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The map label for this gene is ilvY [H]

Identifier: 83720725

GI number: 83720725

Start: 3705670

End: 3707373

Strand: Reverse

Name: ilvY [H]

Synonym: BTH_I3250

Alternate gene names: 83720725

Gene position: 3707373-3705670 (Counterclockwise)

Preceding gene: 83720891

Following gene: 83718774

Centisome position: 97.33

GC content: 71.07

Gene sequence:

>1704_bases
ATGTCGATTTCCCCGGACCGCGAGCAGCGCGCCACCACCGGCGCACGGCTGCTCGTCGACGCCCTGCTCGCGAATCGCGT
CGAGCGCGTGTTCTGTGTTCCCGGCGAGAGCTTTCTCGCCGTCCTCGATTCCCTCGCCGACGAAACCGAGCGCATCCAGA
CCGTCGTCTGCCGGCACGAAGCCGCCGCCGCGAACATGGCGGAAGCCGTCGGCAAGCTGACCGGCCGGCCCGGCATCGCG
TTCGTCACGCGCGGCCCCGGCGCGACGCACGCGTCGATCGGCGTGCACACCGCCTTCCAGGATTCGACGCCGATGATCCT
CTTCATCGGCCAGTGCGCGCGCGAGCATCTCGATCGCGAGGCGTTCCAGGAAATCGACTATCGGCGCATGTTCGGCCAGC
TCGCGAAGTGGGTTGCGCAGATCGACGATCCGCGCCGCATTCCCGAATACCTGAGCCACGCGTTTCACGTCGCGATGTCG
GGCCGGCCCGGCCCCGTCGTGCTCGCGCTGCCCGAGGACGTGCTGTCCGAGCCGTGCGCCGCGCAACCCGTCGCCCCCGC
GGCGAAACGCATCGCCGCCGCGCCGTCGGCCGCGCAGATGAACGAGCTGCGCGAGCGGCTTTCGCGCGCTCGGCGGCCGC
TCGTGATCGCGGGCGGCAGCGGCTGGACGCCCGACGCGTGCGCGGATCTGCGCACGTTCGTCGAACGCTGGCAATTGCCG
ATCGCGTGCGCGTTCCGCTATCAGGACACGTTCGACAACGAGCATCCGCAGTACGCGGGCGACGTCGGCCTCGGCGTGAA
TCCCGAGCTCGCGCGCCGCATCCGCGATGCGGACCTGCTGTTCGCACTCGGCCCGCGCCTCGGCGAAGCGACGACGGGCG
GCTACACGCTGATCGACATTCCGAAGCCGAAGCAGGTGCTCGTCCACGTGCATCAGGGCGCGGACGAGCTGGGACGCGTC
TATGCGGCCGATCTGCCGATCGCCTCCGGCATGCCCGAGATCGCCGCGCAACTCGCCGCGCTCGAGCCGCCGGCATCGCC
CGCGTGGGCGGGCAGCGCCGCCGACGCGCATCGCGCGTATCTCGACTGGCGCGCGCCGCGGCCGATGCCGGGCGACGTGC
AGCTCGGCGACGTGATGCGGCAATTGCGCGAACGCCTGCCGCACGACGCGATCGTGACGAACGGCGCCGGCAACTACGCC
GCATGGCTGCACCGCCACTTCGCATACCGCCACTTCCGCTCGCAGCTCGCGCCGACAAGCGGCGCAATGGGTTACGGCGT
GCCGGCCGCGCTCGCGGCGAAGTCGCTGTATCCGCAACGCACGGTCGTCGCGCTCGCGGGCGACGGCTGCTTCATGATGG
CCGGCAACGAGCTCGCGACCGCGATCCAGTACGGGCTCGCGATCATCGTGCTCGTCGTGAACAACGGTCATTTCGGCACG
ATCCGCATGCATCAGGAGCGCAACTATCCGGCGCGCGTGCACGGCACCGGGCTCACGAACCCGGATTTCGCCGCGTATGC
GCGCGCGTTCGGGGCACACGGCGAGACGGTCGAGCGCACGGCCGATTTCCTGCCCGCGCTCGAACGCGCGCTCGCAAGCG
GTGCGCCCGCGCTGATCGAGATCCGCGTGCCGCAGGACGCGTGCACGCCCGCCGCGACGCTCGAGCAGGTGCGCGAGCAG
GGGTTGCGCGCGCGTCGCGCGTGA

Upstream 100 bases:

>100_bases
GCGCGCGAACATCGCTGCCCTGCAGCACGCGGGCGCGCCTTCCGTCGCCCCTTCAACCGGCGTAAGCTGTACGTCCCGCC
ACGAAGGGAGCCCGTCTTAT

Downstream 100 bases:

>100_bases
GTGGCCGCGCGGCCGACGAGCGCTCCCTCGCGATGACGATGACATTCGACGACACCACGCTGTCGCCCGCCGATGCGCTC
GCGTACCCCGGCACGCTGCT

Product: thiamine pyrophosphate protein

Products: NA

Alternate protein names: ALS; Acetohydroxy-acid synthase [H]

Number of amino acids: Translated: 567; Mature: 566

Protein sequence:

>567_residues
MSISPDREQRATTGARLLVDALLANRVERVFCVPGESFLAVLDSLADETERIQTVVCRHEAAAANMAEAVGKLTGRPGIA
FVTRGPGATHASIGVHTAFQDSTPMILFIGQCAREHLDREAFQEIDYRRMFGQLAKWVAQIDDPRRIPEYLSHAFHVAMS
GRPGPVVLALPEDVLSEPCAAQPVAPAAKRIAAAPSAAQMNELRERLSRARRPLVIAGGSGWTPDACADLRTFVERWQLP
IACAFRYQDTFDNEHPQYAGDVGLGVNPELARRIRDADLLFALGPRLGEATTGGYTLIDIPKPKQVLVHVHQGADELGRV
YAADLPIASGMPEIAAQLAALEPPASPAWAGSAADAHRAYLDWRAPRPMPGDVQLGDVMRQLRERLPHDAIVTNGAGNYA
AWLHRHFAYRHFRSQLAPTSGAMGYGVPAALAAKSLYPQRTVVALAGDGCFMMAGNELATAIQYGLAIIVLVVNNGHFGT
IRMHQERNYPARVHGTGLTNPDFAAYARAFGAHGETVERTADFLPALERALASGAPALIEIRVPQDACTPAATLEQVREQ
GLRARRA

Sequences:

>Translated_567_residues
MSISPDREQRATTGARLLVDALLANRVERVFCVPGESFLAVLDSLADETERIQTVVCRHEAAAANMAEAVGKLTGRPGIA
FVTRGPGATHASIGVHTAFQDSTPMILFIGQCAREHLDREAFQEIDYRRMFGQLAKWVAQIDDPRRIPEYLSHAFHVAMS
GRPGPVVLALPEDVLSEPCAAQPVAPAAKRIAAAPSAAQMNELRERLSRARRPLVIAGGSGWTPDACADLRTFVERWQLP
IACAFRYQDTFDNEHPQYAGDVGLGVNPELARRIRDADLLFALGPRLGEATTGGYTLIDIPKPKQVLVHVHQGADELGRV
YAADLPIASGMPEIAAQLAALEPPASPAWAGSAADAHRAYLDWRAPRPMPGDVQLGDVMRQLRERLPHDAIVTNGAGNYA
AWLHRHFAYRHFRSQLAPTSGAMGYGVPAALAAKSLYPQRTVVALAGDGCFMMAGNELATAIQYGLAIIVLVVNNGHFGT
IRMHQERNYPARVHGTGLTNPDFAAYARAFGAHGETVERTADFLPALERALASGAPALIEIRVPQDACTPAATLEQVREQ
GLRARRA
>Mature_566_residues
SISPDREQRATTGARLLVDALLANRVERVFCVPGESFLAVLDSLADETERIQTVVCRHEAAAANMAEAVGKLTGRPGIAF
VTRGPGATHASIGVHTAFQDSTPMILFIGQCAREHLDREAFQEIDYRRMFGQLAKWVAQIDDPRRIPEYLSHAFHVAMSG
RPGPVVLALPEDVLSEPCAAQPVAPAAKRIAAAPSAAQMNELRERLSRARRPLVIAGGSGWTPDACADLRTFVERWQLPI
ACAFRYQDTFDNEHPQYAGDVGLGVNPELARRIRDADLLFALGPRLGEATTGGYTLIDIPKPKQVLVHVHQGADELGRVY
AADLPIASGMPEIAAQLAALEPPASPAWAGSAADAHRAYLDWRAPRPMPGDVQLGDVMRQLRERLPHDAIVTNGAGNYAA
WLHRHFAYRHFRSQLAPTSGAMGYGVPAALAAKSLYPQRTVVALAGDGCFMMAGNELATAIQYGLAIIVLVVNNGHFGTI
RMHQERNYPARVHGTGLTNPDFAAYARAFGAHGETVERTADFLPALERALASGAPALIEIRVPQDACTPAATLEQVREQG
LRARRA

