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The map label for this gene is kduD [C]

Identifier: 83720998

GI number: 83720998

Start: 3233208

End: 3233981

Strand: Reverse

Name: kduD [C]

Synonym: BTH_I2817

Alternate gene names: 83720998

Gene position: 3233981-3233208 (Counterclockwise)

Preceding gene: 83718886

Following gene: 83718872

Centisome position: 84.9

GC content: 67.18

Gene sequence:

>774_bases
ATGGCAGATCACGGCATCAAGGGCAAAACCGTCATCATCGCGGGCGGCGCGAAGAACCTCGGCGGGCTGATCGCGCGCGA
TCTCGCCGCGCAAGGCGCGAAGGCGGTCGTGATCCACTACAACAGCCCGGGTACGCGGGCAGACGCGGAAGCGACCGTCG
CCGCGGTGAAGGCGGCGGGCGCGCACGCGGTCGCGCTGCAGGCGGACCTGACGACGGCAGGCGCTGTCGAGAAGCTGTTC
GCCGACGCGGTGGCCGCGGTCGGCCGCCCGGACATCGCAATCAATACCGTCGGCAAGGTGCTGAAGAAGCCGTTCGTCGA
GATCACCGAGGCCGAATACGACGAGATGGCGGCCGTCAATTCGAAGACGGCGTTCTTCTTCCTGAAGGAGGCGGGCAAGC
ACGTGAACGACAACGGCAAGATCGTCACGCTCGTCACGTCGCTGCTCGGCGCGTTCACGCCGTTCTATGCGGCCTATGCG
GGGATGAAGGCGCCTGTCGAGCACTTCACGCGCGCGGCCGCGAAGGAGTTCGGCGCGCGCGGCGTCTCGGTGACGGCGGT
GGGGCCGGGCCCGATGGATACGCCGTTCTTCTATCCGGCCGAAGGCGCGGACGCGGTCGCGTACCACAAGACGGCCGCGG
CGCTGTCGCCGTTCTCGAAGACGGGCCTGACCGACATCGAGGACGTCGTGCCGTTCATCCGCCATCTCGTCAGCGACGGC
TGGTGGATCACCGGCCAGACGATCCTGATCAACGGCGGTTATACGACGAAGTAG

Upstream 100 bases:

>100_bases
TGTCAGAATCGATGGCTTTATAAGGATTTTTTGGACTATATCATCCGAAGGCATGCAAGGCCGTATCGGACGGCCTCGCG
CGTCGAAACGGAGAGCAAAC

Downstream 100 bases:

>100_bases
GCGGAGCCCCCGGTGGCGGGGGCGGCGAAGCTCGTGGCGGAGTTTGCGCCGAAGCGGACGCCGCCCCGCGTCCGTTGCGA
ACTCCGCCGCGCCGATCGAT

Product: short chain dehydrogenase

Products: @DEHY06.txt*3-Dehydro-2- Deoxy-D-Gluconate!; NADH. [C]

Alternate protein names: ORFC [H]

Number of amino acids: Translated: 257; Mature: 256

Protein sequence:

>257_residues
MADHGIKGKTVIIAGGAKNLGGLIARDLAAQGAKAVVIHYNSPGTRADAEATVAAVKAAGAHAVALQADLTTAGAVEKLF
ADAVAAVGRPDIAINTVGKVLKKPFVEITEAEYDEMAAVNSKTAFFFLKEAGKHVNDNGKIVTLVTSLLGAFTPFYAAYA
GMKAPVEHFTRAAAKEFGARGVSVTAVGPGPMDTPFFYPAEGADAVAYHKTAAALSPFSKTGLTDIEDVVPFIRHLVSDG
WWITGQTILINGGYTTK

Sequences:

>Translated_257_residues
MADHGIKGKTVIIAGGAKNLGGLIARDLAAQGAKAVVIHYNSPGTRADAEATVAAVKAAGAHAVALQADLTTAGAVEKLF
ADAVAAVGRPDIAINTVGKVLKKPFVEITEAEYDEMAAVNSKTAFFFLKEAGKHVNDNGKIVTLVTSLLGAFTPFYAAYA
GMKAPVEHFTRAAAKEFGARGVSVTAVGPGPMDTPFFYPAEGADAVAYHKTAAALSPFSKTGLTDIEDVVPFIRHLVSDG
WWITGQTILINGGYTTK
>Mature_256_residues
ADHGIKGKTVIIAGGAKNLGGLIARDLAAQGAKAVVIHYNSPGTRADAEATVAAVKAAGAHAVALQADLTTAGAVEKLFA
DAVAAVGRPDIAINTVGKVLKKPFVEITEAEYDEMAAVNSKTAFFFLKEAGKHVNDNGKIVTLVTSLLGAFTPFYAAYAG
MKAPVEHFTRAAAKEFGARGVSVTAVGPGPMDTPFFYPAEGADAVAYHKTAAALSPFSKTGLTDIEDVVPFIRHLVSDGW
WITGQTILINGGYTTK

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=264, Percent_Identity=26.1363636363636, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1789208, Length=261, Percent_Identity=27.9693486590038, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1787335, Length=252, Percent_Identity=25.3968253968254, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI87082160, Length=190, Percent_Identity=30, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790717, Length=197, Percent_Identity=26.3959390862944, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1788459, Length=255, Percent_Identity=26.2745098039216, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI2367365, Length=189, Percent_Identity=29.1005291005291, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1789378, Length=192, Percent_Identity=28.6458333333333, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI87082100, Length=267, Percent_Identity=26.2172284644195, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25147288, Length=254, Percent_Identity=28.3464566929134, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17562906, Length=268, Percent_Identity=27.6119402985075, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17562910, Length=263, Percent_Identity=27.7566539923954, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17544670, Length=271, Percent_Identity=28.0442804428044, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17560220, Length=267, Percent_Identity=26.5917602996255, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17555706, Length=253, Percent_Identity=24.1106719367589, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193204405, Length=266, Percent_Identity=25.9398496240602, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=257, Percent_Identity=23.7354085603113, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562908, Length=267, Percent_Identity=26.2172284644195, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17531453, Length=271, Percent_Identity=25.0922509225092, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24639444, Length=254, Percent_Identity=27.9527559055118, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI28571526, Length=253, Percent_Identity=30.8300395256917, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21355319, Length=266, Percent_Identity=27.8195488721804, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24643142, Length=254, Percent_Identity=25.9842519685039, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.125 [C]

Molecular weight: Translated: 26632; Mature: 26500

Theoretical pI: Translated: 7.93; Mature: 7.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADHGIKGKTVIIAGGAKNLGGLIARDLAAQGAKAVVIHYNSPGTRADAEATVAAVKAAG
CCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHCC
AHAVALQADLTTAGAVEKLFADAVAAVGRPDIAINTVGKVLKKPFVEITEAEYDEMAAVN
CEEEEEEECCCHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCHHHHHHCCHHHHHHCC
SKTAFFFLKEAGKHVNDNGKIVTLVTSLLGAFTPFYAAYAGMKAPVEHFTRAAAKEFGAR
CCHHEEEEEHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
GVSVTAVGPGPMDTPFFYPAEGADAVAYHKTAAALSPFSKTGLTDIEDVVPFIRHLVSDG
CEEEEEECCCCCCCCEEECCCCCCHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHCCC
WWITGQTILINGGYTTK
EEEECCEEEEECCCCCC
>Mature Secondary Structure 
ADHGIKGKTVIIAGGAKNLGGLIARDLAAQGAKAVVIHYNSPGTRADAEATVAAVKAAG
CCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHCC
AHAVALQADLTTAGAVEKLFADAVAAVGRPDIAINTVGKVLKKPFVEITEAEYDEMAAVN
CEEEEEEECCCHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCHHHHHHCCHHHHHHCC
SKTAFFFLKEAGKHVNDNGKIVTLVTSLLGAFTPFYAAYAGMKAPVEHFTRAAAKEFGAR
CCHHEEEEEHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
GVSVTAVGPGPMDTPFFYPAEGADAVAYHKTAAALSPFSKTGLTDIEDVVPFIRHLVSDG
CEEEEEECCCCCCCCEEECCCCCCHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHCCC
WWITGQTILINGGYTTK
EEEECCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 15.4 {2-deoxygluconate}} [C]

Substrates: @DEOX03.txt*2-Deoxy-D-Gluconate!; NAD(+) [C]

Specific reaction: @DEOX03.txt*2-Deoxy-D-Gluconate! + NAD(+) = @DEHY06.txt*3-Dehydro-2- Deoxy-D-Gluconate! + NADH. [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8868443 [H]