAGACG
TTCGTGCCGCGGATGACGAGCACGGGCCATCCGCCGATCGGCGCGCTGAAGACGTTCCAGAAGGATGTCGATGCAATTGC
CGATGCGGCGCGCGATGCGGGGGCGGTGATGCCCGTTGCCGCGACCGTGCAGCAGGTGCTGCGGCTCGGCGCGGCGATGG
GGCTTGCGCAAGCCGATTTCGCGGCGTTCATCGACATCGTGCGGCCGCAGGCGAAGCGCGGCGAGTGA

Upstream 100 bases:

>100_bases
CTTGTAGACGTGGTCGTTCATGGCGTTCTCCGGTGAGTCGTTCGACGTTCGGGCCAGCGGGCAAGGCGCACATCCGGCAT
TCCCGCGCATGCCTTCTTGA

Downstream 100 bases:

>100_bases
CACGCGAGGGCGAATGCGCTTGCGCCGCGCCGGTGCGCGCGGATCGCGTCGAGAAGCGCGCCGAAAGACACGCATGCCGC
CGCGCAAGGCGGCGTTGGGA

Product: oxidoreductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MIGMMGGNFNRYSNERKGEDVDVGFCGPGLMGAPMIRHLLSAGHRVHVWNRTRAKADALAAHGAQVVDTPAELAARAQTV
MLCVLDAQAVGDVVFGASGVLAGDAAARCVTRIVDHSSIPPAATRAYAARAAALGASWVDAPVSGGVPGAEAGTLAVMAG
GAQADVDAVRGLIGAYASRVTHLGDAGAGQTAKLCNQAIVTASVTAIAEAVGLAQASGIDAARLAEALAGGWADSVLLQT
FVPRMTSTGHPPIGALKTFQKDVDAIADAARDAGAVMPVAATVQQVLRLGAAMGLAQADFAAFIDIVRPQAKRGE

Sequences:

>Translated_315_residues
MIGMMGGNFNRYSNERKGEDVDVGFCGPGLMGAPMIRHLLSAGHRVHVWNRTRAKADALAAHGAQVVDTPAELAARAQTV
MLCVLDAQAVGDVVFGASGVLAGDAAARCVTRIVDHSSIPPAATRAYAARAAALGASWVDAPVSGGVPGAEAGTLAVMAG
GAQADVDAVRGLIGAYASRVTHLGDAGAGQTAKLCNQAIVTASVTAIAEAVGLAQASGIDAARLAEALAGGWADSVLLQT
FVPRMTSTGHPPIGALKTFQKDVDAIADAARDAGAVMPVAATVQQVLRLGAAMGLAQADFAAFIDIVRPQAKRGE
>Mature_315_residues
MIGMMGGNFNRYSNERKGEDVDVGFCGPGLMGAPMIRHLLSAGHRVHVWNRTRAKADALAAHGAQVVDTPAELAARAQTV
MLCVLDAQAVGDVVFGASGVLAGDAAARCVTRIVDHSSIPPAATRAYAARAAALGASWVDAPVSGGVPGAEAGTLAVMAG
GAQADVDAVRGLIGAYASRVTHLGDAGAGQTAKLCNQAIVTASVTAIAEAVGLAQASGIDAARLAEALAGGWADSVLLQT
FVPRMTSTGHPPIGALKTFQKDVDAIADAARDAGAVMPVAATVQQVLRLGAAMGLAQADFAAFIDIVRPQAKRGE

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=295, Percent_Identity=28.4745762711864, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI40556376, Length=286, Percent_Identity=30.0699300699301, Blast_Score=119, Evalue=4e-27,
Organism=Escherichia coli, GI1786719, Length=284, Percent_Identity=34.8591549295775, Blast_Score=160, Evalue=8e-41,
Organism=Escherichia coli, GI145693186, Length=284, Percent_Identity=35.5633802816901, Blast_Score=150, Evalue=8e-38,
Organism=Escherichia coli, GI1790315, Length=287, Percent_Identity=28.2229965156794, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789092, Length=295, Percent_Identity=26.4406779661017, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17557316, Length=306, Percent_Identity=27.7777777777778, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24655230, Length=298, Percent_Identity=31.2080536912752, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI19922568, Length=298, Percent_Identity=31.2080536912752, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI28574115, Length=281, Percent_Identity=27.0462633451957, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 31736; Mature: 31736

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGMMGGNFNRYSNERKGEDVDVGFCGPGLMGAPMIRHLLSAGHRVHVWNRTRAKADALA
CCCCCCCCCHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCEEEEECCHHHHHHHHH
AHGAQVVDTPAELAARAQTVMLCVLDAQAVGDVVFGASGVLAGDAAARCVTRIVDHSSIP
HCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCC
PAATRAYAARAAALGASWVDAPVSGGVPGAEAGTLAVMAGGAQADVDAVRGLIGAYASRV
CHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHH
THLGDAGAGQTAKLCNQAIVTASVTAIAEAVGLAQASGIDAARLAEALAGGWADSVLLQT
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHH
FVPRMTSTGHPPIGALKTFQKDVDAIADAARDAGAVMPVAATVQQVLRLGAAMGLAQADF
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AAFIDIVRPQAKRGE
HHHHHHHCCCCCCCC
>Mature Secondary Structure
MIGMMGGNFNRYSNERKGEDVDVGFCGPGLMGAPMIRHLLSAGHRVHVWNRTRAKADALA
CCCCCCCCCHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCEEEEECCHHHHHHHHH
AHGAQVVDTPAELAARAQTVMLCVLDAQAVGDVVFGASGVLAGDAAARCVTRIVDHSSIP
HCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCC
PAATRAYAARAAALGASWVDAPVSGGVPGAEAGTLAVMAGGAQADVDAVRGLIGAYASRV
CHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHH
THLGDAGAGQTAKLCNQAIVTASVTAIAEAVGLAQASGIDAARLAEALAGGWADSVLLQT
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHH
FVPRMTSTGHPPIGALKTFQKDVDAIADAARDAGAVMPVAATVQQVLRLGAAMGLAQADF
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AAFIDIVRPQAKRGE
HHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]