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=582, Percent_Identity=25.9450171821306, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI21361361, Length=575, Percent_Identity=24.3478260869565, Blast_Score=108, Evalue=9e-24,
Organism=Escherichia coli, GI87081685, Length=537, Percent_Identity=29.9813780260708, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI1790104, Length=541, Percent_Identity=27.7264325323475, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI1786717, Length=532, Percent_Identity=28.3834586466165, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1787096, Length=575, Percent_Identity=25.9130434782609, Blast_Score=129, Evalue=6e-31,
Organism=Escherichia coli, GI1788716, Length=581, Percent_Identity=24.7848537005164, Blast_Score=111, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17542570, Length=568, Percent_Identity=25.3521126760563, Blast_Score=125, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI17531301, Length=564, Percent_Identity=25.886524822695, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17531299, Length=564, Percent_Identity=25.886524822695, Blast_Score=119, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6323755, Length=556, Percent_Identity=25.8992805755396, Blast_Score=215, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6320816, Length=546, Percent_Identity=21.2454212454212, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323163, Length=540, Percent_Identity=22.037037037037, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI19922626, Length=483, Percent_Identity=26.7080745341615, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 61307; Mature: 61175

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSISPDREQRATTGARLLVDALLANRVERVFCVPGESFLAVLDSLADETERIQTVVCRHE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
AAAANMAEAVGKLTGRPGIAFVTRGPGATHASIGVHTAFQDSTPMILFIGQCAREHLDRE
HHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEEECCCCCEEEEHHHHHHHHHHHH
AFQEIDYRRMFGQLAKWVAQIDDPRRIPEYLSHAFHVAMSGRPGPVVLALPEDVLSEPCA
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEEECCCCCCEEEECCHHHHCCCCC
AQPVAPAAKRIAAAPSAAQMNELRERLSRARRPLVIAGGSGWTPDACADLRTFVERWQLP
CCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHCCC
IACAFRYQDTFDNEHPQYAGDVGLGVNPELARRIRDADLLFALGPRLGEATTGGYTLIDI
EEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHEECCCCCCCCCCCCEEEEEC
PKPKQVLVHVHQGADELGRVYAADLPIASGMPEIAAQLAALEPPASPAWAGSAADAHRAY
CCCHHHHEEECCCHHHHHHEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
LDWRAPRPMPGDVQLGDVMRQLRERLPHDAIVTNGAGNYAAWLHRHFAYRHFRSQLAPTS
EECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCC
GAMGYGVPAALAAKSLYPQRTVVALAGDGCFMMAGNELATAIQYGLAIIVLVVNNGHFGT
CCCCCCCHHHHHHHHCCCCCEEEEEECCCEEEEECHHHHHHHHHHHEEEEEEEECCCEEE
IRMHQERNYPARVHGTGLTNPDFAAYARAFGAHGETVERTADFLPALERALASGAPALIE
EEEECCCCCCCEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEE
IRVPQDACTPAATLEQVREQGLRARRA
EECCCHHCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SISPDREQRATTGARLLVDALLANRVERVFCVPGESFLAVLDSLADETERIQTVVCRHE
CCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
AAAANMAEAVGKLTGRPGIAFVTRGPGATHASIGVHTAFQDSTPMILFIGQCAREHLDRE
HHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEEECCCCCEEEEHHHHHHHHHHHH
AFQEIDYRRMFGQLAKWVAQIDDPRRIPEYLSHAFHVAMSGRPGPVVLALPEDVLSEPCA
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEEECCCCCCEEEECCHHHHCCCCC
AQPVAPAAKRIAAAPSAAQMNELRERLSRARRPLVIAGGSGWTPDACADLRTFVERWQLP
CCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHCCC
IACAFRYQDTFDNEHPQYAGDVGLGVNPELARRIRDADLLFALGPRLGEATTGGYTLIDI
EEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHEECCCCCCCCCCCCEEEEEC
PKPKQVLVHVHQGADELGRVYAADLPIASGMPEIAAQLAALEPPASPAWAGSAADAHRAY
CCCHHHHEEECCCHHHHHHEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
LDWRAPRPMPGDVQLGDVMRQLRERLPHDAIVTNGAGNYAAWLHRHFAYRHFRSQLAPTS
EECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCC
GAMGYGVPAALAAKSLYPQRTVVALAGDGCFMMAGNELATAIQYGLAIIVLVVNNGHFGT
CCCCCCCHHHHHHHHCCCCCEEEEEECCCEEEEECHHHHHHHHHHHEEEEEEEECCCEEE
IRMHQERNYPARVHGTGLTNPDFAAYARAFGAHGETVERTADFLPALERALASGAPALIE
EEEECCCCCCCEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEE
IRVPQDACTPAATLEQVREQGLRARRA
EECCCHHCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1512571 [H]