Click here to switch to the map view.

The map label for this gene is hslU [H]

Identifier: 83721034

GI number: 83721034

Start: 195371

End: 196714

Strand: Reverse

Name: hslU [H]

Synonym: BTH_I0164

Alternate gene names: 83721034

Gene position: 196714-195371 (Counterclockwise)

Preceding gene: 284159403

Following gene: 83720586

Centisome position: 5.16

GC content: 64.21

Gene sequence:

>1344_bases
GTGAGCACCATGACCCCTGCCGAGATCGTCTCGGAACTCGACAAGCACATCATCGGCCAGGACAAGGCGAAGAAGGCCGT
CGCGGTCGCGCTGCGCAACCGCTGGCGCCGCCAGCAGGTCGCCGAGCCGCTGCGCCAGGAGATCACGCCGAAGAACATCC
TGATGATCGGGCCGACGGGCGTCGGCAAGACCGAGATCGCGCGGCGCCTCGCGAAGCTCGCCGATGCGCCGTTCATCAAG
ATCGAGGCGACGAAGTTCACCGAGGTCGGCTACGTCGGCCGCGACGTCGACAGCATCGTGCGCGACCTGATCGAAATCTC
CGTCAAGCAGACTCGCGAGACGGAAATGCGCAAGGTGCGCAGCAAGGCGACCGATCTCGCCGAAGACCGCATCCTCGACG
TGCTGCTGCCGCAGCCGCGCGCGGTCGGCTTCGGCGCGAGCGTCGAGCATGCGAACGACGACAACAACGCGACGCGCCAG
ACGTTTCGCAAACGCCTGCGCGAAGGCCAGCTCGACGACAAGGAAATCGAGCTCGACATCGAGCAGCCGACGGTCGGCAT
GGACATCATGGCGCCGCCGGGCATGGAAGAGATGACCGAGCAGATCCGCTCGATGTTCTCGAACCTGGGCAGCGGCAAGA
AGCAGCGCCGCAAGGTGAAGATCAAGGAGGCGCTGAAGCTGCTGACCGACGAGGAAGCGGCGAAGATGCTCAACGACGAG
GAAGTGAAGACGAAGGCCGTGCAGAACGTCGAGCAGAACGGCATCGTGTTCCTCGACGAGATCGACAAGATCACGTCGCG
CAACCACGAAGGCGGCGGCGGCGAGGTGTCGAGGCAGGGCGTGCAGCGCGATCTGCTGCCGCTCGTCGAAGGCACGACGA
TCAACACGAAGTACGGGATGGTGAAGACCGATCACATCCTGTTCATCGCGAGCGGCGCATTCCATCTCGCGAAGCCGAGC
GACCTGATTCCGGAGCTGCAGGGGCGCTTTCCGATCCGCGTCGAGCTCGATTCGCTGTCGGTGAAGGATTTCGAAGCGAT
CCTCGTCGCGACCGACGCGAGCCTCGTCAAACAGTATCAGGCGCTCCTCGCGACCGAGGACGTCGCGCTCGAATTCGCCG
ACGACGGCATTCGCCGGCTCGCCGAGATCGCCTATGCGGTCAACGAGAAGACCGAGAACATCGGCGCGCGGCGCCTGTAT
ACGGTGATCGAGAAGCTGCTCGAGGAAGTGTCGTTCGCGGCGGGCAATCATGCCGGCCAAAGCGTGACGATCGATGCGGC
TTACGTCGACCGCGCGCTCGGCGAGGTGTCGAAGGACGAGGATCTGTCGCGCTACGTGCTGTGA

Upstream 100 bases:

>100_bases
CCCTCGCGAGATCGTCGAAAAATCGCTCGCGATCGCGGGCGACATGTGCATCTACACGAACCACAACCGGATCATCGAGA
CCATCGAGTAAGGAGAAGCT

Downstream 100 bases:

>100_bases
CGCGCGGCGGCATCGCCGCCGTTGCTCGAGAAAAGACGGGCAGTCCCTCGCGGGGCTGCCCGTCTTTCGTTTTTCCGCGC
ATCGCTCGCGGATGACGCCG

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MSTMTPAEIVSELDKHIIGQDKAKKAVAVALRNRWRRQQVAEPLRQEITPKNILMIGPTGVGKTEIARRLAKLADAPFIK
IEATKFTEVGYVGRDVDSIVRDLIEISVKQTRETEMRKVRSKATDLAEDRILDVLLPQPRAVGFGASVEHANDDNNATRQ
TFRKRLREGQLDDKEIELDIEQPTVGMDIMAPPGMEEMTEQIRSMFSNLGSGKKQRRKVKIKEALKLLTDEEAAKMLNDE
EVKTKAVQNVEQNGIVFLDEIDKITSRNHEGGGGEVSRQGVQRDLLPLVEGTTINTKYGMVKTDHILFIASGAFHLAKPS
DLIPELQGRFPIRVELDSLSVKDFEAILVATDASLVKQYQALLATEDVALEFADDGIRRLAEIAYAVNEKTENIGARRLY
TVIEKLLEEVSFAAGNHAGQSVTIDAAYVDRALGEVSKDEDLSRYVL

Sequences:

>Translated_447_residues
MSTMTPAEIVSELDKHIIGQDKAKKAVAVALRNRWRRQQVAEPLRQEITPKNILMIGPTGVGKTEIARRLAKLADAPFIK
IEATKFTEVGYVGRDVDSIVRDLIEISVKQTRETEMRKVRSKATDLAEDRILDVLLPQPRAVGFGASVEHANDDNNATRQ
TFRKRLREGQLDDKEIELDIEQPTVGMDIMAPPGMEEMTEQIRSMFSNLGSGKKQRRKVKIKEALKLLTDEEAAKMLNDE
EVKTKAVQNVEQNGIVFLDEIDKITSRNHEGGGGEVSRQGVQRDLLPLVEGTTINTKYGMVKTDHILFIASGAFHLAKPS
DLIPELQGRFPIRVELDSLSVKDFEAILVATDASLVKQYQALLATEDVALEFADDGIRRLAEIAYAVNEKTENIGARRLY
TVIEKLLEEVSFAAGNHAGQSVTIDAAYVDRALGEVSKDEDLSRYVL
>Mature_446_residues
STMTPAEIVSELDKHIIGQDKAKKAVAVALRNRWRRQQVAEPLRQEITPKNILMIGPTGVGKTEIARRLAKLADAPFIKI
EATKFTEVGYVGRDVDSIVRDLIEISVKQTRETEMRKVRSKATDLAEDRILDVLLPQPRAVGFGASVEHANDDNNATRQT
FRKRLREGQLDDKEIELDIEQPTVGMDIMAPPGMEEMTEQIRSMFSNLGSGKKQRRKVKIKEALKLLTDEEAAKMLNDEE
VKTKAVQNVEQNGIVFLDEIDKITSRNHEGGGGEVSRQGVQRDLLPLVEGTTINTKYGMVKTDHILFIASGAFHLAKPSD
LIPELQGRFPIRVELDSLSVKDFEAILVATDASLVKQYQALLATEDVALEFADDGIRRLAEIAYAVNEKTENIGARRLYT
VIEKLLEEVSFAAGNHAGQSVTIDAAYVDRALGEVSKDEDLSRYVL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790366, Length=447, Percent_Identity=65.324384787472, Blast_Score=594, Evalue=1e-171,
Organism=Escherichia coli, GI1786642, Length=102, Percent_Identity=47.0588235294118, Blast_Score=97, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24648291, Length=274, Percent_Identity=30.2919708029197, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24648289, Length=274, Percent_Identity=30.2919708029197, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 49759; Mature: 49627

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTMTPAEIVSELDKHIIGQDKAKKAVAVALRNRWRRQQVAEPLRQEITPKNILMIGPTG
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCC
VGKTEIARRLAKLADAPFIKIEATKFTEVGYVGRDVDSIVRDLIEISVKQTRETEMRKVR
CCHHHHHHHHHHHCCCCEEEEEECCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SKATDLAEDRILDVLLPQPRAVGFGASVEHANDDNNATRQTFRKRLREGQLDDKEIELDI
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEE
EQPTVGMDIMAPPGMEEMTEQIRSMFSNLGSGKKQRRKVKIKEALKLLTDEEAAKMLNDE
CCCCCCCEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHCCHH
EVKTKAVQNVEQNGIVFLDEIDKITSRNHEGGGGEVSRQGVQRDLLPLVEGTTINTKYGM
HHHHHHHHHHHCCCEEEEEHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEECCCCCC
VKTDHILFIASGAFHLAKPSDLIPELQGRFPIRVELDSLSVKDFEAILVATDASLVKQYQ
EEECEEEEEECCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCHHHHHHHH
ALLATEDVALEFADDGIRRLAEIAYAVNEKTENIGARRLYTVIEKLLEEVSFAAGNHAGQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SVTIDAAYVDRALGEVSKDEDLSRYVL
EEEEHHHHHHHHHHCCCCCCCHHHHCC
>Mature Secondary Structure 
STMTPAEIVSELDKHIIGQDKAKKAVAVALRNRWRRQQVAEPLRQEITPKNILMIGPTG
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCC
VGKTEIARRLAKLADAPFIKIEATKFTEVGYVGRDVDSIVRDLIEISVKQTRETEMRKVR
CCHHHHHHHHHHHCCCCEEEEEECCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SKATDLAEDRILDVLLPQPRAVGFGASVEHANDDNNATRQTFRKRLREGQLDDKEIELDI
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEE
EQPTVGMDIMAPPGMEEMTEQIRSMFSNLGSGKKQRRKVKIKEALKLLTDEEAAKMLNDE
CCCCCCCEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHCCHH
EVKTKAVQNVEQNGIVFLDEIDKITSRNHEGGGGEVSRQGVQRDLLPLVEGTTINTKYGM
HHHHHHHHHHHCCCEEEEEHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEECCCCCC
VKTDHILFIASGAFHLAKPSDLIPELQGRFPIRVELDSLSVKDFEAILVATDASLVKQYQ
EEECEEEEEECCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCHHHHHHHH
ALLATEDVALEFADDGIRRLAEIAYAVNEKTENIGARRLYTVIEKLLEEVSFAAGNHAGQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SVTIDAAYVDRALGEVSKDEDLSRYVL
EEEEHHHHHHHHHHCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA