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The map label for this gene is yogA [H]

Identifier: 83720926

GI number: 83720926

Start: 1621079

End: 1622245

Strand: Reverse

Name: yogA [H]

Synonym: BTH_I1436

Alternate gene names: 83720926

Gene position: 1622245-1621079 (Counterclockwise)

Preceding gene: 83720603

Following gene: 83720038

Centisome position: 42.59

GC content: 68.72

Gene sequence:

>1167_bases
ATGCGGCGCGCGTGCCGTCCGGCGCGATTCGCGCACGCACGTGTGCGGCACGCGCGGCGTAGGACACGCATGCGCGCCGG
CGTTCCCCTGCCGCCATTCGGAACGCATCGGCCGCACACCACGCGGCGCGCTCGCTCACCACTCACCGGAGTCGAATCGA
TGAAAGCCATCATGTTGCGTCAGCCCGCCGGCCTCGAGCACCTCGAACGCGTGACGCTCACCGATCCTGGCGCGCCCGCC
GCGGGCGAAATCCGCGTTCGCATTCACGCGAGCTCGCTCAACTATCACGATCTCGGCGTCGTCACCGGCAGGCTGAGCAC
GGCCGACAAGCGCATTCCGATGTCGGACGGCGCGGGCGTTGTCGAAGCGATCGGCGAAGGCGTCACGGAGTTCGCGGTCG
GCGACGCGGTCGTGTCGACCTTCTTCCCGCAATGGCTCGACGGCGGGCCGAGCACCGCGGACTTCGCGACGGTGCCGGGC
GACGGCGTCGACGGCTACGCGCGCGAGACGGTCGTACGCCCAGCGCATTGGTTCACGCACGCGCCGAAGGGCTACACGCA
CGAGGAAGCCGCGACGCTGACGACGGCGGGCCTCACCGGCTGGCGCGCGCTCGTCGTCGACGGCCGCTTGAAGGCTGGAG
ACAGCGTGCTCGTGCTCGGCACGGGCGGCGTGTCGATCTTCGCGCTGCAGTTCGCGAAACGCATGGGCGCGACCGTGATC
GCCACGTCGTCGTCGGACGAAAAGCTGGAGCGCGCGCGCCAGCTGGGCGCGGATCACGTCGTCAACTACCGTCGCGACGC
AAACTGGGCCGCGAAGGTGCTCGAGCAGACAAACGGGCGCGACGTCGACCACGTGATCGAAGTGGGCGGCCCGGACACGC
TCCCGCAATCGATCCAGGCGTGCAGGATCGGCGGCCATATCGCGCTGATCGGCGTGCTGACGGGGATTGCCGGCCCCGTG
CCGACCGTCGCGCTGATGGCACGCCAGCAGAACCTGCAAGGCCTGATCGTCGGCAGTCGACGACATCAGATCGACATGGT
GCGTGCGATCGACGCAACCGGCATCAAGCCGGTAATCGATCGCACGTTCGCGCTCGACGACATCGCCGATGCGTTCAGCC
ACCAGGCGGCCGGCAAGCACTTCGGCAAGATCTGCCTGTCGATCTGA

Upstream 100 bases:

>100_bases
CCTACAAAATTGATAGTACCGGCGTTAATTGTACGTTCTTGCATCAAAGGAAGTACGTGCGGACAATTTGCCCATCCGCC
GCCGATCTCAGGGCGGCCGA

Downstream 100 bases:

>100_bases
GCGAAGCGGCGCGAGCGGCCCGCGACGCCCGCGCCGGCCATGCGCCTTACGACGCTCAGCGCATCGGCCTGCGCCTCGTG
TGAACGATCGGATTGTGCCG

Product: zinc-containing alcohol dehydrogenase

Products: Glycerol; Nicotinamide adenine dinucleotide [C]

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MRRACRPARFAHARVRHARRRTRMRAGVPLPPFGTHRPHTTRRARSPLTGVESMKAIMLRQPAGLEHLERVTLTDPGAPA
AGEIRVRIHASSLNYHDLGVVTGRLSTADKRIPMSDGAGVVEAIGEGVTEFAVGDAVVSTFFPQWLDGGPSTADFATVPG
DGVDGYARETVVRPAHWFTHAPKGYTHEEAATLTTAGLTGWRALVVDGRLKAGDSVLVLGTGGVSIFALQFAKRMGATVI
ATSSSDEKLERARQLGADHVVNYRRDANWAAKVLEQTNGRDVDHVIEVGGPDTLPQSIQACRIGGHIALIGVLTGIAGPV
PTVALMARQQNLQGLIVGSRRHQIDMVRAIDATGIKPVIDRTFALDDIADAFSHQAAGKHFGKICLSI

Sequences:

>Translated_388_residues
MRRACRPARFAHARVRHARRRTRMRAGVPLPPFGTHRPHTTRRARSPLTGVESMKAIMLRQPAGLEHLERVTLTDPGAPA
AGEIRVRIHASSLNYHDLGVVTGRLSTADKRIPMSDGAGVVEAIGEGVTEFAVGDAVVSTFFPQWLDGGPSTADFATVPG
DGVDGYARETVVRPAHWFTHAPKGYTHEEAATLTTAGLTGWRALVVDGRLKAGDSVLVLGTGGVSIFALQFAKRMGATVI
ATSSSDEKLERARQLGADHVVNYRRDANWAAKVLEQTNGRDVDHVIEVGGPDTLPQSIQACRIGGHIALIGVLTGIAGPV
PTVALMARQQNLQGLIVGSRRHQIDMVRAIDATGIKPVIDRTFALDDIADAFSHQAAGKHFGKICLSI
>Mature_388_residues
MRRACRPARFAHARVRHARRRTRMRAGVPLPPFGTHRPHTTRRARSPLTGVESMKAIMLRQPAGLEHLERVTLTDPGAPA
AGEIRVRIHASSLNYHDLGVVTGRLSTADKRIPMSDGAGVVEAIGEGVTEFAVGDAVVSTFFPQWLDGGPSTADFATVPG
DGVDGYARETVVRPAHWFTHAPKGYTHEEAATLTTAGLTGWRALVVDGRLKAGDSVLVLGTGGVSIFALQFAKRMGATVI
ATSSSDEKLERARQLGADHVVNYRRDANWAAKVLEQTNGRDVDHVIEVGGPDTLPQSIQACRIGGHIALIGVLTGIAGPV
PTVALMARQQNLQGLIVGSRRHQIDMVRAIDATGIKPVIDRTFALDDIADAFSHQAAGKHFGKICLSI

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI22538446, Length=355, Percent_Identity=27.0422535211268, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI22538444, Length=355, Percent_Identity=27.0422535211268, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI47519420, Length=348, Percent_Identity=29.0229885057471, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI194239674, Length=334, Percent_Identity=26.6467065868263, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI13236495, Length=334, Percent_Identity=26.6467065868263, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI262073058, Length=295, Percent_Identity=27.1186440677966, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI71743840, Length=282, Percent_Identity=26.5957446808511, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI18379349, Length=335, Percent_Identity=25.0746268656716, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI28557745, Length=339, Percent_Identity=27.4336283185841, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI194239676, Length=229, Percent_Identity=28.82096069869, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI41872631, Length=315, Percent_Identity=25.7142857142857, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI156627571, Length=329, Percent_Identity=25.8358662613982, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI87081918, Length=318, Percent_Identity=26.1006289308176, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1787863, Length=358, Percent_Identity=26.536312849162, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1790485, Length=263, Percent_Identity=27.7566539923954, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1789651, Length=289, Percent_Identity=26.9896193771626, Blast_Score=62, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17507255, Length=326, Percent_Identity=25.4601226993865, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319520, Length=350, Percent_Identity=25.4285714285714, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323961, Length=305, Percent_Identity=25.9016393442623, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323729, Length=352, Percent_Identity=24.4318181818182, Blast_Score=73, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6323099, Length=354, Percent_Identity=24.5762711864407, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319955, Length=293, Percent_Identity=25.5972696245734, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6322619, Length=293, Percent_Identity=25.5972696245734, Blast_Score=70, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6319621, Length=350, Percent_Identity=25.1428571428571, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324486, Length=305, Percent_Identity=25.2459016393443, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24581345, Length=222, Percent_Identity=29.2792792792793, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI221330659, Length=221, Percent_Identity=29.4117647058824, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI19920632, Length=221, Percent_Identity=29.4117647058824, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.1 [C]

Molecular weight: Translated: 41550; Mature: 41550

Theoretical pI: Translated: 10.43; Mature: 10.43

Prosite motif: PS00012 PHOSPHOPANTETHEINE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRACRPARFAHARVRHARRRTRMRAGVPLPPFGTHRPHTTRRARSPLTGVESMKAIMLR
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHC
QPAGLEHLERVTLTDPGAPAAGEIRVRIHASSLNYHDLGVVTGRLSTADKRIPMSDGAGV
CCCCHHHHHEEEECCCCCCCCCEEEEEEEECCCCCCCCEEEECCCCCCCCCCCCCCCCHH
VEAIGEGVTEFAVGDAVVSTFFPQWLDGGPSTADFATVPGDGVDGYARETVVRPAHWFTH
HHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHCCCHHHHCC
APKGYTHEEAATLTTAGLTGWRALVVDGRLKAGDSVLVLGTGGVSIFALQFAKRMGATVI
CCCCCCCHHHHHEECCCCCCCEEEEEECCCCCCCEEEEEECCCHHHHHHHHHHHCCCEEE
ATSSSDEKLERARQLGADHVVNYRRDANWAAKVLEQTNGRDVDHVIEVGGPDTLPQSIQA
EECCCHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHCCCCCHHHHEECCCCCCCHHHHHH
CRIGGHIALIGVLTGIAGPVPTVALMARQQNLQGLIVGSRRHQIDMVRAIDATGIKPVID
HHCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCCHHHH
RTFALDDIADAFSHQAAGKHFGKICLSI
HHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRRACRPARFAHARVRHARRRTRMRAGVPLPPFGTHRPHTTRRARSPLTGVESMKAIMLR
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHC
QPAGLEHLERVTLTDPGAPAAGEIRVRIHASSLNYHDLGVVTGRLSTADKRIPMSDGAGV
CCCCHHHHHEEEECCCCCCCCCEEEEEEEECCCCCCCCEEEECCCCCCCCCCCCCCCCHH
VEAIGEGVTEFAVGDAVVSTFFPQWLDGGPSTADFATVPGDGVDGYARETVVRPAHWFTH
HHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHCCCHHHHCC
APKGYTHEEAATLTTAGLTGWRALVVDGRLKAGDSVLVLGTGGVSIFALQFAKRMGATVI
CCCCCCCHHHHHEECCCCCCCEEEEEECCCCCCCEEEEEECCCHHHHHHHHHHHCCCEEE
ATSSSDEKLERARQLGADHVVNYRRDANWAAKVLEQTNGRDVDHVIEVGGPDTLPQSIQA
EECCCHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHCCCCCHHHHEECCCCCCCHHHHHH
CRIGGHIALIGVLTGIAGPVPTVALMARQQNLQGLIVGSRRHQIDMVRAIDATGIKPVID
HHCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCCHHHH
RTFALDDIADAFSHQAAGKHFGKICLSI
HHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NAD+; NADH [C]

Metal ions: Co2+ Zn2+-depleted [C]

Kcat value (1/min): 150 [C]

Specific activity: 19

Km value (mM): 0.2 {tryptophol}} 0.0074 {NAD+}} 0.0069 {NAD+}} 13 {ethylene} 6 {methanol}} 27 {pentanol}} 0.44 {1-butanol}} 120 {ethanol}} 0.91 {acetaldehyde}} 0.1 {acetaldehyde}} 0.005 {1-octanol}} 0.004 {benzyl} 0.005 {cyclohe

Substrates: D-Glyceraldehyde; H+; Nicotinamide adenine dinucleotide - reduced [C]

Specific reaction: D-Glyceraldehyde + H+ + Nicotinamide adenine dinucleotide - reduced <==> Glycerol + Nicotinamide adenine dinucleotide [C]

General reaction: Redox reaction [C]

Inhibitor: 2, 2'-Bipyridyl; 4-Methyl pyrazole acetaldehyde; 8-Amino-6-methoxyquinoline; 8-Hydroxy quinoline-5-sulfonic acid; Acetaldehyde; Dipicolinic acid; EDTA; Ethanol; GSH; Heptafluorbutanol; Imidazole; Iodoacetamide; Iodoacetate; Isobutyramide EDTA; NAD+; NADH;

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]